Blunted epidermal L-tryptophan metabolism in vitiligo affects immune response and ROS scavenging by Fenton chemistry, Part 1: Epidermal H 2O2/ONOO--mediated stress abrogates tryptophan hydroxylase and dopa decarboxylase activities, leading to low serotonin and melatonin levels

FASEB Journal

Volumn 26, Issue 6, 2012, Pages 2457-2470

  Schallreuter, Karin U ^a,b   Salem, Mohamed A E L ^a,b   Gibbons, Nick C J ^a,b   Martinez, Aurora ^c   Slominski, Radomir ^b   Lüdemann, Jürgen ^a   Rokos, Hartmut ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Calcium channel; Hydrogen peroxide; MITF; Peroxynitrite

Indexed keywords

AROMATIC LEVO AMINO ACID DECARBOXYLASE; HYDROGEN PEROXIDE; MELATONIN; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; ENZYME ACTIVITY; FENTON REACTION; FOURIER TRANSFORMATION; HUMAN; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MELANOCYTE; NITRATION; OXIDATION; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAMAN SPECTROMETRY; TRYPTOPHAN METABOLISM; VITILIGO; WESTERN BLOTTING;

ADULT; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DOPA DECARBOXYLASE; EPIDERMIS; HUMANS; HYDROGEN PEROXIDE; MELATONIN; MIDDLE AGED; OXIDATION-REDUCTION; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES; SEROTONIN; TRYPTOPHAN; TRYPTOPHAN HYDROXYLASE; VITILIGO;

EID: 84861778310     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-197137     Document Type: Article

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