Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier

Anesthesiology

Volumn 112, Issue 3, 2010, Pages 586-594

  Yu, Binglan ^a   Shahid, Mohd ^a   Egorina, Elena M ^a   Sovershaev, Mikhail A ^a   Raher, Michael J ^a   Lei, Chong ^a   Wu, Mei X ^a   Bloch, Kenneth D ^a   Zapol, Warren M ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Critical Care and Pain Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; NITRIC OXIDE; OXYGEN; PHENYLEPHRINE; POLYMERIZED HEMOGLOBIN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; HEMODYNAMICS; HYPERTENSION; IN VITRO STUDY; LUNG VASOCONSTRICTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASOCONSTRICTION;

EID: 77649157927     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e3181cd7838     Document Type: Article

References (17)

1. Moore EE, Moore FA, Fabian TC, Bernard AC, Fulda GJ, Hoyt DB, Duane TM, Weireter LJ Jr, Gomez GA, Cipolle MD, Rodman GH Jr, Malangoni MA, Hides GA, Omert LA, Gould SA; PolyHeme Study Group: Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: The USA multicenter trial. J Am Coll Surg 2009; 208:1-13
2. Yu B, Bloch KD, Zapol WM: Hemoglobin based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med 2009; 19:103-107
3. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM: Cell-free hemoglobin-based blood substitutes and risk of myo-cardial infarction and death: A meta-analysis. JAMA 2008; 299:2304-2312
4. Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO III, Schechter AN, Gladwin MT: Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002; 8:1383-1389
5. Gladwin MT, Sachdev V, Jison MJ, Shizukuda Y, Plehn JF, Minter K, Brown B, Coles WA, Nichols JS, Ernst I, Hunter LA, Blackwelder WC, Schechter AN, Rodgers GP, Castro O, Ognibene FP: Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004; 350:886-895
6. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM: Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation 2008; 117:1982-1990
7. Yu B, Volpato GP, Chang K, Bloch KD, Zapol MW: Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. ANESTHESIOLOGY 2009; 110:113-122
8. Iaccarino G, Cipolletta E, Fiorillo A, Annecchiarico M, Ciccarelli M, Cimini V, Koch WJ, Trimarco B: Beta (2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension. Circulation 2002; 106:349-355
9. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M: A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol 2008; 295:H2495-502
10. Pannirselvam M, Wiehler WB, Anderson T, Triggle CR: Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products. Br J Pharmacol 2005; 144:953-960
11. Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND: A high-fat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression. J Appl Physiol 2005; 98:203-210
12. Jahr JS, Walker V, Manoochehri K: Blood substitutes as pharmacotherapies in clinical practice. Curr Opin Anaes-thesiol 2007; 20:325-330
13. Rice J, Philbin N, Light R, Arnaud F, Setinbach T, McGwin G, Collier S, Malkevich N, Moon-Massatt P, Rentko V, Pearce LB, Ahlers S, McCarron R, Handrigan M, Freilich D: The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock. J Trauma 2008; 64: 1240-1257
14. Atz AM, Wessel DL: Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. ANESTHESIOLOGY 1999; 91: 307-310
15. Belmadani S, Palen DI, Gonzalez-Villalobos RA, Boulares HA, Martrougui K: Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db/db mice. Diabetes 2008; 57:1629-1637
16. Rother RP, Bell L, Hillmen P, Gladwin MT: The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: A novel mechanism of human disease. JAMA 2005; 293:1653-1662
17. Wang P, Ba ZF, Chaudry HI: Endothelial cell dysfunction occurs very early following trauma-hemorrhage and persists despite fluid resuscitation. Am J Physiol Heart Circ Physiol 1993; 265:H973-9