Insulin resistance, obesity, hypertension, and renal sodium transport

International Journal of Hypertension

Volumn 2011, Issue , 2011, Pages

  Horita, Shoko ^a   Seki, George ^a   Yamada, Hideomi ^a   Suzuki, Masashi ^a   Koike, Kazuhiko ^a   Fujita, Toshiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMILORIDE; BICARBONATE SODIUM COTRANSPORTER; EPITHELIAL SODIUM CHANNEL; INSULIN; PROTEIN KINASE WNK1; PROTEIN KINASE WNK4; SODIUM PROTON EXCHANGE PROTEIN 3;

BASOLATERAL MEMBRANE; BLOOD PRESSURE REGULATION; HEREDITARY HYPERTENSION; HUMAN; HYPERTENSION; INSULIN RESISTANCE; KIDNEY COLLECTING TUBULE; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE CELL; NEPHRON; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SODIUM TRANSPORT;

EID: 84861650862     PISSN: 20900384     EISSN: 20900392     Source Type: Journal    
DOI: 10.4061/2011/391762     Document Type: Review

References (91)

1. Hall J. E., Hildebrandt D. A., Kuo J., Obesity hypertension: role of leptin and sympathetic nervous system. American Journal of Hypertension 2001 14 6 103S 115S 2-s2.0-0034993097 (Pubitemid 32506704)
2. Kahn B. B., Flier J. S., Obesity and insulin resistance. Journal of Clinical Investigation 2000 106 4 473 481 2-s2.0-0033849777 (Pubitemid 30666380)
3. Reaven G. M., Hoffman B. B., A role for insulin in the aetiology and course of hypertension? The Lancet 1987 2 8556 435 437 2-s2.0-0023214682
4. Tsutsu N., Nunoi K., Kodama T., Nomiyama R., Iwase M., Fujishima M., Lack of association between blood pressure and insulin in patients with insulinoma. Journal of Hypertension 1990 8 5 479 482 2-s2.0-0025011729 (Pubitemid 20347083)
5. Hall J. E., Hyperinsulinemia: a link between obesity and hypertension? Kidney International 1993 43 6 1402 1417 2-s2.0-0027264911 (Pubitemid 23161431)
6. Hayashi K., Fujiwara K., Oka K., Nagahama T., Matsuda H., Saruta T., Effects of insulin on rat renal microvessels: studies in the isolated perfused hydronephrotic kidney. Kidney International 1997 51 5 1507 1513 2-s2.0-0030992110 (Pubitemid 27239905)
7. Steinberg H. O., Brechtel G., Johnson A., Fineberg N., Baron A. D., Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. Journal of Clinical Investigation 1994 94 3 1172 1179 2-s2.0-0028030813
8. Jiang Z. Y., Lin Y. W., Clemont A., Feener E. P., Hein K. D., Igarashi M., Yamauchi T., White M. F., King G. L., Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. Journal of Clinical Investigation 1999 104 4 447 457 2-s2.0-0032719024 (Pubitemid 29534329)
9. Li R., Zhang H., Wang W., Wang X., Huang Y., Huang C., Gao F., Vascular insulin resistance in prehypertensive rats: role of PI3-kinase/Akt/eNOS signaling. European Journal of Pharmacology 2010 628 13 140 147 2-s2.0-73649129537 10.1016/j.ejphar.2009.11.038
10. Finch D., Davis G., Bower J., Kirchner K., Effect of insulin on renal sodium handling in hypertensive rats. Hypertension 1990 15 5 514 518 2-s2.0-0025257585 (Pubitemid 20148044)
11. Rocchini A. P., Katch V., Kveselis D., Moorehead C., Martin M., Lampman R., Gregory M., Insulin and renal sodium retention in obese adolescents. Hypertension 1989 14 4 367 374 2-s2.0-0024467081 (Pubitemid 19256537)
12. Sechi L. A., Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity. Journal of Hypertension 1999 17 9 1229 1237 2-s2.0-0032708963 10.1097/00004872-199917090- 00001 (Pubitemid 29509500)
13. Bourdeau J. E., Chen E. R. Y., Carone F. A., Insulin uptake in the renal proximal tubule. American Journal of Physiology 1973 225 6 1399 1404 2-s2.0-0015899533
