A duplex "Gemini" prodrug of naltrexone for transdermal delivery

Journal of Controlled Release

Volumn 97, Issue 2, 2004, Pages 283-290

  Hammell, Dana C ^a   Hamad, Mohamed ^a   Vaddi, Haranath K ^a   Crooks, Peter A ^a   Stinchcomb, Audra L ^a  

^a University of Kentucky   (United States)

Author keywords

Human skin; Naltrexone; Percutaneous absorption; Prodrugs; Transdermal drug delivery

Indexed keywords

ALCOHOLS; CARBON DIOXIDE; HYDROLYSIS; MECHANICAL PERMEABILITY; SKIN;

NALTREXONE (NTX); TRANSDERMAL DRUG DELIVERY;

DRUG PRODUCTS;

3,3' BIS(N CYCLOPROPYLMETHYL 4,5 EPOXY 14 HYDROXYMORPHINAN 6 ON 3 YL)CARBONATE; NALTREXONE; NALTREXONE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG HYDROLYSIS; DRUG PENETRATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SKIN PENETRATION;

ADMINISTRATION, CUTANEOUS; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG STABILITY; HUMANS; NALTREXONE; NARCOTIC ANTAGONISTS; PRODRUGS; SKIN; SKIN ABSORPTION; SOLUBILITY; TIME FACTORS;

EID: 2942551392     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.03.020     Document Type: Article

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