Antioxidative effects of azelnidipine on mesangial cell proliferation induced by highly concentrated insulin

European Journal of Pharmacology

Volumn 567, Issue 3, 2007, Pages 252-257

  Manabe, Seiko ^a   Okura, Takafumi ^a   Fukuoka, Tomikazu ^a   Higaki, Jitsuo ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Azelnidipine; Extracellular signal regulated kinase; Insulin; Mesangial cell; Oxidative stress

Indexed keywords

APOCYNIN; AZELNIDIPINE; CALCIUM ANTAGONIST; DIHYDROPYRIDINE DERIVATIVE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NIFEDIPINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DIABETIC NEPHROPATHY; ENZYME PHOSPHORYLATION; HYPERINSULINEMIA; INSULIN RESISTANCE; MESANGIUM; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACETOPHENONES; ANIMALS; ANTIOXIDANTS; AZETIDINECARBOXYLIC ACID; BLOTTING, WESTERN; CALCIUM CHANNEL BLOCKERS; CELL PROLIFERATION; DIHYDROPYRIDINES; DNA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYPOGLYCEMIC AGENTS; INSULIN; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 34250886902     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.02.022     Document Type: Article

References (26)

1. Baron A.D. Hemodynamic actions of insulin. Am. J. Physiol. 267 (1994) E187-E202
2. Baynes J.W., and Thorpe S.R. Role of oxidative stress in diabetic complications. Diabetes 48 (1999) 1-9
3. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 (2001) 813-820
4. Cockcroft J.R. Exploring vascular benefits of endothelium-derived nitric oxide. Am. J. Hypertens. 18 (2005) 177S-183S
5. Cominacini L., Pasini A.F., Garbin U., Pastorino A.M., Davoli A., Nava C., Campagnole M., Rossato P., and Cascio V.L. Antioxidant activity of different dihydropyridines. Biochem. Biophys. Res. Commun. 302 (2003) 679-684
6. Despres J.P., Lamarche B., Mauriege P., Cantin B., Dagenais G.R., Moorjani S., and Jupien P.J. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N. Engl. J. Med. 334 (1996) 952-957
7. Fukuoka T., Kitami Y., Okura T., and Hiwada K. Transcriptional regulation of platelet-derived growth factor α receptor gene via CCAAT/enhancer-binding protein-δ in vascular smooth muscle cells. J. Biol. Chem. 274 (1999) 25576-25582
8. Goldstein B.J., Mahadev K., Wu X., Zhu L., and Motoshima H. Role of insulin-induced reactive oxygen species in the insulin signal pathway. Antioxid. Redox Signal. 7 (2005) 1021-1031
9. Ha H., and Kim K.H. Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C. Diabetes Res. Clin. Pract. 45 (1999) 147-151
10. Lin C.L., Wang F.S., Kuo Y.R., Huang Y.H., Huang H.C., Sun Y.C., and Kuo Y.H. Ras modulation of superoxide activates ERK-dependent fibronectin expression in diabetes-induced renal injuries. Kidney Int. 69 (2006) 1593-1600
11. Locatelli F., Pozzoni P., and Del Vecchio L. Renal replacement therapy in patients with diabetes and end-stage renal disease. J. Am. Soc. Nephrol. 15 Suppl. 1 (2004) S25-S29
12. 2 and plays an integral role in insulin signaling transduction. Mol. Cell. Biol. 24 (2004) 1844-1854
13. Matsui T., Yamagishi S., Nakamura K., Kikuchi S., and Inoue H. Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and downregulation of pigment epithelium-derived factor mRNA levels in microvascular endothelial cells. Drug. Exp. Clin. Res. 31 (2005) 215-219
14. Meyer J.W., and Schmitt M.E. A central role for the endothelial NADPH oxidase in atherosclerosis. FEBS Lett. 472 (2000) 1-4
15. Misra R.P. Isolation of glomeruli from mammalian kidneys by graded sieving. Am. J. Clin. Pathol. 58 (1972) 135-139
16. Mogensen C.E., and Cooper M.E. Diabetic renal disease: from recent studies to improved clinical practice. Diabet. Med. 21 (2004) 4-17
17. Naito Y., Shimozawa M., Manabe H., Nakabe N., Katada K., Kokura S., Yoshida N., Ichikawa H., Kon T., and Yoshikawa T. Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. Eur. J. Pharmacol. 28 (2006) 11-18
18. Okura T., Igase M., Kitami Y., Fukuoka T., Maguchi M., Kohara K., and Hiwada K. Platelet-derived growth factor induces apoptosis in vascular smooth muscle cells: roles of the Bcl-2 family. Biochim. Biophys. Acta 1403 (1998) 245-253
19. Pyorala M., Miettinen H., Laakso M., and Pyorala K. Hyperinsulinemia predicts coronary heart disease risk in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study. Circulation 98 (1998) 398-404
20. Reaven G.M. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease. J. Clin. Endocrinol. Metab. 88 (2003) 2399-2403
21. Robinson M.J., and Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9 (1997) 180-186
22. Sarafidis P.A., and Ruilope L.M. Insulin resistance, hyperinsulinemia, and renal injury: mechanisms and implications. Am. J. Nephrol. 26 (2006) 232-244
23. Wesson L.G. Physical factors and glomerulosclerosis. Cause or coincidence?. Nephron 78 (1988) 125-130
24. Widmann C., Gibson S., Jarpe M.B., and Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79 (1999) 143-180
25. Yang Z.H., Kitami Y., Takata Y., Okura T., and Hiwada K. Targeted overexpression of CCAAT/enhancer-binding protein-δ evokes enhanced gene transcription of platelet-derived growth factor α-receptor in vascular smooth muscle cells. Circ. Res. 89 (2001) 503-508
26. Yoram Y., and Ahuva L. Azelnidipine (CS-905), a novel dihydropyridine calcium channel blocker with gradual onset and prolonged duration of action. Cardiovasc. Drug. Rev. 13 (1995) 137-148