Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: Possible c-Src-mediated pathway

Carcinogenesis

Volumn 21, Issue 12, 2000, Pages 2267-2274

  Vogel, Christoph ^a   Boerboom, Anne Marie J F ^a   Baechle, Claudia ^a   El Bahay, Claudia ^a   Kahl, Regine ^a   Degen, Gisela H ^b   Abel, Josef ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ARACHIDONIC ACID DERIVATIVE; BENZO[A]PYRENE; CCAAT ENHANCER BINDING PROTEIN; CIS ACTING ELEMENT; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIOXIN; DNA; DNA BINDING PROTEIN; GELDANAMYCIN; GLUTATHIONE TRANSFERASE; HERBIMYCIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROTEIN; MESSENGER RNA; PHORBOL ESTER; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTANOID; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THROMBOXANE; TRANS ACTING FACTOR; TRANSCRIPTION FACTOR; TUMOR PROMOTER; UNINDEXED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE MUTATION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROMOTER REGION; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REPORTER GENE; TRANSCRIPTION REGULATION; TUMOR PROMOTION;

EID: 0034521528     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.12.2267     Document Type: Article

References (71)

1. Yes, but do they still get headaches?
2. Prostaglandin synthase 2
3. Cyclooxygenase-2 inhibitors in tumorigenesis
4. Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs
5. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase
6. Characterization of the human gene PTGS2 encoding prostaglandin endoperoxide synthase-2
7. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells
8. Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines
9. An E-box region within the prostaglandin endoperoxide synthase-2 (PGS-2) promoter is required for transcription in rat ovarian granulosa cells
10. Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells
11. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element
12. Transcriptional roles of nuclear factor B and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
13. v-src-transformed 3T3 fibroblasts
14. Benzo[a]pyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells
15. Regulation of prostaglandin endoperoxide H synthase-2 expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
16. Induction of human prostaglandin H synthase-2 (PGHS-2) mRNA by TCDD
17. Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin
18. Modulation of prostaglandin H synthase-2 mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice
19. The Ah receptor and mechanism of dioxin toxicity
20. Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis
21. ARA9 modifies agonist signaling through an increase in cytosolic aryl hydrocarbon receptor
22. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization
23. Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (aryl hydrocarbon) receptor
24. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo
25. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
26. Identification of c-src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway
27. Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells
28. Human cyclooxygenase-2 cDNA
29. 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates expression of the prostaglandin G/H synthase-2 gene in rat thymocytes
30. Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice
31. b-3 alleles
32. Influence of acetaminophen treatment and hydrogen peroxide treatment on the release of a CINC-related protein and TNF-α from rat hepatocyte cultures
33. Effect of transforming growth factor-β1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: Clues for independent down-regulation in A549 cells
34. Cloning and expression of rat PGHS- (Cox-)2 cDNA
35. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat
36. Induction and developmental expression of cytochrome P4501A1 messenger mRNA in rat and human tissues: Detection by the polymerase chain reaction
37. Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction
38. Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor
39. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
40. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells
41. Differential toxicities of TCDD in vivo among normal, c-src knockout, geldanamycin- and quercetin-treated mice
42. Radicicol, a protein tyrosine kinase inhibitor, supresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis
43. v-Src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor
44. Specific protein-DNA interactions at a xenobiotic-responsive element: Copurification of dioxin receptor and DNA-binding activity
45. The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis
46. The leucine zipper: A hypothetical structure common to a new class of DNA binding proteins
47. The C/EBP family of transcription factors in the liver and other organs
48. Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex
49. Src
50. 2,3,7,8-Tetrachlorodibenzo-p-dioxin causes increases in expression of c-erb-A and levels of protein-tyrosine kinases in selected tissues of responsive mouse strains
51. Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation
52. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation of c-Src protein kinase in liver WB-F344 cells
53. Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation
54. Benzoquinoid ansamycins (herbimycin A and geldanamycin) interfere with the maturation of growth factor receptor tyrosine kinases
55. v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
56. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover
57. Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt
58. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum
59. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
60. Expression of cyclooxyagenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
61. Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level
62. Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated β-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in APC
63. 1 delay in cells overexpressing prostaglandin endoperoxide synthase-2
64. Cyclooxygenase-2: Regulation and relevance in inflammation
65. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
66. Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin
67. Expression of cyclooxygenase-1 and -2 in human colorectal cancer
68. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis
69. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells
70. Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells
71. Suppression of C/EBPα and induction of C/EBPβ by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse adipose tissue and liver