Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice

Toxicological Sciences

Volumn 127, Issue 2, 2012, Pages 547-554

  Yoshioka, Wataru ^a   Aida Yasuoka, Keiko ^a   Fujisawa, Nozomi ^a   Kawaguchi, Tatsuya ^a   Ohsako, Seiichiroh ^a   Hara, Shuntaro ^b   Uematsu, Satoshi ^c   Akira, Shizuo ^c   Tohyama, Chiharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Developmental toxicity; Dioxin; Kidney

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; HYDRONEPHROSIS; KNOCKOUT MOUSE; LACTATION; MALE; MOUSE; NEWBORN; NONHUMAN; PROSTAGLANDIN BLOOD LEVEL;

MUS;

EID: 84861474835     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs115     Document Type: Article

References (40)

1. Antonucci, R., Cuzzolin, L., Arceri, A., and Fanos, V. (2007). Urinary prostaglandin E(2) in the newborn and infant. Prostaglandins Other Lipid Mediat. 84, 1-13.
2. Benador, N. M., Grau, G. E., Ruef, C., and Girardin, E. P. (1995). Endogenous TNF-alpha modulates the proliferation of rat mesangial cells and their prostaglandin E2 synthesis. Microvasc. Res. 50, 154-161.
3. Bryant, P. L., Schmid, J. E., Fenton, S. E., Buckalew, A. R., and Abbott, B. D. (2001). Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha. Toxicol. Sci. 62, 103-114.
4. Couture, L. A., Harris, M. W., and Birnbaum, L. S. (1990). Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam. Appl. Toxicol. 15, 142-150.
5. Couture-Haws, L., Harris, M. W., Lockhart, A. C., and Birnbaum, L. S. (1991a). Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 107, 402-412.
6. Couture-Haws, L., Harris, M. W., McDonald, M. M., Lockhart, A. C., and Birnbaum, L. S. (1991b). Hydronephrosis in mice exposed to TCDDcontaminated breast milk: Identification of the peak period of sensitivity and assessment of potential recovery. Toxicol. Appl. Pharmacol. 107, 413-428.
7. Dong, B., Nishimura, N., Vogel, C. F., Tohyama, C., and Matsumura, F. (2010). TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys. Biochem. Pharmacol. 79, 487-497.
8. Dragin, N., Dalton, T. P., Miller, M. L., Shertzer, H. G., and Nebert, D. W. (2006). For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J. Biol. Chem. 281, 18591-18600.
9. Gonzalez, F. J., and Fernandez-Salguero, P. (1998). The aryl hydrocarbon receptor: Studies using the AHR-null mice. Drug Metab. Dispos. 26, 1194-1198.
10. JECFA (2002). Fifty-Seventh Report of the Joint FAO/WHO Expert Committee on Food Additives, pp. 121-146. WHO Technical Report Series, No. 909. Geneva, Switzerland.
11. Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh-Ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., Ohuchi, K., et al. (2004). Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. J. Biol. Chem. 279, 33684-33695.
12. Kemter, E., Rathkolb, B., Bankir, L., Schrewe, A., Hans, W., Landbrecht, C., Klaften, M., Ivandic, B., Fuchs, H., Gailus-Durner, V., et al. (2010). Mutation of the Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia. Am. J. Physiol. Renal Physiol. 298, F1405-F1415.
13. Kinehara, M., Fukuda, I., Yoshida, K., and Ashida, H. (2009). Aryl hydrocarbon receptor-mediated induction of the cytosolic phospholipase A(2)alpha gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma Hepa-1c1c7 cells. J. Biosci. Bioeng. 108, 277-281.
14. Liem, A. K., Furst, P., and Rappe, C. (2000). Exposure of populations to dioxins and related compounds. Food Addit. Contam. 17, 241-259.
15. Lorenz, J. N., Baird, N. R., Judd, L. M., Noonan, W. T., Andringa, A., Doetschman, T., Manning, P. A., Liu, L. H., Miller, M. L., and Shull, G. E. (2002). Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. J. Biol. Chem. 277, 37871-37880.
16. Matsumura, F. (2009). The significance of the nongenomic pathway in mediating inflammatory signaling of the dioxin-activated Ah receptor to cause toxic effects. Biochem. Pharmacol. 77, 608-626.
17. Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T. N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., et al. (1997). Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2, 645-654.
18. Moore, J. A., Gupta, B. N., Zinkl, J. G., and Vos, J. G. (1973). Postnatal effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ. Health Perspect. 5, 81-85.
19. Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh, S., et al. (2000). Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275, 32783-32792.
20. Nishimura, N., Matsumura, F., Vogel, C. F., Nishimura, H., Yonemoto, J., Yoshioka, W., and Tohyama, C. (2008). Critical role of cyclooxygenase-2 activation in pathogenesis of hydronephrosis caused by lactational exposure of mice to dioxin. Toxicol. Appl. Pharmacol. 231, 374-383.
21. Nishimura, N., Yonemoto, J., Nishimura, H., and Tohyama, C. (2006). Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-pdioxin. Toxicology 227, 117-126.
22. Pohjanvirta, R., and Tuomisto, J. (1994). Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: Effects, mechanisms, and animal models. Pharmacol. Rev. 46, 483-549.
23. Poland, A., and Glover, E. (1980). 2,3,7,8,-Tetrachlorodibenzo-p-dioxin: Segregation of toxicity with the Ah locus. Mol. Pharmacol. 17, 86-94.
24. Poland, A., Palen, D., and Glover, E. (1994). Analysis of the four alleles of the murine aryl hydrocarbon receptor. Mol. Pharmacol. 46, 915-921.
25. Rao, R., Hao, C. M., and Breyer, M. D. (2004). Hypertonic stress activates glycogen synthase kinase 3beta-mediated apoptosis of renal medullary interstitial cells, suppressing an NFkappaB-driven cyclooxygenase-2-dependent survival pathway. J. Biol. Chem. 279, 3949-3955.
26. Rao, R., Zhang, M. Z., Zhao, M., Cai, H., Harris, R. C., Breyer, M. D., and Hao, C. M. (2005). Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am. J. Physiol. Renal Physiol. 288, F642-F649.
27. Rozen, S., and Skaletsky, H. (2000). Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132, 365-386.
28. Sawano, H., Haneda, M., Sugimoto, T., Inoki, K., Koya, D., and Kikkawa, R. (2002). 15-Deoxy-delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. Kidney Int. 61, 1957-1967.
29. Schecter, A., and Gasiewicz, T. A. (2003). In Dioxins and Health, 2nd ed.Wiley, Hoboken, NJ.
30. Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., and Bradfield, C. A. (1996). Characterization of a murine Ahr null allele: Involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. U.S.A. 93, 6731-6736.
31. Schneider, A., Zhang, Y., Zhang, M., Lu, W. J., Rao, R., Fan, X., Redha, R., Davis, L., Breyer, R. M., Harris, R., et al. (2004). Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney. Kidney Int. 65, 1205-1213.
32. Sciullo, E. M., Vogel, C. F., Li, W., and Matsumura, F. (2008). Initial and extended inflammatory messages of the nongenomic signaling pathway of the TCDD-activated Ah receptor in U937 macrophages. Arch. Biochem. Biophys. 480, 143-155.
33. Sola-Villa, D., Camacho, M., Sola, R., Soler, M., Diaz, J. M., and Vila, L. (2006). IL-1beta induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells. Kidney Int. 70, 1935-1941.
34. Takahashi, N., Chernavvsky, D. R., Gomez, R. A., Igarashi, P., Gitelman, H. J., and Smithies, O. (2000). Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc. Natl. Acad. Sci. U.S.A. 97, 5434-5439.
35. Theobald, H. M., and Peterson, R. E. (1997). In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-rho-dioxin: Effects on development of the male and female reproductive system of the mouse. Toxicol. Appl. Pharmacol. 145, 124-135.
36. Thomae, T. L., Glover, E., and Bradfield, C. A. (2004). A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis. J. Biol. Chem. 279, 30189-30194.
37. Uematsu, S., Matsumoto, M., Takeda, K., and Akira, S. (2002). Lipopolysaccharidedependent prostaglandin E(2) production is regulated by the glutathionedependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J. Immunol. 168, 5811-5816.
38. Vogel, C., Boerboom, A. M., Baechle, C., El-Bahay, C., Kahl, R., Degen, G. H., and Abel, J. (2000). Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: Possible c-Src-mediated pathway. Carcinogenesis 21, 2267-2274.
39. Yoshioka, W., Akagi, T., Nishimura, N., Shimizu, H., Watanabe, C., and Tohyama, C. (2009). Severe toxicity and cyclooxygenase (COX)-2 mRNA increase by lithium in the neonatal mouse kidney. J. Toxicol. Sci. 34, 519-525.
40. Yoshioka, W., Peterson, R. E., and Tohyama, C. (2011). Molecular targets that link dioxin exposure to toxicity phenotypes. J. Steroid Biochem. Mol. Biol. 127, 96-101.