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Volumn 264, Issue 1, 2008, Pages 93-100

Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells

Author keywords

Akt; Chondroitin sulfate; iNOS; NF B; Styela clava tunic; VCAM 1

Indexed keywords

CHONDROITIN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

EID: 42649098227     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.01.022     Document Type: Article
Times cited : (56)

References (44)
  • 1
    • 19544387406 scopus 로고    scopus 로고
    • Inflammation-associated cancer: NF-(B is the lynchpin
    • Li Q., Withoff S., and Verma I.M. Inflammation-associated cancer: NF-(B is the lynchpin. Trends Immunol. 26 (2005) 318-325
    • (2005) Trends Immunol. , vol.26 , pp. 318-325
    • Li, Q.1    Withoff, S.2    Verma, I.M.3
  • 2
    • 33847628325 scopus 로고    scopus 로고
    • Humoral immunity, inflammation and cancer
    • Tan T.T., and Coussens L.M. Humoral immunity, inflammation and cancer. Curr. Opin. Immunol. 19 (2007) 209-216
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 209-216
    • Tan, T.T.1    Coussens, L.M.2
  • 3
    • 33644550593 scopus 로고    scopus 로고
    • Statins prevent NF-kappaB transactivation independently of the IKK-pathway in human endothelial cells
    • Hölschermann H., Schuster D., Parviz B., Haberbosch W., Tillmanns H., and Muth H. Statins prevent NF-kappaB transactivation independently of the IKK-pathway in human endothelial cells. Atherosclerosis 185 (2006) 240-245
    • (2006) Atherosclerosis , vol.185 , pp. 240-245
    • Hölschermann, H.1    Schuster, D.2    Parviz, B.3    Haberbosch, W.4    Tillmanns, H.5    Muth, H.6
  • 4
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: linking inflammation and immunity to cancer development and progression
    • Karin M., and Greten F.R. NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5 (2005) 749-759
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 5
    • 33746862576 scopus 로고    scopus 로고
    • Naturally occurring NF-κB inhibitors
    • Nam N.H. Naturally occurring NF-κB inhibitors. Mini Rev. Med. Chem. 6 (2006) 945-951
    • (2006) Mini Rev. Med. Chem. , vol.6 , pp. 945-951
    • Nam, N.H.1
  • 6
    • 12944273470 scopus 로고    scopus 로고
    • Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas: anti-tumor and anti-angiogenic activity in vivo
    • Matsumoto G., Namekawa J., Muta M., Nakamura T., Bando H., Tohyama K., Toi M., and Umezawa K. Targeting of NF-κB pathways by DHMEQ, a novel inhibitor of breast carcinomas: anti-tumor and anti-angiogenic activity in vivo. Clin. Cancer Res. 11 (2005) 1287-1293
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1287-1293
    • Matsumoto, G.1    Namekawa, J.2    Muta, M.3    Nakamura, T.4    Bando, H.5    Tohyama, K.6    Toi, M.7    Umezawa, K.8
  • 7
    • 33846180402 scopus 로고    scopus 로고
    • In vitro effects of chondroitin sulfate
    • Fioravanti A., and Collodel G. In vitro effects of chondroitin sulfate. Adv. Pharmacol. 53 (2006) 449-465
    • (2006) Adv. Pharmacol. , vol.53 , pp. 449-465
    • Fioravanti, A.1    Collodel, G.2
  • 8
    • 0036645073 scopus 로고    scopus 로고
    • Neoglycans, carbodiimide-modified glycosaminoglycans: a new class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis
    • Pumphrey C.Y., Theus A.M., Li S., Parrish R.S., and Sanderson R.D. Neoglycans, carbodiimide-modified glycosaminoglycans: a new class of anticancer agents that inhibit cancer cell proliferation and induce apoptosis. Cancer Res. 62 (2002) 3722-3728
    • (2002) Cancer Res. , vol.62 , pp. 3722-3728
    • Pumphrey, C.Y.1    Theus, A.M.2    Li, S.3    Parrish, R.S.4    Sanderson, R.D.5
  • 10
    • 33645805413 scopus 로고    scopus 로고
    • A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration
    • Rolls A., Cahalon L., Bakalash S., Avidan H., Lider O., and Schwartz M. A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration. FASEB J. 20 (2006) 547-549
    • (2006) FASEB J. , vol.20 , pp. 547-549
