Isotretinoin-loaded nanocapsules: Stability and cutaneous penetration by tape stripping in human and pig skin

Journal of Biomedical Nanotechnology

Volumn 8, Issue 2, 2012, Pages 258-271

  Bettoni, Clarissa C ^a   Felippi, Cândice C ^a   De Andrade, Cristiane ^a   Raffin, Renata P ^a   Jager, Alessandro ^a   Guterres, Sílvia S ^a   Dalla Costa, Teresa ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cutaneous delivery; Human skin; Isotretinoin; Nanocapsules; Pig skin; Tape stripping in vitro

Indexed keywords

CUTANEOUS DELIVERY; HUMAN SKIN; IN-VITRO; ISOTRETINOIN; PIG SKIN;

NANOCAPSULES; SKIN; ZETA POTENTIAL;

MAMMALS;

ISOTRETINOIN; POLYCAPROLACTONE;

ANIMAL TISSUE; ARTICLE; DRUG FORMULATION; DRUG STABILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NANOEMULSION; NANOENCAPSULATION; NONHUMAN; PHOTODEGRADATION; PHYSICAL CHEMISTRY; SKIN PENETRATION; SWINE;

ADHESIVES; ANIMALS; DRUG STABILITY; GELS; HUMANS; ISOTRETINOIN; LIGHT; NANOCAPSULES; PHOTOLYSIS; POLYESTERS; SCATTERING, RADIATION; SKIN; SKIN ABSORPTION; SWINE;

EID: 84861467680     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2012.1381     Document Type: Article

References (59)

