Synthesis of multidrug resistance modulator LY335979 labeled with deuterium and tritium

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 39, Issue 1, 1997, Pages 49-58

  Czeskis, Boris A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Deuterium labeling; LY335979; Multidrug resistance modulator; Tritium labeling

Indexed keywords

DEUTERIUM;

ACIDIC CONDITIONS; DEUTERIUM LABELLING; GLYCIDOL; HYDROXYQUINOLINES; LABELINGS; LY335979; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE MODULATOR; PALLADIUM ON CARBONS; TRITIUM LABELING;

TRITIUM;

DEUTERIUM; QUINOLINE DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG; ZOSUQUIDAR;

ARTICLE; DRUG SYNTHESIS; ISOTOPE LABELING; MULTIDRUG RESISTANCE;

EID: 0031020830     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199701)39:1<49::AID-JLCR938>3.0.CO;2-M     Document Type: Article

References (17)

1. Endicott, J. A. and Ling, V. - Annu. Rev. Biochem. 58: 137 (1989).
2. Bradley, G. and Ling, V. - Cancer Metastasis Rev. 13: 223 (1994).
3. Pfister, J. R.; Makra, F.; Muehldorf, A. V.; Wu, H.; Nelson, J. T.; Cheung, P.; Bruno, N. A.; Casey, S. M.; Zutshi, N; and Slate, D. L. - Bioorg. Med. Chem. Lett. 5: 2473 (1995).
4. Slate, D. L.; Bruno, N. A.; Casey, S. M.; Zutshi, N; Garvin, L. J.; Wu, H.; and Pfister, J. R. - Anticancer Res. 15: 811 (1995).
5. Review: Smalley, R. K. In: Quinolines (The Chemistry of Heterocyclic Compounds); Jones, G. Ed.; Wiley-Interscience: London, 1977; Vol. 32, Part 1, p. 319.
6. Review: Scriven, E. F. K. In: Comprehensive Heterocyclic Chemistry; Katritzky, A. R. and Rees, C. W. Eds.; Pergamon Press: Oxford, 1984, Vol. 2, p. 198.
7. Skraup, Z. H. - Monatsh. 3: 531 (1882).
8. Claus, A. and Howitz, H. - J. Prakt. Chem. 152: 433 (1891).
9. Claus, A. and Howitz, H. - J. Prakt. Chem. 160: 532 (1895).
10. Claus, A. - J. Prakt. Chem. 161: 335 (1896).
11. Koch, V. and Schnatterer, S. - Synthesis, 497 (1990).
12. Review: Parker, R. E. and Isaacs, N. S. - Chem. Rev. 59: 737 (1959).
13. Review: Larock, R. C. Comprehensive Organic Transformations, VCH: New York, 1989, p. 628.
14. An, Z.; D'Aloisio, R.; and Venturello, C. - Synthesis, 1229 (1992), and references cited therein.
15. Sudha, R.; Narasimhan, K. M.; Saraswathy, V. G.; and Sankararaman, S. - J. Org. Chem. 61: 1877 (1996), and references cited therein.
16. Pless, J. - Helv. Chim. Acta, 59: 499 (1976).
17. 3H Custom Preparations), Amersham International plc, Cardiff Laboratories, Whitchurch, Cardiff, CF4 7YT, UK.