In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase

Journal of Investigative Dermatology Symposium Proceedings

Volumn 4, Issue 1, 1999, Pages 91-96

  Schallreuter, Karin U ^a,b   Moore, Jeremy ^a   Wood, John M ^a   Beazley, Wayne D ^a   Gaze, David C ^a   Tobin, Desmond J ^a   Marshall, Harriet S ^a   Panske, Angela ^b   Panzig, Eberhard ^b   Hibberts, Nigel A ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Oxidative stress; Repigmentation; Tetrahydrobiopterin

Indexed keywords

EDETIC ACID DERIVATIVE; HYDROGEN PEROXIDE; MANGANESE DERIVATIVE; PSEUDOCATALASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDERMIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOCYTE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; ULTRAVIOLET B RADIATION; VITILIGO;

EID: 0032884755     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jidsp.5640189     Document Type: Conference Paper

References (43)

1. Armarego WLF: Chemical and biological reactions and reduced pterins. Lect Heterocycl Chem 7:121-130, 1984
2. Armarego WLF, Randles D, Taguchi H: Peroxidase catalysed aerobic degradation of 5,6,7,8-tetrahydrobiopterin at physiological pH. Eur J Biochem 135:393-403, 1983
3. Aronoff S: Catalase: kinetics of photo-oxidation. Science 150:72-73, 1965
4. Beazley WD, Gaze D, Panske A, Panzig E, Schallreuter KU: Serum selenium levels and blood glutathione peroxidase activities in vitiligo. Br J Dermatol 141:301-304, 1999
5. Bhawan J, Bhutani LK: Keratinocyte damage in vitiligo. J Cutaneous Path 10:207-212, 1983
6. Boissy R, Liu YY, Medrano EE, Nordlund JJ: Structural aberration of the rough endoplasmic reticulum and melanosome compartmentalisation in long term cultures of melanocytes from vitiligo patients. J Invest Dermatol 97:395-404, 1991
7. Bystryn JC: Serum antibodies in vitiligo patients. Clin Dermatol 2:136-145, 1989
8. Davis MD, Ribeiro P, Tipper J, Kaufman S: "7-Tetrahydrobiopterin", a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydrolases. Proc Natl Acad Sci USA 89:10108-10113, 1992
9. De Luca C, Grandinetti M, Stancato A, Passi S, Puddu P: Involvement of epidermal oxidative stress in vitiligo and pityriasis versicolor. Pigment Cell Res 10:356, 1997
10. Harada T, Kagamiyama H, Hatakeyama K: Feedback regulatory mechanisms for the control of GTP cyclohydrolase I activity. Science 260:1507-1510, 1993
11. Harning R, Cui J, Bystryn JC: Relation between the incidence and level of pigment cell antibodies and disease activity in vitiligo. J Invest Dermatol 97:1078-1080, 1991
12. Kaufman S, Fisher DB. Pterin-requiring aromatic amino acid hydroxylases. In: Hayaishi O (ed). Molecular Mechanisms of Oxygen Activation. New York: Academic Press, 1974, pp. 285-369
13. Kwon NS, Nathan CF, Stuehr DJ: Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem 264:20496-20501, 1989
14. LePoole IC, Das PK, van den Wijngaard RM, Bos JD, Westerhof W: Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 2:146-153, 1993a
15. LePoole IC, van den Wijngaard RM, Westerhof W, Dutrieux RP, Das PK: Presence or absence of melanocytes in vitiligo lesions: an immunohistochemical investigation. J Invest Dermatol 100:816-822, 1993b
16. LePoole IC, van den Wijngaard RM, Smit NP, Oesting J, Westerhof W, Pavel S: Catechol-O-methyltransferase in vitiligo. Arch Dermatol Res 286:81-86, 1994
17. Maresca V, Roccella M, Roccella F, et al: Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. J Invest Dermatol 109:310-313, 1997
18. Marks DB, Marks AD, Smith CM. Oxygen metabolism and oxygen toxicity. In: Basic Medical Biochemistry: A clinical approach. Williams and Wilkins. Baltimore, 1996, pp. 327-340
19. Medrano EE, Nordlund JJ: Successful culture of adult human melanocytes obtained from normal and vitiligo donors. J Invest Dermatol 95:441-445, 1990
20. Milstien S, Jaffe H, Kowlessur D, Bonner TI: Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J Biol Chem 271:19743-19751, 1996
