FG020326 sensitized multidrug resistant cancer cells to docetaxel-mediated apoptosis via enhancement of caspases activation

Molecules

Volumn 17, Issue 5, 2012, Pages 5442-5458

  Wang, Xiu Wen ^a   Wang, Xiao Kun ^a   Zhang, Xu ^a   Liang, Yong Ju ^a   Shi, Zhi ^a   Chen, Li Ming ^a   Fu, Li Wu ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

Apoptosis; Cancer; Caspase; FG020326; Multiple drug resistance; P glycoprotein

Indexed keywords

ACRYLIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; DOCETAXEL; GLYCOPROTEIN P; IMIDAZOLE DERIVATIVE; METHYL 3 (4 (4,5 BIS(4 (ISOPROPYL(METHYL)AMINO)PHENYL) 1H IMIDAZOL 2 YL)PHENYL)ACRYLATE; METHYL 3-(4-(4,5-BIS(4-(ISOPROPYL(METHYL)AMINO)PHENYL)-1H-IMIDAZOL-2-YL)PHENYL)ACRYLATE; TAXOID;

APOPTOSIS; ARTICLE; CELL STRAIN KB; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG RESISTANCE; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; HUMAN; METABOLISM; MULTIDRUG RESISTANCE; TUMOR CELL LINE;

ACRYLATES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; IMIDAZOLES; KB CELLS; P-GLYCOPROTEINS; TAXOIDS;

EID: 84861522853     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17055442     Document Type: Article

References (46)

