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Volumn 295, Issue 5, 2008, Pages

Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA

Author keywords

Adenosine 3 ,5 cyclic monophosphate dependent protein kinase; Protein kinase A consensus phosphorylation sites; Single site mutated GDI

Indexed keywords

ALANINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANOSINE TRIPHOSPHATE; PROTEIN GDI ALPHA; RHO FACTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 57349199406     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00139.2008     Document Type: Article
Times cited : (48)

References (42)
  • 1
    • 0033105628 scopus 로고    scopus 로고
    • Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway
    • Adamson P, Etienne S, Couraud PO, Calder V, Greenwood J. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. J Immunol 162: 2964-2973, 1999.
    • (1999) J Immunol , vol.162 , pp. 2964-2973
    • Adamson, P.1    Etienne, S.2    Couraud, P.O.3    Calder, V.4    Greenwood, J.5
  • 2
    • 9144268981 scopus 로고    scopus 로고
    • RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65
    • Anwar KN, Fazal F, Malik AB, Rahman A. RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J Immunol 173: 6965-6972, 2004.
    • (2004) J Immunol , vol.173 , pp. 6965-6972
    • Anwar, K.N.1    Fazal, F.2    Malik, A.B.3    Rahman, A.4
  • 4
    • 0034048989 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate regulates the expression of the intercellular adhesion molecule and the inducible nitric oxide synthase in brain endothelial cells
    • Balyasnikova IV, Pelligrino DA, Greenwood J, Adamson P, Dragon S, Raza H, Galea E. Cyclic adenosine monophosphate regulates the expression of the intercellular adhesion molecule and the inducible nitric oxide synthase in brain endothelial cells. J Cereb Blood Flow Metab 20: 688-699, 2000.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 688-699
    • Balyasnikova, I.V.1    Pelligrino, D.A.2    Greenwood, J.3    Adamson, P.4    Dragon, S.5    Raza, H.6    Galea, E.7
  • 8
    • 34250177621 scopus 로고    scopus 로고
    • Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation
    • Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR, Birukov KG. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 313: 2504-2520, 2007.
    • (2007) Exp Cell Res , vol.313 , pp. 2504-2520
    • Birukova, A.A.1    Zagranichnaya, T.2    Fu, P.3    Alekseeva, E.4    Chen, W.5    Jacobson, J.R.6    Birukov, K.G.7
  • 11
    • 0034819755 scopus 로고    scopus 로고
    • Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung
    • Chiba Y, Ishii Y, Kitamura S, Sugiyama Y. Activation of rho is involved in the mechanism of hydrogen-peroxide-induced lung edema in isolated perfused rabbit lung. Microvasc Res 62: 164-171, 2001.
    • (2001) Microvasc Res , vol.62 , pp. 164-171
    • Chiba, Y.1    Ishii, Y.2    Kitamura, S.3    Sugiyama, Y.4
  • 12
    • 0030071625 scopus 로고    scopus 로고
    • Signaling pathways regulated by Rho-like proteins: A possible role in tumor formation and metastasis (Review)
    • Collard JG. Signaling pathways regulated by Rho-like proteins: A possible role in tumor formation and metastasis (Review). Int J Oncol 8: 131-138, 1996.
    • (1996) Int J Oncol , vol.8 , pp. 131-138
    • Collard, J.G.1
  • 13
    • 14944377651 scopus 로고    scopus 로고
    • Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase
    • Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105: 1950-1955, 2005.
    • (2005) Blood , vol.105 , pp. 1950-1955
    • Cullere, X.1    Shaw, S.K.2    Andersson, L.3    Hirahashi, J.4    Luscinskas, F.W.5    Mayadas, T.N.6
  • 14
    • 21744432683 scopus 로고    scopus 로고
    • GDIs: Central regulatory molecules in Rho GTPase activation
    • DerMardirossian C, Bokoch GM. GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol 15: 356-363, 2005.
    • (2005) Trends Cell Biol , vol.15 , pp. 356-363
    • DerMardirossian, C.1    Bokoch, G.M.2
  • 15
    • 33750522653 scopus 로고    scopus 로고
    • Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling
