7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo

Biochemical and Biophysical Research Communications

Volumn 422, Issue 3, 2012, Pages 387-392

  Yu, Qing ^a,b   Chang, Qing ^b   Liu, Xia ^b   Gong, Shusheng ^a   Ye, Keqiang ^b   Lin, Xi ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

7,8,3' Trihydroxyflavone; Cochlea; Gjb2 deletion; Mouse model; Neuronal degeneration; Neurotrophic factors; Small molecule; Spiral ganglion neurons; TrkB receptor

Indexed keywords

7,8,3' TRIHYDROXYFLAVONE; CONNEXIN 26; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; DRUG POTENCY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SPIRAL GANGLION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL SURVIVAL; CYTOPROTECTION; FLAVONES; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTROPHIN 3; RECEPTOR, TRKB; SPIRAL GANGLION;

ANIMALIA; MUS;

EID: 84861930149     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.154     Document Type: Article

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