    • Rolls, A.1    Cahalon, L.2    Bakalash, S.3    Avidan, H.4    Lider, O.5    Schwartz, M.6
  • 12
    • 0033692913 scopus 로고    scopus 로고
    • Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha
    • Murakami A., Kawabata K., Koshiba T., Gao G., Nakamura Y., Koshimizu K., and Ohigashi H. Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha. Cancer Res. 60 (2000) 6326-6331
    • (2000) Cancer Res. , vol.60 , pp. 6326-6331
    • Murakami, A.1    Kawabata, K.2    Koshiba, T.3    Gao, G.4    Nakamura, Y.5    Koshimizu, K.6    Ohigashi, H.7
  • 13
    • 0019788391 scopus 로고
    • Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion
    • Colburn N.H., Wendel E.J., and Abruzzo G. Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion. Proc. Natl. Acad. Sci. USA 78 (1981) 6912-6916
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 6912-6916
    • Colburn, N.H.1    Wendel, E.J.2    Abruzzo, G.3
  • 14
    • 0018682173 scopus 로고
    • Tumour promoter induces anchorage independence irreversibly
    • Colburn N.H., Former B.F., Nelson K.A., and Yuspa S.H. Tumour promoter induces anchorage independence irreversibly. Nature 281 (1979) 589-591
    • (1979) Nature , vol.281 , pp. 589-591
    • Colburn, N.H.1    Former, B.F.2    Nelson, K.A.3    Yuspa, S.H.4
  • 15
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunolo. Methods 65 (1983) 55-63
    • (1983) J. Immunolo. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 16
    • 33645782015 scopus 로고    scopus 로고
    • TNF-α in cancer treatment: molecular insights, antitumor effects, and clinical utility
    • Van Horssen R., Ten Hagen T.L., and Eggermont A.M. TNF-α in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist 11 (2006) 397-408
    • (2006) Oncologist , vol.11 , pp. 397-408
    • Van Horssen, R.1    Ten Hagen, T.L.2    Eggermont, A.M.3
  • 17
    • 14044277556 scopus 로고    scopus 로고
    • Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus
    • Kabe Y., Ando K., Hirao S., Yoshida M., and Handa H. Redox regulation of NF-κB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid. Redox Signal. 7 (2005) 395-403
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 395-403
    • Kabe, Y.1    Ando, K.2    Hirao, S.3    Yoshida, M.4    Handa, H.5
  • 18
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M., and Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
    • (2002) Nat. Immunol. , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 19
    • 0033595893 scopus 로고    scopus 로고
    • How NF-κB is activated: the role of the IκBα kinase (IKK) complex
    • Karin M. How NF-κB is activated: the role of the IκBα kinase (IKK) complex. Oncogene 18 (1999) 6867-6874
    • (1999) Oncogene , vol.18 , pp. 6867-6874
    • Karin, M.1
  • 20
    • 27744496768 scopus 로고    scopus 로고
    • The biology of p38 kinase: a central role in inflammation
    • Schieven G.L. The biology of p38 kinase: a central role in inflammation. Curr. Top Med. Chem. 5 (2005) 921-928
    • (2005) Curr. Top Med. Chem. , vol.5 , pp. 921-928
    • Schieven, G.L.1
  • 21
    • 0033517190 scopus 로고    scopus 로고
    • NF-κB is a target of AKT in anti-apoptotic PDGF signaling
    • Romashkova J.A., and Makarov S.S. NF-κB is a target of AKT in anti-apoptotic PDGF signaling. Nature 401 (1999) 86-90
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 22
    • 0033517189 scopus 로고    scopus 로고
    • NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., and Donner D.B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401 (1999) 82-85
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 23
    • 33749183547 scopus 로고    scopus 로고
    • Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-(B signaling pathway
    • Tong Q., Zheng L., Lin L., Li B., Wang D., and Li D. Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-(B signaling pathway. Am. J. Respir. Cell Mol. Biol. 35 (2006) 444-456
    • (2006) Am. J. Respir. Cell Mol. Biol. , vol.35 , pp. 444-456
