Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: Impact on phospholipase D activity and recruitment of small GTPases to membranes

Journal of Leukocyte Biology

Volumn 71, Issue 2, 2002, Pages 367-377

  Thibault, Nathalie ^a   Burelout, Chantal ^a   Harbour, Danielle ^a   Borgeat, Pierre ^a   Naccache, Paul H ^a   Bourgoin, Sylvain G ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

ADA; cAMP; Phosphodiesterase; Protein kinase C

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2',5' DIDEOXYADENOSINE; 4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; ADENOSINE A2A RECEPTOR; ADENOSINE DEAMINASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANOSINE TRIPHOSPHATASE; ISOPRENALINE; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE D;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR OCCUPANCY;

4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ADENOSINE DEAMINASE; CELL MEMBRANE; CYCLIC AMP; HUMANS; MONOMERIC GTP-BINDING PROTEINS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE D; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION;

ADA;

EID: 0036486826     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Gessi, S., Varani, K., Merighi, S., Ongini, E., Borea, P. A. (2000) A(2A) adenosine receptors in human peripheral blood cells. Br. J. Pharmacol. 129, 2-11.
2. Cronstein, B. N., Kramer, S. B., Weissmann, G., Hirschhorn, R. (1983) Adenosine: a physiological modulator of superoxide anion generation by human neutrophils. J. Exp. Med. 158, 1160-1177.
3. Cronstein, B. N. (1994) Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol. 76, 5-13.
4. Cronstein, B. N., Levin, R. I., Philips, M., Hirschhorn, R., Abramson, S. B., Weissmann, G. (1992) Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors. J. Immunol. 148, 2201-2206.
5. Zalavary, S., Bengtsson, T. (1998) Adenosine inhibits actin dynamics in human neutrophils: evidence for the involvement of cAMP. Eur. J. Cell Biol. 75, 128-139.
6. Krump, E., Lemay, G., Borgeat, P. (1996) Adenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo. Br. J. Pharmacol. 117, 1639-1644.
7. Colli, S., Tremoli, E. (1991) Multiple effects of dipyridamole on neutrophils and mononuclear leukocytes: adenosine-dependent and adenosineindependent mechanisms. J. Lab. Clin. Med. 118, 136-145.
8. Krump, E., Picard, S., Mancini, J., Borgeat, P. (1997) Suppression of leukotriene B4 biosynthesis by endogenous adenosine in ligand-activated human neutrophils. J. Exp. Med. 186, 1401-1406.
9. Bullough, D. A., Magill, M. J., Firestein, G. S., Mullane, K. M. (1995) Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes. J. Immunol. 155, 2579-2586.
10. Bouma, M. G., Jeunhomme, T. M., Boyle, D. L., Dentener, M. A., Voitenok, N. N., van den Wildenberg, F. A., Buurman, W. A. (1997) Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. J. Immunol. 158, 5400-5408.
11. Firestein, G. S., Bullough, D. A., Erion, M. D., Jimenez, R., Ramirez-Weinhouse, M., Barankiewicz, J., Smith, C. W., Gruber, H. E., Mullane, K. M. (1995) Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins. J. Immunol. 154, 326-334.
12. Rosengren, S., Bong, G. W., Firestein, G. S. (1995) Anti-inflammatory effects of an adenosine kinase inhibitor. Decreased neutrophil accumulation and vascular leakage. J. Immunol. 154, 5444-5451.
13. Cronstein, B. N., Levin, R. I., Belanoff, J., Weissmann, G., Hirschhorn, R. (1986) Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J. Clin. Investig. 78, 760-770.
