-
1
-
-
79960393247
-
'Genetic profiling' and ovarian cancer therapy
-
(review)
-
N. Vella 'Genetic profiling' and ovarian cancer therapy Mol. Med. Rep. 4 2011 771 777 (review)
-
(2011)
Mol. Med. Rep.
, vol.4
, pp. 771-777
-
-
Vella, N.1
-
2
-
-
0039923005
-
Marine organisms as a source of new anticancer agents
-
G. Schwartsmann Marine organisms as a source of new anticancer agents Lancet Oncol. 2 2001 221 225
-
(2001)
Lancet Oncol.
, vol.2
, pp. 221-225
-
-
Schwartsmann, G.1
-
3
-
-
0033981511
-
Antitumor compounds from tunicates
-
K.L. Rinehart Antitumor compounds from tunicates Med. Res. Rev. 20 1999 1 27
-
(1999)
Med. Res. Rev.
, vol.20
, pp. 1-27
-
-
Rinehart, K.L.1
-
4
-
-
0038461995
-
Drugs from the deep: Marine natural products as drug candidates
-
B. Haefner Drugs from the deep: marine natural products as drug candidates Drug Discov. Today 8 2003 536 544
-
(2003)
Drug Discov. Today
, vol.8
, pp. 536-544
-
-
Haefner, B.1
-
5
-
-
2542511641
-
Comparison of fascaplysin and related alkaloids: A study of structures, cytotoxicities, and sources
-
N.L. Segraves Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources J. Nat. Prod. 67 2004 783 792
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 783-792
-
-
Segraves, N.L.1
-
6
-
-
78649779398
-
JBIR-66, a new metabolite isolated from tunicate-derived Saccharopolyspora sp. SS081219JE-28
-
M. Takagi JBIR-66, a new metabolite isolated from tunicate-derived Saccharopolyspora sp. SS081219JE-28 Biosci. Biotechnol. Biochem. 74 2010 2355 2357
-
(2010)
Biosci. Biotechnol. Biochem.
, vol.74
, pp. 2355-2357
-
-
Takagi, M.1
-
7
-
-
4344628103
-
Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian
-
E. Schmidt Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian J. Nat. Prod. 67 2004 1341 1345
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1341-1345
-
-
Schmidt, E.1
-
8
-
-
0034632436
-
Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
-
C. Cuevas Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B Org. Lett. 2 2000 2545 2548
-
(2000)
Org. Lett.
, vol.2
, pp. 2545-2548
-
-
Cuevas, C.1
-
9
-
-
78650619951
-
Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the immune and nervous system, and other miscellaneous mechanisms of action
-
A. Mayer Marine pharmacology in 2007-8: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous system, and other miscellaneous mechanisms of action Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 153 2011 191 222
-
(2011)
Comp. Biochem. Physiol. C: Toxicol. Pharmacol.
, vol.153
, pp. 191-222
-
-
Mayer, A.1
-
10
-
-
36749071496
-
Aplidine: A paradigm of how to handle the activity and toxicity of a novel marine anticancer poison
-
C. Le Tourneau Aplidine: a paradigm of how to handle the activity and toxicity of a novel marine anticancer poison Curr. Pharm. Des. 13 2007 3427 3439
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 3427-3439
-
-
Le Tourneau, C.1
-
11
-
-
0000448995
-
Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anti-cancer agents
-
I. Manzanares Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anti-cancer agents Curr. Med. Chem. Anticancer Agents 1 2001 257 276
-
(2001)
Curr. Med. Chem. Anticancer Agents
, vol.1
, pp. 257-276
-
-
Manzanares, I.1
-
12
-
-
9244243061
-
Small-molecule natural products: New structures, new activities
-
D.D. Baker, and K.A. Alvi Small-molecule natural products: new structures, new activities Curr. Opin. Biotechnol. 15 2004 576 583
-
(2004)
Curr. Opin. Biotechnol.
, vol.15
, pp. 576-583
-
-
Baker, D.D.1
Alvi, K.A.2
-
15
-
-
77954087341
-
Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates
-
J. Robert Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates Dev. Comp. Immunol. 34 2010 915 925
-
(2010)
Dev. Comp. Immunol.
