Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling

Biochemical Journal

Volumn 421, Issue 3, 2009, Pages 473-482

  Schröfelbauer, Bärbel ^a,c   Raffetseder, Johanna ^a   Hauner, Maria ^a,d   Wolkerstorfer, Andrea ^a   Ernst, Wolfgang ^b   Szolar, Oliver H J ^a  

^a Onepharm Research and Development GmbH   (Austria)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Hepacult GmbH   (Germany)

Author keywords

Cell membrane; Cytokine; Glycyrrhizin; Inflammation; Signalling; Toll like receptor (TLR)

Indexed keywords

CYTOKINE; GLYCYRRHIZIN; INFLAMMATION; SIGNALLING; TOLL-LIKE RECEPTOR (TLR);

CYTOLOGY; DNA; GENES; LIPID BILAYERS; MACROPHAGES; MEMBRANES; NUCLEIC ACIDS; PATHOLOGY; SUGARS; TUMORS;

CELL MEMBRANES;

GLYCYRRHIZIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CELL SURFACE RECEPTOR; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CONCENTRATION RESPONSE; DOWN REGULATION; GENE EXPRESSION; GLYCYRRHIZA; IMMUNE RESPONSE; LIPID BILAYER; MICROARRAY ANALYSIS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; RECEPTOR BINDING; REGULATORY MECHANISM; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL MEMBRANE; GLYCYRRHIZA; GLYCYRRHIZIC ACID; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 69249228693     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082416     Document Type: Article

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