The effects of carbohydrate ingestion during endurance running on post-exercise inflammation and hepcidin levels

European Journal of Applied Physiology

Volumn 112, Issue 5, 2012, Pages 1889-1898

  Sim, Marc ^a   Dawson, Brian ^a   Landers, Grant ^a   Wiegerinck, Erwin T ^b   Swinkels, Dorine W ^b   Townsend, Mary Anne ^c   Trinder, Debbie ^d   Peeling, Peter ^a,e  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c FREMANTLE HOSPITAL   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e AUSTRALIAN INSTITUTE OF SPORT   (Australia)

Author keywords

Cytokines; Endurance running; Exercise; Hemolysis; Iron deWciency

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; CYTOKINE; HEPCIDIN; IRON;

ADULT; ARTICLE; BLOOD; CARBOHYDRATE DIET; ENDURANCE; EXERCISE; EXERCISE TEST; HEMOLYSIS; HUMAN; INFLAMMATION; MALE; PHYSIOLOGY; RUNNING;

ANTIMICROBIAL CATIONIC PEPTIDES; CYTOKINES; DIETARY CARBOHYDRATES; EXERCISE; EXERCISE TEST; HEMOLYSIS; HUMANS; INFLAMMATION; IRON; MALE; PHYSICAL ENDURANCE; RUNNING; YOUNG ADULT;

EID: 84861528290     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-011-2156-0     Document Type: Article

References (48)