1. G. Yosipovitch, M. Tang, A. G. Dawn, M. Chen, C. L. Goh, Y. H. Chan, and L. F. Seng, Study of psychological stress, sebum production and acne vulgaris in adolescents. Acta Derm. Venereol. 87, 135 (2007).
2. A. M. Layton, A review on the treatment of acne vulgaris. Int. J. Clin. Pract. 60, 64 (2006).
3. A. Thielitz, A. Krautheim, and H. Gollnick, Update in retinoid therapy of acne. Dermatol. Ther. 19, 272 (2006).
4. A. Thielitz, M. B. Abdel-Naser, J. W. Fluhr, C. C. Zouboulis, and H. Gollnick, Topical retinoids in acne: An evidence-based overview. J. Dtsch. Dermatol. Ges. 8, S15 (2010).
5. S. L. Rolewski, Clinical Review: Topical Retinoids. Dermatol. Nurs. 15, 447 (2003).
6. B. J. Jensen, L. A. Mcgann, V. Kachevsky, and T. J. Franz, The negligible systemic availability of retinoids with multiple and excessive topical application of isotretinoin 0.05% gel (Isotrex) in patients with acne vulgaris. J. Am. Acad. Dermatol. 24, 425 (1991).
7. C. Chen, B. K. Jensen, G. Mistry, R. Wyss, M. Zultak, I. H. Patel, and A. K. Rakhit, Negligible systemic absorption of topical isotretinoin cream: Implications for teratogenicity. J. Clin. Pharmacol. 37, 279 (1997).
8. A. Krautheim and H. P. M. Gollnick, Transdermal penetration of topical drugs used in the treatment of acne. Clin. Pharmacokinet. 42, 1287 (2003).
9. E. V. Smith, D. J. Grindlay, and H. C. Williams, What's new in acne? An analysis of systematic reviews published in 2009-2010. Clin. Exp. Dermatol. 36, 119 (2011).
10. A. L. Zaenglein, Topical retinoids in the treatment of acne vulgaris. Semin. Cutan. Med. Surg. 27, 177 (2008).
11. J. C. Fallon, A. Buckley, and G. Murphy, Allergic contact dermatitis after isotretinoin treatment for acne. J. Eur. Acad. Dermatol. Venereol. 22, 1377 (2008).
12. J. Liu, W. Hu, H. Chen, Q. Ni, H. Xu, and X. Yang, Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int. J. Pharm. 328, 191 (2007).
13. G. Ioele, E. Cione, A. Risoli, G. Genchi, and G. Ragno, Accelerated photostability study of tretinoin and isotretinoin in liposome formulations. Int. J. Pharm. 293, 251 (2005).
14. G. Cevc, Lipid vesicles and other colloids as drug carriers on the skin. Adv. Drug. Deliv. Rev. 56, 675 (2004).
15. G. Barratt, Colloidal drug carriers: achievements and perspectives. Cell. Mol. Life. Sci. 60, 21 (2003).
16. S. S. Guterres, M. P. Alves, and A. R. Pohlmann, Polymeric nanoparticles, nanospheres and nanocapsules for cutaneous applications. Drug Target Insights. 2, I47 (2007).
17. R. Gatti, M. G. Gioia, and V. Cavrini, Analysis and stability study of retinoids in pharmaceuticals by LC with fluorescence detection. J. Pharm. Biomed. Anal. 23, 147 (2000).
18. J. J. Escobar-Chávez, V. Merino-Sanjuán, M. López-Cervantes, Z. Urban-Morlan, E. Piñón-Segundo, D. Quintanar-Guerrero, and A. Ganem-Quintanar, The tape stripping technique as a method for drug quantification in skin. J. Pharm. Pharm. Sci. 11, 104 (2008).
19. C. Herkenne, I. Alberti, A. Naik, Y. N. Kalia, F.-X. Mathy, V. Préat, and R. H. Guy. In vivo methods for the assessment of topical drug bioavailability. Pharm. Res. 25, 87 (2008).
20. H. Wagner, K.-H. Kostka, C-M. Lehr, and U. F. Schaefer, Drug distribution in human skin using two different in vitro test systems: comparison with in vivo data. Pharm. Res. 17, 1475 (2000).
21. H. Wagner, K.-H. Kostka, C.-M. Lehr, and U. F. Schaefer, Human skin penetration of flufenamic acid: In vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject. J. Invest. Dermatol. 118, 540 (2002).
22. C. Herkenne, A. Naik, Y. N. Kalia, J. Hadgraft, and R. H. Guy, Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man. Pharm. Res. 23, 1850 (2006).
23. A. Henning, D. Neumann, K.-H. Kostka, C.-M. Lehr, and U. F. Schaefer, Influence of human skin specimens consisting of different skin layers on the result of in vitro permeation experiments. Skin Pharmacol. Physiol. 21, 81 (2008).
24. F. P. Schmook, J. G. Meingassner, and A. Billich, Comparison of human skin or epidermis models with human and animal skin in in vitro percutaneous absorption. Int. J. Pharm. 215, 51 (2001).
25. U. Jacobi, H. Taube, U. F. Schäfer, W. Sterry, and J. Lademann, Comparison of four different in vitro systems to study the reservoir capacity of the stratum corneum. J. Control. Release. 103, 61 (2005).
26. B. Godin and E. Touitou, Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models. Adv. Drug. Deliv. Rev. 59, 1152 (2007).
27. V. Vallet, C. Cruz, D. Josse, A. Bazire, G. Lallement, and I. Boudry, In vitro percutaneous penetration of organophosphorus compounds using full-thickness and split-thickness pig and human skin. Toxicol. In Vitro 21, 1182 (2007).
28. A. M. Barbero and H. F. Frasch, Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. Toxicol. In Vitro 23, 1 (2009).
29. H. Fessi, F. Puisieux, J.-P. Devissaguet, N. Ammoury, and S. Benita, Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55, r1 (1989).
30. B. M. Tashtoush, E. L. Jacobson, and M. K. Jacobson, A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations. J. Pharm. Biomed. Anal. 43, 859 (2007).
31. Organization for Economic Cooperation and Development (OECD): Skin absorption: In vitro method, test guideline No 428, Guidelines for the Testing of Chemicals, Paris, OECD, 1, 4, 1-8 (2004).
32. H. Lboutounne, J.-F. Chaulet, C. Ploton, F. Falson, and F. Pirot, Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(ε- caprolactone) nanocapsule encapsulated form and as a digluconate. J. Control. Release. 82, 319 (2002).