14. Nakamura R., Emmanouel D. S., Katz A. I., Insulin binding sites in various segments of the rabbit nephron. Journal of Clinical Investigation 1983 72 1 388 392 2-s2.0-0020608862 (Pubitemid 13025880)
15. Butlen D., Vadrot S., Roseau S., Morel F., Insulin receptors along the rat nephron: [125I] insulin binding in microdissected glomeruli and tubules. Pflugers Archiv European Journal of Physiology 1988 412 6 604 612 2-s2.0-0023805087
16. Rabkin R., Ryan M. P., Duckworth W. C., The renal metabolism of insulin. Diabetologia 1984 27 3 351 357 2-s2.0-0021134511 (Pubitemid 14044457)
17. Cortney M. A., Sawin L. L., Weiss D. D., Renal tubular protein absorption in the rat. Journal of Clinical Investigation 1970 49 1 1 4 2-s2.0-0014703259
18. Rabkin R., Simon N. M., Steiner S., Colwell J. A., Effect of renal disease on renal uptake and excretion of insulin in man. The New England Journal of Medicine 1970 282 4 182 187 2-s2.0-0014958273
19. DeFronzo R. A., Cooke C. R., Andres R., The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. Journal of Clinical Investigation 1975 55 4 845 855 2-s2.0-0016659653
20. Baum M., Insulin stimulates volume absorption in the rabbit proximal convoluted tubule. Journal of Clinical Investigation 1987 79 4 1104 1109 2-s2.0-0023198508 (Pubitemid 17065490)
21. + exchange activity in proximal tubules from normotensive and hypertensive rats. American Journal of Physiology 1991 260 5 F695 F703 2-s2.0-0025858999
22. + exchanger 3. Journal of Biological Chemistry 2001 276 33 31296 31304 2-s2.0-0035903178 10.1074/jbc.M103900200 (Pubitemid 37385000)
23. + exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. Journal of Biological Chemistry 2003 278 19 16494 16501 2-s2.0-0038269099 10.1074/jbc.M300580200 (Pubitemid 36799509)
24. Shiue H., Musch M. W., Wang Y., Chang E. B., Turner J. R., Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. Journal of Biological Chemistry 2005 280 2 1688 1695 2-s2.0-12544256432 10.1074/jbc.M409471200
25. + exchanger 3: biphasic response and glucocorticoid dependence. American Journal of Physiology 2002 283 3 F532 F539 2-s2.0-0036720326
26. + exchanger NHE3 by insulin. American Journal of Physiology 2007 292 2 F577 F585 2-s2.0-33846883310 10.1152/ajprenal.00240.2006 (Pubitemid 46220524)
27. Talor Z., Emmanouel D. S., Katz A. I., Insulin (INS) stimulates Na-K-ATPase activity of basolateral (BL) renal tubular membranes. Kidney International 1982 21 supplement 1 266 (Pubitemid 12104679)
28. Rivera C., Santos-Reyes H., Martinez-Maldonado M., Response of dog renal Na,K-ATPase to insulin in vitro. Renal Physiology 1978 1 2 74 83 2-s2.0-0018247960 (Pubitemid 9225451)
29. Feraille E., Carranza M. L., Rousselot M., Favre H., Insulin enhances sodium sensitivity of Na-K-ATPase in isolated rat proximal convoluted tubule. American Journal of Physiology 1994 267 1 F55 F62 2-s2.0-0027981732
30. 3 cotransporter: IX. Modulation by insulin, epidermal growth factor and carbachol. Regulatory Peptides 1998 77 13 155 161 2-s2.0-0032538311 10.1016/S0167-0115(98)00115-3 (Pubitemid 28467102)
31. Kirchner K. A., Insulin increases loop segment chloride reabsorption in the euglycemic rat. American Journal of Physiology 1988 255 6 F1206 F1213 2-s2.0-0024270261
32. Ito O., Kondo Y., Takahashi N., Kudo K., Igarashi Y., Omata K., Imai Y., Abe K., Insulin stimulates NaCl transport in isolated perfused MTAL of Henle's loop of rabbit kidney. American Journal of Physiology 1994 267 2 F265 F270 2-s2.0-0028145195