21. Moellmann G, Klein-Angerer S, Scollay DA, Nordlund JJ, Lerner A: Extracellular granular material and degeneration of keratinocytes in normally pigmented epidermis of patients with vitiligo. J Invest Dermatol 79:321-330, 1982
22. Morrone A, De Picardo M, Luca C, Terminali O, Passi S, Ippolito F: Catecholamines and vitiligo. Pigment Cell Res 5:58-62, 1992
23. Nordlund JJ, Ortonne JP: Vitiligo and depigmentation. Current Prob Dermatol 4:3-30, 1992
24. Norris DA, Kissinger GM, Naughton GM, Bystryn JC: Evidence for immunologic mechanisms in human vitiligo: Patients' sera induce damage to human melanocytes in vitro by complement-mediated damage and antibody-dependent cellular cytotoxicity. J Invest Dermatol 90:783-789, 1988a
25. Norris DA, Capin L, Muglia JJ, Osborn RL, Zerbe GO, Bystryn JC, Tonnesen MG: Enhanced susceptibility of melanocytes to different immunologic effector mechanisms in vitro. Pigment Cell Res 1 (Suppl.):113-123, 1988b
26. Ortonne JP, Bose SK: Vitiligo: Where do we stand? Pigment Cell Res 8:61-72, 1993
27. Pittelkow MR, Shipley GD: Serum free culture of normal human melanocytes: growth kinetics and growth factor requirements. J Cell Physiol 140:565-576, 1989
28. Schallreuter KU, Pittelkow MR: Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin. Arch Dermatol Res 280:137-139, 1988
29. Schallreuter KU, Pittelkow MR, Wood JM: Free radical reduction by thioredoxin reductase at the surface of normal and vitiliginous human keratinocytes. J Invest Dermatol 87:728-732, 1986
30. Schallreuter KU, Pittelkow MR, Wood JM: EF-hands calcium binding regulates the thioredoxin reductase/thioredoxin electron transfer in human keratinocytes. Biochem Biophys Res Commun 162:1311-1316, 1989
31. Schallreuter KU, Wood JM, Berger J: Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol 97:1081-1085, 1991
32. Schallreuter KU, Wood JM, Pittelkow MR, Swanson NN, Steinkrans V: Increased in vitro expression of beta-2-adrenoceptors in differentiating lesional keratinocytes of vitiligo patients. Arch Dermatol Res 285:216-220, 1993
33. Schallreuter KU, Wood JM, Pittelkow MR, Gütlich M, Lemke KR, Rödl W, Swanson NN, Hitzemann K, Ziegler I: Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263:1444-1446, 1994a
34. Schallreuter KU, Wood JM, Lemke KR, Pittelkow MR, Lindsey NJ, Gütlich M, Ziegler I: Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo. Biochim Biophys Acta 1226:181-192, 1994b
35. Schallreuter KU, Büttner G, Pittelkow MR, Wood JM, Swanson NN, Körner C: The cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun 204:43-48, 1994c
36. Schallreuter KU, Wood JM, Lemke KR, Levenig C: Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short term UVB exposure: a case study on 33 patients. Dermatol 190:223-229, 1995
37. Schallreuter KU, Wood JM, Pittelkow MR, Büttner G, Swanson NN, Körner C, Ehrke C: Increased monoamine oxidase A activity in the epidermis of patients with vitiligo. Arch Dermatol Res 288:14-18, 1996
38. Schallreuter KU, Zschiesche M, Moore J, Panske A, Hibberts NA, Herrmann FH, Metelmann HR, Sawatzki J: In vivo evidence for compromised phenylalanine metabolism in vitiligo. Biochem Biophys Res Commun 243:395-399, 1998a
39. Schallreuter KU, Wood JM, Körner C, Harle KM, Schulz-Douglas V, Werner ER: 6-tetrahydrobiopterin functions as a UVB-light switch for de novo melanogenesis. Biochim Biophys Acta 1382: 339-344, 1998b
40. Schallreuter-Wood KU, Pittelkow MR, Swanson NN: Defective calcium transport in vitiliginous melanocytes. Arch Dermatol Res 288:11-13, 1996
41. Stryer L: Biochemistry. Freeman & Co., New York, 1988, pp. 592-593
42. Wood JM, Schallreuter-Wood KU, Lindsey NJ, Callaghan S, Gardner MLG: A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Biochem Biophys Res Commun 206:480-485, 1995
43. Yohn JJ, Norris DA, Yrastorza DG, Buno IJ, Leff JA, Hake SS, Repine JE: Disparate antioxidant enzyme activities in cultured human cutaneous fibroblasts, keratinocytes and melanocytes. J Invest Dermatol 97:405-409, 1991