Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH-binding and tetramerization domains: A genetic predisposition for an altered catalase in patients with vitiligo?

Experimental Dermatology

Volumn 17, Issue 4, 2008, Pages 366-371

  Wood, John M ^a   Gibbons, Nicholas C J ^a,b   Chavan, Bhaven ^a   Schallreuter, Karin U ^a,b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Active site; Catalase; Molecular modelling; NADPH binding domain; Tetramerization domain

Indexed keywords

CATALASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAMER;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GENETIC PREDISPOSITION; HETEROZYGOSITY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PROTEIN BINDING; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; VITILIGO; WILD TYPE;

AMINO ACID SUBSTITUTION; BINDING SITES; CATALASE; COMPUTER SIMULATION; DATABASES, PROTEIN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROGEN PEROXIDE; MODELS, CHEMICAL; NADP; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; VITILIGO;

EID: 40349114615     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00699.x     Document Type: Article

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