14. Flamand, N., Boudreault, S., Picard, S., Austin, M., Surette, M. E., Plante, H., Krump, E., Vallee, M. J., Gilbert, C., Naccache, P. H., Laviolette, M., Borgeat, P. (2000) Adenosine, a potent natural suppressor of arachidonic acid release and leukotriene biosynthesis in human neutrophils. Am. J. Res. Crit. Care Med. 161, S88-S94.
15. Thibault, N., Harbour, D., Borgeat, P., Naccache, P. H., Bourgoin, S. G. (2000) Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases. Blood 95, 519-527.
16. Cronstein, B. N., Eberle, M. A., Gruber, H. E., Levin, R. I. (1991) Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc. Natl. Acad. Sci. USA 88, 2441-2445.
17. Forman, M. B., Velasco, C. E., Jackson, E. K. (1993) Adenosine attenuates reperfusion injury following regional myocardal ischemia. Cardiovasc. Res. 27, 9-17.
18. Marts, B. C., Baudendistel, L. J., Naunheim, K. S., Dahms, T. E. (1993) Protective effect of 2-chloroadenosine on lung ischemia reperfusion injury. J. Surg. Res. 54, 523-529.
19. Fredholm, B. B. (1994) Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46, 143-156.
20. Walker, B. A., Hagenlocker, B. E., Douglas, V. K., Ward, P. A. (1990) Effects of adenosine on inositol 1,4,5-trisphosphate formation and intracellular calcium changes in formyl-Met-Leu-Phe-stimulated human neutrophils. J. Leukoc. Biol. 48, 281-283.
21. Cronstein, B. N., Kramer, S. B., Rosenstein, E. D., Korchak, H. M., Weissmann, G., Hirschhorn, R. (1988) Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization. Biochem. J. 252, 709-715.
22. Agwu, D. E., McCall, C. E., McPhail, L. C. (1991) Regulation of phospholipase D-induced hydrolysis of choline-containing phosphoglycerides by cyclic AMP in human neutrophils. J. Immunol. 146, 3895-3903.
23. Tyagi, S. R., Olson, S. C., Burnham, D. N., Lambeth, J. D. (1991) Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation. J. Biol. Chem. 266, 3498-3504.
24. Regier, D. S., Greene, D. G., Sergeant, S., Jesaitis, A. J., McPhail, L. C. (2000) Phosphorylation of p22phox is mediated by phospholipase D-dependent and -independent mechanisms. Correlation of NADPH oxidase activity and p22phox phosphorylation. J. Biol. Chem. 275, 28406-28412.
25. Cronstein, B. N., Haines, K. A., Kolasinski, S., Reibman, J. (1992) Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil. Blood 80, 1052-1057.
26. Iannone, M. A., Wolberg, G., Zimmerman, T. P. (1989) Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine. J. Biol. Chem. 264, 20177-20180.
27. Hannon, J. P., Bray-French, K. M., Phillips, R. M., Fozard, J. R. (1998) Further pharmacological characterization of the adenosine receptor subtype mediating inhibition of oxidative burst in human isolated neutrophils. Drug Dev. Res. 43, 214-224.
28. Sullivan, G. W., Linden, J. (1998) Role of A2a adenosine receptors in inflammation. Drug Dev. Res. 45, 103-112.
29. Revan, S., Montesinos, M. C., Naime, D., Landau, S., Cronstein, B. N. (1996) Adenosine A2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase. J. Biol. Chem. 271, 17114-17118.
30. Houle, M. G., Kahn, R. A., Naccache, P. H., Bourgoin, S. (1995) ADP-ribosylation factor translocation correlates with potentiation of GTP gamma S-stimulated phospholipase D activity in membrane fractions of HL-60 cells. J. Biol. Chem. 270, 22795-22800.
31. Teixeira, M. M., Gristwood, R. W., Cooper, N., Hellewell, P. G. (1997) Phosphodiesterase (PDE) 4 inhibitors: anti-inflammatory drugs of the future? Trends Pharmacol. Sci. 18, 164-170.
