Synthesis and evaluation of ketorolac ester prodrugs for transdermal delivery

Journal of Pharmaceutical Sciences

Volumn 92, Issue 5, 2003, Pages 1008-1017

  Doh, Hea Jeong ^a   Cho, Won Jea ^b   Yong, Chul Soon ^c   Choi, Han Gon ^c   Kim, Jung Sun ^d   Lee, Chi Ho ^a   Kim, Dae Duk ^a  

^a Pusan National University   (South Korea)

^b Chonnam National University   (South Korea)

^c Yongnam University ^*  (South Korea)

^d Dongseo University   (South Korea)

Author keywords

Alkyl ester prodrug; Ketorolac; Transdermal delivery

Indexed keywords

5 BENZOYL 2,3 DIHDYRO 1H PYRROLIZINE 1 CARBOXYLIC ACID BUTYL ESTER; 5 BENZOYL 2,3 DIHDYRO 1H PYRROLIZINE 1 CARBOXYLIC ACID ISOPROPYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID ETHYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID ISOBUTYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID METHYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID PENTYL ESTER; 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXYLIC ACID PROPYL ESTER; K 001; K 002; K 003; K 004; K 005; K 006; K 007; KETOROLAC; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG DEGRADATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MALE; NONHUMAN; PARTITION COEFFICIENT; RAT; ROOM TEMPERATURE; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0242516016     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10353     Document Type: Article

References (21)

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