    • Tong, Q.1    Zheng, L.2    Lin, L.3    Li, B.4    Wang, D.5    Li, D.6
  • 24
    • 33847066366 scopus 로고    scopus 로고
    • Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt
    • Kang J.S., Yoon Y.D., Han M.H., Han S.B., Lee K., Park S.K., and Kim H.M. Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt. Int. Immunopharmacol. 7 (2007) 491-499
    • (2007) Int. Immunopharmacol. , vol.7 , pp. 491-499
    • Kang, J.S.1    Yoon, Y.D.2    Han, M.H.3    Han, S.B.4    Lee, K.5    Park, S.K.6    Kim, H.M.7
  • 25
    • 0036484856 scopus 로고    scopus 로고
    • Chronic inflammation and cancer
    • Shacter E., and Weitzman S.A. Chronic inflammation and cancer. Oncology 16 (2002) 217-226
    • (2002) Oncology , vol.16 , pp. 217-226
    • Shacter, E.1    Weitzman, S.A.2
  • 26
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kB activation
    • Surh Y.J., Chun K.S., Cha H.H., Han S.S., Keum Y.S., Park K.K., and Lee S.S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kB activation. Mutat. Res. 480-481 (2001) 243-268
    • (2001) Mutat. Res. , vol.480-481 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3    Han, S.S.4    Keum, Y.S.5    Park, K.K.6    Lee, S.S.7
  • 27
    • 27144544615 scopus 로고    scopus 로고
    • Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin
    • Chiang Y.M., Lo C.P., Chen Y.P., Wang S.Y., Yang N.S., Kuo Y.H., and Shyur L.F. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. Br. J. Pharmacol. 146 (2005) 352-363
    • (2005) Br. J. Pharmacol. , vol.146 , pp. 352-363
    • Chiang, Y.M.1    Lo, C.P.2    Chen, Y.P.3    Wang, S.Y.4    Yang, N.S.5    Kuo, Y.H.6    Shyur, L.F.7
  • 28
    • 0031901747 scopus 로고    scopus 로고
    • Molecular biology of nitric oxide synthases
    • Geller D.A., and Billiar T.R. Molecular biology of nitric oxide synthases. Cancer Metastasis Rev. 17 (1998) 7-23
    • (1998) Cancer Metastasis Rev. , vol.17 , pp. 7-23
    • Geller, D.A.1    Billiar, T.R.2
  • 29
    • 0031556534 scopus 로고    scopus 로고
    • Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide
    • Murata J., Tada M., Iggo R.D., Sawamura Y., Shinohe Y., and Abe H. Nitric oxide as a carcinogen: analysis by yeast functional assay of inactivating p53 mutations induced by nitric oxide. Mutat. Res. 379 (1997) 211-218
    • (1997) Mutat. Res. , vol.379 , pp. 211-218
    • Murata, J.1    Tada, M.2    Iggo, R.D.3    Sawamura, Y.4    Shinohe, Y.5    Abe, H.6
  • 30
    • 0038645387 scopus 로고    scopus 로고
    • H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin
    • Satomi Y., Bu P., Okuda M., Tokuda H., and Nishino H. H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin. Cancer Lett. 196 (2003) 17-22
    • (2003) Cancer Lett. , vol.196 , pp. 17-22
    • Satomi, Y.1    Bu, P.2    Okuda, M.3    Tokuda, H.4    Nishino, H.5
  • 31
    • 1542399059 scopus 로고    scopus 로고
    • Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kB
    • Chun K.S., Cha H.H., Shin J.W., Na H.K., Park K.K., Chung W.Y., and Surh Y.J. Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kB. Carcinogenesis 25 (2004) 445-454
    • (2004) Carcinogenesis , vol.25 , pp. 445-454
    • Chun, K.S.1    Cha, H.H.2    Shin, J.W.3    Na, H.K.4    Park, K.K.5    Chung, W.Y.6    Surh, Y.J.7
  • 32
    • 0042065108 scopus 로고    scopus 로고
    • Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma
    • Ding Y.B., Chen G.Y., Xia J.G., Zang X.W., Yang H.Y., and Yang L. Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J. Gastroenterol. 9 (2003) 1409-1414
    • (2003) World J. Gastroenterol. , vol.9 , pp. 1409-1414
    • Ding, Y.B.1    Chen, G.Y.2    Xia, J.G.3    Zang, X.W.4    Yang, H.Y.5    Yang, L.6
  • 33
    • 22644432694 scopus 로고    scopus 로고
    • Anti-cancer effect of iNOS and its correlation with angiogenesis in gastric cancer
    • Wang G.Y., Ji B., and Gu J.H. Anti-cancer effect of iNOS and its correlation with angiogenesis in gastric cancer. World J. Gastroenterol. 11 (2005) 3830-3833
    • (2005) World J. Gastroenterol. , vol.11 , pp. 3830-3833
