Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(ε-caprolactone) nanocapsule encapsulated form and as a digluconate

Journal of Controlled Release

Volumn 82, Issue 2-3, 2002, Pages 319-334

  Lboutounne, Hassan ^a   Chaulet, Jean François ^b   Ploton, Christine ^c   Falson, Françoise ^a   Pirot, Fabrice ^a  

^a UNIVERSITÉ LYON 1   (France)

^b HIA Desgenettes   (France)

^c HÔPITAL DEBROUSSE   (France)

Author keywords

Chlorhexidine; Nanocapsules; Porcine ear skin; Staphylococcus epidermidis; Stratum corneum, Tape stripping

Indexed keywords

ANTIINFECTIVE AGENT; CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; EPIKURON; GLUCONIC ACID; LABRAFAC HYDROPHILE; NANOCAPSULE; NT 72150; OCTANOIC ACID; POLYCAPROLACTONE; POLYMER; POLYSORBATE 80; SOLVENT; TWEEN; UNCLASSIFIED DRUG; WL 1219; AQUAPLAST, CAPROLACTONE; DRUG DERIVATIVE; POLYESTER; TOPICAL ANTIINFECTIVE AGENT;

ABSORPTION SPECTROSCOPY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATION; COLLOID; CORRELATION ANALYSIS; DRUG SOLUTION; DRUG SYNTHESIS; EAR; ELECTROPHORESIS; HYDROGEL; IN VITRO STUDY; NONHUMAN; PHOTON; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SKIN SURFACE; STAPHYLOCOCCUS EPIDERMIDIS; STRATUM CORNEUM; TECHNIQUE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECT; DRUG FORMULATION; ELECTRON MICROSCOPY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE COCCI; MICROBIOLOGICAL EXAMINATION; NANOTECHNOLOGY; SKIN ABSORPTION; STAPHYLOCOCCUS INFECTION; SWINE;

ANIMAL; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EAR; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE COCCI; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; NANOTECHNOLOGY; POLYESTERS; SKIN ABSORPTION; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; SWINE; ANIMALS;

EID: 0037151320     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00142-6     Document Type: Article

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