    • DerMardirossian C, Rocklin G, Seo JY, Bokoch GM. Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling. Mol Biol Cell 17: 4760-4768, 2006.
    • (2006) Mol Biol Cell , vol.17 , pp. 4760-4768
    • DerMardirossian, C.1    Rocklin, G.2    Seo, J.Y.3    Bokoch, G.M.4
  • 16
    • 3042839349 scopus 로고    scopus 로고
    • Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase
    • DerMardirossian C, Schnelzer A, Bokoch GM. Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell 15: 117-127, 2004.
    • (2004) Mol Cell , vol.15 , pp. 117-127
    • DerMardirossian, C.1    Schnelzer, A.2    Bokoch, G.M.3
  • 17
    • 0037805583 scopus 로고    scopus 로고
    • Serine phosphorylation negatively regulates RhoA in vivo
    • Ellerbroek SM, Wennerberg K, Burridge K. Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 278: 19023-19031, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 19023-19031
    • Ellerbroek, S.M.1    Wennerberg, K.2    Burridge, K.3
  • 18
    • 0034660145 scopus 로고    scopus 로고
    • Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling
    • Essler M, Staddon JM, Weber PC, Aepfelbacher M. Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. J Immunol 164: 6543-6549, 2000.
    • (2000) J Immunol , vol.164 , pp. 6543-6549
    • Essler, M.1    Staddon, J.M.2    Weber, P.C.3    Aepfelbacher, M.4
  • 19
    • 0029015774 scopus 로고
    • The Rho Family GTPases RhoA, Rac1, and Cdc42Hs regulate transcriptional activity by SRF
    • Hill CS, Wynne J, Treisman R. The Rho Family GTPases RhoA, Rac1, and Cdc42Hs regulate transcriptional activity by SRF. Cell 81: 1159-1170, 1995.
    • (1995) Cell , vol.81 , pp. 1159-1170
    • Hill, C.S.1    Wynne, J.2    Treisman, R.3
  • 20
    • 0034603198 scopus 로고    scopus 로고
    • Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI
    • Hoffman GR, Nassar N, Cerione RA. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell 100: 345-356, 2000.
    • (2000) Cell , vol.100 , pp. 345-356
    • Hoffman, G.R.1    Nassar, N.2    Cerione, R.A.3
  • 22
    • 34548791299 scopus 로고    scopus 로고
    • GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability
    • Knezevic N, Roy A, Timblin B, Konstantoulaki M, Sharma T, Malik AB, Mehta D. GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol Cell Biol 27: 6323-6333, 2007.
    • (2007) Mol Cell Biol , vol.27 , pp. 6323-6333
    • Knezevic, N.1    Roy, A.2    Timblin, B.3    Konstantoulaki, M.4    Sharma, T.5    Malik, A.B.6    Mehta, D.7
  • 23
    • 24144444059 scopus 로고    scopus 로고
    • Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    • Kooistra MR, Corada M, Dejana E, Bos JL. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 579: 4966-4972, 2005.
    • (2005) FEBS Lett , vol.579 , pp. 4966-4972
    • Kooistra, M.R.1    Corada, M.2    Dejana, E.3    Bos, J.L.4
  • 24
    • 0030040750 scopus 로고    scopus 로고
    • Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes
    • Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, Bertoglio J. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J 15: 510-519, 1996.
    • (1996) EMBO J , vol.15 , pp. 510-519
    • Lang, P.1    Gesbert, F.2    Delespine-Carmagnat, M.3    Stancou, R.4    Pouchelet, M.5    Bertoglio, J.6
  • 28
    • 0037414792 scopus 로고    scopus 로고
    • Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation
    • Manganello JM, Huang JS, Kozasa T, Voyno-Yasenetskaya TA,. Le Breton GC. Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem 278: 124-130, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 124-130
    • Manganello, J.M.1    Huang, J.S.2    Kozasa, T.3    Voyno-Yasenetskaya, T.A.4    Le Breton, G.C.5
  • 29
    • 0035933870 scopus 로고    scopus 로고
    • Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    • Mehta D, Rahman A, Malik AB. Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J Biol Chem 276: 22614-22620, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 22614-22620
    • Mehta, D.1    Rahman, A.2    Malik, A.B.3
  • 30
