The co-drug of conjugated hydroquinone and azelaic acid to enhance topical skin targeting and decrease penetration through the skin

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 2, 2012, Pages 369-378

  Hsieh, Pei Wen ^a   Al Suwayeh, Saleh A ^b   Fang, Chia Lang ^c   Lin, Chwan Fwu ^d   Chen, Chun Che ^a   Fang, Jia You ^a,d  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Azelaic acid; Co drug; Hydroquinone; Prodrug; Skin delivery

Indexed keywords

AZELAIC ACID; HYDROQUINONE; PRODRUG;

ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SOLUBILITY; ERYTHEMA; ESTERIFICATION; FEMALE; HYDROLYSIS; HYPERPIGMENTATION; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; SKIN ABSORPTION; SKIN PENETRATION; SKIN TEST; STRATUM CORNEUM; THERMODYNAMICS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; DICARBOXYLIC ACIDS; DRUG DELIVERY SYSTEMS; FEMALE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; HYDROQUINONES; MICE; MICE, NUDE; PERMEABILITY; PRODRUGS; SKIN; SKIN ABSORPTION; THERMODYNAMICS;

EID: 84861608854     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.03.006     Document Type: Article

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