33. Takahashi N., Ito O., Abe K., Tubular effects of insulin. Hypertension Research 1996 19 1 S41 S45 2-s2.0-0029825466
34. +-ATPase activity via PKC alpha in rat medullary thick ascending limb. Diabetologia 2003 46 1 124 131 2-s2.0-0037283248 (Pubitemid 36237755)
35. Loffing J., Korbmacher C., Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Archiv 2009 458 1 111 135 2-s2.0-64149085069 10.1007/s00424-009-0656-0
36. Blazer-Yost B. L., Liu X., Helman S. I., Hormonal regulation of eNaCs: insulin and aldosterone. American Journal of Physiology 1998 274 5 C1373 C1379 2-s2.0-0031832526
37. +-ATPase in rat collecting duct. Journal of Physiology 1995 488 1 171 180 2-s2.0-0028876468
38. +-adenosine triphosphatase α -subunits in rat skeletal mescle. Endocrinology 2001 142 8 3474 3482 2-s2.0-0034918706 10.1210/en.142.8.3474 (Pubitemid 32681755)
39. + channels by aldosterone: role of Sgk1. Clinical and Experimental Pharmacology and Physiology 2008 35 2 235 241 2-s2.0-38148999357 10.1111/j.1440-1681.2007.04844.x
40. Loffing J., Flores S. Y., Staub O., Sgk kinases and their role in epithelial transport. Annual Review of Physiology 2006 68 461 490 2-s2.0-33646060747 10.1146/annurev.physiol.68.040104.131654
41. White M. F., Maron R., Kahn C. R., Insulin rapidly stimulates tyrosine phosphorylation of a M(r)-185,000 protein in intact cells. Nature 1985 318 6042 183 186 2-s2.0-0022347547 (Pubitemid 16192587)
42. Sun X. J., Rothenberg P., Kahn C. R., Backer J. M., Araki E., Wilden P. A., Cahill D. A., Goldstein B. J., White M. F., Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991 352 6330 73 77 2-s2.0-0025813375 10.1038/352073a0 (Pubitemid 21896701)
43. Sun X. J., Wang L. M., Zhang Y., Yenush L., Myers M. G., Glasheen E., Lane W. S., Pierce J. H., White M. F., Role of IRS-2 in insulin and cytokine signalling. Nature 1995 377 6545 173 177 2-s2.0-0029148591
44. White M. F., The IRS-signalling system: a network of docking proteins that mediate insulin action. Molecular and Cellular Biochemistry 1998 182 1-2 3 11 2-s2.0-0031918624 10.1023/A:1006806722619 (Pubitemid 28181643)
45. Brüning J. C., Winnay J., Cheatham B., Kahn C. R., Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS- 2 in IRS-1-deficient cells. Molecular and Cellular Biology 1997 17 3 1513 1521 2-s2.0-0040973209 (Pubitemid 27097381)
46. Araki E., Lipes M. A., Patti M. E., Bruning J. C., Haag B., Johnson R. S., Kahn C. R., Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994 372 6502 186 190 2-s2.0-0028032895 10.1038/372186a0 (Pubitemid 24347839)
47. Kubota N., Tobe K., Terauchi Y., Eto K., Yamauchi T., Suzuki R., Tsubamoto Y., Komeda K., Nakano R., Miki H., Satoh S., Sekihara H., Sciacchitano S., Lesniak M., Aizawa S., Nagai R., Kimura S., Akanuma Y., Taylor S. I., Kadowaki T., kadowaki-3im@h.u-tokyo.ac.jp Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β -cell hyperplasia. Diabetes 2000 49 11 1880 1889
48. Kido Y., Burks D. J., Withers D., Bruning J. C., Kahn C. R., White M. F., Accili D., Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. Journal of Clinical Investigation 2000 105 2 199 205 2-s2.0-0033966768 (Pubitemid 30054359)
49. Zheng Y., Yamada H., Sakamoto K., Horita S., Kunimi M., Endo Y., Li Y., Tobe K., Terauchi Y., Kadowaki T., Seki G., Fujita T., Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. Journal of the American Society of Nephrology 2005 16 8 2288 2295 2-s2.0-28444433729 10.1681/ASN.2005020193 (Pubitemid 41725046)