, vol.34
, pp. 915-925
-
-
Robert, J.1
-
16
-
-
0013341410
-
Immunodefense in tunicates: Cells and molecules
-
H. Sawada, H. Yokosawa, C.C. Lambert, Springer-Verlag
-
E.L. Cooper, and N. Parrinello Immunodefense in tunicates: cells and molecules H. Sawada, H. Yokosawa, C.C. Lambert, The Biology of Ascidians 2001 Springer-Verlag 383 394
-
(2001)
The Biology of Ascidians
, pp. 383-394
-
-
Cooper, E.L.1
Parrinello, N.2
-
17
-
-
79953311098
-
A lytic mechanism based on soluble phospholypases A2 (sPLA2) and β-galactoside specific lectins is exerted by Ciona intestinalis (ascidian) unilocular refractile hemocytes against K562 cell line and mammalian erythrocytes
-
V. Arizza A lytic mechanism based on soluble phospholypases A2 (sPLA2) and β-galactoside specific lectins is exerted by Ciona intestinalis (ascidian) unilocular refractile hemocytes against K562 cell line and mammalian erythrocytes Fish Shellfish Immunol. 30 2011 1014 1023
-
(2011)
Fish Shellfish Immunol.
, vol.30
, pp. 1014-1023
-
-
Arizza, V.1
-
18
-
-
79951719571
-
Novel pharmacological targets from Indian cone snails
-
M.S. Ramasamy, and S. Manikandan Novel pharmacological targets from Indian cone snails Mini Rev. Med. Chem. 11 2011 125 130
-
(2011)
Mini Rev. Med. Chem.
, vol.11
, pp. 125-130
-
-
Ramasamy, M.S.1
Manikandan, S.2
-
19
-
-
29744440644
-
Antiesophageal cancer activity from Southern African marine organisms
-
C.E. Whibley Antiesophageal cancer activity from Southern African marine organisms Ann. N. Y. Acad. Sci. 1056 2005 405 412
-
(2005)
Ann. N. Y. Acad. Sci.
, vol.1056
, pp. 405-412
-
-
Whibley, C.E.1
-
20
-
-
0034142130
-
Highlights of marine natural products chemistry (1972-1999)
-
D.J. Faulkner Highlights of marine natural products chemistry (1972-1999) Nat. Prod. Rep. 17 2000 1 6
-
(2000)
Nat. Prod. Rep.
, vol.17
, pp. 1-6
-
-
Faulkner, D.J.1
-
21
-
-
79251496420
-
Marine natural products
-
J.W. Blunt Marine natural products Nat. Prod. Rep. 28 2011 196 268
-
(2011)
Nat. Prod. Rep.
, vol.28
, pp. 196-268
-
-
Blunt, J.W.1
-
22
-
-
58149189779
-
Drug development from marine natural products
-
T.F. Molinsky Drug development from marine natural products Nat. Rev. Drug Discov. 8 2009 69 85
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 69-85
-
-
Molinsky, T.F.1
-
23
-
-
62149117325
-
Discovery of natural product anticancer agents from biodiverse organisms
-
A.D. Kinghorn Discovery of natural product anticancer agents from biodiverse organisms Curr. Opin. Drug. Discov Devel. 12 2009 189 196
-
(2009)
Curr. Opin. Drug. Discov Devel.
, vol.12
, pp. 189-196
-
-
Kinghorn, A.D.1
-
24
-
-
79956042688
-
NMR and protein structure in drug design: Application to cyclotides and conotoxins
-
N.L. Daly NMR and protein structure in drug design: application to cyclotides and conotoxins Eur. Biophys. J. 40 2011 359 370
-
(2011)
Eur. Biophys. J.
, vol.40
, pp. 359-370
-
-
Daly, N.L.1
-
25
-
-
33748094828
-
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure-activity relationship
-
J. Uddin Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: isolation, structure elucidation, and structure-activity relationship Bioorg. Med. Chem. 14 2006 6954 6961
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 6954-6961
-
-
Uddin, J.1
-
26
-
-
8944252332
-
Structure-activity relationships of the didemnins
-
R. Sakai Structure-activity relationships of the didemnins J. Med. Chem. 39 1996 2819 2834
-
(1996)
J. Med. Chem.
, vol.39
, pp. 2819-2834
-
-
Sakai, R.1
-
27
-
-
33751096434
-
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
-
M. Donia Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians Nat. Chem. Biol. 2 2006 729 735
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 729-735
-
-
Donia, M.1
-
28
-
-
27144454498
-
Biology bacteriocyte-associated endosymbionts of plant sap-sucking insects
-
P. Baumann Biology bacteriocyte-associated endosymbionts of plant sap-sucking insects Annu. Rev. Microbiol. 59 2005 155 189
-
(2005)
Annu. Rev. Microbiol.
