RANKL induces heterogeneous DC-STAMPlo and DC-STAMPhi osteoclast precursors of which the DC-STAMPlo precursors are the master fusogens

Journal of Cellular Physiology

Volumn 223, Issue 1, 2010, Pages 76-83

  Mensah, Kofi A ^a,b   Ritchlin, Christopher T ^a   Schwarz, Edward M ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; CD9 ANTIGEN; DENDRITIC CELL SPECIFIC TRANSMEMBRANE PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1A2; OSTEOCLAST DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL FUSION; CELL POPULATION; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; IMMUNOPRECIPITATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; WESTERN BLOTTING;

ACID PHOSPHATASE; ANIMALS; ANTIGENS, CD; ANTIGENS, CD47; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL FUSION; CELLS, CULTURED; FLOW CYTOMETRY; IMMUNOPROLIFERATIVE DISORDERS; ISOENZYMES; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; NERVE TISSUE PROTEINS; OSTEOCLASTS; PHENOTYPE; PROTEIN MULTIMERIZATION; RANK LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS; TIME FACTORS;

ORYCTOLAGUS CUNICULUS;

EID: 75749112899     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22012     Document Type: Article

References (37)

1. Anandarajah AP, Schwarz EM, Totterman S, Monu J, Feng CY, Shao T, Haas-Smith SA, Ritchlin CT. 2008. The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritis. Ann Rheum Dis 67:296-301.
2. Boyle WJ, Simonet WS, Lacey DL. 2003. Osteoclast differentiation and activation. Nature 423:337-342.
3. Chen EH, Grote E, Mohler W, Vignery A. 2007. Cell-cell fusion. FEBS Lett 581:2181-2193.
4. Cohen SB, Dore RK, Lane NE, Ory PA, Peterfy CG, Sharp JT, van der HeijdeD, Zhou L, Tsuji W, Newmark R., 2008. Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 58:1299-1309.
5. DalbethN, Smith T, Nicolson B,Clark B, Callon K,NaotD,Haskard DO, McQueen FM, Reid IR, Cornish J. 2008. Enhanced osteoclastogenesis in patients with tophaceous gout: Urate crystals promote osteoclast development through interactions with stromal cells. Arthritis Rheum 58:1854-1865.
6. de Vries TJ, Schoenmaker T, Beertsen W, van der Neut R, Everts V. 2005. Effect of CD44 deficiency on in vitro and in vivo osteoclast formation. J Cell Biochem 94:954-966.
7. Eggelmeijer F, Papapoulos SE, van Paassen HC, Dijkmans BA, Breedveld FC. 1994. Clinical and biochemical response to single infusion of pamidronate in patients with active rheumatoid arthritis: A double blind placebo controlled study. J Rheumatol 21:2016-2020.
8. Eleveld-Trancikova D, Triantis V, Moulin V, Looman MW, Wijers M, Fransen JA, Lemckert AA, Havenga MJ, Figdor CG, Janssen RA, Adema GJ. 2005. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. J Leukoc Biol 77:337-343.
9. Goldring SR, Gravallese EM. 2000. Mechanisms of bone loss in inflammatory arthritis: Diagnosis and therapeutic implications. Arthritis Res 2:33-37.
10. Hartgers FC, Vissers JL, Looman MW, van Zoelen C, Huffine C, Figdor CG, Adema GJ. 2000. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. Eur J Immunol 30:3585-3590.
11. Hayashi T, Kaneda T, Toyama Y, Kumegawa M, Hakeda Y. 2002. Regulation of receptor activator ofNF-kappa B ligand-induced osteoclastogenesis by endogenous interferon-beta (INF-beta) and suppressors of cytokine signaling (SOCS). The possible counteracting role of SOCSs- in IFN-beta-inhibited osteoclast formation. J Biol Chem 277:27880-27886.
12. Hayer S, Steiner G, Gortz B, Reiter E, Tohidast-Akrad M, Amling M, Hoffmann O, Redlich K, Zwerina J, Skriner K, Hilberg F, Wagner EF, Smolen JS, Schett G. 2005. CD44 is a determinant of inflammatory bone loss. J Exp Med 201:903-914.
13. Heinemann DE, Siggelkow H, Ponce LM, Viereck V, Wiese KG, Peters JH. 2000. Alkaline phosphatase expression during monocyte differentiation. Overlapping markers as a link between monocytic cells, dendritic cells, osteoclasts and osteoblasts. Immunobiology 202:68-81.
14. Ishii M, Iwai K, Koike M, Ohshima S, Kudo-Tanaka E, Ishii T, Mima T, Katada Y, Miyatake K, Uchiyama Y, Saeki Y. 2006. RANKL-induced expression of tetraspanin CD9 in lipid raft membranemicrodomain is essential for cell fusion during osteoclastogenesis. J Bone Miner Res 21:965-976.
