Erratum: Genetic modifiers of hypertension in soluble guanylate cyclase a1-deficient mice (Journal of Clinical Investigation (2012) 122, 6 (2316-2325) DOI:10.1172/JCI60119);Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice

Journal of Clinical Investigation

Volumn 122, Issue 6, 2012, Pages 2316-2325

  Buys, Emmanuel S ^a   Raher, Michael J ^a   Kirby, Andrew ^b   Mohd, Shahid ^a   Baron, David M ^a   Hayton, Sarah R ^a   Tainsh, Laurel T ^a   Sips, Patrick Y ^a   Rauwerdink, Kristen M ^a   Yan, Qingshang ^c   Tainsh, Robert E T ^a   Shakartzi, Hannah R ^a   Stevens, Christine ^b   Decaluwé, Kelly ^d   Rodrigues Machado, Maria Da Gloria ^a   Malhotra, Rajeev ^a   Van De Voorde, Johan ^d   Wang, Tong ^c   Brouckaert, Peter ^d,e   Daly, Mark J ^b   Bloch, Kenneth D ^a   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GHENT UNIVERSITY   (Belgium)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; ENALAPRIL; GUANYLATE CYCLASE; GUANYLATE CYCLASE ALPHA 1; LOSARTAN; PLACEBO; RENIN; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 1; CONTROLLED STUDY; DNA MODIFICATION; ENZYME DEFICIENCY; GENETIC CODE; HUMAN; HYPERTENSION; LINKAGE ANALYSIS; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; VASODILATATION;

EID: 84861806608     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI65763     Document Type: Erratum

References (85)