, vol.59
, pp. 155-189
-
-
Baumann, P.1
-
29
-
-
0034795861
-
Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species
-
M.J. Uddin Haterumaimides F-I, four new cytotoxic diterpene alkaloids from an ascidian Lissoclinum species J. Nat. Prod. 64 2001 1169 1173
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 1169-1173
-
-
Uddin, M.J.1
-
30
-
-
38349022673
-
Ecdysteroids from the Antarctic tunicate Synoicum adareanum
-
Y. Miyata Ecdysteroids from the Antarctic tunicate Synoicum adareanum J. Nat. Prod. 70 2007 1859 1864
-
(2007)
J. Nat. Prod.
, vol.70
, pp. 1859-1864
-
-
Miyata, Y.1
-
31
-
-
34147201260
-
Hydroperoxysterols from the tunicate Eudistoma sp
-
P.J. Sung Hydroperoxysterols from the tunicate Eudistoma sp. Chem. Pharm. Bull. 55 2007 666 668
-
(2007)
Chem. Pharm. Bull.
, vol.55
, pp. 666-668
-
-
Sung, P.J.1
-
32
-
-
67649491097
-
A renaissance in marine pharmacology: From preclinical curiosity to clinical reality
-
K.B. Glaser, and A.M. Mayer A renaissance in marine pharmacology: from preclinical curiosity to clinical reality Biochem. Pharmacol. 78 2009 440 448
-
(2009)
Biochem. Pharmacol.
, vol.78
, pp. 440-448
-
-
Glaser, K.B.1
Mayer, A.M.2
-
33
-
-
47249085698
-
Molecular pathology and potential therapeutic targets in soft-tissue sarcoma
-
R. Todd, and J. Lunec Molecular pathology and potential therapeutic targets in soft-tissue sarcoma Expert Rev. Anticancer Ther. 8 2008 939 948
-
(2008)
Expert Rev. Anticancer Ther.
, vol.8
, pp. 939-948
-
-
Todd, R.1
Lunec, J.2
-
34
-
-
1842840932
-
Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay
-
E. Ulukaya Interference by anti-cancer chemotherapeutic agents in the MTT-tumor chemosensitivity assay Chemotherapy 50 2004 43 50
-
(2004)
Chemotherapy
, vol.50
, pp. 43-50
-
-
Ulukaya, E.1
-
35
-
-
79952177798
-
Death of tumor cells. Photodynamic reaction in apoptosis induction in cancer cells
-
A. Chwilkowska Death of tumor cells. Photodynamic reaction in apoptosis induction in cancer cells Pol. Merkur. Lekarski. 30 2011 45 48
-
(2011)
Pol. Merkur. Lekarski.
, vol.30
, pp. 45-48
-
-
Chwilkowska, A.1
-
37
-
-
84861597848
-
MTT growth assays in ovarian cancer
-
D.M. Spinner MTT growth assays in ovarian cancer Methods Mol. Med. 39 2001 175 177
-
(2001)
Methods Mol. Med.
, vol.39
, pp. 175-177
-
-
Spinner, D.M.1
-
38
-
-
41649117700
-
Cytotoxic metabolites from the Okinawan ascidian Diplosoma virens
-
T. Ogi Cytotoxic metabolites from the Okinawan ascidian Diplosoma virens Molecules 13 2008 595 602
-
(2008)
Molecules
, vol.13
, pp. 595-602
-
-
Ogi, T.1
-
39
-
-
54249139074
-
Marine pharmacology in 2005-2006: Antitumor and cytotoxic compounds
-
A. Mayer, and K. Gustafson Marine pharmacology in 2005-2006: antitumor and cytotoxic compounds Eur. J. Can. 44 2008 2357 2387
-
(2008)
Eur. J. Can.
