sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 2, 2009, Pages

  Buys, Emmanuel S ^a   Cauwels, Anje ^b   Raher, Michael J ^a,b   Passeri, Jonathan J ^a   Hobai, Ion ^a   Cawley, Sharon M ^b   Rauwerdink, Kristen M ^a   Thibault, Helene ^a   Sips, Patrick Y ^a   Thoonen, Robrecht ^b   Scherrer Crosbie, Marielle ^a   Ichinose, Fumito ^a   Brouckaert, Peter ^b   Bloch, Kenneth D ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Left ventricular function; Mice; Nitric oxide; Sepsis; Soluble guanylate cyclase

Indexed keywords

CALCIUM ION; CYCLIC GMP; ENDOTOXIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE ALPHA1BETA1; NITRIC OXIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; HEART LEFT VENTRICLE FAILURE; HEART PROTECTION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK;

ANIMALS; BLOOD PRESSURE; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ENDOTOXINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUANYLATE CYCLASE; KAPLAN-MEIERS ESTIMATE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEPSIS; SHOCK, CARDIOGENIC; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 68049091104     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00367.2009     Document Type: Article

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