50. Goodyear L. J., Giorgino F., Sherman L. A., Carey J., Smith R. J., Dohm G. L., Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. Journal of Clinical Investigation 1995 95 5 2195 2204 2-s2.0-0028903232
51. Friedman J. E., Ishizuka T., Shao J., Huston L., Highman T., Catalano P., Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes. Diabetes 1999 48 9 1807 1814 2-s2.0-0032848778 10.2337/diabetes.48.9.1807 (Pubitemid 29415201)
52. Rondinone C. M., Wang L. M., Lonnroth P., Wesslau C., Pierce J. H., Smith U., Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences of the United States of America 1997 94 8 4171 4175 2-s2.0-0030890580 10.1073/pnas.94.8.4171 (Pubitemid 27180518)
53. Carvalho E., Jansson P. A., Axelsen M., Eriksson J. W., Huang X., Groop L., Rondinone C., Sjöström L., Smith U., Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB Journal 1999 13 15 2173 2178 2-s2.0-0032779156
54. Al-Rasheed N. M., Willars G. B., Brunskill N. J., C-peptide signals via G α to protect against TNF- α -mediated apoptosis of opossum kidney proximal tubular cells. Journal of the American Society of Nephrology 2006 17 4 986 995 2-s2.0-33645469061 10.1681/ASN.2005080797
55. Wajant H., Pfizenmaier K., Scheurich P., Tumor necrosis factor signaling. Cell Death and Differentiation 2003 10 1 45 65 2-s2.0-0037276438 10.1038/sj.cdd.4401189 (Pubitemid 36511832)
56. Peraldi P., Spiegelman B., TNF- α and insulin resistance: summary and future prospects. Molecular and Cellular Biochemistry 1998 182 1-2 169 175 2-s2.0-0031892271 10.1023/A:1006865715292 (Pubitemid 28181660)
57. Hotamisligil G. S., The role of TNF α and TNF receptors in obesity and insulin resistance. Journal of Internal Medicine 1999 245 6 621 625 2-s2.0-0032587240 10.1046/j.1365-2796.1999.00490.x (Pubitemid 29278870)
58. Uysal K. T., Wiesbrock S. M., Marino M. W., Hotamisligil G. S., Protection from obesity-induced insulin resistance in mice lacking TNF- α function. Nature 1997 389 6651 610 614 2-s2.0-0030756346 10.1038/39335 (Pubitemid 27446179)
59. Shoelson S. E., Lee J., Goldfine A. B., Inflammation and insulin resistance. Journal of Clinical Investigation 2006 116 7 1793 1801 2-s2.0-33745861300 10.1172/JCI29069
60. Amin MD. R., Malakooti J., Sandoval R., Dudeja P. K., Ramaswamy K., IFN- γ and TNF- α regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1. American Journal of Physiology 2006 291 5 C887 C896 2-s2.0-33751112510 10.1152/ajpcell.00630.2005 (Pubitemid 44771808)
61. Amin M. D. R., Dudeja P. K., Ramaswamy K., Malakooti J., Involvement of Sp1 and Sp3 in differential regulation of human NHE3 promoter activity by sodium butyrate and IFN- γ /TNF- α American Journal of Physiology 2007 293 1 G374 G382 2-s2.0-34547107899 10.1152/ajpgi.00128.2007 (Pubitemid 47105167)
62. Shahid M., Francis J., Majid D. S. A., Tumor necrosis factor- α induces renal vasoconstriction as well as natriuresis in mice. American Journal of Physiology 2008 295 6 F1836 F1844 2-s2.0-57349173002 10.1152/ajprenal.90297. 2008
63. DiPetrillo K., Coutermarsh B., Gesek F. A., Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy during diabetes. American Journal of Physiology 2003 284 1 F113 F121 2-s2.0-0037213986 (Pubitemid 35471291)
64. DiPetrillo K., Coutermarsh B., Soucy N., Hwa J., Gesek F., Tumor necrosis factor induces sodium retention in diabetic rats through sequential effects on distal tubule cells. Kidney International 2004 65 5 1676 1683 2-s2.0-2342534406 10.1111/j.1523-1755.2004.00606.x (Pubitemid 38591015)