1. Asano S, Okano A, Ozawa K, Nakahata T, Ishibashi T, Koike K, Kimura H, Tanioka Y, Shibuya A, Hirano T (1990) In vivo eVects of recombinant human interleukin-6 in primates: stimulated production of platelets. Blood 75(8): 1602-1605 (Pubitemid 20145744)
2. Beard J, Tobin B (2000) Iron status and exercise. Am J Clin Nutr 72(2): 594S-597S (Pubitemid 30650059)
3. Bessis MC, Breton-Gorius J (1957) Iron particles in normal erythroblasts and normal and pathological erythrocytes. J Cell Biol 3(3): 503-504
4. Brouns F (1991) Etiology of gastrointestinal disturbances during endurance events. Scand J Med Sci Sports 1(2): 66-77
5. Burstein SA, Downs T, Friese P, Lynam S, Anderson S, Henthorn J, Epstein RB, Savage K (1992) Thrombocytopoiesis in normal and sublethally irradiated dogs: response to human interleukin-6. Blood 80(2): 420-428
6. Coyle EF, Montain SJ (1992) BeneWts of Xuid replacement with carbohydrate during exercise. Med Sci Sport Exerc 24(9): 324-330
7. Coyle EF, Hagberg JM, Hurley BF, Martin WH, Ehsani AA, Holloszy JO (1983) Carbohydrate feeding during prolonged strenuous exercise can delay fatigue. J Appl Physiol 55(1): 230-235 (Pubitemid 13075346)
8. Daries HN, Noakes TD, Dennis SC (2000) EVect of Xuid intake volume on 2-h running performances in a 25°C environment. Med Sci Sport Exerc 32(10): 1783-1789
9. Fallon KE (2001) The acute phase response and exercise: the ultramarathon as prototype exercise. Clin J Sport Med 11(1): 38-43 (Pubitemid 32062199)
10. Feelders RA, Kuiper-Kramer EP, van Eijk HG (1999) Structure, function and clinical signiWcance of transferrin receptors. Clin Chem Lab Med 37(1): 1-10 (Pubitemid 29097247)
11. Flowers CH, Skikne BS, Covell AM, Cook JD (1989) The clinical measurement of serum transferrin receptor. J Lab Clin Med 114(4): 368-377 (Pubitemid 19253270)
12. Giblett ER (1968) The haptoglobin system. Ser Haemotol 1: 3-20
13. Helge JW, Stallknecht B, Pedersen BK, Galbo H, Kiens B, Richter EA (2003) The eVect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. J Physiol 546(1): 299-305 (Pubitemid 36104989)
14. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA (1990) Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 75(1): 102-107 (Pubitemid 20031496)
15. Jentjens R, Moseley L, Waring R, Harding L, Jeukendrup A (2004a) Oxidation of combined ingestion of glucose and fructose during exercise. J Appl Physiol 96(4): 1277-1284 (Pubitemid 38392661)
16. Jentjens R, Venables M, Jeukendrup A (2004b) Oxidation of exogenous glucose, sucrose, and maltose during prolonged cycling exercise. J Appl Physiol 96(4): 1285-1291 (Pubitemid 38392662)
17. Jones AM, Doust JH (1996) A 1% treadmill grade most accurately reXects the energetic cost of outdoor running. J Sports Sci 14(4): 321-327 (Pubitemid 26326486)
18. Kataranovski M, Magic Z, Pejnovic N (1999) Early inXammatory cytokine and acute phase protein response under the stress of thermal injury in rats. Physiol Res 48(6): 473-482 (Pubitemid 30019557)
19. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, Neufer PD (2001) Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: inXuence of muscle glycogen content. FASEB J 15(14): 2748-2750
20. Lukaski HC (2004) Vitamin and mineral status: eVects on physical performance. Nutrition 20(7-8): 632-644 (Pubitemid 38801484)
21. Lymboussaki A, Pignatti E, Montosi G, Garuti C, Haile DJ, Pietrangelo A (2003) The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression. J Hepatol 39(5): 710-715 (Pubitemid 37372178)
22. Macdougall IC, Cooper AC (2002) Erythropoietin resistance: the role of inXammation and pro-inXammatory cytokines. Nephrol Dial Transplant 17(11): 39-43 (Pubitemid 35277063)
23. Malope BI, MacPhail AP, Alberts M, Hiss DC (2001) The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status. Br J Haematol 115(1): 84-89 (Pubitemid 32995099)
24. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A, Davis JM (1997) Carbohydrate and the cytokine response to 2.5 hof running. J Appl Physiol 82(5): 1662-1667 (Pubitemid 27203876)
25. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T (2004a) IL-6 mediates hypoferremia of inXammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113(9): 1271-1276 (Pubitemid 39069926)
26. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004b) Hepcidin regulates cellular iron eZux by binding to ferroportin and inducing its internalization. Science 306(5704): 2090-2093 (Pubitemid 40007660)
27. Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR, Henson DA, Utter A, Davis JM, Williams F, Butterworth DE (1998) InXuence of mode and carbohydrate on the cytokine response to heavy exertion. Med Sci Sport Exerc 30(5): 671-678 (Pubitemid 28210989)
28. Nikolaidis MG, Michailidis Y, Mougios V (2003) Variation of soluble transferrin receptor and ferritin concentrations in human serum during recovery from exercise. Eur J Appl Physiol 89(5): 500-502 (Pubitemid 36806010)
29. Noakes TD (1993) Fluid replacement during exercise. Exerc Sport Sci Rev 21(1): 297-330
30. Noakes T (2003) Fluid replacement during marathon running. Clin JSport Med 13(5): 309-318 (Pubitemid 37210527)
31. Pedersen BK, Steensberg A, Schjerling P (2001) Exercise and interleukin- 6. Curr Opin Hematol 8(3): 137-141
32. Peeling P, Dawson B, Goodman C, Landers G, Trinder D (2008) Athletic induced iron deWciency: new insights into the role of inXammation, cytokines and hormones. Eur J Appl Physiol 103(4): 381-391
33. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck E, Swinkels D, Trinder D (2009a) Cumulative eVects of consecutive running sessions on hemolysis, inXammation and hepcidin activity. Eur J Appl Physiol 106(1): 51-59
34. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck E, Swinkels D, Trinder D (2009b) EVects of exercise on hepcidin response and iron metabolism during recovery. Int J Sport Nutr Exerc Metab 19(6): 583-597
35. Peeling P, Dawson B, Goodman C, Landers G, Wiegerinck E, Swinkels D, Trinder D (2009c) Training surface and intensity: inXammation, hemolysis, and hepcidin expression. Med Sci Sport Exerc 41(5): 1138-1145
36. Reeder BJ, Wilson MT (2005) Hemoglobin and myoglobin associated oxidative stress: from molecular mechanisms to disease states. Curr Med Chem 12: 2741-2751 (Pubitemid 41601571)
37. Robson-Ansley P, Walshe I, Ward D (2010) The eVect of carbohydrate ingestion on plasma interleukin-6, hepcidin and iron concentrations following prolonged exercise. Cytokine 53(2): 196-200
38. Roecker L, Meier-Buttermilch R, Brechtel L, Nemeth E, Ganz T(2005) Iron-regulatory protein hepcidin is increased in female athletes after a marathon. Eur J Appl Physiol 95(5): 569-571 (Pubitemid 41762564)
39. Saris WH, Goodpaster BH, Jeukendrup AE, Brouns F, Halliday D, Wagenmakers AJ (1993) Exogenous carbohydrate oxidation from diVerent carbohydrate sources during exercise. J Appl Physiol 75(5): 2168-2172 (Pubitemid 23352392)
40. Sawka MN, Burke LB, Eicher RE, Maughan RJ, Monain SJ, Stachenfeld NS (1996) Exercise and Xuid replacement. Med Sci Sports Exerc 28: 1-7
41. SchiVman SS, Booth BJ, Losee ML, Pecore SD, Warwick ZS (1995) Bitterness of sweeteners as a function of concentration. Brain Res Bull 36(5): 505-513
42. Schumacher YO, Schmid A, Konig D, Berg A (2002) EVects of exercise on soluble transferrin receptor and other variables of the iron status. Br J Sports Med 36(3): 195-199 (Pubitemid 34651938)
43. Steensberg A, Febbraio MA, Osada T, Schjerling P, Van Hall G, Saltin B, Pedersen BK (2001) Interleukin-6 production in contracting human skeletal muscle is inXuenced by pre-exercise muscle glycogen content. J Physiol 537(2): 633-639 (Pubitemid 33130517)
44. Telford RD, Sly GJ, Hahn AG, Cunningham RB, Bryant C, Smith JA (2003) Footstrike is the major cause of hemolysis during running. J Appl Physiol 94(1): 38-42 (Pubitemid 36014293)
45. Van Vlierberghe H, Langlois M, Delanghe J (2004) Haptoglobin polymorphisms and iron homeostasis in health and in disease. Clin Chim Acta 345(1-2): 35-42 (Pubitemid 38749169)
46. Villarino AV, Huang E, Hunter CA (2004) Understanding the pro- and anti-inXammatory properties of IL-27. J Immunol 173(2): 715-720 (Pubitemid 38924243)
47. Wagenmakers AJ, Brouns F, Saris WH, Halliday D (1993) Oxidation rates of orally ingested carbohydrates during prolonged exercise in men. J Appl Physiol 75(6): 2774-2780 (Pubitemid 24008400)
48. Wallis GA, Rowlands DS, Shaw C, Jentsens R, Jeukendrup AE (2005) Oxidation of combined ingestion of maltodextrins and fructose during exercise. Med Sci Sport Exerc 37(3): 426-432 (Pubitemid 40354452)