Specific interaction of the diastereomers 7(R)- and 7(S)- tetrahydrobiopterin with phenylalanine hydroxylase: Implications for understanding primapterinuria and vitiligo

FASEB Journal

Volumn 20, Issue 12, 2006, Pages

  Pey, Angel L ^a   Martinez, Aurora ^a   Charubala, Ramamurthy ^b   Maitland, Derek J ^c   Teigen, Knut ^a   Calvo, Ana ^a   Pfleiderer, Wolfgang ^b   Wood, John M ^c   Schallreuter, Karin U ^c  

^a UNIVERSITY OF BERGEN   (Norway)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Isothermal titration calorimetry; NMR; Pterin 4a carbinolamine dehydratase

Indexed keywords

6 ERYTHRO 5,6,7,8 TETRAHYDROBIOPTERIN; PHENYLALANINE 4 MONOOXYGENASE; PTERIN 4A CARBINOLAMINE DEHYDRATASE; PTERIN DERIVATIVE; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; BIOPTERIN; DRUG DERIVATIVE; PRIMAPTERIN; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BINDING SITE; CATALYSIS; DEPIGMENTATION; DIASTEREOISOMER; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; HUMAN; MUTATION; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PATHOGENESIS; PHENYLKETONURIA; PRIMAPTERINURIA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS; VITILIGO; BINDING COMPETITION; COMPUTER SIMULATION; DRUG ANTAGONISM; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; SPECTROFLUOROMETRY; STEREOISOMERISM; SYNTHESIS; URINE;

BINDING SITES; BINDING, COMPETITIVE; BIOPTERIN; COMPUTER SIMULATION; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; PHENYLALANINE HYDROXYLASE; PROTEIN BINDING; PTERINS; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM; TYROSINE 3-MONOOXYGENASE; VITILIGO;

EID: 33845624501     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-5835fje     Document Type: Article

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