33. M. J. Fresno Contreras, M. M. Jiménez Soriano, and A. Ramírez Diéguez. In vitro percutaneous absorption of all-trans retinoic acid applied in free form or encapsulated in stratum corneum lipid liposomes. Int. J. Pharm. 297, 134 (2005).
34. Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP): Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients. S.C.o.C.P.a.N.-F.P.I.f.C. (SCCNFP), Editor (2003).
35. J. Lademann, H.-J. Weigmann, S. Schanzer, H. Richter, H. Audring, C. Antoniou, G. Tsikrikas, H. Gers-Barlag, and W. Sterry, Optical investigations to avoid the disturbing influences of furrows and wrinkles quantifying penetration of drugs and cosmetics into the skin by tape stripping. J. Biomed. Opt. 10, 054015 (2005).
36. M. P. Alves, A. L. Scarrone, M. Santos, A. R. Pohlmann, and S. S. Guterres, Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int. J. Pharm. 341, 215 (2007).
37. C. C. Müller-Goymann, Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration. Eur. J. Pharm. Biopharm. 58, 343 (2004).
38. M. L. Hans, A. M. Lowman, Biodegradable nanoparticles for drug delivery and targeting. Curr. Opin. Solid State Mater. Sci. 6, 319 (2002).
39. S. R. Schaffazick, S. S. Guterres, L. L. Freitas, and A. R. Pohlmann, Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos. Quim. Nova. 26, 726 (2003).
40. A. F. Ourique, A. R. Pohlmann, S. S. Guterres, and R. C. R. Beck, Tretinoin-loaded nanocapsules: Preparation, physicochemical characterization, and photostability study. Int. J. Pharm. 352, 1 (2008).
41. M. Sznitowska, S. Janicki, and A. Baczek, Studies on the effect of pH on the lipoidal route of penetration across stratum corneum. J. Control. Release. 76, 327 (2001).
42. E. M. Lima, D. G. A. Diniz, and N. R. Antoniosi-Filho, Development of a gas chromatography method for the determination of isotretinoin and its degradation products in pharmaceuticals. J. Pharm. Biomed. Anal. 38, 678 (2005).
43. M. Mengual, G. Meunier, I. Cayre, K. Puech, and P. Snabre, Characterisation of instability of concentrated dispersions by a new optical analyzer: The Turbiscan MA 1000. Colloids Surf. A Physicochem. Eng. Asp. 152, 111 (1999).
44. C. Lemarchand, P. Couvreur, M. Besnard, D. Constantini, and R. Gref, Novel polyester-polysaccharide nanoparticles. Pharm. Res. 20, 1284 (2003).
45. V. M. P. Maio, P. E. Fröehlich, and A. M. Bergold, Interconversão tretinoína/isotretinoína: Um problema no preparo de formulações farmacêuticas. Acta Farm. Bonaer. 22, 249 (2003).
46. A. C. Krakowski, S. Stendardo, and L. F. Eichenfield, Practical considerations in acne treatment and the clinical impact of topical combination therapy. Pediatr. Dermatol. 25, 1 (2008).
47. V. Weiss-Angeli, F. S. Poletto, L. R. Zancan, F. Baldasso, A. R. Pohlmann, and S. S. Guterres, Nanocapsules of octyl methoxycinnamate containing quercetin delayed the photodegradation of both components under ultraviolet a radiation. J. Biomed. Nanotechnol. 4, 80 (2008).
48. R. Nankervis, S. S. Davis, N. H. Day, and P. N. Shaw, Intestinal lymphatic transport of three retinoids in the rat after oral administration: Effect of lipophilicity and lipid vehicle. Int. J. Pharm. 130, 57 (1996).
49. T. S. Poet and J. N. Mcdougal, Skin absorption and human risk assessment. Chem. Biol. Interact. 140, 19 (2002).
50. V. Jenning, A. Gysler, M. Schäfer-Korting, and S. Gohla, Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin. Eur. J. Pharm. Sci. 49, 211 (2000).
51. R. Alvarez-Román, A. Naik, Y. N. Kalia, and R. H. Guy, Enhancement of topical delivery from biodegradable nanoparticles. Pharm. Res. 21, 1818 (2004).
52. S. Y. Lin, S. J. Hou, T. H. Hsu, and F. L. Yeh, Comparisons of different animal skins with human skin in drug percutaneous penetration studies. Methods Find. Exp. Clin. Pharmacol. 14, 645 (1992).
53. J. Luengo, B. Weiss, M. Schneider, A. Ehlers, F. Stracke, K. König, K.-H. Kostka, C.-M. Lehr, and U. F. Schaefer, Influence of nanoencapsulation on human skin transport of flufenamic acid. Skin Pharmacol. Physiol. 19, 190 (2006).
54. J. Lademann, F. Knorr, H. Richter, U. Blume-Peytavi, A. Vogt, C. Antoniou, W. Sterry, and A. Patzelt, Hair follicles - An efficient storage and penetration pathway for topically applied substances. Skin Pharmacol. Physiol. 21, 150 (2008).
55. A. Patzelt, H. Richter, R. Buettemeyer, H. J. R. Huber, U. Blume-Peytavi, W. Sterry, and J. Lademann, Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo. Eur. J. Pharm. Biopharm. 70, 234 (2008).
56. R. Alvarez-Román, A. Naik, Y. N. Kalia, R. H. Guy, and H. Fessi, Skin penetration and distribution of polymeric nanoparticles. J. Control. Release. 99, 53 (2004).
57. J. Lademann, H. Richter, A. Teichmann, N. Otberg, U. Blume-Peytavi, J. Luengo, B. Weib, U. F. Schaefer, C.-M. Lehr, R. Wepf, and W. Sterry, Nanoparticles - An efficient carrier for drug delivery into the hair follicles. Eur. J. Pharm. Biopharm. 66, 159 (2007).
58. J. Shim, H. S. Kang, W. Park, S. Han, J. Kim, and I. Chang, Transdermal delivery of minoxidil with block copolymer nanoparticles. J. Control. Release. 97, 477 (2004).
59. F. Netzlaff, U. F. Schaefer, C.-M. Lehr, P. Meiers, J. Stahl, M. Kietzmann, and F. Niedorf, Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments. Altern. Lab. Anim. 34, 499 (2006).