, vol.44
, pp. 2357-2387
-
-
Mayer, A.1
Gustafson, K.2
-
40
-
-
0033517190
-
NF-kB is a target of AKT in anti-apoptotic PDGF signalling
-
J.A. Romashkova, and S.S. Makarov NF-kB is a target of AKT in anti-apoptotic PDGF signalling Nature 401 1999 86 90
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
41
-
-
33847628325
-
Humoral immunity, inflammation and cancer
-
T.T. Tan, and L.M. Coussens Humoral immunity, inflammation and cancer Curr. Opin. Immunol. 19 2007 209 216
-
(2007)
Curr. Opin. Immunol.
, vol.19
, pp. 209-216
-
-
Tan, T.T.1
Coussens, L.M.2
-
42
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
43
-
-
36749048070
-
Targeting selectins and selectin ligands in inflammation and cancer
-
S.R. Barthel Targeting selectins and selectin ligands in inflammation and cancer Expert Opin. Ther. Targets 11 2007 1473 1491
-
(2007)
Expert Opin. Ther. Targets
, vol.11
, pp. 1473-1491
-
-
Barthel, S.R.1
-
44
-
-
0035451363
-
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kB activation
-
Y.J. Surh Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kB activation Mutat. Res. 480-481 2001 243 268
-
(2001)
Mutat. Res.
, vol.480-481
, pp. 243-268
-
-
Surh, Y.J.1
-
45
-
-
42649098227
-
Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells
-
C.S. Xu Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells Cancer Lett. 264 2008 93 100
-
(2008)
Cancer Lett.
, vol.264
, pp. 93-100
-
-
Xu, C.S.1
-
46
-
-
80052401501
-
Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin
-
E.O. Kozlowski Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin J. Thromb. Haemost. 9 2011 1807 1815
-
(2011)
J. Thromb. Haemost.
, vol.9
, pp. 1807-1815
-
-
Kozlowski, E.O.1
-
47
-
-
0029590022
-
Eilatin: A novel marine alkaloid inhibits in vitro proliferation of progenitor cells in chronic myeloid leukemia patients
-
M. Einat Eilatin: a novel marine alkaloid inhibits in vitro proliferation of progenitor cells in chronic myeloid leukemia patients Exp. Hematol. 23 1995 1439 1444
-
(1995)
Exp. Hematol.
, vol.23
, pp. 1439-1444
-
-
Einat, M.1
-
48
-
-
0029153279
-
Potent antileukemic activity of the novel agents norsegoline and dibezine
-
M. Einat Potent antileukemic activity of the novel agents norsegoline and dibezine Clin. Cancer Res. 1 1995 823 829
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 823-829
-
-
Einat, M.1
-
49
-
-
0029142846
-
Sensitivity of hematopoietic progenitors of acute myeloblastic leukemia to new compounds derived from marine organisms
-
M. Lishner Sensitivity of hematopoietic progenitors of acute myeloblastic leukemia to new compounds derived from marine organisms Leukemia 9 1995 1543 1548
-
(1995)
Leukemia
, vol.9
, pp. 1543-1548
-
-
Lishner, M.1
-
50
-
-
67651108947
-
Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of octacyclic analogue of eilatin
-
L. Bouffier Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of octacyclic analogue of eilatin Bioorg. Med. Chem. Lett. 19 2009 4836 4838
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 4836-4838
-
-
Bouffier, L.1
-
51
-
-
0037085026
-
Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10
-
M.C. Edler Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10 Biochem. Pharmacol. 63 2002 707 715
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 707-715
-
-
Edler, M.C.1
-
52
-
-
0038102301
-
Diazonamide A and a synthetic structural analog: Disruptive effects on mitosis and cellular microtubules and analysis with their interactions with tubulin
-
Z. Cruz-Monserrate Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis with their interactions with tubulin Mol. Pharmacol. 63 2003 1273 1280
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 1273-1280
-
-
Cruz-Monserrate, Z.1
-
53
-
-
33847788820
-
Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division
-
G. Wang Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division Proc. Natl. Acad. Sci. U. S. A. 104 2007 2068 2073
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 2068-2073
-
-
Wang, G.1
-
54
-
-
41749110005
-
The synthetic challenge of diazonamide A, a macrocylic indole bis-oxazole marine natural product
-
M. Lachia, and C.J. Moody The synthetic challenge of diazonamide A, a macrocylic indole bis-oxazole marine natural product Nat. Prod. Rep. 25 2008 227 253
-
(2008)
Nat. Prod. Rep.