    • 2142650641 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: A comparison with H-89
    • Meja KK, Catley MC, Cambridge LM, Barnes PJ, Lum H, Newton R, Giembycz MA. Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. J Pharmacol Exp Ther 309: 833-844, 2004.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 833-844
    • Meja, K.K.1    Catley, M.C.2    Cambridge, L.M.3    Barnes, P.J.4    Lum, H.5    Newton, R.6    Giembycz, M.A.7
  • 31
    • 0035825193 scopus 로고    scopus 로고
    • Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
    • Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol 152: 111-126, 2001.
    • (2001) J Cell Biol , vol.152 , pp. 111-126
    • Michaelson, D.1    Silletti, J.2    Murphy, G.3    D'Eustachio, P.4    Rush, M.5    Philips, M.R.6
  • 32
    • 0027378646 scopus 로고
    • Isoproterenol antagonizes endothelial permeability induced by thrombin and thrombin receptor peptide
    • Minnear FL, DeMichele MA, Leonhardt S, Andersen TT, Teitler M. Isoproterenol antagonizes endothelial permeability induced by thrombin and thrombin receptor peptide. J Appl Physiol 75: 1171-1179, 1993.
    • (1993) J Appl Physiol , vol.75 , pp. 1171-1179
    • Minnear, F.L.1    DeMichele, M.A.2    Leonhardt, S.3    Andersen, T.T.4    Teitler, M.5
  • 33
    • 0028843677 scopus 로고
    • Tumour necrosis factor alpha-induced oxidative burst in neutrophils adherent to fibronectin: Effects of cyclic AMP-elevating agents
    • Ottonello L, Morone MP, Dapino P, Dallegri F. Tumour necrosis factor alpha-induced oxidative burst in neutrophils adherent to fibronectin: effects of cyclic AMP-elevating agents. Br J Haematol 91: 566-570, 1995.
    • (1995) Br J Haematol , vol.91 , pp. 566-570
    • Ottonello, L.1    Morone, M.P.2    Dapino, P.3    Dallegri, F.4
  • 34
    • 0034844297 scopus 로고    scopus 로고
    • Update on pulmonary edema: The role and regulation of endothelial barrier function
    • Patterson CE, Lum H. Update on pulmonary edema: the role and regulation of endothelial barrier function. Endothelium 8: 75-105, 2001.
    • (2001) Endothelium , vol.8 , pp. 75-105
    • Patterson, C.E.1    Lum, H.2
  • 35
    • 0027246226 scopus 로고
    • Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1
    • Pober JS, Slowik MR, De Luca LG, Ritchie AJ. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J Immunol 150: 5114-5123, 1993.
    • (1993) J Immunol , vol.150 , pp. 5114-5123
    • Pober, J.S.1    Slowik, M.R.2    De Luca, L.G.3    Ritchie, A.J.4
  • 36
    • 0038172667 scopus 로고    scopus 로고
    • PKA inhibits RhoA activation: A protection mechanism against endothelial barrier dysfunction
    • Qiao J, Huang F, Lum H. PKA inhibits RhoA activation: a protection mechanism against endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 284: L972-L980, 2003.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Qiao, J.1    Huang, F.2    Lum, H.3
  • 37
    • 33747749486 scopus 로고    scopus 로고
    • Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells
    • Sands WA, Woolson HD, Milne GR, Rutherford C, Palmer TM. Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Mol Cell Biol 26: 6333-6346, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 6333-6346
    • Sands, W.A.1    Woolson, H.D.2    Milne, G.R.3    Rutherford, C.4    Palmer, T.M.5
  • 38
    • 0344465840 scopus 로고    scopus 로고
    • Potential role of MCP-1 in endothelial cell tight junction 'opening': Signaling via Rho and Rho kinase
    • Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci 116: 4615-4628, 2003.
    • (2003) J Cell Sci , vol.116 , pp. 4615-4628
    • Stamatovic, S.M.1    Keep, R.F.2    Kunkel, S.L.3    Andjelkovic, A.V.4
  • 41
    • 2642615752 scopus 로고    scopus 로고
    • Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    • Wojciak-Stothard B, Entwistle A, Garg R, Ridley AJ. Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol 176: 150-165, 1998.
    • (1998) J Cell Physiol , vol.176 , pp. 150-165
    • Wojciak-Stothard, B.1    Entwistle, A.2    Garg, R.3    Ridley, A.J.4


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