α-Tocopherol pro-vitamins: Synthesis, hydrolysis and accumulation in rabbit ear skin

Journal of Controlled Release

Volumn 99, Issue 3, 2004, Pages 403-413

  Ostacolo, C ^a   Marra, F ^b   Laneri, S ^a   Sacchi, A ^a   Nicoli, S ^b   Padula, C ^b   Santi, P ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Antioxidant; Hydrolysis; Pro vitamin; Tocopherol; Transdermal

Indexed keywords

ACETATE DERIVATIVES; ENZYMATIC METABOLISM;

ENZYMES; ESTERS; GELS; HYDROLYSIS; HYDROPHILICITY; SYNTHESIS (CHEMICAL);

VITAMINS;

ALANINE ALPHA TOCOPHERYL ESTER; ALANINE DERIVATIVE; ALCOHOL; ALPHA TOCOPHEROL; DRUG VEHICLE; ESTER DERIVATIVE; ESTERASE; GLYCINE ALPHA TOCOPHERYL ESTER; GLYCINE DERIVATIVE; N TERT BUTOXYCARBONYL GLYCINE ALPHA TOCOPHERYL ESTER; PROPYLENE GLYCOL; PYROGLUTAMIC ACID; PYROGLUTAMIC ACID ALPHA TOCOPHERYL ESTER; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CREAM; DERMIS; DRUG ACCUMULATION; DRUG HYDROLYSIS; DRUG PENETRATION; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG SYNTHESIS; EAR; ENZYME METABOLISM; EPIDERMIS; EVALUATION; GEL; HYDROPHILICITY; LIVER; NONHUMAN; PRIORITY JOURNAL; RABBIT; VITAMIN METABOLISM;

ALANINE; ALPHA-TOCOPHEROL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG EVALUATION, PRECLINICAL; EAR; ESTERASES; GLYCINE; HYDROLYSIS; LIVER; PERMEABILITY; PRODRUGS; PYRROLIDONECARBOXYLIC ACID; RABBITS; SKIN; SKIN ABSORPTION; SWINE; TISSUE DISTRIBUTION;

EID: 4644278187     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.08.002     Document Type: Article

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