, vol.25
, pp. 227-253
-
-
Lachia, M.1
Moody, C.J.2
-
55
-
-
33847784307
-
Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity
-
N.S. Williams Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity Proc. Natl. Acad. Sci. U. S. A. 104 2007 2074 2079
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 2074-2079
-
-
Williams, N.S.1
-
56
-
-
47549083345
-
Mollamides B and C, cyclic hexapeptides from the indonesian tunicate Didemnum molle
-
M.S. Donia Mollamides B and C, cyclic hexapeptides from the indonesian tunicate Didemnum molle J. Nat. Prod. 71 2008 941 945
-
(2008)
J. Nat. Prod.
, vol.71
, pp. 941-945
-
-
Donia, M.S.1
-
57
-
-
33749011163
-
The NCI60 human tumor cell line anticancer drug screen
-
R.H. Shoemaker The NCI60 human tumor cell line anticancer drug screen Nat. Rev. Can. 6 2006 813 823
-
(2006)
Nat. Rev. Can.
, vol.6
, pp. 813-823
-
-
Shoemaker, R.H.1
-
58
-
-
0037178354
-
Kottamides A-D: Novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae
-
D.R. Appleton Kottamides A-D: novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae J. Org. Chem. 67 2002 5402 5404
-
(2002)
J. Org. Chem.
, vol.67
, pp. 5402-5404
-
-
Appleton, D.R.1
-
59
-
-
0025899234
-
Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture
-
A.H. Cory Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture Cancer Commun. 3 1991 207 212
-
(1991)
Cancer Commun.
, vol.3
, pp. 207-212
-
-
Cory, A.H.1
-
60
-
-
77955505177
-
A review of trabectedin (ET-743): A unique mechanism of action
-
M. D'Incalci, and C.M. Galmarini A review of trabectedin (ET-743): a unique mechanism of action Mol. Cancer Ther. 9 2010 2157 2163
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 2157-2163
-
-
D'Incalci, M.1
Galmarini, C.M.2
-
61
-
-
77953685524
-
The odyssey of marine pharmaceuticals: A current pipeline perspective
-
A. Mayer The odyssey of marine pharmaceuticals: a current pipeline perspective Trends Pharmacol. Sci. 31 2010 255 265
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 255-265
-
-
Mayer, A.1
-
62
-
-
0019469697
-
Didemnins: Antiviral and antitumor depsipeptides from a carribean tunicate
-
K.L. Rinehart Jr. Didemnins: antiviral and antitumor depsipeptides from a carribean tunicate Science 212 1981 933 935
-
(1981)
Science
, vol.212
, pp. 933-935
-
-
Rinehart, Jr.K.L.1
-
63
-
-
0023026034
-
Didemnin B. the first marine compound entering clinical trials as an antineoplastic agent
-
H.G. Chun Didemnin B. The first marine compound entering clinical trials as an antineoplastic agent Invest. New Drugs 4 1986 279 284
-
(1986)
Invest. New Drugs
, vol.4
, pp. 279-284
-
-
Chun, H.G.1
-
64
-
-
0029114876
-
Mechanism of protein synthesis inhibition by didemnin B in vitro
-
B.V. SirDeshpande, and P.L. Toogood Mechanism of protein synthesis inhibition by didemnin B in vitro Biochemistry 34 1995 9177 9184
-
(1995)
Biochemistry
, vol.34
, pp. 9177-9184
-
-
Sirdeshpande, B.V.1
Toogood, P.L.2
-
65
-
-
0029923405
-
Protein tyrosine kinase inhibitors prevent didemnin B-induced apoptosis in HL-60 cells
-
K.L. Johnson Protein tyrosine kinase inhibitors prevent didemnin B-induced apoptosis in HL-60 cells FEBS Lett. 383 1996 1 5
-
(1996)
FEBS Lett.
, vol.383
, pp. 1-5
-
-
Johnson, K.L.1
-
66
-
-
0033635276
-
Pharmaceutical development of anticancer agents derived from marine sources
-
B. Nuijen Pharmaceutical development of anticancer agents derived from marine sources Anticancer Drugs 11 2000 793 811
-
(2000)
Anticancer Drugs
, vol.11
, pp. 793-811
-
-
Nuijen, B.1
-
67
-
-
0029670281
-
Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
-
J.L. Urdiales Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates Cancer Lett. 102 1996 31 37
-
(1996)
Cancer Lett.
