Hepatoprotective and antioxidant activity of standardized herbal extracts

Pharmacognosy Magazine

Volumn 8, Issue 30, 2012, Pages 116-123

  Deepak, Hiraganahalli Bhaskarmurthy ^a   Chandrasekaran, Chinampudur Velusami ^a   Dethe, Shekhar ^a   Mundkinajeddu, Deepak ^a   Pandre, Manoj Kumar ^a   Balachandran, Jaya ^a   Agarwal, Amit ^a  

^a Natural Remedies Pvt Ltd   (India)

Author keywords

Acacia catechu; Camellia sinensis; cellular antioxidant activity assay; hepatoprotection; Mangifera indica; Phyllanthus emblica; Punica granatum

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ACACIA CATECHU EXTRACT; ASCORBIC ACID; CATECHIN; CORILAGIN; ELLAGIC ACID; EMBLICA OFFICINALIS EXTRACT; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN GALLATE; FREE RADICAL; GALLIC ACID; GALLIC ACID METHYL ESTER; GREEN TEA EXTRACT; HERBACEOUS AGENT; MANGIFERA INDICA EXTRACT; MANGIFERIN; PLANT EXTRACT; POMEGRANATE EXTRACT; PUNICALAGIN; QUERCETIN; TERT BUTYL HYDROPEROXIDE; TROLOX C; UNCLASSIFIED DRUG;

ACACIA CATECHU; ANTIOXIDANT ACTIVITY; ARTICLE; ASSAY; BARK; CELL DAMAGE; CELL STRAIN HEPG2; CELL VIABILITY; CELLULAR ANTIOXIDANT ACTIVITY ASSAY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; EMBLICA OFFICINALIS; FLUORESCENCE; FRUIT; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MANGO; METABOLITE; NONHUMAN; OXYGEN RADICAL ABSORBANCE CAPACITY ASSAY; PLANT LEAF; POMEGRANATE; TEA;

EID: 84861715202     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.96553     Document Type: Article

References (56)

