Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo

British Journal of Nutrition

Volumn 104, Issue 3, 2010, Pages 336-345

  Boomgaarden, Inka ^a   Egert, Sarah ^a   Rimbach, Gerald ^a   Wolffram, Siegfried ^a   Müller, Manfred J ^a   Döring, Frank ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Microarrays; Monocytes; Placebo controlled studies; Quercetin

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; EARLY GROWTH RESPONSE FACTOR 1; GALACTOSYLTRANSFERASE; GANGLIOSIDE GM2; GLYCAN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANZYME A; HEPATOMA DERIVED GROWTH FACTOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 7 RECEPTOR; JANUS KINASE 1; JANUS KINASE 2; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANGANESE SUPEROXIDE DISMUTASE; N ACETYLGALACTOSAMINE 3 BETA GALACTOSYLTRANSFERASE 1; PLACEBO; QUERCETIN; RNA; SERINE PROTEINASE INHIBITOR; SIALYLTRANSFERASE; SIGMA OPIATE RECEPTOR; STAT1 PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTOME; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; NUCLEIC ACID; PLANT EXTRACT; POLYSACCHARIDE;

ADULT; APOPTOSIS; ARTICLE; CARBOHYDRATE SYNTHESIS; CARDIOVASCULAR RISK; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; FEMALE; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IN VIVO STUDY; LIPID METABOLISM; MALE; METHODOLOGY; MICROARRAY ANALYSIS; MONOCYTE; NUCLEIC ACID METABOLISM; PATIENT COMPLIANCE; PHENOTYPE; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VOLUNTEER; BIOSYNTHESIS; CARDIOVASCULAR DISEASE; CONTROLLED CLINICAL TRIAL; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK;

ADULT; ANTIOXIDANTS; APOPTOSIS; CARDIOVASCULAR DISEASES; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; IMMUNE SYSTEM; MALE; MIDDLE AGED; MONOCYTES; NUCLEIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PLANT EXTRACTS; POLYSACCHARIDES; QUERCETIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK; YOUNG ADULT;

EID: 77955482085     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510000711     Document Type: Article

References (39)

1. Hertog MG, Feskens EJ, Hollman PC, et al. (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007-1011.
2. Sampson L, Rimm E, Hollman PC, et al. (2002) Flavonol and flavone intakes in US health professionals. J Am Diet Assoc 102, 1414-1420.
3. Day AJ, Mellon F, Barron D, et al. (2001) Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 35, 941-952.
4. Arts IC & Hollman PC (2005) Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr 81, 317S-325S.
5. Williamson G & Manach C (2005) Bioavailability and bioeffi-cacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81, 243S-255S.
6. Ames BN (1983) Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221, 1256-1264.
7. Halliwell B (1993) The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis 23, Suppl. 1, 118-126.
8. Houstis N, Rosen ED & Lander ES (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944-948.
9. Formica JV & Regelson W (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 33, 1061-1080.
10. Kawai Y, Nishikawa T, Shiba Y, et al. (2008) Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 283, 9424-9434.
11. Lodi F, Jimenez R, Moreno L, et al. (2009) Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endo-thelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis 204, 34-39.
12. Boesch-Saadatmandi C, Pospissil RT, Graeser AC, et al. (2009) Effect of quercetin on paraoxonase 2 levels in RAW264.7 macrophages and in human monocytes-role of quercetin metabolism. Int J Mol Sci 10, 4168-4177.
13. Murtaza I, Marra G, Schlapbach R, et al. (2006) A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray. Biotechnol Appl Biochem 45, 29-36.
14. Soundararajan R, Wishart AD, Rupasinghe HP, et al. (2008) Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem 283, 2231-2245.
15. van Erk MJ, Roepman P, van der Lende TR, et al. (2005) Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr 44, 143-156.
16. de Boer VC, van Schothorst EM, Dihal AA, et al. (2006) Chronic quercetin exposure affects fatty acid catabolism in rat lung. Cell Mol Life Sci 63, 2847-2858.
17. Dihal AA, van der Woude H, Hendriksen PJ, et al. (2008) Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis. Proteomics 8, 45-61.
18. Boots AW, Wilms LC, Swennen EL, et al. (2008) In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition 24, 703-710.
19. de Pascual-Teresa S, Johnston KL, DuPont MS, et al. (2004) Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo. J Nutr 134, 552-557.
20. Mutch DM, Crespy V, Clough J, et al. (2006) Hepatic cyto-chrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver. Am J Physiol Gastrointest Liver Physiol 291, G63-G72.
21. Egert S, Wolffram S, Bosy-Westphal A, et al. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138, 1615-1621.
22. Egert S, Bosy-Westphal A, Seiberl J, et al. (2009) Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr 102, 1065-1074.
23. Klapper M, Dopner M, Vock C, et al. (2006) Expression analysis of genes involved in fat assimilation in human monocytes. IUBMB Life 58, 435-440.
24. Dennis G Jr, Sherman BT, Hosack DA, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4, P3.
25. Brazma A, Hingamp P, Quackenbush J, et al. (2001) Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29, 365-371.
26. 10 on release of pro-inflammatory chemokines in the human monocytic cell line THP-1. Biofactors 31, 211-217.
27. Tsuchiya S, Yamabe M, Yamaguchi Y, et al. (1980) Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer 26, 171-176.
28. 2DDCT method. Methods 25, 402-408.
29. Eady JJ, Wortley GM, Wormstone YM, et al. (2005) Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers. Physiol Genomics 22, 402-411.
30. Radich JP, Mao M, Stepaniants S, et al. (2004) Individual-specific variation of gene expression in peripheral blood leukocytes. Genomics 83, 980-988.
31. Whitney AR, Diehn M, Popper SJ, et al. (2003) Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci \USA 100, 1896-1901.
32. Lyons PA, Koukoulaki M, Hatton A, et al. (2007) Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification. BMC Genomics 8, 64.
33. Pagmantidis V, Meplan C, van Schothorst EM, et al. (2008) Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr 87, 181-189.
34. McEver RP (2002) Selectins: lectins that initiate cell adhesion under flow. Curr Opin Cell Biol 14, 581-586.
35. Sperandio M (2006) Selectins and glycosyltransferases in leukocyte rolling in vivo. FEBS J 273, 4377-4389. (Pubitemid 44401589)
36. Sperandio M, Thatte A, Foy D, et al. (2001) Severe impairment of leukocyte rolling in venules of core 2 glucosaminyl-transferase-deficient mice. Blood 97, 3812-3819.
37. Babaev VR, Chew JD, Ding L, et al. (2008) Macro-phage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab 8, 492-501.
38. Ermak N, Lacour B, Drueke TB, et al. (2008) Role of reactive oxygen species and Bax in oxidized low density lipo-protein-induced apoptosis of human monocytes. Atherosclerosis 200, 247-256.
39. Stoneman V, Braganza D, Figg N, et al. (2007) Monocyte/ macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ Res 100, 884-893.