Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 18820-18830

  Fu, Wen ^a   Ruangkittisakul, Araya ^b   MacTavish, David ^a   Shi, Jenny Y ^a   Ballanyi, Klaus ^b   Jhamandas, Jack H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELLULAR LEVELS; CYTOSOLIC; HEK-293; HEK293 CELLS; INTRACELLULAR CA; INTRACELLULAR SIGNALING PATHWAYS; ISOFORMS; MECHANISM OF ACTION; MICROMOLAR CONCENTRATION; MULTIPLE PATHWAYS; NEURODEGENERATIVE; PROTEIN KINASE A; RECEPTOR ANTAGONISTS; RECEPTOR TARGETS; STABLE EXPRESSION; THERAPEUTIC TARGETS; TYPE 2 DIABETES MELLITUS;

CELL DEATH; ENZYMES; NEURODEGENERATIVE DISEASES; PEPTIDES; SIGNAL TRANSDUCTION;

GLYCOPROTEINS;

AMYLIN; AMYLIN RECEPTOR; AMYLIN RECEPTOR 3; AMYLOID BETA PROTEIN[1-42]; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL LEVEL; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

AMYLOID BETA-PEPTIDES; CELL LINE; HUMANS; IMMUNOHISTOCHEMISTRY; RECEPTORS, ISLET AMYLOID POLYPEPTIDE; SIGNAL TRANSDUCTION;

EID: 84861547526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.331181     Document Type: Article

References (37)