, vol.102
, pp. 31-37
-
-
Urdiales, J.L.1
-
68
-
-
0034632436
-
Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B
-
C. Cuevas Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B Org. Lett. 2 2000 2545 2548
-
(2000)
Org. Lett.
, vol.2
, pp. 2545-2548
-
-
Cuevas, C.1
-
69
-
-
61549104994
-
Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem
-
C. Cuevas, and A. Francesch Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem Nat. Prod. Rep. 26 2009 322 337
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 322-337
-
-
Cuevas, C.1
Francesch, A.2
-
70
-
-
0034611483
-
A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents
-
E.J. Martinez, and E.J. Corey A new, more efficient, and effective process for the synthesis of a key pentacyclic intermediate for production of ecteinascidin and phthalascidin antitumor agents Org. Lett. 2 2000 993 996
-
(2000)
Org. Lett.
, vol.2
, pp. 993-996
-
-
Martinez, E.J.1
Corey, E.J.2
-
71
-
-
80051585674
-
Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells
-
D. Soares Trabectedin and its C subunit modified analogue PM01183 attenuate nucleotide excision repair and show activity toward platinum-resistant cells Mol. Cancer Ther. 10 2011 1481 1489
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1481-1489
-
-
Soares, D.1
-
72
-
-
79958053392
-
Trabectedin: Safety and efficacy in the treatment of advanced sarcoma
-
C. Gajdos, and A. Elias Trabectedin: safety and efficacy in the treatment of advanced sarcoma Clin. Med. Insights Oncol. 16 2011 35 43
-
(2011)
Clin. Med. Insights Oncol.
, vol.16
, pp. 35-43
-
-
Gajdos, C.1
Elias, A.2
-
73
-
-
65649116202
-
Clinical outcome of ET-743 (Trabectedin; Yondelis) in high-grade uterine sarcomas: Report on five patients and a review of the literature
-
F. Amant Clinical outcome of ET-743 (Trabectedin; Yondelis) in high-grade uterine sarcomas: report on five patients and a review of the literature Int. J. Gynecol. Cancer 19 2009 245 248
-
(2009)
Int. J. Gynecol. Cancer
, vol.19
, pp. 245-248
-
-
Amant, F.1
-
74
-
-
46749092063
-
Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma
-
P. Schoffski Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma Expert Opin. Pharmacother. 9 2008 1609 1618
-
(2008)
Expert Opin. Pharmacother.
, vol.9
, pp. 1609-1618
-
-
Schoffski, P.1
-
75
-
-
0242559104
-
Preclinical and clinical results with the natural marine product ET-743
-
M. D'Incalci, and J. Jimeno Preclinical and clinical results with the natural marine product ET-743 Expert Opin. Investig. Drugs 12 2003 1843 1853
-
(2003)
Expert Opin. Investig. Drugs
, vol.12
, pp. 1843-1853
-
-
D'Incalci, M.1
Jimeno, J.2
-
76
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
-
Y. Takebayashi Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair Nat. Med. 7 2001 961 966
-
(2001)
Nat. Med.
, vol.7
, pp. 961-966
-
-
Takebayashi, Y.1
-
77
-
-
0027074330
-
Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)
-
C. Malochet-Grivois Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) Anticancer Drug Des. 7 1992 493 502
-
(1992)
Anticancer Drug Des.
, vol.7
, pp. 493-502
-
-
Malochet-Grivois, C.1
-
78
-
-
75149198747
-
Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.
-
T. Ogi Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp. Mar. Drugs 7 2009 816 832
-
(2009)
Mar. Drugs
, vol.7
, pp. 816-832
-
-
Ogi, T.1
-
79
-
-
0842281347
-
A profile of the in vitro antitumor activity of lissoclinolide
-
A.D. Richardson, and C.M. Ireland A profile of the in vitro antitumor activity of lissoclinolide Toxicol. Appl. Pharmacol. 195 2004 55 61
-
(2004)
Toxicol. Appl. Pharmacol.