65. Schmidt C., Höcherl K., Schweda F., Kurtz A., Bucher M., Regulation of renal sodium transporters during severe inflammation. Journal of the American Society of Nephrology 2007 18 4 1072 1083 2-s2.0-34047221398 10.1681/ASN.2006050454 (Pubitemid 46536893)
66. Riquier-Brison A. D. M., Leong P. K. K., Pihakaski-Maunsbach K., McDonough A. A., Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. American Journal of Physiology 2010 298 1 F177 F186 2-s2.0-74049118932 10.1152/ajprenal.00464.2009
67. El-Atat F. A., Stas S. N., Mcfarlane S. I., Sowers J. R., The relationship between hyperinsulinemia, hypertension and progressive renal disease. Journal of the American Society of Nephrology 2004 15 11 2816 2827 2-s2.0-16644385307 10.1097/01.ASN.0000133698.80390.37 (Pubitemid 41103390)
68. Velloso L. A., Folli F., Perego L., Saad M. J. A., The multi-faceted cross-talk between the insulin and angiotensin II signaling systems. Diabetes/Metabolism Research and Reviews 2006 22 2 98 107 2-s2.0-33644982837 10.1002/dmrr.611
69. Lastra G., Dhuper S., Johnson M. S., Sowers J. R., sowersj@health. missouri.edu Salt, aldosterone, and insulin resistance: impact on the cardiovascular system. Nature Reviews Cardiology 2010 7 10 577 584 10.1038/nrcardio.2010.123
70. +-HC O3- cotransporter by angiotensin II type 1A receptor. Hypertension 2002 40 5 707 712 2-s2.0-0036842017 10.1161/01.HYP.0000036449. 70110.DE (Pubitemid 35278608)
71. Zheng Y., Horita S., Hara C., Kunimi M., Yamada H., Sugaya T., Goto A., Fujita T., Seki G., Biphasic regulation of renal proximal bicarbonate absorption by luminal AT receptor. Journal of the American Society of Nephrology 2003 14 5 1116 1122 2-s2.0-0037408542 10.1097/01.ASN.0000064700.58048.C1 (Pubitemid 36514654)
72. +-HC O3- transport. Journal of the American Society of Nephrology 2008 19 2 252 259 2-s2.0-39049112134 10.1681/ASN.2007030289 (Pubitemid 351240647)
73. Zhang S. L., Chen X., Hsieh T. J., Leclerc M., Henley N., Allidina A., Hallé J. P., Brunette M. G., Filep J. G., Tang S. S., Ingelfinger J. R., Chan J. S. D., Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells. Journal of Endocrinology 2002 172 2 333 344 2-s2.0-18244365862 10.1677/joe.0.1720333 (Pubitemid 34183082)
74. Xu B. E., English J. M., Wilsbacher J. L., Stippec S., Goldsmith E. J., Cobb M. H., WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. Journal of Biological Chemistry 2000 275 22 16795 16801 2-s2.0-0034595634 10.1074/jbc.275.22.16795 (Pubitemid 30398913)
75. Wilson F. H., Disse-Nicodème S., Choate K. A., Ishikawa K., Nelson-Williams C., Desitter I., Gunel M., Milford D. V., Lipkin G. W., Achard J. M., Feely M. P., Dussol B., Berland Y., Unwin R. J., Mayan H., Simon D. B., Farfel Z., Jeunemaitre X., Lifton R. P., Human hypertension caused by mutations in WNK kinases. Science 2001 293 5532 1107 1112 2-s2.0-17944373014 10.1126/science.1062844 (Pubitemid 32758085)
76. McCormick J. A., Yang C. L., Ellison D. H., WNK kinases and renal sodium transport in health and disease: an integrated view. Hypertension 2008 51 3 588 596 2-s2.0-40449098229 10.1161/HYPERTENSIONAHA.107.103788
77. Safar M. E., Boudier H. S., Vascular development, pulse pressure, and the mechanisms of hypertension. Hypertension 2005 46 1 205 209 2-s2.0-21744442575 10.1161/01.HYP.0000167992.80876.26 (Pubitemid 40946515)
78. Yang C. L., Angell J., Mitchell R., Ellison D. H., WNK kinases regulate thiazide-sensitive Na-Cl cotransport. Journal of Clinical Investigation 2003 111 7 1039 1045 2-s2.0-0037382807 10.1172/JCI200317443 (Pubitemid 36397480)
