Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models

Journal of Controlled Release

Volumn 160, Issue 1, 2012, Pages 48-56

  Loo, Yihua ^a,b   Grigsby, Christopher L ^a   Yamanaka, Yvonne J ^a   Chellappan, Malathi K ^a   Jiang, Xuan ^c   Mao, Hai Quan ^c   Leong, Kam W ^a  

^a Duke University   (United States)

^b Johns Hopkins University   (United States)

^c Johns Hopkins University   (United States)

Author keywords

Caco2; DNA nanoparticle; GI epithelium models; Nonviral gene transfer; Oral gene delivery; Transcytosis

Indexed keywords

CACO2; CELLULAR MODEL; CO-CULTURES; COCULTURE; COMPARATIVE STUDIES; ENTEROCYTES; GENE DELIVERY; HEPG2 CELLS; IN-VIVO; INTESTINAL CELLS; INTESTINAL EPITHELIUM; MRNA EXPRESSION; NANOPARTICLE SURFACE CHARGE; NON-VIRAL GENE DELIVERY; NONVIRAL; NONVIRAL GENE TRANSFER; PEGYLATION; PROTEIN EXPRESSIONS; SYNTHETIC POLYMERS; THERAPEUTIC EFFECTS; THREE ORDERS OF MAGNITUDE; TIGHT JUNCTIONS; TRANSCYTOSIS; TRANSEPITHELIAL ELECTRICAL RESISTANCES; TRANSPORT EXPERIMENTS;

CELL CULTURE; CONFOCAL MICROSCOPY; DNA; GENE TRANSFER; INSULIN; SEMICONDUCTOR QUANTUM DOTS;

NANOPARTICLES;

CHITOSAN; DNA; HUMAN INSULIN; LIPID; LUCIFERASE; MESSENGER RNA; NANOPARTICLE; POLY(PHOSPHORAMIDATE DIPROPYLAMINE); POLYETHYLENEIMINE; POLYMER; PROTAMINE; QUANTUM DOT; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; COMPARATIVE STUDY; COMPLEX FORMATION; CONFOCAL MICROSCOPY; ELECTRIC RESISTANCE; ENDOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; INTESTINE EPITHELIUM; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATIC ELECTRICITY; TIGHT JUNCTION; TRANSCYTOSIS; TRANSEPITHELIAL ELECTRICAL RESISTANCE; TRANSGENE; ZETA POTENTIAL;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; COCULTURE TECHNIQUES; DNA; DRUG CARRIERS; ENDOCYTOSIS; HEP G2 CELLS; HT29 CELLS; HUMANS; INSULIN; INTESTINAL MUCOSA; MODELS, BIOLOGICAL; NANOPARTICLES; PLASMIDS; RNA, MESSENGER; TRANSFECTION;

EID: 84861532281     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.01.041     Document Type: Article

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