1. Wolf PL. Biochemical diagnosis of liver diseases. Indian J Clin Biochem 1999;14:59-90.
2. Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984;219:1-14. (Pubitemid 14171443)
3. Halliwell B, Gutteridge JM. Free radicals in Biology and Medicine. 3rd ed. Oxford: University Press; 1999. p. 936.
4. Jakus V. The role of free radicals, oxidative stress and antioxidant systems in diabetic vascular disease. Bratisl Lek Listy 2000;101:541-51.
5. Roberfroid MB, Viehe HG, Remacle J. Free radicals in drug research. Advances in drug research. Vol.16. London: Academic Press Ltd; 1984. p. 1-84.
6. Recknagel RO. A new direction in the study of carbon tetrachloride hepatotoxicity. Life Sci 1983;33:401-8. (Pubitemid 13064779)
7. Wendel A, Feurensteins S, Konz KH. Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. Biochem Pharmacol 1979;28:2051-5. (Pubitemid 9214912)
8. Dianzani MU, Muzio G, Biocca ME, Canuto RA. Lipid peroxidation in fatty liver induced by caffeine in rats. Int J Tissue React 1991;13:79-85.
9. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity. Toxicol Sci 2002;65:166-76. (Pubitemid 34121108)
10. Xu J, Ma M, Purcell WM. Characterization of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers. Toxicol App Pharmacol 2003;189:100-11. (Pubitemid 36638278)
11. Thabrew MI, Hughes RD, McFarlane IG. Screening of hepatoprotective plant constituents using a HepG2 cell cytotoxicity assay. J Pharm Pharmacol 1997;49:1132-5. (Pubitemid 27496730)
12. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 1998;93:139-43. (Pubitemid 29063954)
13. Ravikumar V, Shivashangari KS, Devaki T. Hepatoprotective activity of Tridax procumbens against D-galactosamine/ lipopolysaccharide-induced hepatitis in rats. J Ethnopharmacol 2006;101:55-60.
14. Pramyothin P, Udomuksorn W, Poungshompoo S, Chaichantipyuth C. Hepatoprotective effect of Andrographis paniculata and its constituent andrographolide on ethanol hepatotoxicity in rats. Asia Pac J Pharmacol 1994;9:73-8. (Pubitemid 24250317)
15. Eastwood M.A. Interaction of dietary antioxidant in vivo: how fruits and vegetables prevent diseases. QJM 1999;92:527-30. (Pubitemid 29430051)
16. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63. (Pubitemid 14203433)
17. Chandrasekaran CV, Sundarajan K, David K, Agarwal A. In vitro efficacy and safety of poly-herbal formulations Toxicol In Vitro 2010 24 885-97
18. Wolfe KL, Liu RH. Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods and dietary supplements. J Agric Food Chem 2007;55:8896-907. (Pubitemid 350105534)
19. Dávalos A, Gómez-Cordovés C, Bartolomé B. Extending applicability of the Oxygen Radical Absorbance Capacity (ORAC-Fluorescein) assay. J Agric Food Chem 2004;52:48-54.
20. Auddy B, Ferreira M, Blasina F, Lafon L, Arredondo F, Dajas F, et al. Screening of antioxidant activity of three Indian medicinal plants, traditionally used for the management of neurodegenerative diseases. J Ethnopharmacol 2003;84:131-8 (Pubitemid 36329154)
21. Vani T, Rajini M, Sarkar S, Shishoo CJ. Antioxidant properties of the Ayurvedic Formulation-Triphala and its constituents. Int J Pharmacogn 1997;35:313-7.
22. Ou B, Hampsch-Woodill M, Prior RL. Development and Validation of an Improved Oxygen Radical Absorbance Capacity Assay Using Fluorescein as the Fluorescent Probe. J Agric Food Chem 2001;49:4619-26. (Pubitemid 32988695)
23. Dhir H, Roy AK, Sharma A, Talukder G. Modification of clastogenicity of lead and aluminium in mouse bone marrow cells by dietary ingestion of Phyllanthus emblica fruit extract. Mutat Res 1990;241:305-12. (Pubitemid 20207964)
24. Malar HL, Bai SM. Hepatoprotective activity of Phyllanthus emblica against paracetamol induced hepatic damage in Wister Albino Rats. Afr J Basic Appl Sci 2009;1:21-5.
25. Gulati RK, Agarwal S, Agarwal SS. Hepatoprotective studies of Phyllanthus emblica Linn. and quercetin. Indian J Exp Biol 1995;33:261-8.
26. Bhattacharya A, Kumar M, Ghosal S, Bhattacharya SK. Effect of bioactive tannoid principles of Emblica officinalis on iron-induced hepatic toxicity in rats. Phytomedicine 2000;7:173-5. (Pubitemid 30307618)
27. Tasduq SA, Kaisar P, Gupta DK, Kapahi BK, Maheshwari HS, Jyotsna S, et al. Protective effects of 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver-toxicity. Phytother Res 2005;19:193-7. (Pubitemid 40827640)
28. Sultana S, Ahmad S, Khan N, Jehangir T. Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol 2005;43:430-6. (Pubitemid 40678887)
29. Pramyothin P, Samosorn P, Poungshompoo S, Caichantipyuth C. The protective effects of Phyllanthus emblica extract on ethanol induced rat hepatic injury. J Ethnopharmacol 2006;107:361-4. (Pubitemid 44344426)
