Poly (D,L-lactic acid) macroporous guidance scaffolds seeded with Schwann cells genetically modified to secrete a bi-functional neurotrophin implanted in the completely transected adult rat thoracic spinal cord

Biomaterials

Volumn 27, Issue 3, 2006, Pages 430-442

  Hurtado, Andres ^a   Moon, Lawrence D F ^a   Maquet, Véronique ^c   Blits, Bas ^a   Jérôme, Robert ^c   Oudega, Martin ^a,b  

^a UNIVERSITY OF MIAMI   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Apoptosis; BDNF; Biodegradable; Caspase 3; CNS regeneration; NT 3; Poly ( hydroxyacid); Polymer; Schwann cells; Spinal cord injury

Indexed keywords

CELLS; GENES; IMPLANTS (SURGICAL); NEUROLOGY;

APOPTOSIS; BDNF; BIODEGRADABLE; CNS REGENERATION; COSPASE-3; NT-3; POLY(Α-HYDROXYACID); SCHWANN CELL; SPINAL CHORD INJURY;

BIOMATERIALS;

CHONDROITIN SULFATE; FIBRIN; GLYCOSAMINOGLYCAN; GREEN FLUORESCENT PROTEIN; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN 3;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BIOLOGICAL ACTIVITY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HINDLIMB; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MOTOR PERFORMANCE; MYELINATION; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHWANN CELL; SPINAL GANGLION; SPINAL NERVE; THORACIC SPINAL CORD; TIME SERIES ANALYSIS; TRANSGENE; VASCULARIZATION;

ANIMALS; AXONS; BLOOD VESSELS; CELL ENLARGEMENT; CELL SURVIVAL; CHONDROITIN SULFATES; CULTURE MEDIA, CONDITIONED; FEMALE; GANGLIA, SPINAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEINS; GUIDED TISSUE REGENERATION; HINDLIMB; IMPLANTS, EXPERIMENTAL; LACTIC ACID; NEOVASCULARIZATION, PHYSIOLOGIC; NERVE FIBERS, MYELINATED; NERVE GROWTH FACTORS; NERVE REGENERATION; NEUROTROPHIN 3; POLYMERS; RATS; RATS, INBRED F344; SCHWANN CELLS; SPINAL CORD; SPINAL CORD INJURIES; THORACIC VERTEBRAE; TRANSFECTION;

EID: 26844448005     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2005.07.014     Document Type: Article

References (24)

1. A. Chen, X.M. Xu, N. Kleitman, and M.B. Bunge Methylprednisilone administration improves axonal regeneration into SC grafts in transected adult rat thoracic spinal cord Exp Neurol 138 1996 261 276
2. T. Takami, M. Oudega, M.L. Bates, P.M. Wood, N. Kleitman, and M.B. Bunge Schwann cell but not olfactory ensheathing glia transplants improve hindlimb performance in the moderately contused adult rat thoracic spinal cord J Neurosci 22 15 2002 6670 6681
3. X.M. Xu, V. Guenard, N. Kleitman, P. Aebischer, and M.B. Bunge A combination of BDNF and NT-3 promotes supraspinal axonal regeneration into Schwann cell grafts in adult rat thoracic spinal cord Exp. Neurol 134 1995 261 272
4. X.M. Xu, A. Chen, V. Guénard, N. Kleitman, and M.B. Bunge Bridging Schwann cell transplants promote axonal regeneration from both the proximal and distal stumps of transacted adult rat spinal cord J Neurocytol 26 1997 1 16
5. M. Oudega, X.M. Xu, V. Guenard, N. Kleitman, and M.B. Bunge A combination of insulin-like growth factor and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord Glia 19 1997 247 258
6. S.E. Gautier, M. Oudega, M. Fragoso, P. Chapon, G.W. Plant, and M.B. Bunge Poly(alpha-hydroxyacids) for application in the spinal cord: resorbability and biocompatibility with adult Schwann cells and spinal cord J Biomed Mater Res 42 1998 642 654
7. M. Oudega, S.E. Gautier, P. Chapon, M. Fragoso, M.L. Bates, and J.-M. Parel Axonal regeneration into Schwann cell grafts within resorbable poly(alpha-hydroxyacid) guidance channels in the adult rat spinal cord Biomaterials 22 10 2001 1125 1136
8. C.M. Patist, M.B. Mulder, S.E. Gautier, V. Maquet, R. Jerome, and M. Oudega Freeze-dried poly(d,l-lactic acid) macroporous guidance scaffolds impregnated with brain-derived neurotrophic factor in the transected adult rat thoracic spinal cord Biomaterials 25 9 2004 1569 1582
9. R. Urfer, P. Tsoulfas, D. Soppet, E. Escandon, L.F. Parada, and L.G. Presta The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin EMBO J 13 24 1994 5896 5909
10. P. Menei, C. Montero-Menei, S.R. Whittemore, R.P. Bunge, and M.B. Bunge Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord Eur J Neurosci 10 1998 607 621
11. T.K. Morrissey, N. Kleitman, and R.P. Bunge Isolation and functional characterization of Schwann cells derived from adult peripheral nerve J Neurosci 11 8 1991 2433 2442
12. B. Blits, P.A. Dijkhuizen, G.J. Boer, and J. Verhaagen Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function Exp Neurol 164 1 2000 25 37
13. P.A. Dijkhuizen, R.J. Pasterkamp, W.T. Hermens, F. de Winter, R.J. Giger, and J. Verhaagen Adenoviral vector-mediated gene delivery to injured rat peripheral nerve J Neurotrauma 15 6 1998 387 397
14. S. Blacher, V. Maquet, F. Schils, D. Martin, J. Schoenen, G. Moonen, R. Jerome, and J.-P. Pirard Image analysis of the axonal ingrowth into poly(d,l-lactide) porous scaffolds in relation to the 3-D porous structure Biomaterials 24 6 2003 1033 1044
15. V. Maquet, D. Martin, F. Scholtes, R. Franzen, J. Schoenen, and G. Moonen Poly(d,l-lactide) foams modified by poly(ethylene oxide)-block-poly(d,l- lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration Biomaterials 22 2001 1137 1146
16. S. Kumar The apoptotic cysteine protease CPP32 Int J Biochem Cell Biol 29 3 1997 393 396
17. D.M. Basso, M.S. Beattie, and J.C. Bresnahan A sensitive and reliable locomotor rating scale for open field testing in rats J Neurotrauma 12 1995 1 21
18. D.M. Basso, M.S. Beattie, and J.C. Bresnahan Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection Exp Neurol 139 1996 244 256
19. M.F.L. Meijs, L. Timmers, D.D. Pearse, P.A. Tresco, M.L. Bates, and E.A.J. Joosten Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord J Neurotrauma 2004 in press
20. B. Blits, M. Oudega, G.J. Boer, M.B. Bunge, and J. Verhaagen Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hindlimb function Neurosci 118 1 2003 271 281
21. M.S. Beattie, G.E. Hermann, R.C. Rogers, and J.C. Bresnahan Cell death in models of spinal cord injury Prog Brain Res 137 2002 37 47
22. C.H. Tator, and M.G. Fehlings Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms J Neurosurg 75 1 1991 15 26
23. K.L. Brewer, J.R. Bethea, and R.P. Yezierski Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury Exp Neurol 159 2 1999 484 493
24. J.D. Guest, A. Rao, L. Olson, M.B. Bunge, and R.P. Bunge The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord Exp Neurol 148 1997 502 522