32. Johnson, R. A., Desaubry, L., Bianchi, G., Shoshani, I., Lyons Jr., E., Taussig, R., Watson, P. A., Cali, J. J., Krupinski, J., Pieroni, J. P., Iyengar, R. (1997) Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J. Biol. Chem. 272, 8962-8966.
33. Schaap, P., van Ments-Cohen, M., Soede, R. D., Brandt, R., Firtel, R. A., Dostmann, W., Genieser, H. G., Jastorff, B., van Haastert, P. J. (1993) Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. J. Biol. Chem. 268, 6323-6331.
34. Hidaka, H., Inagaki, M., Kawamoto, S., Sasaki, Y. (1984) Isoquinoline-sulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23, 5036-5041.
35. Feoktistov, I., Biaggioni, I. (1997) Adenosine A2B receptors. Pharmacol. Rev. 49, 381-402.
36. Collis, M. G., Hourani, S. M. (1993) Adenosine receptor subtypes. Trends Pharmacol. Sci. 14, 360-366.
37. Fredholm, B. B., Zhang, Y., van der Ploeg, I. (1996) Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes. Naunyn-Schmiedeberg's Arch. Pharmacol. 354, 262-267.
38. Varani, K., Gessi, S., Dionisotti, S., Ongini, E., Borea, P. A. (1998) [H-3]-SCH 58261 labelling of functional A(2A) adenosine receptors in human neutrophil membranes. Br. J. Pharmacol. 123, 1723-1731.
39. Falleni, A., Trincavelli, M. L., Macchia, M., Salvetti, F., Hamdan, M., Calvani, F., Gremigni, V., Lucacchini, A., Martini, C. (1999) A(1) adenosine receptors in human neutrophils: direct binding and electron microscope visualization. J. Cell. Biochem. 75, 235-244.
40. Jackowski, S., Sha'afi, R. I. (1979) Response of adenosine cyclic 3′,5′-monophosphate level in rabbit neutrophils to the chemotactic peptide formyl-methionyl-leucyl-phenylalanine. Mol. Pharmacol. 16, 473-481.
41. Cronstein, B. N., Haines, K. A. (1992) Stimulus-response uncoupling in the neutrophil. Adenosine A2-receptor occupancy inhibits the sustained, but not the early, events of stimulus transduction in human neutrophils by a mechanism independent of actin-filament formation. Biochem. J. 281, 631-635.
42. Tsuruta, S., Ito, S., Mikawa, H. (1992) Adenosine inhibits divalent cation influx across human neutrophil plasma membrane via surface adenosine A2 receptors. Cell. Signal. 4, 543-551.
43. Bourgoin, S., Plante, E., Gaudry, M., Naccache, P. H., Borgeat, P., Poubelle, P. E. (1990) Involvement of a phospholipase D in the mechanism of action of granulocyte-macrophage colony-stimulating factor (GM-CSF): priming of human neutrophils in vitro with GM-CSF is associated with accumulation of phosphatidic acid and diradylglycerol. J. Exp. Med. 172, 767-777.
44. Olah, M. E. (1997) Identification of A2a adenosine receptor domains involved in selective coupling to Gs. Analysis of chimeric A1/A2a adenosine receptors. J. Biol. Chem. 272, 337-344.
45. Tucker, A. L., Jia, L., Holeton, D., Taylor, A. J., Linden, J. (2000) Dominance of G(s) in doubly G(s)/G(i)-coupled chimaeric A(1)/A(2) adenosine receptors in HEK-293 cells. Biochem. J. 352, 203-210.
46. Verghese, M. W., Fox, K., McPhail, L. C., Snyderman, R. (1985) Chemoattractant-elicited alterations of cAMP levels in human polymorphonuclear leukocytes require a Ca2+-dependent mechanism which is independent of transmembrane activation of adenylate cyclase. J. Biol. Chem. 260, 6769-6775.
47. Nakashima, S., Mizutani, T., Nakamura, Y., Takemura, S. O., Nakamura, M., Miyata, H., Katagiri, Y., Nozawa, Y. (1995) Effects of selective phosphodiesterase type IV inhibitor, rolipram, on signal transducing phospholipases in neutrophil: inhibition of phospholipases A(2), D but not C. Comp. Biochem. Physiol. 112C, 137-143.
