Brazilein-induced contraction of rat arterial smooth muscle involves activation of Ca2+ entry and ROK, ERK pathways

European Journal of Pharmacology

Volumn 580, Issue 3, 2008, Pages 366-371

  Shen, Jia ^a   Yip, Siewting ^a   Wang, Zhixing ^a   Wang, Wei ^a   Xing, Dongming ^a   Du, Lijun ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Aorta; Brazilein; Calcium; Contraction; ERK; MLCK; ROK

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 6A,7 DIHYDRO 3,6A,10 TRIHYDROXY BENZ[B]INDENO[1,2 D]PYRAN 9 (6H) ONE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ATROPINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAZILEIN; CAESALPINIA SAPPAN EXTRACT; CAFFEINE; CALCIUM; CALCIUM ANTAGONIST; INOSITOL 1,4,5 TRISPHOSPHATE; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN LIGHT CHAIN KINASE; N(G) NITROARGININE METHYL ESTER; NIMODIPINE; NITRIC OXIDE SYNTHASE; PHENTOLAMINE; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; PROPRANOLOL; PROTEIN KINASE C; RHO KINASE; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY MUSCLE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CALCIUM TRANSPORT; DRUG EFFECT; DRUG INHIBITION; DRUG RESPONSE; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL PROCESSING; THORACIC AORTA;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; AORTA, THORACIC; BENZOPYRANS; CAESALPINIA; CAFFEINE; CALCIUM; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INDENES; MALE; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NIMODIPINE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 38549134417     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.11.012     Document Type: Article

References (25)

1. Argye E.H. Systemic blood pressure and stroke outcome and recurrence. Curr. Atheroscler. Rep. 6 (2004) 274-280
2. Bae I.K., Min H.Y., Han A.R., Seo E.K., and Lee S.K. Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. Eur. J. Pharmacol 513 (2005) 237-242
3. Chantal D., Inkyeom K., Carrie L.S., Regent L., and Kathleen G.M. A role for MAP kinase in differentiated smooth muscle contraction evoked by alpha-adrenoceptor stimulation. Am. J. Physiol. Cell Physiol. 275 (1998) 1081-1086
4. Denise H.R., and Liu X. Effect of vasoactive therapy on cerebral circulation. Crit. Care Clin. 22 (2006) 221-243
5. Fukata Y., Amano M., and Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol. Sci. 22 (2001) 32-39
6. Horn J., and Linburg M. Calcium antagonists for ischemic stroke a systematic review. Stroke 32 (2001) 570-576
7. Horowitz A., Menice C.B., Laporte R., and Morgan K.G. Mechanisms of smooth muscle contraction. Physiol. Rev. 76 (1996) 967-1003
8. Hu C.M., Kang J.J., Lee C.C., Li C.H., Liao J.W., and Cheng Y.W. Induction of vasorelaxation through activation of nitric oxide synthase in endothelial cells by brazilin. Eur. J. Pharmacol. 468 (2003) 37-45
9. Hwang G.S., Kim J.Y., Chang T.S., Jeon S.D., So D.S., and Moon C.K. Effects of brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. Arch. Pharm.Res. 21 (1998) 774-778
10. Joseph F.C., and Gail P.G. Vascular smooth muscle function: the physiology and pathology of vasoconstriction. Pathophysiology 12 (2005) 35-45
11. Khil L.Y., Cheon A.J., Chang T.S., and Moon C.K. Effects of calcium on brazilin-induced glucose transport in isolated rat epididymal adipocytes. Biochem. Pharmacol. 54 (1997) 97-101
12. 2+ channels. Science 287 (2000) 1647-1651
13. 2+ signalling, cell death and stroke. Trends Neurosci. 29 (2006) 75-81
14. Markus H.S. Cerebral perfusion and stroke. J. Neurol. Neurosurg. Psychiatry 75 (2004) 353-361
15. 2+ release. J. Biochem. 122 (1997) 498-505
16. Salamanca D.A., and Khalil R.A. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem. Pharmacol. 70 (2005) 1537-1547
17. Sanguinetti M.C., and Kass R.S. Regulation of cardiac calcium channel current and contractile activity by the dihydropyridine Bay K 8644 is voltage-dependent. J. Mol. Cell. Cardiol. 16 (1984) 667-670
18. Shen J., Zhang H., Lin H., Su H., Xing D., and Du L. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur. J. Pharmacol. 558 (2007) 88-95
19. 2+-dependent regulation of vascular tone. J. Anesth. 21 (2007) 220-231
20. 2+ sensitivity in vascular smooth muscle cells. J. Anesth. 21 (2007) 232-242
21. 2+ channel antagonists and neuroprotection from cerebral ischemia. Eur. J. Pharmacol. 363 (1998) 1-15
22. Webb R.C. Smooth muscle contraction and relaxation. Advan. Physiol. Educ. 27 (2003) 201-206
23. + channel blockade on the vasorelaxant activity of cromakalim, Pinacidil and nicorandil. Eur. J. Pharmacol. 152 (1988) 131-339
24. Ye M., Xie W.D., Lei F., Meng Z., Zhao Y.N., Su H., and Du L.J. Brazilein, an important immunosuppressive component from Caesalpinia sappan L. Int. Immunopharmacol 6 (2006) 426-432
25. Zhao Y.N., Pan Y., Tao J.L., Xing D.M., and Du L.J. Study on cardioactive effects of Brazilein. Pharmacology 76 (2006) 76-83