Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells

Cellular Signalling

Volumn 24, Issue 8, 2012, Pages 1504-1514

  Jones, Sarah E ^a   Palmer, Timothy M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cyclic AMP; Epithelial cells; Prostate cancer; RhoA

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL EXPANSION; CELL STRAIN LNCAP; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENDRITE; ENZYME ACTIVATION; MUTANT; NERVE CELL GROWTH; NEUROSECRETORY CELL; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

CARCINOMA, NEUROENDOCRINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPITHELIAL CELLS; HUMANS; MALE; PHENOTYPE; PHOSPHORYLATION; PHOSPHOSERINE; PROSTATIC NEOPLASMS; RHOA GTP-BINDING PROTEIN; TUMOR CELLS, CULTURED;

EID: 84861551709     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.03.018     Document Type: Article

References (49)

1. Lang S.H., Frame F.M., Collins A.T. The Journal of Pathology 2009, 217:299-306.
2. Taylor L.G., Canfield S.E., Du X.L. Cancer 2009, 115:2388-2399.
3. Levine G.N., D'Amico A.V., Berger P., Clark P.E., Eckel R.H., Keating N.L., Milani R.V., Sagalowsky A.I., Smith M.R., Zakai N. CA: A Cancer Journal for Clinicians 2010, 60:194-201.
4. Shariff A.H., Ather M.H. Urology 2006, 68:2-8.
5. Pienta K.J. Urology 2009, 73:S11-S20.
6. Yuan T.C., Veeramani S., Lin M.F. Endocrine-Related Cancer 2007, 14:531-547.
7. Bang Y.J., Pirnia F., Fang W.G., Kang W.K., Sartor O., Whitesell L., Ha M.J., Tsokos M., Sheahan M.D., Nguyen P., Niklinski W.T., Myers C.E., Trepel J.B. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:5330-5334.
8. Bologna M., Festuccia C., Muzi P., Biordi L., Ciomei M. Cancer 1989, 63:1714-1720.
9. Noordzij M.A., vanWeerden W.M., deRidder C.M.A., van der Kwast T.H., Schroder F.H., van Steenbrugge G.J. American Journal of Pathology 1996, 149:859-871.
10. Horoszewicz J.S., Leong S.S., Kawinski E., Karr J.P., Rosenthal H., Chu T.M., Mirand E.A., Murphy G.P. Cancer Research 1983, 43:1809-1818.
11. Saeed B., Zhang H.C., Ng S.C. Prostate 1997, 31:145-152.
12. Deeble P.D., Murphy D.J., Parsons S.J., Cox M.E. Molecular and Cellular Biology 2001, 21:8471-8482.
13. Palmer J., Ernst M., Hammacher A., Hertzog P.J. Prostate 2005, 62:282-289.
14. Cox M.E., Deeble P.D., Bissonette E.A., Parsons S.J. Journal of Biological Chemistry 2000, 275:13812-13818.
15. Cox M.E., Deeble P.D., Lakhani S., Parsons S.J. Cancer Research 1999, 59:3821-3830.
16. Murray A.J. Science Signaling 2008, 1:re4.
17. Naviglio S., Caraglia M., Abbruzzese A., Chiosi E., Di Gesto D., Marra M., Romano M., Sorrentino A., Sorvillo L., Spina A., Illiano G. Expert Opinion on Therapeutic Targets 2009, 13:83-92.
18. Sassone-Corsi P. The International Journal of Biochemistry & Cell Biology 1998, 30:27-38.
19. Conkright M.D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J.B., Montminy M. Molecular Cell 2003, 12:413-423.
20. Johannessen M., Delghandi M.P., Moens U. Cellular Signalling 2004, 16:1211-1227.
21. de Rooij J., Zwartkruis F.J.T., Verheijen M.H.G., Cool R.H., Nijman S.M.B., Wittinghofer A., Bos J.L. Nature 1998, 396:474-477.
22. Kopperud R., Krakstad C., Selheim F., Døskeland S.O. FEBS Letters 2003, 546:121-126.
23. Roscioni S.S., Elzinga C.R.S., Schmidt M. Naunyn-Schmiedeberg's Archives of Pharmacology 2008, 377:345-357.