1. Wilson, C.R.; Sauer, J.; Hooser, S.B. Taxines: A review of the mechanism and toxicity of yew (Taxus spp.) alkaloids. Toxicon 2001, 39, 175-185.
2. Blagosklonny, M.V.; Fojo, T. Molecular effects of paclitaxel: Myths and reality (a critical review). Int. J. Cancer 1999, 83, 151-156.
3. Pucci, B.; Bellincampi, L.; Tafani, M.; Masciullo, V.; Melino, G.; Giordano, A. Paclitaxel induces apoptosis in Saos-2 cells with CD95L upregulation and Bcl-2 phosphorylation. Exp. Cell Res. 1999, 252, 134-143.
4. Goncalves, A.; Braguer, D.; Carles, G.; Andre, N.; Prevot, C.; Briand, C. Caspase-8 activation independent of CD95/CD95-L interaction during paclitaxel-induced apoptosis in human colon cancer cells (HT29-D4). Biochem. Pharmacol. 2000, 60, 1579-1584.
5. Wang, T.H.; Wang, H.S.; Soong, Y.K. Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer 2000, 88, 2619-2628.
6. Takahashi, M.; Kigawa, J.; Minagawa, Y.; Itamochi, H.; Shimada, M.; Kamazawa, S.; Sato, S.; Akeshima, R.; Terakawa, N. Sensitivity to paclitaxel is not related to p53-dependent apoptosis in ovarian cancer cells. Eur. J. Cancer 2000, 36, 1863-1868.
7. Tan, M.; Jing, T.; Lan, K.H.; Neal, C.L.; Li, P.; Lee, S.; Fang, D.; Nagata, Y.; Liu, J.; Arlinghaus, R.; et al. Phosphorylation on tyrosine-15 of p34Cdc2 by ErbB2 inhibits p34Cdc2 activation and is involved in resistance to taxol-induced apoptosis. Mol. Cell 2002, 9, 993-1004.
8. Taniguchi, T.; Takahashi, M.; Shinohara, F.; Sato, T.; Echigo, S.; Rikiishi, H. Involvement of NF-kappaB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma. Int. J. Mol. Med. 2005, 15, 667-673.
9. Ling, V. Multidrug resistance: Molecular mechanisms and clinical relevance. Cancer Chemother. Pharmacol. 1997, 40, S3-S8.
10. Chen, L.M.; Wu, X.P.; Ruan, J.W.; Liang, Y.J.; Ding, Y.; Shi, Z.; Wang, X.W.; Gu, L.Q.; Fu, L.W. Screening novel, potent multidrug-resistant modulators from imidazole derivatives. Oncol. Res. 2004, 14, 355-362.
11. Fu, L.W.; Deng, Z.A.; Pan, Q.C.; Fan, W. Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Res. 2001, 21, 2273-2280.
12. Krishna, R.; Mayer, L.D. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci. 2000, 11, 265-283.
13. Sikic, B.I.; Fisher, G.A.; Lum, B.L.; Halsey, J.; Beketic-Oreskovic, L.; Chen, G. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein. Cancer Chemother. Pharmacol. 1997, 40, S13-S19.
14. Garnier-Suillerot, A.; Marbeuf-Gueye, C.; Salerno, M.; Loetchutinat, C.; Fokt, I.; Krawczyk, M.; Kowalczyk, T.; Priebe, W. Analysis of drug transport kinetics in multidrug-resistant cells: Implications for drug action. Curr. Med. Chem. 2001, 8, 51-64.
15. Smyth, M.J.; Krasovskis, E.; Sutton, V.R.; Johnstone, R.W. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc. Natl. Acad. Sci. USA 1998, 95, 7024-7029.
16. Johnstone, R.W.; Cretney, E.; Smyth, M.J. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999, 93, 1075-1085.
17. Robinson, L.J.; Roberts, W.K.; Ling, T.T.; Lamming, D.; Sternberg, S.S.; Roepe, P.D. Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry 1997, 36, 11169-11178.
18. Berger, W.; Micksche, M.; Elbling, L. Effects of multidrug resistance-related ATP-binding-cassette transporter proteins on the cytoskeletal activity of cytochalasins. Exp. Cell Res. 1997, 237, 307-317.
19. Kang, C.D.; Ahn, B.K.; Jeong, C.S.; Kim, K.W.; Lee, H.J.; Yoo, S.D.; Chung, B.S.; Kim, S.H. Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoproteinunrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein. Exp. Cell Res. 2000, 256, 300-307.
20. Coultas, L.; Strasser, A. The molecular control of DNA damage-induced cell death. Apoptosis 2000, 5, 491-507.
21. Kim, R.; Emi, M.; Tanabe, K. Caspase-dependent and -independent cell death pathways after DNA damage. Oncol. Rep. 2005, 14, 595-599.
22. Ruefli, A.A.; Smyth, M.J.; Johnstone, R.W. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 2000, 95, 2378-2385.
23. Reed, J.C. Cytochrome c: Can't live with it-Can't live without it. Cell 1997, 91, 559-562.
24. Orrenius, S. Mitochondrial regulation of apoptotic cell death. Toxicol. Lett. 2004, 149, 19-23.
25. Kluck, R.M.; Bossy-Wetzel, E.; Green, D.R.; Newmeyer, D.D. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 1997, 275, 1132-1136.
26. Susin, S.A.; Lorenzo, H.K.; Zamzami, N.; Marzo, I.; Snow, B.E.; Brothers, G.M.; Mangion, J.; Jacotot, E.; Costantini, P.; Loeffler, M.; et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999, 397, 441-446.
27. Nutt, L.K.; Gogvadze, V.; Uthaisang, W.; Mirnikjoo, B.; McConkey, D.J.; Orrenius, S. Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis. Cancer Biol. Ther. 2005, 4, 459-467.
28. Zou, H.; Henzel, W.J.; Liu, X.; Lutschg, A.; Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997, 90, 405-413.
29. Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S.M.; Ahmad, M.; Alnemri, E.S.; Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91, 479-489.
30. Luo, X.; Budihardjo, I.; Zou, H.; Slaughter, C.; Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94, 481-490.
31. Li, H.; Zhu, H.; Xu, C.J.; Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998, 94, 491-501.
32. Konopleva, M.; Zhao, S.; Xie, Z.; Segall, H.; Younes, A.; Claxton, D.F.; Estrov, Z.; Kornblau, S.M.; Andreeff, M. Apoptosis. Molecules and mechanisms. Adv. Exp. Med. Biol. 1999, 457, 217-236.
33. Houghton, J.A. Apoptosis and drug response. Curr. Opin. Oncol. 1999, 11, 475-481.
34. Li, J.; Sasaki, H.; Sheng, Y.L.; Schneiderman, D.; Xiao, C.W.; Kotsuji, F.; Tsang, B.K. Apoptosis and chemoresistance in human ovarian cancer: Is Xiap a determinant? Biol. Signals Recept. 2000, 9, 122-130.
35. Costantini, P.; Jacotot, E.; Decaudin, D.; Kroemer, G. Mitochondrion as a novel target of anticancer chemotherapy. J. Natl. Cancer Inst. 2000, 92, 1042-1053.
36. Kidd, V.J.; Lahti, J.M.; Teitz, T. Proteolytic regulation of apoptosis. Semin. Cell Dev. Biol. 2000, 11, 191-201.
37. Cao, D.X.; Qiao, B.; Ge, Z.Q.; Yuan, Y.J. Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004, 214, 103-113.
38. Yin, X.M.; Wang, K.; Gross, A.; Zhao, Y.; Zinkel, S.; Klocke, B.; Roth, K.A.; Korsmeyer, S.J. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999, 400, 886-891.
39. Varfolomeev, E.E.; Schuchmann, M.; Luria, V.; Chiannilkulchai, N.; Beckmann, J.S.; Mett, I.L.; Rebrikov, D.; Brodianski, V.M.; Kemper, O.C.; Kollet, O.; et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998, 9, 267-276.
40. Herr, I.; Debatin, K.M. Cellular stress response and apoptosis in cancer therapy. Blood 2001, 98, 2603-2614.
41. Ruan, J.W.; Fu, L.W.; Huang, Z.S.; Chen, L.M.; Ma, L.; Gu, L.Q. Studies on synthesis of multiaryl-substituted imidazoles and reversal activity on the multidrug resistance. Chem. J. Chin. Univ. 2004, 25, 870-873.
42. Zhang, X.H.; Zhang, F.Y.; Ji, X.J.; Li, Z.Y. Vincristine-resistant human KB cell line and mechanism of multidrug resistance. Yao Xue Xue Bao 1994, 29, 246-251.
43. Fu, L.W.; Pan, Q.C.; Huang, W.L.; Yang, X.P. Reversal of tumor multidrug resistance by 2-phenyl-3-(3',5'-dimorpholinomethyl-4'-hydroxy)-benzoyl-indole (HWL-12). Zhongguo Yao Li Xue Bao 1998, 19, 77-80.
44. Herr, I.; Wilhelm, D.; Bohler, T.; Angel, P.; Debatin, K.M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 1997, 16, 6200-6208.
45. Hishikawa, K.; Oemar, B.S.; Tanner, F.C.; Nakaki, T.; Luscher, T.F.; Fujii, T. Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7. J. Biol. Chem. 1999, 274, 37461-37466.
46. Jiang, X.H.; Wong, B.C.; Yuen, S.T.; Jiang, S.H.; Cho, C.H.; Lai, K.C.; Lin, M.C.; Kung, H.F.; Lam, S.K. Arsenic trioxide induces apoptosis in human gastric cancer cells through up-regulation of p53 and activation of caspase-3. Int. J. Cancer 2001, 91, 173-179.