Effect of angiotensin type 2 receptor over-expression on the rat mesangial cell fibrotic phenotype: Effect of gender

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 13, Issue 2, 2012, Pages 221-231

  Pawluczyk, Izabella Z A ^a,b   Harris, Kevin P G ^a,b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Angiotensin type 2 receptor; fibrosis; mesangial cells

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; FIBRONECTIN; KALLIKREIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROSIS; GENE OVEREXPRESSION; GENETIC TRANSFECTION; KIDNEY FIBROSIS; MALE; MESANGIUM CELL; NONHUMAN; PHENOTYPE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SEX DIFFERENCE; SUPERNATANT; UPREGULATION;

EID: 84861902763     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320311432185     Document Type: Article

References (49)

1. Taal MW, Brenner BM. Renoprotective benefits of RAS inhibition: From ACE inhibitors to angiotensin II antagonists. Kidney Int. 2000 ; 57: 1803-1817 (Pubitemid 30252273)
2. Matsukawa T, Ichikawa I. Biological functions of angiotensin and its receptors. Ann Rev Physiol. 1997 ; 59: 395-412 (Pubitemid 27142448)
3. Siragy HM, Carey RM. Protective role of the angiotensin AT2 receptor in a renal wrap hypertension model. Hypertension. 1999 ; 33: 1237-1242 (Pubitemid 29230980)
4. Siragy HM, Inagami T, Ichiki T, Carey RM. Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype 2 (AT2) angiotensin receptor. Proc Natl Acad Sci USA. 1999 ; 96: 6506-6510 (Pubitemid 29256696)
5. Morrissey JJ, Klahr S. Effect of AT2 receptor blockade on the pathogenesis of renal fibrosis. Am J Physiol. 1999 ; 276: F39 - F45
6. Hashimoto N, Maeshima Y, Satoh M, et al. Overexpression of angiotensin type 2 receptor ameliorates glomerular injury in a mouse remnant kidney model. Am J Renal Physiol. 2004 ; 286: F516 - F525
7. Ohkubo N, Matsubara H, Nozawa Y, et al. Angiotensin type 2 receptors are re-expressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation. 1997 ; 96: 46-54
8. Esteban V, Ruperez M, Vita JR, et al. Effect of simultaneous blockade of AT1 and AT2 receptors on the NFΰB pathway and renal inflammatory response. Kidney Int. 2003 ; 64: S33 - S38
9. Horiuchi M, Akishita M, Dzau VJ. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension. 1999 ; 33: 613-621 (Pubitemid 29091636)
10. Dinh DT, Frauman AG, Johnston CI, Fabiani ME. Angiotensin receptors: distribution, signalling and function. Clin Sci. 2001 ; 100: 481-492 (Pubitemid 32434113)
11. Mog M, Iwai M, Horiuchi M. New insights into the regulation of angiotensin receptors. Curr Opin Nephrol Hypertension. 2009 ; 18: 138-143
12. Jin X-Q, Fukuda N, Su J-Z, et al. Angiotensin II type2 receptor gene transfer downregulates angiotensin II type 1a receptor in vascular smooth muscle cells. Hypertension. 2002 ; 39: 3255-3265
13. Li H, Qi Y, Li C, et al. Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells. Mol Cancer Ther. 2009 ; 8: 3255-3265
14. Pawluczyk IZA, Tan EKC, Harris KPG. Rat mesangial cells exhibit sex specific profibrotic and proinflammatory phenoptypes. Nephrol Dial Transpl. 2009 ; 24: 1753-1758
15. Komukai K, Mochizuki S, Yoshimura M. Grnder and the renin-angiotensin- aldosterone system. Fund Clin Pharmacol. 2010 ; 24: 687-698
16. Zimpelmann J, Burns KD. Angiotensin II AT2 receptors inhibit growth responses in proximal tubule cells. Am J Renal Physiol. 2001 ; 281: F300 - F308
17. Martin J, Knowlden J, Davies M, Williams JD. Identification and independent regulation of human mesangial cell metalloproteinases. Kidney Int. 1994 ; 46: 877-885 (Pubitemid 24272048)
18. Pawluczyk IZA, Tan EKC, Lodwick D, Harris KPG. Kallikrein gene 'knock-down' by siRNA transfection induces a pro-fibrotic phenotype in rat mesangial cells. J Hypertension. 2008 ; 26: 93-101 (Pubitemid 350294854)
19. Sade K, Schwartz D, Wolman Y, et al. Time course of lipopolysaccharide- induced nitric oxide synthase mRNA expression in rat glomeruli. J Lab Clin Med. 1999 ; 134: 471-477 (Pubitemid 29530696)
20. Tamura T, Jamous MA, Kitazato KT, et al. Endothelial damage due to impaired nitric oxide bioavailability triggers cerebral aneurysm formation in female rats. J Hypertension. 2009 ; 27: 1284-1292
21. Sim M-K, Chen W-S. Effects of losartan on angiotensin receptors in the hypertrophic rat heart. Regul Peptides. 2006 ; 137: 140-146 (Pubitemid 44838979)
22. Schmid C, Castrop H, Reitbauer J, Della Bruna R, Kurtz A. Dietary salt intake modulates angiotensin II type 1 receptor gene expression. Hypertension. 1997 ; 29: 923-929 (Pubitemid 27152460)
23. Pawluczyk IZA, Harris KPG. Macrophages promote pro-sclerotic responses in cultured rat mesangial cells. A mechanism for the initiation of glomerulosclerosis. J Am Soc Nephrol. 1997 ; 8: 1525-1536 (Pubitemid 27496470)
