The inhibitory effects of m-nisoldipine on the 5-hydroxytryptamine-induced proliferation of pulmonary artery smooth muscle cells via Ca 2+ antagonism and antioxidant mechanisms

European Journal of Pharmacology

Volumn 686, Issue 1-3, 2012, Pages 32-40

  Chen, Xueyan ^a,b,c   Liu, Huanlong ^c   Pan, Zhenhua ^a,b,c   Miao, Qingfeng ^a,b,c   Zhang, Yongjian ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b Key Laboratory of New Drug Pharmacology and Toxicology   (China)

^c HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Calcium; M nisoldipine; Proliferation; Pulmonary artery smooth muscle cells; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; BROXURIDINE; CYCLINE; MESSENGER RNA; META NISOLDIPINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS; REACTIVE OXYGEN METABOLITE; SEROTONIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM ANTAGONISM; CALCIUM CELL LEVEL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME REPRESSION; MALE; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DNA; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, SMOOTH MUSCLE; NISOLDIPINE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PULMONARY ARTERY; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SEROTONIN;

EID: 84861607842     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.04.044     Document Type: Article

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