Enhanced neurotrophin-3 bioactivity and release from a nanoparticle-loaded composite hydrogel

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 666-675

  Stanwick, Jason C ^a   Baumann, M Douglas ^a,b   Shoichet, Molly S ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Drug delivery; Hydrogel; Nanoparticle; Neurotrophin 3; Poly(lactic co glycolic acid) (PLGA); Spinal cord injury

Indexed keywords

AXONAL OUTGROWTH; BIOACTIVE PROTEINS; CELL-BASED; CO-ENCAPSULATION; COMPOSITE HYDROGELS; CONTINUUM MODEL; CONTROLLED RELEASE; CONVENTIONAL METHODS; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYALURONAN; IN-VITRO; IN-VIVO; INJECTABLE HYDROGELS; LOCAL DELIVERY; MAGNESIUM CARBONATE; METHYL CELLULOSE; NANOPARTICLE FORMULATION; NEUROTROPHIN-3; PARTICLE SURFACE; PLGA NANOPARTICLES; POLY(LACTIC-CO-GLYCOLIC ACID); PROCESSING PARAMETERS; SPINAL CORD INJURIES (SCI); SUSTAINED RELEASE;

BIOACTIVITY; CELLULOSE; CONTINUUM MECHANICS; DRUG DELIVERY; DRUG PRODUCTS; NANOCOMPOSITE FILMS; NANOPARTICLES; PATIENT REHABILITATION; POLYETHYLENE GLYCOLS;

HYDROGELS;

EXCIPIENT; HYALURONIC ACID; MACROGOL; MAGNESIUM CARBONATE; METHYLCELLULOSE; NANOPARTICLE; NEUROTROPHIN 3; POLYGLACTIN; TREHALOSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; FEMALE; FREEZE DRYING; HYDROGEL; KINETICS; NANOENCAPSULATION; NANOFABRICATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; STORAGE; ULTRASOUND;

ANIMALS; EMBRYO, MAMMALIAN; FEMALE; GANGLIA, SPINAL; HUMANS; HYALURONIC ACID; HYDROGELS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MAGNESIUM; METHYLCELLULOSE; NANOPARTICLES; NEURITES; NEUROTROPHIN 3; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 84861980006     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.03.024     Document Type: Article

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