Teratogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-α

Toxicological Sciences

Volumn 62, Issue 1, 2001, Pages 103-114

  Bryant, P LaMont ^a,c   Schmid, Judith E ^b   Fenton, Suzanne E ^b   Buckalew, Angela R ^b   Abbott, Barbara D ^b  

^a IL   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Cleft plate; EGF; EGF receptor; Hydronephrosis; TCDD; TGF

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CORN OIL; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALCULATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CLEFT PALATE; CLINICAL RESEARCH; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; EPITHELIUM CELL; EXPOSURE; FEEDING; FEMALE; FETUS; FETUS DEATH; FETUS RESORPTION; FETUS WEIGHT; GENOTYPE; GESTATIONAL AGE; HYDRONEPHROSIS; INCIDENCE; KNOCKOUT MOUSE; LIVER WEIGHT; MALE; MOUSE; NIDATION; NONHUMAN; PARAMETER; PLACENTA WEIGHT; PREGNANCY; PROTEIN EXPRESSION; SURVIVAL; TERATOGENICITY; URINARY TRACT; WEIGHT GAIN;

ABNORMALITIES, DRUG-INDUCED; ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CLEFT PALATE; ENVIRONMENTAL POLLUTANTS; EPIDERMAL GROWTH FACTOR; FEMALE; HYDRONEPHROSIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; PREGNANCY; REPRODUCTION; TERATOGENS; TETRACHLORODIBENZODIOXIN; TOXICITY TESTS; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMALIA; ZEA MAYS;

EID: 0034953010     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/62.1.103     Document Type: Article

References (58)

1. TCDD alters medial epithelial cell differentiation during palatogenesis
2. Retinoic acid-induced alterations in the expression of growth factors in embryonic mouse palatal shelves
3. TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD
4. TCDD-induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses
5. Retinoids and epidermal growth factor alter embryonic mouse palatal epithelial and mesenchymal cell differentiation in organ culture
6. Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-alpha and epidermal growth factor
7. Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: Increased incidence of cleft palate in mice
8. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes
9. Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-alpha expression in embryonic mouse urinary tract
10. Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin
11. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Recent advances toward understanding the mechanism
12. Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
13. Hydronephrosis in mice exposed to TCDD contaminated breast milk: Identification of the peak period of sensitivity and assessment of potential recovery
14. Epidermal growth factor and transforming growth factor-alpha induce differential processing of the epidermal growth factor receptor
15. Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: Potential involvement of alternate epidermal growth factor receptor ligands
16. Modulation of growth factor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin
17. Epidermal growth factor and transforming growth factor-alpha: Differential intracellular routing and processing of ligand-receptor complexes
18. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
19. Determination of polychlorodibenzo-p-dioxins and related compounds in commercial chlorophenols
20. Inductive interactions in the development of the mouse metanephros
21. Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor
22. Species differences in estrogen receptors and in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure
23. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney
24. Regulation of EGF receptor and transforming growth factor-alpha expression
25. Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha
26. Transforming growth factor alpha: Expression, regulation, and biological activities
27. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
28. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
29. Induction of transforming growth factor-alpha in activated human alveolar macrophages
30. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
31. Birth defects in the Seveso area after TCDD contamination
32. Toxicopathology characteristics of the halogenated aromatics
33. The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs
34. Characterization and interpretation of kidney anomalies associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
35. Critical period of carbon tetrachloride-induced pregnancy loss in Fischer-344 rats, with insights into the detection of resorption sites by ammonium sulfide staining
36. A multidisciplinary approach to toxicological screening: II. Developmental toxicity
37. Nonadditive developmental toxicity in mixtures of trichloroethylene, Di(2-ethylexyl) phthalate, and heptachlor in a 5×5×5 design
38. Embryotoxic effects in mice treated with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin
39. Effects of small doses of dioxins on the immune system of marmosets and rats
40. Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons
41. Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand
42. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
43. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced cleft palate in the mouse: Evidence for alterations in palatal shelf fusion
44. Mouse prepro-epidermal growth factor synthesis by the kidney and other tissues
45. The Seveso accident: Medical survey of a TCDD exposure
46. EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney
47. Early organogenesis of the kidney
48. Transforming growth factor-alpha: A more potent angiogenic mediator than epidermal growth factor
49. Toxicology of chlorinated dibenzo-p-dioxins
50. Betacellulin: A mitogen from pancreatic beta cell tumors
51. Structure and function of human amphiregulin: A member of the epidermal growth factor family
52. Localization of epidermal growth factor precursor in tooth and lung during embryonic mouse development
53. The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells
54. Developmental expression of transforming growth factors alpha and beta in mouse fetus
55. Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain
56. "Apparent hydronephrosis" as a normal aspect of renal development in late gestation of rats: The effect of methyl salicylate