24. Deeble P.D., Cox M.E., Frierson H.F., Sikes R.A., Palmer J.B., Davidson R.J., Casarez E.V., Amorino G.P., Parsons S.J. Cancer Research 2007, 67:3663-3672.
25. Ravni A., Vaudry D., Gerdin M.J., Eiden M.V., Falluel-Morel A., Gonzalez B.J., Vaudry H., Eiden L.E. Molecular Pharmacology 2008, 73:1688-1708.
26. Kiermayer S., Biondi R.M., Imig J., Plotz G., Haupenthal J., Zeuzem S., Piiper A. Molecular Biology of the Cell 2005, 16:5639-5648.
27. Sfakianos M.K., Eisman A., Gourley S.L., Bradley W.D., Scheetz A.J., Settleman J., Taylor J.R., Greer C.A., Williamson A., Koleske A.J. Journal of Neuroscience 2007, 27:10982-10992.
28. Jeon C.Y., Kim H.J., Morii H., Mori N., Settleman J., Lee J.Y., Kim J., Kim S.C., Park J. Journal of Cellular Physiology 2010, 224:786-794.
29. Jeon C.Y., Kim H.J., Lee J.Y., Kim J., Kim S.C., Park J.B. Experimental & Molecular Medicine 2010, 42:335-344.
30. Nusser N., Gosmanova E., Makarova N., Fujiwara Y., Yang L., Guo F., Luo Y., Zheng Y., Tigyi G. Cellular Signalling 2005, 18:704-714.
31. Sands W.A., Woolson H.D., Milne G.R., Rutherford C., Palmer T.M. Molecular and Cellular Biology 2006, 26:6333-6346.
32. Thibault N., Burelout C., Harbour D., Borgeat P., Naccache P.H., Bourgoin S.G. Journal of Leukocyte Biology 2002, 71:367-377.
33. Laurenza A., Sutkowski E.M., Seamon K.B. Trends in Pharmacological Sciences 1989, 10:442-447.
34. Christensen A.E., Selheim F., de Rooij J., Dremier S., Schwede F., Dao K.K., Martinez A., Maenhaut C., Bos J.L., Genieser H.G., Døskeland S.O. Journal of Biological Chemistry 2003, 278:35394-35402.
35. Ha C.H., Kim J.Y., Zhao J.J., Wang W.Y., Jhun B.S., Wong C., Jin Z.G. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:15467-15472.
36. Mayr B., Montminy M. Nature Reviews. Molecular Cell Biology 2001, 2:599-609.
37. Chaturvedi D., Cohen M.S., Taunton J., Patel T.B. Journal of Biological Chemistry 2009, 284:23670-23681.
38. Ellerbroek S.M., Wennerberg K., Burridge K. Journal of Biological Chemistry 2003, 278:19023-19031.
39. Qiao J., Huang F., Lum H. American Journal of Physiology. Lung Cellular and Molecular Physiology 2003, 284:L972-L980.
40. Maekawa M., Ishizaki T., Boku S., Watanabe N., Fujita A., Iwamatsu A., Obinata T., Ohashi K., Mizuno K., Narumiya S. Science 1999, 285:895-898.
41. Watanabe N., Madaule P., Reid T., Ishizaki T., Watanabe G., Kakizuka A., Saito Y., Nakao K., Jockusch B.M., Narumiya S. EMBO Journal 1997, 16:3044-3056.
42. Wilde C., Genth H., Aktories K., Just I. Journal of Biological Chemistry 2000, 275:16478-16483.
43. Estrach S., Schmidt S., Diriong S., Penna A., Blangy A., Fort P., Debant A. Current Biology 2002, 12:307-312.
44. Dong J.M., Leung T., Manser E., Lim L. Journal of Biological Chemistry 1998, 273:22554-22562.
45. Ishizaki T., Uehata M., Tamechika I., Keel J., Nonomura K., Maekawa M., Narumiya S. Molecular Pharmacology 2000, 57:976-983.
46. Chen Y.C., Wang Y., Yu H., Wang F.W., Xu W.R. Experimental Biology and Medicine 2005, 230:731-741.
47. Qiao J., Holian O., Lee B.S., Huang F., Zhang J., Lum H. American Journal of Physiology. Cell Physiology 2008, 295:C1161-C1168.
48. Murthy K.S., Zhou H.P., Grider J.R., Makhlouf G.M. American Journal of Physiology. Gastrointestinal and Liver Physiology 2003, 284:G1006-G1016.
49. Lang P., Gesbert F., Delespine-Carmagnat M., Stancou R., Pouchelet M., Bertoglio J. EMBO Journal 1996, 15:510-519.