, vol.195
, pp. 55-61
-
-
Richardson, A.D.1
Ireland, C.M.2
-
80
-
-
33846953920
-
Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, against human solid-tumor-derived cell lines
-
T. Oda Cytotoxicity of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian Lissoclinum cf. badium, against human solid-tumor-derived cell lines Biol. Pharm. Bull. 30 2007 385 387
-
(2007)
Biol. Pharm. Bull.
, vol.30
, pp. 385-387
-
-
Oda, T.1
-
81
-
-
0035688166
-
Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species
-
T.N. Makarieva Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species J. Nat. Prod. 64 2001 1559 1561
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 1559-1561
-
-
Makarieva, T.N.1
-
82
-
-
52949100654
-
Cytotoxic activity of a dichloromethane extract and fractions obtained from Eudistoma vannamei (Tunicata: Ascidiacea)
-
P.C. Jimenez Cytotoxic activity of a dichloromethane extract and fractions obtained from Eudistoma vannamei (Tunicata: Ascidiacea) Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 151 2008 391 398
-
(2008)
Comp. Biochem. Physiol. A: Mol. Integr. Physiol.
, vol.151
, pp. 391-398
-
-
Jimenez, P.C.1
-
83
-
-
0035204029
-
New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde
-
M.A. Rashid New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde J. Nat. Prod. 64 2001 1454 1456
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 1454-1456
-
-
Rashid, M.A.1
-
84
-
-
0037467004
-
Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum (1)
-
N. Oku Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum (1) J. Am. Chem. Soc. 125 2003 2044 2045
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 2044-2045
-
-
Oku, N.1
-
85
-
-
52949147844
-
Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents
-
R. Takeara Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents Comp. Biochem. Physiol. A: Mol. Integr. Physiol. 151 2008 363 369
-
(2008)
Comp. Biochem. Physiol. A: Mol. Integr. Physiol.
, vol.151
, pp. 363-369
-
-
Takeara, R.1
-
86
-
-
0037462329
-
Haouamines A and B: A new class of alkaloids from the ascidian Aplidium haouarianum
-
L. Garrido Haouamines A and B: a new class of alkaloids from the ascidian Aplidium haouarianum J. Org. Chem. 68 2003 293 299
-
(2003)
J. Org. Chem.
, vol.68
, pp. 293-299
-
-
Garrido, L.1
-
87
-
-
32244442128
-
Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and it synthetic analogs
-
S.N. Fedorov Evaluation of cancer-preventive activity and structure-activity relationships of 3-demethylubiquinone Q2, isolated from the ascidian Aplidium glabrum, and it synthetic analogs Pharm. Res. 23 2006 70 81
-
(2006)
Pharm. Res.
, vol.23
, pp. 70-81
-
-
Fedorov, S.N.1
-
88
-
-
79951546028
-
Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus
-
H. Choi Tuberatolides, potent FXR antagonists from the Korean marine tunicate Botryllus tuberatus J. Nat. Prod. 74 2011 90 94
-
(2011)
J. Nat. Prod.
, vol.74
, pp. 90-94
-
-
Choi, H.1
-
89
-
-
0035094947
-
New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum
-
A. Aiello New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum J. Nat. Prod. 64 2001 219 221
-
(2001)
J. Nat. Prod.
, vol.64
, pp. 219-221
-
-
Aiello, A.1
-
90
-
-
0033760037
-
Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species
-
M.T. Davies-Coleman Stolonic acids A and B, new cytotoxic cyclic peroxides from an Indian Ocean ascidian Stolonica species J. Nat. Prod. 63 2000 1411 1413
-
(2000)
J. Nat. Prod.
, vol.63
, pp. 1411-1413
-
-
Davies-Coleman, M.T.1
-
91
-
-
0029585731
-
Cytotoxicity reactions in the solitary tunicate Styelaplicata
-
D.A. Raftos, and A. Hutchinson Cytotoxicity reactions in the solitary tunicate Styelaplicata Dev. Comp. Immunol. 19 1995 463 471
-
(1995)
Dev. Comp. Immunol.
, vol.19
, pp. 463-471
-
-
Raftos, D.A.1
Hutchinson, A.2
-
92
-
-
84872209471
-
Fellows of Harvard College (Cambridge, MA)
-
Corey, E.J. Fellows of Harvard College (Cambridge, MA). Synthetic analogs of ecteinascidin 743, 6569859
-
Synthetic Analogs of Ecteinascidin
, vol.743
, pp. 6569859
-
-
Corey, E.J.1
|