Low-density lipoprotein receptor deficiency causes impaired osteoclastogenesis and increased bone mass in mice because of defect in osteoclastic cell-cell fusion

Journal of Biological Chemistry

Volumn 287, Issue 23, 2012, Pages 19229-19241

  Okayasu, Mari ^a,b   Nakayachi, Mai ^a   Hayashida, Chiyomi ^a   Ito, Junta ^a   Kaneda, Toshio ^c   Masuhara, Masaaki ^a,d   Suda, Naoto ^a   Sato, Takuya ^a   Hakeda, Yoshiyuki ^a  

^a MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^b UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^c HOSHI UNIVERSITY   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE FORMATION; BONE MASS; BONE RESORPTION; CELL-CELL FUSION; HYPERLIPIDEMIA; IN-VIVO; LOW DENSITY LIPOPROTEINS; MASTER REGULATORS; MOLECULAR MECHANISM; MULTINUCLEATED CELLS; OSTEOCLAST DIFFERENTIATION; OSTEOCLAST FORMATION; OSTEOCLAST PRECURSOR; OSTEOCLASTOGENESIS; RANK SIGNALING; RECEPTOR ACTIVATOR; TARTRATE-RESISTANT ACID PHOSPHATASE; TRANS-MEMBRANE PROTEINS; V-ATPASE; VASCULAR CALCIFICATION; WILD TYPES; WILD-TYPE CELLS;

BONE; CELL MEMBRANES; CHEMICAL ACTIVATION; DEFECT DENSITY; DEFECTS; DISEASES; MAMMALS; PHOSPHATASES;

CELL CULTURE;

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ADENOSINE TRIPHOSPHATASE; CATHEPSIN K; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN KINASE B; SCAVENGER RECEPTOR A; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ARTICLE; BONE MASS; CELL CULTURE; CELL FUSION; CELL LINEAGE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CULTURE MEDIUM; DENDRITIC CELL; DOSE RESPONSE; ENZYME ACTIVATION; LIPOPROTEIN DEFICIENCY; LOW DENSITY LIPOPROTEIN RECEPTOR DEFICIENCY; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BONE AND BONES; BONE RESORPTION; CELL DIFFERENTIATION; CELL FUSION; CELL MEMBRANE; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; ORGAN SIZE; OSTEOCLASTS; OSTEOPOROSIS; PROTO-ONCOGENE PROTEINS C-AKT; RANK LIGAND; RECEPTORS, LDL; VACUOLAR PROTON-TRANSLOCATING ATPASES;

MUS;

EID: 84861741761     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323600     Document Type: Article

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