30. Haque R, Bin-Hafeez B, Ahmad I, Parvez S, Pandey S, Raisuddin S. Protective effect of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum Exp Toxicol 2001;20: 643-50. (Pubitemid 34308569)
31. Graham HN. Green tea composition, consumption and polyphenol chemistry. Prev Med 1992;21:334-50.
32. Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus SA, Kris- Etherton PM. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr 2001;74:596-602. (Pubitemid 33015145)
33. Benelli R, Vene R, Bisacchi D, Garbisa S, Albini A. Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. Biol Chem 2002;383:101-5. (Pubitemid 34224032)
34. El-Beshbishy AH. Hepatoprotective effect of green tea (Camellia sinensis) extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol 2005;38:563-70.
35. Sengottuvelu S, Duraisami S, Nandhakumar J, Duraisami R, Vasudevan M. Hepatoprotective Activity of Camellia sinensis and its 3 Possible Mechanism of Action. Iran J Pharmacol Ther 2008;7:9-14.
36. Sai K, Kai S, Umemura T, Tanimura A, Hasegawa R, Inoue T, et al. Protective effect of green tea on hepatotoxicity, oxidative DNA damage and cell proliferation in the rat liver induced by repeated oral administration of 2-nitropropane. Food Chem Toxicol 1998;36:1043-51. (Pubitemid 29002885)
37. He P, Noda Y, Sugiyama K. Green Tea suppresses lipopolysaccharide-induced liver injury in d-galactosaminesensitized rats. J Nutr 2001;131:1560-7. (Pubitemid 32422983)
38. Chidambara Murthy KN, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem 2002;50: 4791-5. (Pubitemid 34856146)
39. Kaur G, Jabbar Z, Athar M, Alam MS. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem Toxicol 2006;44:984-93. (Pubitemid 43850067)
40. Celik I, Temur A, Isik I. Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats. Food Chem Toxicol 2009;47:145-9.
41. Ajila CM, Prasada Rao UJ. Protection against hydrogen peroxide induced oxidative damage in rat erythrocytes by Mangifera indica L. peel extract. Food Chem Toxicol 2008;46:303-9. (Pubitemid 350235775)
42. Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol 2001;78:133-7. (Pubitemid 32994781)
43. Prasad S, Kalra N, Shukla Y. Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice. Mol Nutr Food Res 2007;51:352-9. (Pubitemid 47083670)
44. Percival SS, Talcott ST, Chin ST, Mallak AC, Lounds-Singleton A, Pettit-Moore J. Neoplastic transformation of BALB/3T3 cells and cell cycle of HL-60 cells are inhibited by mango (Mangifera indica L.) juice and mango juice extracts. J Nutr 2006;136: 1300-4.
45. Martinez SG, Jalil EC, Giuliani A, Leon FOS, Ram S, Delgado HR, Nunez AJ. Mangifera indica L. (Vimang) reduces ischemia induced neuronal loss and oxidative damage in Gerbil brain. Free Radic Res 2002;32:1-7.
46. Remirez D, Tafazoli S, Delgado R, Harandi AA, O'Brien PJ. Preventing hepatocyte oxidative stress cytotoxicity with Mangifera indica L. extract (Vimang). Drug Metabol Drug Interact 2005;21:19-29. (Pubitemid 41123740)
47. Rodeiro I., Donato MT, Jiménez N, Garrido G, Delgado R, Gómez-Lechón MJ. Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes. Food Chem Toxicol 2007;45:2506-12. (Pubitemid 47600457)
48. Rodeiro I, Donato MT, Martínez I, Hernández I, Garrido G, González-Lavaut JA, et al. Potential hepatoprotective effects of new Cuban natural products in rat hepatocytes culture. Toxicol Vitro 2008a;5:1242-9.
49. Rodeiro I, Donato MT, Lahoz A, González-Lavaut JA, Laguna A, Castell JV, et al. Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes. Chem Biol Interact 2008;172:1-10. (Pubitemid 351284549)
50. Pourahmad J, Eskandari MR, Shakibaei R, Kamalinejad M. A search for hepatoprotective activity of fruit extract of Mangifera indica L. against oxidative stress cytotoxicity. Plants Foods Hum Nutr 2010;65:83-9.
51. Jayasekhar P, Mohanan PV, Rathinam K. Hepatoprotective activity of ethyl acetate extract of Acacia catechu. Indian J Pharmacol 1997;29:426-8. (Pubitemid 28035748)
52. Ray D, Sharatchandra Kh, Thokchom IS. Antipyretic, antidiarrhoeal, hypoglycemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu Wild in Albino rats. Indian J Pharmacol 2006;6:408-13. (Pubitemid 44862797)
53. Pingale SS. Hepatoprotection by Acacia catechu in CCl4 induced liver dysfunction. Int J Pharm Sci Rev Res 2010;1:150-4.
54. Rage N, Dahanukar S, Karandikar SM. Hepatoprotective effect of cyanidanol against carbon tetrachloride induced liver damage. Indian Drugs 1984;22:556-560.
55. Rajnarayana K, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoid classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol 2001;33:2-16. (Pubitemid 32232936)
56. Rush GF, Gorski JR, Ripple MG, Sowinski J, Bugelski P, Hewitt WR. Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes. Toxicol Appl Pharmacol 1985;78:473-83. (Pubitemid 16163415)