48. Le Stunff, H., Dokhac, L., Harbon, S. (2000) The roles of protein kinase C and tyrosine kinases in mediating endothelin-1-stimulated phospholipase D activity in rat myometrium: differential inhibition by ceramides and cyclic AMP. J. Pharmacol. Exp. Ther. 292, 629-637.
49. Ruan, Y., Kan, H., Parmentier, J. H., Fatima, S., Allen, L. F., Malik, K. U. (1998) Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: inhibition by protein kinase A. J. Pharmacol. Exp. Ther. 284, 576-585,
50. Mamoon, A. M., Smith, J., Baker, R. C., Farley, J. M. (1999) Activation of protein kinase A increases phospholipase D activity and inhibits phospholipase D activation by acetylcholine in tracheal smooth muscle. J. Pharmacol. Exp. Ther. 291, 1188-1195.
51. Ginsberg, J., Gupta, S., Matowe, W. C., Kline, L., Brindley, D. N. (1997) Activation of phospholipase D in FRTL-5 thyroid cells by forskolin and dibutyryl-cyclic adenosine monophosphate. Endocrinology 138, 3645-3651.
52. Marcil, J., Harbour, D., Houle, M. G., Naccache, P. H., Bourgoin, S. (1999) Monosodium urate-crystal-stimulated phospholipase D in human neutrophils. Biochem. J. 337, 185-192.
53. Hammond, S. M., Altshuller, Y. M., Sung, T. C., Rudge, S. K., Rose, K., Engebrecht, J., Morris, A. J., Frohman, M. A. (1995) Human ADPribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J. Biol. Chem. 270, 29640-29643.
54. Exton, J. H. (1997) New developments in phospholipase D. J. Biol. Chem. 272, 15579-15582.
55. Fensome, A., Whatmore, J., Morgan, C., Jones, D., Cockcroft, S. (1998) ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J. Biol. Chem. 273, 13157-13164.
56. Laudanna, C., Campbell, J. J., Butcher, E. C. (1997) Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants. J. Biol. Chem. 272, 24141-24144.
57. Lang, P., Gesbert, F., Delespine-Carmagnat, M., Stancou, R., Pouchelet, M., Bertoglio, J. (1996) Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J. 15, 510-519.
58. Kwak, J. Y., Uhlinger, D. J. (2000) Downregulation of phospholipase D by protein kinase A in a cell-free system of human neutrophils. Biochem. Biophys. Res. Commun. 267, 305-310.
59. Martin, M. E., Hidalgo, J., Rosa, J. L., Crottet, P., Velasco, A. (2000) Effect of protein kinase A activity on the association of ADP-ribosylation factor 1 to Golgi membranes. J. Biol. Chem. 275, 19050-19059.
60. Yasui, K., Agematsu, K., Shinozaki, K., Hokibara, S., Nagumo, H., Nakazawa, T., Komiyama, A. (2000) Theophylline induces neutrophil apoptosis through adenosine A(2A) receptor antagonism. J. Leukoc. Biol. 67, 529-535.
61. Zalavary, S., Bengtsson, T. (1998) Modulation of the chemotactic peptideand immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine. Eur. J. Pharmacol. 354, 215-225.
62. Flamand, N., Plante, H., Picard, S., Austin, M., Surette, M. E., Krump, E., Bourgoin, S., Borgeat, P. (2001) Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear cells. Drug Dev. Res. 52, 397-405.
63. McPhail, L. C., Waite, K. A., Regier, D. S., Nixon, J. B., Qualliotine-Mann, D., Zhang, W-X., Wallin, R., Sergeant, S. (1999) A novel lipid kinase target for the second lipid messenger phosphatidic acid. Biochim. Biophys. Acta 1439, 277-290.
64. Bourgoin, S., Grinstein, S. (1992) Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. J. Biol. Chem. 267, 11908-11916.
65. Bokoch, G. M. (2000) Regulation of cell function by Rho family GTPases. Immunol. Res. 21, 139-148.