1. Chiti, F., and Dobson, C. M. (2006) Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 75, 333-366 (Pubitemid 44118036)
2. Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., and Jones, E. (2011) Alzheimer disease. Lancet 377, 1019-1031
3. Castellani, R. J., Rolston, R. K., and Smith, M. A. (2010) Alzheimer disease. Dis. Mon. 56, 484-546
4. Höppener, J. W., Ahrén, B., and Lips, C. J. (2000) Islet amyloid and type 2 diabetes mellitus. N Engl. J. Med. 343, 411-419 (Pubitemid 30626125)
5. Hebda, J. A., and Miranker, A. D. (2009) The interplay of catalysis and toxicity by amyloid intermediates on lipid bilayers: Insights from type II diabetes. Annu. Rev. Biophys. 38, 125-152
6. Andreetto, E., Yan, L. M., Caporale, A., and Kapurniotu, A. (2011) Dissecting the role of single regions of an IAPP mimic and IAPP in inhibition of Aβ40 amyloid formation and cytotoxicity. Chembiochem. 12, 1313-1322
7. Rezaei-Ghaleh, N., Andreetto, E., Yan, L. M., Kapurniotu, A., and Zweckstetter, M. (2011) Interaction between amyloid β peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide. PLoS One 6, e20289
8. Lim, Y. A., Rhein, V., Baysang, G., Meier, F., Poljak, A., Raftery, M. J., Guilhaus, M., Ittner, L. M., Eckert, A., and Götz, J. (2010) Aβ and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10, 1621-1633
9. Ahtiluoto, S., Polvikoski, T., Peltonen, M., Solomon, A., Tuomilehto, J., Winblad, B., Sulkava, R., and Kivipelto, M. (2010) Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study. Neurology 75, 1195-1202
10. Akter, K., Lanza, E. A., Martin, S. A., Myronyuk, N., Rua, M., and Raffa, R. B. (2011) Diabetes mellitus and Alzheimer disease: Shared pathology and treatment? Br. J. Clin. Pharmacol. 71, 365-376
11. Götz, J., Ittner, L. M., and Lim, Y. A. (2009) Common features between diabetes mellitus and Alzheimer disease. Cell Mol. Life Sci. 66, 1321-1325
12. Jhamandas, J. H., Li, Z., Westaway, D., Yang, J., Jassar, S., and MacTavish, D. (2011) Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am. J. Pathol. 178, 140-149
13. Jhamandas, J. H., and MacTavish, D. (2004) Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J. Neurosci. 24, 5579-5584 (Pubitemid 38812640)
14. Thathiah, A., and De Strooper, B. (2011) The role of G protein-coupled receptors in the pathology of Alzheimer disease. Nat. Rev. Neurosci. 12, 73-87
15. Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., and Foord, S. M. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 54, 233-246 (Pubitemid 34575714)
16. Hay, D. L., Christopoulos, G., Christopoulos, A., Poyner, D. R., and Sexton, P. M. (2005) Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes. Mol. Pharmacol. 67, 1655-1665 (Pubitemid 40594165)
17. Kuwasako, K., Cao, Y. N., Nagoshi, Y., Tsuruda, T., Kitamura, K., and Eto, T. (2004) Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. Mol. Pharmacol. 65, 207-213 (Pubitemid 38113901)
18. Morfis, M., Tilakaratne, N., Furness, S. G., Christopoulos, G., Werry, T. D., Christopoulos, A., and Sexton, P. M. (2008) Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 149, 5423-5431
19. Drisaldi, B., Coomaraswamy, J., Mastrangelo, P., Strome, B., Yang, J., Watts, J. C., Chishti, M. A., Marvi, M., Windl, O., Ahrens, R., Major, F., Sy, M. S., Kretzschmar, H., Fraser, P. E., Mount, H. T., and Westaway, D. (2004) Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset proapoptotic activity of the Doppel helix B/B′ region. J. Biol. Chem. 279, 55443-55454 (Pubitemid 40066545)
20. Quinn, J. M., Morfis, M., Lam, M. H., Elliott, J., Kartsogiannis, V., Williams, E. D., Gillespie, M. T., Martin, T. J., and Sexton, P. M. (1999) Calcitonin receptor antibodies in the identification of osteoclasts. Bone 25, 1-8 (Pubitemid 29322054)
21. +] of confocally-imaged respiratory center neurons in online-calibrated newborn rat brainstem slices. J. Neurosci. 26, 11870-11880
22. Haass, C., and Selkoe, D. J. (2007) Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer amyloid-β peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112 (Pubitemid 46432529)
23. Glabe, C. G. (2006) Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol. Aging 27, 570-575
24. Stine, W. B., Jr., Dahlgren, K. N., Krafft, G. A., and LaDu, M. J. (2003) In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278, 11612-11622 (Pubitemid 36792723)
25. Beeley, N. R., and Prickett, K. S. (1996) The amylin, CGRP, and calcitonin family of peptides. Expert Opin. Ther. Patents 6, 555-567
26. Berridge, M. J., Lipp, P., and Bootman, M. D. (2000) The versatility and universality of calcium signaling. Nat. Rev. Mol. Cell Biol. 1, 11-21
27. Purdue, B. W., Tilakaratne, N., and Sexton, P. M. (2002) Molecular pharmacology of the calcitonin receptor. Receptors Channels 8, 243-255
28. Raggatt, L. J., Evdokiou, A., and Findlay, D. M. (2000) Sustained activation of Erk1/2 MAPK and cell growth suppression by the insert-negative, but not the insert-positive isoform of the human calcitonin receptor. J. Endocrinol. 167, 93-105
29. Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M., and Sexton, P. M. (1999) Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol. Pharmacol. 56, 235-242 (Pubitemid 29309833)
30. Tilakaratne, N., Christopoulos, G., Zumpe, E. T., Foord, S. M., and Sexton, P. M. (2000) Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment. J. Pharmacol. Exp. Ther. 294, 61-72 (Pubitemid 30434671)
31. Bhogal, R., Smith, D. M., and Bloom, S. R. (1992) Investigation and characterization of binding sites for islet amyloid polypeptide in rat membranes. Endocrinology 130, 906-913
32. Huang, X., Yang, J., Chang, J. K., and Dun, N. J. (2010) Amylin suppresses acetic acid-induced visceral pain and spinal c-fos expression in the mouse. Neuroscience 165, 1429-1438
33. Walker, C. S., Conner, A. C., Poyner, D. R., and Hay, D. L. (2010) Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol. Sci. 31, 476-483
34. Enns, L. C., and Ladiges, W. (2010) Protein kinase A signaling as an antiaging target. Ageing Res. Rev. 9, 269-272
35. Lappano, R., and Maggiolini, M. (2011) G protein-coupled receptors: Novel targets for drug discovery in cancer. Nat. Rev. Drug Discov. 10, 47-60
36. Franke, T. F. (2008) PI3K/Akt: Getting it right matters. Oncogene 27, 6473-6488
37. Subramaniam, S., and Unsicker, K. (2010) ERK and cell death: ERK1/2 in neuronal death. FEBS J. 277, 22-29