1. Fields LE, Burt VL, Cutler JA, Hughes J, Roccella EJ, Sorlie P. The burden of adult hypertension in the United States 1999 to 2000: a rising tide. Hypertension. 2004;44(4):398-404. (Pubitemid 39281486)
2. Kung H-C, Hoyert DL, Xu J, Murphy SL. Deaths: final data for 2005. Natl Vital Stat Rep. 2008;56(10):1-120.
3. Newton-Cheh C, et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009;41(6):666-676.
4. Newton-Cheh C, et al. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet. 2009;41(3):348-353.
5. Conen D, Cheng S, Steiner LL, Buring JE, Ridker PM, Zee RY. Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. J Hypertens. 2009;27(3):476-483.
6. Kato N, et al. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet. 2011;43(6):531-538.
7. Ehret GB, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011;478(7367):103-109.
8. Johnson AD, et al. Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension. 2011;57(5):903-910.
9. Ruilope LM. Hypertension in 2010: blood pressure and the kidney. Nat Rev Nephrol. 2011;7(2):73-74.
10. Mendelsohn ME. In hypertension, the kidney is not always the heart of the matter. J Clin Invest. 2005;115(4):840-844. (Pubitemid 40489387)
11. Michael SK, et al. High blood pressure arising from a defect in vascular function. Proc Natl Acad Sci U S A. 2008;105(18):6702-6707. (Pubitemid 351754570)
12. Rees DD, Palmer RM, Moncada S. Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci U S A. 1989;86(9):3375-3378. (Pubitemid 19129614)
13. Huang PL, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995;377(6546):239-242.
14. Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med. 1990;323(1):22-27. (Pubitemid 20209468)
15. Friebe A, Mergia E, Dangel O, Lange A, Koesling D. Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007;104(18):7699-7704. (Pubitemid 47185969)
16. Russwurm M, Behrends S, Harteneck C, Koesling D. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem J. 1998;335(pt 1):125-130. (Pubitemid 28477058)
17. Mergia E, Russwurm M, Zoidl G, Koesling D. Major occurrence of the new alpha(2)beta(1) isoform of NO-sensitive guanylyl cyclase in brain. Cell Signal. 2003;15(2):189-195. (Pubitemid 35449122)
18. Buys ES, et al. Gender-specific hypertension and responsiveness to nitric oxide in sGC{alpha}1 knockout mice. Cardiovasc Res. 2008;79(1):179-186. (Pubitemid 351881935)
19. Nimmegeers S, Sips P, Buys E, Brouckaert P, Van de Voorde J. Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res. 2007;76(1):149-159. (Pubitemid 47362046)
20. Sips PY, Brouckaert P, Ichinose F. The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. Basic Res Cardiol. 2011;106(4):635-643.
21. Buys ES, et al. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009;297(2):H654-H663.
22. Rapp JP, Wang SM, Dene H. A genetic polymorphism in the renin gene of Dahl rats cosegregates with blood pressure. Science. 1989;243(4890):542-544. (Pubitemid 19048756)
23. Piccini N, Knopf JL, Gross KW. A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Cell. 1982;30(1):205-213. (Pubitemid 13237098)
24. Dickinson DP, Gross KW, Piccini N, Wilson CM. Evolution and variation of renin genes in mice. Genetics. 1984;108(3):651-667. (Pubitemid 15208410)
25. Field LJ, Gross KW. Ren-1 and Ren-2 loci are expressed in mouse kidney. Proc Natl Acad Sci U S A. 1985;82(18):6196-6200. (Pubitemid 16223925)
26. Vanneste G, Dhaese I, Sips P, Buys E, Brouckaert P, Lefebvre RA. Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice. J Physiol. 2007;584(pt 3):907-920. (Pubitemid 350031931)
27. Atochin DN, et al. Soluble guanylate cyclase alpha-1beta1 limits stroke size and attenuates neurological injury. Stroke. 2010;41(8):1815-1819.
28. Levy D, et al. Genome-wide association study of blood pressure and hypertension. Nat Genet. 2009;41(6):677-687.
29. Azam M, Gupta G, Chen W, Wellington S, Warburton D, Danziger RS. Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat. Hypertension. 1998;32(1):149-154. (Pubitemid 28324139)
30. Hilbert P, et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature. 1991;353(6344):521-529.
31. Jacob HJ, et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991;67(1):213-224. (Pubitemid 121001437)
32. Deng Y, Rapp JP. Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl saltsensitive rats. Nat Genet. 1992;1(4):267-272.
33. Wade CM, Daly MJ. Genetic variation in laboratory mice. Nat Genet. 2005;37(11):1175-1180. (Pubitemid 41568696)
34. Hoit BD, et al. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics. 2002;79(5):679-685. (Pubitemid 34499483)
35. Gurley SB, et al. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006;116(8):2218-2225. (Pubitemid 44162331)
36. Lum C, Shesely EG, Potter DL, Beierwaltes WH. Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension. 2004;43(1):79-86. (Pubitemid 38031914)
37. Salzler HR, et al. Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus. Kidney Int. 2007;72(10):1226-1232. (Pubitemid 350059664)
38. Deng AY, Dene H, Rapp JP. Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest. 1994;94(1):431-436. (Pubitemid 24218122)
39. Pravenec M, et al. Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J Clin Invest. 1995;96(4):1973-1978.
40. Wright FA, et al. Genome scan for blood pressure loci in mice. Hypertension. 1999;34(4 pt 1):625-630. (Pubitemid 29496444)
41. Rapp JP. Genetic analysis of inherited hypertension in the rat. Physiol Rev. 2000;80(1):135-172. (Pubitemid 30060563)
42. Stoll M, et al. New target regions for human hypertension via comparative genomics. Genome Res. 2000;10(4):473-482. (Pubitemid 30259077)
43. Moore N, et al. Renin gene polymorphisms and haplotypes, blood pressure, and responses to reninangiotensin system inhibition. Hypertension. 2007;50(2):340-347. (Pubitemid 47205783)
44. Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. Eur J Hum Genet. 2009;17(12):1650-1657.
45. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007;59(3):251-287. (Pubitemid 47481436)
46. Peters J, Munter K, Bader M, Hackenthal E, Mullins JJ, Ganten D. Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium. J Clin Invest. 1993;91(3):742-747. (Pubitemid 23095245)
47. Jacke K, Witte K, Lemmer B. Mechanisms involved in the blunted nitric oxide-cGMP pathway in hypertensive TGR(mREN2)27 rats. Eur J Pharmacol. 2001;415(1):27-30. (Pubitemid 32197615)
48. Campbell DJ, Valentijn AJ, Condron R. Purification and amino-terminal sequence of rat kidney renin: evidence for a two-chain structure. J Hypertens. 1991;9(1):29-33.
49. Inagami T. Structure and function of renin. J Hypertens Suppl. 1989;7(2):S3-S8. (Pubitemid 19133426)
50. Brunner H, et al. Endothelial function and dysfunction. Part II: association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23(2):233-246. (Pubitemid 40279622)
51. Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011;123(20):2263-2273.
52. Wagner C, Kurtz A. Regulation of renal renin release. Curr Opin Nephrol Hypertens. 1998;7(4):437-441. (Pubitemid 28341758)
53. Lu M, Wang X, Wang W. Nitric oxide increases the activity of the apical 70-pS K+ channel in TAL of rat kidney. Am J Physiol. 1998; 274(5 pt 2):F946-F950.
54. Wang WH. The cGMP-dependent protein kinase stimulates the basolateral 18-pS K channel of the rat CCD. Am J Physiol Cell Physiol. 2000; 278(6):C1212-C1217. (Pubitemid 30432405)
55. Maron BA, et al. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem. 2009;284(12):7665-7672.
56. Crowley SD, et al. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest. 2005; 115(4):1092-1099. (Pubitemid 40489414)
57. Pentz ES, Lopez ML, Kim HS, Carretero O, Smithies O, Gomez RA. Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiol Genomics. 2001;6(1):45-55. (Pubitemid 33676474)
58. Hatakeyama H, Miyamori I, Fujita T, Takeda Y, Takeda R, Yamamoto H. Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells. J Biol Chem. 1994;269(39):24316- 24320.
59. Jaffe IZ, et al. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest. 2010;120(11):3891-3900.
60. Cat AN, Touyz RM. A new look at the renin-angiotensin system - focusing on the vascular system. Peptides. 2011;32(10):2141-2150.
61. Romagni P, Rossi F, Guerrini L, Quirini C, Santiemma V. Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis. 2003;166(2):345-349. (Pubitemid 36071693)
62. Schmidt BM, et al. Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension. 2003;42(2):156-160. (Pubitemid 36944589)
63. Meurer S, et al. Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation. Circ Res. 2009; 105(1):33-41.
64. Stasch JP, et al. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest. 2006;116(9):2552-2561.
65. Reckelhoff JF. Sex steroids, cardiovascular disease, and hypertension: unanswered questions and some speculations. Hypertension. 2005;45(2):170-174. (Pubitemid 40179952)
66. Ingelfinger JR, Pratt RE, Roth TP, Dzau VJ. Processing of one-chain to two-chain renin in the mouse submandibular gland is influenced by androgen. Pediatr Res. 1989;25(4):332-335. (Pubitemid 19099801)
67. Tronik D, Rougeon F. Thyroxine and testosterone transcriptionally regulate renin gene expression in the submaxillary gland of normal and transgenic mice carrying extra copies of the Ren2 gene. FEBS Lett. 1988;234(2):336-340.
68. Baltatu O, Cayla C, Iliescu R, Andreev D, Jordan C, Bader M. Abolition of hypertension-induced endorgan damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. J Am Soc Nephrol. 2002;13(11):2681-2687. (Pubitemid 35216036)
69. Krege JH, et al. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995;375(6527):146-148.
70. O'Donnell CJ, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation. 1998;97(18):1766-1772.
71. Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov. 2006;5(9):755-768. (Pubitemid 44323702)
72. Stasch JP, Dembowsky K, Perzborn E, Stahl E, Schramm M. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol. 2002;135(2):344-355. (Pubitemid 34151166)
73. Brandes RP, et al. Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase. Hypertension. 2000;35(1 pt 2):231-236. (Pubitemid 30054178)
74. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics. 1995; 139(3):1421-1428.
75. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet. 1995;11(3):241-247.
76. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989;121(1):185-199.
77. Aoyagi T, et al. Vasopressin regulates the renin-angiotensin-aldosterone system via V1a receptors in macula densa cells. Am J Physiol Renal Physiol. 2008;295(1):F100-F107.
78. Kapur NK, et al. Hemodynamic modulation of endocardial thromboresistance. Circulation. 2007;115(1):67-75. (Pubitemid 46058613)
79. Brown MJ. Aliskiren. Circulation. 2008;118(7):773-784.
80. Jensen C, Herold P, Brunner HR. Aliskiren: the first renin inhibitor for clinical treatment. Nat Rev Drug Discov. 2008;7(5):399-410. (Pubitemid 351619112)
81. Williams JS. Hypertension: spironolactone and resistant hypertension. Nat Rev Endocrinol. 2010;6(5):248-250.
82. Jacke K, Witte K, Huser L, Behrends S, Lemmer B. Contribution of the renin-angiotensin system to subsensitivity of soluble guanylyl cyclase in TGR(mREN2)27 rats. Eur J Pharmacol. 2000;403(1-2):27-35.
83. Wang T, Inglis FM, Kalb RG. Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice. Am J Physiol Renal Physiol. 2000;279(3):F518-F524.
84. Yu B, et al. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010;112(3):586-594.
85. Atochin DN, et al. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007;117(7):1961-1967. (Pubitemid 47036330)