79. Golbang A. P., Cope G., Hamad A., Murthy M., Liu C. H., Cuthbert A. W., O'Shaughnessy K. M., Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. American Journal of Physiology 2006 291 6 F1369 F1376 2-s2.0-33845361061 10.1152/ajprenal.00468.2005 (Pubitemid 44887251)
80. Cai H., Cebotaru V., Wang Y. H., Zhang X. M., Cebotaru L., Guggino S. E., Guggino W. B., WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Kidney International 2006 69 12 2162 2170 2-s2.0-33745076253 10.1038/sj.ki.5000333 (Pubitemid 43882102)
81. Ohta A., Rai T., Yui N., Chiga M., Yang S. S., Lin S. H., Sohara E., Sasaki S., Uchida S., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Human Molecular Genetics 2009 18 20 3978 3986 2-s2.0-70349581037 10.1093/hmg/ddp344
82. Yang C. L., Zhu X., Wang Z., Subramanya A. R., Ellison D. H., Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. Journal of Clinical Investigation 2005 115 5 1379 1387 2-s2.0-18244373189 10.1172/JCI200522452 (Pubitemid 40629058)
83. Subramanya A. R., Yang C. L., Zhu X., Ellison D. H., Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. American Journal of Physiology 2006 290 3 F619 F624 2-s2.0-33645557214 10.1152/ajprenal.00280.2005 (Pubitemid 43724963)
84. Rinehart J., Kahle K. T., De Los Heros P., Vazquez N., Meade P., Wilson F. H., Hebert S. C., Gimenez I., Gamba G., Lifton R. P., WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl cotransporters required for normal blood pressure homeostasis. Proceedings of the National Academy of Sciences of the United States of America 2005 102 46 16777 16782 2-s2.0-28044458544 10.1073/pnas.0508303102 (Pubitemid 41688853)
85. Yang C. L., Zhu X., Ellison D. H., The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. Journal of Clinical Investigation 2007 117 11 3403 3411 2-s2.0-36048938340 10.1172/JCI32033 (Pubitemid 350096996)
86. Heise C. J., Xu B.-E., Deaton S. L., Cha S.-K., Cheng C.-J., Earnest S., Sengupta S., Juang Y.-C., Stippec S., Xu Y., Zhao Y., Huang C.-L., Cobb M. H., melanie.Cobb@utsouthwestern.edu Serum and Glucocorticoid-induced Kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. Journal of Biological Chemistry 2010 285 33 25161 25167 10.1074/jbc.M110.103432
87. Vitari A. C., Deak M., Collins B. J., Morrice N., Prescott A. R., Phelan A., Humphreys S., Alessi D. R., WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate. Biochemical Journal 2004 378 1 257 268 2-s2.0-1542314814 10.1042/BJ20031692 (Pubitemid 38299565)
88. Sohara E., Rai T., Ohta A., Ohta e., Sasaki S., Uchida S., Novel Insulin-WNK4-NCC phosphorylation cascade is involved in pathogenesis of PHA II caused by WNK4 R1185C mutation. Proceedings of the 42nd Annual Meeting of American Society of Nephrology November 2009 San Diego, Calif, USA F-FC279
89. Ellison D. H., Oyama T. T., Yang C. L., Rogers S., Beard D. r., Komers R., Altered WNK4/NCC signaling in a rat model of insulin resistance. Proceedings of the 42nd Annual Meeting of American Society of Nephrology November 2009 SA-FC432
90. Huang C. L., Kuo E., Mechanisms of Disease: WNK-ing at the mechanism of salt-sensitive hypertension. Nature Clinical Practice Nephrology 2007 3 11 623 630 2-s2.0-35549003692 10.1038/ncpneph0638 (Pubitemid 350012824)
91. Hoorn E. J., Van Der Lubbe N., Zietse R., The renal WNK kinase pathway: a new link to hypertension. Nephrology Dialysis Transplantation 2009 24 4 1074 1077 2-s2.0-65349116796 10.1093/ndt/gfp013