    • Wang, G.Y.1    Ji, B.2    Gu, J.H.3
  • 34
    • 33745881021 scopus 로고    scopus 로고
    • Bortezomib (Belcade)-a new therapeutic strategy for patients with refractory multiple myeloma
    • Goranov S.E., and Goranova-Marinova V.S. Bortezomib (Belcade)-a new therapeutic strategy for patients with refractory multiple myeloma. Folia. Med. 47 (2005) 11-19
    • (2005) Folia. Med. , vol.47 , pp. 11-19
    • Goranov, S.E.1    Goranova-Marinova, V.S.2
  • 35
    • 34147099560 scopus 로고    scopus 로고
    • TNFR1-induced NF-kB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    • Zhou Z., Connell C.M., and MacEwan D.J. TNFR1-induced NF-kB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells. Cell Signal. 19 (2007) 1238-1248
    • (2007) Cell Signal. , vol.19 , pp. 1238-1248
    • Zhou, Z.1    Connell, C.M.2    MacEwan, D.J.3
  • 36
    • 4243687105 scopus 로고    scopus 로고
    • The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive
    • Dhar A., Young M.R., and Colburn N.H. The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Mol. Cell. Biochem. 234-235 (2002) 185-193
    • (2002) Mol. Cell. Biochem. , vol.234-235 , pp. 185-193
    • Dhar, A.1    Young, M.R.2    Colburn, N.H.3
  • 38
    • 0036709174 scopus 로고    scopus 로고
    • Nuclear factor-kappa B and cancer: its role in prevention and therapy
    • Bharti A.C., and Aggarwal B.B. Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem. Pharmacol. 64 (2002) 883-888
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 883-888
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 39
    • 33847168466 scopus 로고    scopus 로고
    • IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges
    • Strnad J., and Burke J.R. IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges. Trends Pharmacol. Sci. 28 (2007) 142-148
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 142-148
    • Strnad, J.1    Burke, J.R.2
  • 40
    • 33750494955 scopus 로고    scopus 로고
    • Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-κB and AP-1 as prime targets
    • Kundu J.K., Shin Y.K., and Surh Y.J. Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-κB and AP-1 as prime targets. Biochem. Pharmacol. 72 (2006) 1506-1515
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1506-1515
    • Kundu, J.K.1    Shin, Y.K.2    Surh, Y.J.3
  • 42
    • 33846849163 scopus 로고    scopus 로고
    • Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoloquiritigenin through NF-κB signal disruption
    • Kwon H.M., Choi Y.J., Choi J.S., Kang S.W., Bae J.Y., Kang I.J., Jun J.G., Lee S.S., Lim S.S., and Kang Y.H. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoloquiritigenin through NF-κB signal disruption. Exp. Biol. Med. 232 (2007) 235-245
    • (2007) Exp. Biol. Med. , vol.232 , pp. 235-245
    • Kwon, H.M.1    Choi, Y.J.2    Choi, J.S.3    Kang, S.W.4    Bae, J.Y.5    Kang, I.J.6    Jun, J.G.7    Lee, S.S.8    Lim, S.S.9    Kang, Y.H.10
  • 43
    • 34147191559 scopus 로고    scopus 로고
    • Involvement of MAPKs and NF-κB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells
    • Lin W.N., Luo S.F., Lee C.W., Wang C.C., Wang J.S., and Yang C.M. Involvement of MAPKs and NF-κB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells. Cell Signal. 19 (2007) 1258-1267
    • (2007) Cell Signal. , vol.19 , pp. 1258-1267
    • Lin, W.N.1    Luo, S.F.2    Lee, C.W.3    Wang, C.C.4    Wang, J.S.5    Yang, C.M.6
  • 44
    • 0042734447 scopus 로고    scopus 로고
    • Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a phosphatidylinositol 3'-kinase pathway
    • Kim W., Moon S.O., Lee S., Sung M.J., Kim S.H., and Park S.K. Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a phosphatidylinositol 3'-kinase pathway. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1377-1383
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1377-1383
    • Kim, W.1    Moon, S.O.2    Lee, S.3    Sung, M.J.4    Kim, S.H.5    Park, S.K.6


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