15. Iwasaki R, Ninomiya K, Miyamoto K, Suzuki T, Sato Y, Kawana H, Nakagawa T, Suda T, Miyamoto T. 2008. Cell fusion in osteoclasts plays a critical role in controlling bone mass and osteoblastic activity. Biochem Biophys Res Commun 377:899-904.
16. JacquinC,Gran DE, Lee SK, Lorenzo JA, Aguila HL. 2006. Identification of multiple osteoclast precursor populations in murine bone marrow. J Bone Miner Res 21:67-77.
17. Jarrett SJ, Conaghan PG, Sloan VS, Papanastasiou P,Ortmann CE, O'Connor PJ, Grainger AJ, Emery P. 2006. Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis. Arthritis Rheum 54:1410-1414.
18. Kukita T, Wada N, Kukita A, Kakimoto T, Sandra F, Toh K, Nagata K, Iijima T, Horiuchi M, Matsusaki H, Hieshima K, Yoshie O, Nomiyama H. 2004. RANKL-induced DC-STAMP is essential for osteoclastogenesis. J Exp Med 200:941-946.
19. Li P, Schwarz EM, O'Keefe RJ,Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L. 2004. Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis Rheum 50:265-276.
20. Lundberg P, Koskinen C, Baldock PA, Lothgren H, Stenberg A, Lerner UH, Oldenborg PA. 2007. Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction. Biochem Biophys Res Commun 352:444-448.
21. Milligan G. 2004. G protein-coupled receptor dimerization: Function and ligand pharmacology. Mol Pharmacol 66:1-7.
22. Nose M, Yamazaki H, Hagino H, Morio Y, Hayashi S, Teshima R. 2009. Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients. J Bone Miner Metab 27:57-65.
23. Ralston SH, Hacking L, Willocks L, Bruce F, Pitkeathly DA. 1989. Clinical, biochemical, and radiographic effects of aminohydroxypropylidene bisphosphonate treatment in rheumatoid arthritis. Ann Rheum Dis 48:396-399.
24. Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. 2003. Mechanisms of TNF-alpha-and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 111:821-831.
25. Rivollier A, Mazzorana M, Tebib J, Piperno M, Aitsiselmi T, Rabourdin-Combe C, Jurdic P, Servet-Delprat C. 2004. Immature dendritic cell transdifferentiation into osteoclasts: A novel pathway sustained by the rheumatoid arthritis microenvironment. Blood 104: 4029-4037.
26. Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT. 2006. Autoimmunity and bone. Ann NY Acad Sci 1068:275-283.
27. Staege H, Brauchlin A, Schoedon G, Schaffner A. 2001. Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. Immunogenetics 53:105-113.
28. Takeshita S, Kaji K, Kudo A. 2000. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res 15:1477-1488.
29. Teitelbaum SL. 2000. Bone resorption by osteoclasts. Science 289:1504-1508.
30. Valleala H, Laasonen L, Koivula MK, Mandelin J, Friman C, Risteli J, Konttinen YT. 2003. Two year randomized controlled trial of etidronate in rheumatoid arthritis: Changes in serum aminoterminal telopeptides correlate with radiographic progression of disease. J Rheumatol 30:468-473.
31. Vandooren B, Melis L, Veys EM, Tak PP, Baeten D. 2009. In vitro spontaneous osteoclastogenesis of human peripheral blood mononuclear cells is not crucially dependent on T lymphocytes. Arthritis Rheum 60:1020-1025.
32. Vignery A. 2005. Macrophage fusion: The making of osteoclasts and giant cells. J Exp Med 202:337-340.
33. Yagi M, Miyamoto T, Sawatani Y, Iwamoto K, Hosogane N, Fujita N, Morita K, Ninomiya K, Suzuki T, Miyamoto K,Oike Y, Takeya M, Toyama Y, Suda T. 2005. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med 202:345-351.
34. Yagi M, Miyamoto T, Toyama Y, Suda T. 2006. Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab 24:355-358.
35. Yagi M, Ninomiya K, Fujita N, Suzuki T, Iwasaki R, Morita K, HosoganeN,Matsuo K, Toyama Y, Suda T, Miyamoto T. 2007. Induction of DC-STAMP by alternative activation and downstream signaling mechanisms. J Bone Miner Res 22:992-1001.
36. Yang M, Birnbaum MJ, MacKay CA, Mason-Savas A, Thompson B, Odgren PR. 2008.
37. Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation. J Cell Physiol 215:497-505.