24. Tsutsumi Y, Matsubara H, Masaki , et al. Angiotensin II type 2 receptor over-expression activates the vascular kinin system nd causes vasodilation. J Clin Invest. 1999 ; 104: 925-935 (Pubitemid 29536342)
25. IZA Pawluczyk, Patel SR, Harris KPG. Pharmacological enhancement of the kallikrein-kinin system promotes anti-fibrotic responses in human mesangial cells. Cell Physiol Biochem. 2006 ; 18: 327-336 (Pubitemid 44948043)
26. Brassard P, Amiri F, Schiffrin EL. Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodelling and matrix metalloproteinases in resistance arteries. Hypertension. 2005 ; 46: 589-606
27. Mancina R, De Gasparo M, Thomas K, De Hertogh R. Sex steroid modulation of AT2 receptors in human myometrium. J Clin Endocrinol Metab. 1996 ; 81: 1753-1757 (Pubitemid 26152458)
28. Seltzer A, Pinto JE, Viglione PN, et al. Estrogens regulate angiotensin-converting enzyme and angiotensin receptors in female rat anterior pituitary. Neuroendocrinology. 1992 ; 55: 460-467
29. Silva-Antonialli MM, Tostes RC, Fernandes L, et al. A lower ration of AT1/AT2 receptors of angiotensin II is found in female than in male spontaneously hypertensive rats. Cardiovascular Res. 2004 ; 62: 587-93 (Pubitemid 38648973)
30. Kurisu S, Ozono R, Oshima T, et al. Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension. 2003 ; 41: 99-107 (Pubitemid 36056799)
31. Ichiki T, Kambayashi Y, Inagami T. Multiple growth factors modulate mRNA expression of angiotensin type 2 receptor in R3T3 cells. Circ Res. 1995 ; 77: 1070-1076
32. Jing T, Wang H, Srivenugopal KS, et al. Conditional expression of type 2 angiotensin II receptor in rat vascular smooth muscle cells reveals the interplay of the angiotensin system in matrix metalloproteinase 2 expression and vascular remodelling. Int J Mol Med. 2009 ; 24: 103-110
33. Krishnamurthi K, Verbalis JG, Zheng W, Wu Z, Clerch LB, Sandberg K. Estrogen regulates angiotensin AT1 receptor expression via cytosolic proteins that bind to the 5′ leader sequence of the receptor mRNA. Endocrinology. 1999 ; 140: 5435-5438
34. Sullivan JC, Semprun-Prieto L, Boesen EI, Pollock DM, Pollock JS. Sex and sex hormones influence the development of albumniuria and renal macrophage infiltration in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2007 ; 293: R1573 - R1579
35. Naito T, Ma L-J, Yang H, et al. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis. Am J Physiol Renal Physiol. 2010 ; 298: F683 - F691
36. Pawluczyk IZA, Patel SR, Harris KPG. The role of bradykinin in the anti-fibrotic effects of perindoprilat on human mesangial cells. Kidney Int. 2004 1251 ; 65 :
37. Pawluczyk IZA, Patel SR, Harris KPG. The role of the alpha 1 adrenoceptor in modulating human mesangial cell matrix production. Nephrol Dial Transpl. 2006 ; 21: 2417-2424 (Pubitemid 44644512)
38. Madeddu P, Emanueli C, Song Q, et al. Regulation of bradykinin B2receptor expression by estrogen. Br J Pharmacol. 1997 ; 121: 1763-1769 (Pubitemid 27343408)
39. Millat LJ, Abdel-Rahman EM, Siragy HM. AngiotensinII and nitric oxide: a question of balance. Regul Pept. 1999 ; 81: 10
40. Wang PHM, Cenedeze MA, Campanholle G, et al. Deletion of bradykinin B1 receptor reduces renal fibrosis. Int Immunopharmacol. 2008 ; 9: 653-657
41. Wang PH, Campanholle G, Cenedeze MA, et al. Bradykinin B1 receptor antagonism is beneficial in renal ischemia-reperfusion injury. PLoS ONE. 2008 ; 3: e3050
42. Kakoki M, McGarrah RW, Kim HS, Smithies O. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci USA. 2007 ; 104: 7576-7581 (Pubitemid 47185948)
43. Noda M, Kariura Y, Pannasch U, Nishikawa K, Wang L, Seike T, et al. Neuroprotective role of bradykinin because of the attenuation of pro-inflammatory cytokine release from activated microglia. J Neurochem. 2007 ; 101: 397-410 (Pubitemid 46525267)
44. Pawluczyk IZA, Harris KPG. ACE inhibitors ameliorate macrophage stimulated mesangial cell fibronectin production 1995;. Nephrol Dial Transpl. 1995 2392 ; 10 :
45. Anderson PW, Zhang XY, Tian J, et al. Insulin and angiotensin II are additive in stimulating TGFβ1 and matrix mRNAs in mesangial cells. Kidney Int. 1996 ; 50: 745-753 (Pubitemid 26302661)
46. Miura S, Karnik SS. Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis. EMBO J. 2002 ; 19: 4026-4035
47. Miura S, Karnik SS, Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signalling independent of receptor conformation and ligand stimulation. J Biol Chem. 2005 ; 280: 18237-18244 (Pubitemid 41389069)
48. Koike G, Horiuchi M, Yamada Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 ; 203: 1842-1850 (Pubitemid 24321580)
49. Lane PH. Estrogen receptors in the kidney: lessons from genetically altered mice. Gender Med. 2008 ; 5: S11 - S18