Effects of losartan on angiotensin receptors in the hypertrophic rat heart

Regulatory Peptides

Volumn 137, Issue 3, 2006, Pages 140-146

  Sim, Meng Kwoon ^a   Chen, Woei Shin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Angiotensins; AT1 receptors; Binding studies; Cardiac hypertrophy; Losartan; Rats

Indexed keywords

ANGIOTENSIN II [1 SARCOSINE 8 ISOLEUCINE]; ANGIOTENSIN RECEPTOR; IODINE 125; LOSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA COARCTATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

1-SARCOSINE-8-ISOLEUCINE ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BASE SEQUENCE; CARDIOMEGALY; DNA PRIMERS; DOWN-REGULATION; LOSARTAN; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RNA, MESSENGER;

EID: 33751528185     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2006.07.002     Document Type: Article

References (24)

1. 1 expression. Hypertension 23 (1994) 587-592
2. Inagami T., Guo D.F., and Kitami Y. Molecular biology of angiotensin II receptor: an overview. J Hypertens 12 suppl 10 (1994) S83-S94
3. 2 receptors in ventricles of hypertrophic rat hearts. Regul Pept 117 (2004) 207-212
4. 2-receptor subtypes in hypertrophied rats hearts. Am J Physiol 267 (1994) H844-H852
5. Nunez E., Hosoya K., Susic D., and Frohlich E.D. Enalapril and losartan reduced cardiac mass and improved coronary hemodynamics in SHR. Hypertension 29 (1997) 519-524
6. Mizuno K., Tani M., Hashimoto S., Niimura S., Sanada H., Watanabe H., Ohtsuki M., and Fukuchi S. Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats. Life Sci 51 (1992) 367-374
7. Everett A.D., Fisher A., McReddie A.T., and Harris M. Development regulation of angiotensin type 1 and 2 receptor gene expression and heart growth. J Mol Cell Cardiol 29 (1997) 141-148
8. Kitami Y., Okura T., Marumoto K., Wakamiya R., and Hiwada K. Differential gene expression and regulation of type-1 angiotensin II receptor subtypes in the rat. Biochem Biophys Res Commun 188 (1992) 446-452
9. Christen Y., Waeber B., Nussberger J., Porchet M., Borland R.M., Lee R.J., Maggon K., Shum L., Timmermans P.B., and Brunner H.R. Oral a ministration of DuP753, a specific angiotenisn II receptor antagonist, to normal male volunteers: inhibition of pressor response to exogenous angiotensin I and II. Circulation 83 (1991) 1333-1342
10. Goldberg M.R., Tanaka W., Barchowsky A., Bradstreet T.E., McCrea J., Lo M.W., McWilliams Jr. E.J., and Bjornsson T.D. Effects of losartan on blood pressure, plasma renin activity and angiotensin II in volunteers. Hypertension 21 (1993) 704-713
11. 1-angiotensin I analogues on rabbit pulmonary artery. Regul Pept 106 (2002) 39-46
12. 1) receptor-mediated accumulation of angiotensin II in tissues and its intracellular half-life intracellular half-life in vivo. Hypertension 30 (1997) 42-49
13. Zahradka k.P., Yau L., Lalonde C., Buchko J., and Thomas S. Modulation of the vascular smooth muscle angiotensin subtype 2 (AT2) receptor by angiotensin II. Biochem Biophys Res Commun 252 (1998) 476-480
14. Shibata K., Makino I., Shibaguchi H., Niwa M., Katsuragi T., and Furukawa T. Up-regulation of angiotensin type-2 receptor mRNA by angiotensin II in rat cortical cells. Biochem Biophys Res Commun 239 (1997) 633-637
15. Mukawa H., Toki Y., Miyazaki Y., Matsui H., Okumura K., and Ito T. Angiotensin II type 2 receptor blockade partially negates antihypertrophic effects of type 1 receptor blockade on pressure-overload rat cardiac hypertrophy. Hypertens Res 26 (2003) 89-95
16. Jones E.S., Black M.J., and Widdop R.E. Angiotensin AT2 receptor contributes to cardiovascular remodeling of aged rats during chronic AT1 receptor blockade. J Mol Cell Cardiol 37 (2004) 1023-1030
17. Miura S., and Karnik S.S. Ligand-independent signals from angiotensin II type 2 receptor induces apoptosis. EMBO J 19 (2000) 4026-4035
18. Miuri S., Karnik S.S., and Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation. J Biol Chem 280 (2005) 18237-18244
19. 1 blockade and angiotensin-converting enzyme (ACE) inhibition in (CHF 146) cardiomyopathic hamsters: effect on cardiac hypertrophy and survival. Cardiovasc Res 43 (1999) 77-85
20. Wollert K.C., and Drexler H. The renin-angiotensin system and experimental heart failure. Cardiovasc Res 43 (1999) 838-849
21. 2 receptor, and nuclear factor-κB activation. Kidney Int 61 (2002) 2272-2273
22. Phillips S.A., Drenjancevic-Peric I., Fribee J.C., and Lombard J.H. Chronic AT1 receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries. Am J Physiol 287 (2004) H545-H552
23. Zhu J.j., Yu M., Friesema J., Huang T., Roman R.J., and Lombard J.H. Salt-induced angiotensin II suppression impairs the response of cerebral artery smooth muscle cells to prostaglandin. Am J Physiol 288 (2005) H908-H913
24. Drenjancevic-Peric I., and Lombard J.H. Reduced angiotensin II and oxidative stress contribute to impaired vasodilation in Dahl salt-sensitive rats on low-salt diet. Hypertension 45 (2005) 687-691