In vitro percutaneous penetration of organophosphorus compounds using full-thickness and split-thickness pig and human skin

Toxicology in Vitro

Volumn 21, Issue 6, 2007, Pages 1182-1190

  Vallet, V ^a   Cruz, C ^a   Josse, D ^a   Bazire, A ^a   Lallement, G ^a   Boudry, I ^a  

^a CENTRE DE RECHERCHES   (France)

Author keywords

DFP; DSM; Full thickness skin; Human; In vitro; Organophosphorus compounds; Percutaneous penetration; Pig; Split thickness skin

Indexed keywords

DEMENTON METHYL; DYFLOS; O ETHYL [2 (DIISOPROPYLAMINO)ETHYL]METHYL PHOSPHONOTHIOATE; ORGANOPHOSPHORUS COMPOUND; PESTICIDE; SARIN; SOMAN; UNCLASSIFIED DRUG;

ABDOMEN; ADULT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; DIFFUSION; EAR; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; NONHUMAN; SKIN; SKIN PENETRATION; SKIN PERMEABILITY; SKINFOLD THICKNESS; SWINE; TOXICOKINETICS;

ABDOMEN; ADULT; ANIMALS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; EAR; FEMALE; HUMANS; ISOFLUROPHATE; MIDDLE AGED; PESTICIDES; SKIN; SKIN ABSORPTION; SWINE; THIOPHOSPHORIC ACID ESTERS;

SUIDAE;

EID: 34547820769     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2007.03.007     Document Type: Article

References (55)

1. Archibald B.A., Solomon K.R., and Stephenson G.R. Estimating pirimicarb exposure to greenhouse workers using video imaging. Archives of Environmental Contamination and Toxicology 27 (1994) 126-129
2. Ballantyne B., and Marrs T.C. Overview of the biological and clinical aspects of organophosphates and carbamates. In: Ballantyne B., and Marrs T.C. (Eds). Clinical and experimental toxicology of organophosphates and carbamates (1992), Butterworth-Heinemann, London 3-14
3. Benech-Kieffer F., Wegrich P., Schwarzenbach R., Klecak G., Weber T., Leclaire J., and Schaefer H. Percutaneous absorption of sunscreens in vitro: interspecies comparison, skin models and reproducibility aspects. Skin Pharmacology and Applied Skin Physiology 13 (2000) 324-335
4. Benford D.J., Cocker J., Sartorelli P., Schneider T., van Hemmen J., and Firth J.G. Dermal route in systemic exposure. Scandinavian Journal of Work Environment and Health 25 (1999) 511-520
5. Bronaugh R.L., and Franz T.J. Vehicle effects on percutaneous absorption: in vivo and in vitro comparisons with human skin. British Journal of Dermatology 115 (1986) 1-11
6. Bronaugh R.L., Stewart R.F., and Congdon E.R. Methods for in vitro percutaneous absorption studies. II. Animal models for human skin. Toxicology and Applied Pharmacology 62 (1982) 481-488
7. Bronaugh R.L., Krealing M.E.K., and Yourick J.J. Determination of percutaneous absorption by in vitro techniques. In: Bronaugh R.L., and Maibach H.I. (Eds). Percutaneous absorption: Drugs-Cosmetics-Mechanisms-Methodology. fourth ed. (2005), Taylor and Francis, Kentucky distribution Center, USA
8. Carver M.P., Williams P.L., and Riviere J.E. The isolated perfused porcine skin flap. III. Percutaneous absorption pharmacokinetics of organophosphates, steroids, benzoic acid, and caffeine. Toxicology and Applied Pharmacology 97 (1989) 324-337
9. Chellquist E.M., and Reifenrath W.G. Distribution and fate of diethyl malonate and diisopropyl fluorophosphate on pig skin in vitro. Journal of Pharmaceutical Sciences 77 (1988) 850-854
10. Chilcott R.P., Barai N., Beezer A.E., Brain S.I., Brown M.B., Bunge A.L., Burgess S.E., Cross S., Dalton C.H., Dias M., Farinha A., Finnin B.C., Gallagher S.J., Green D.M., Gunt H., Gwyther R.L., Heard C.M., Jarvis C.A., Kamiyama F., Kasting G.B., Ley E.E., Lim S.T., McNaughton G.S., Morris A., Nazemi M.H., Pellett M.A., Du Plessis J., Quan Y.S., Raghavan S.L., Roberts M., Romonchuk W., Roper C.S., Schenk D., Simonsen L., Simpson A., Traversa B.D., Trottet L., Watkinson A., Wilkinson S.C., Williams F.M., Yamamoto A., and Hadgraft J. Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials. Journal of Pharmaceutical Sciences 94 (2005) 632-638
11. Chilcott R.P., Dalton C.H., Hill I., Davison C.M., Blohm K.L., Clarkson E.D., and Hamilton M.G. Evaluation of a barrier cream against the chemical warfare agent VX using the domestic white pig. Basic Clinical Pharmacology and Toxicology 97 (2005) 35-38
12. Clowes H.M., Scott R.C., and Heylings J.R. Skin absorption: flow-through or static diffusion cells. Toxicology in Vitro 8 (1994) 827-830
13. Czerwinski S.E., Skvorak J.P., Maxwell D.M., Lenz D.E., and Baskin S.I. Effect of octanol:water partition coefficients of organophosphorus compounds on biodistribution and percutaneous toxicity. Journal of Biochemistry and Molecular Toxicology 20 (2006) 241-246
14. Dalton C.H., Hattersley I.J., Rutter S.J., and Chilcott R.P. Absorption of the nerve agent VX (O-ethyl-S-[2(di-isopropylamino)ethyl] methyl phosphonothioate) through pig, human and guinea pig skin in vitro. Toxicology in Vitro 20 (2006) 1532-1536
15. Dick I.P., and Scott R.C. Pig ear skin as an in vitro model for human skin permeability. Journal of Pharmacy and Pharmacology 44 (1992) 640-645
16. Dugard P.H. Skin permeability theory in relation to measurements of percutaneous absorption in toxicology. In: Marzulli F.N., and Maibach H.I. (Eds). Advances in Modern Toxicology. Dermatotoxicology and Pharmacology vol. 4 (1977), John Wiley and sons, London, New York 525-550
17. Ellman G.L., Courtney K.D., Andres Jr. V., and Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology 7 (1961) 88-95
18. Feldmann R.J., and Maibach H.I. Absorption of some organics compounds through the skin in man. Journal of Investigative Dermatology 54 (1970) 399-404
19. Fischer S., Arad A., and Margalit R. Liposome-formulated enzymes for organophosphates scavenging: butyrylcholinesterase and demeton-S. Archives of Biochemistry and Biophysics 434 (2005) 108-115
20. Franz T.J. Percutaneous absorption on the relevance of in vitro data. Journal of Investigative Dermatology 64 (1975) 190-195
21. Fredriksson T. Hydrolysis of Soman and Tabun (two organophosphorus cholinesterase inhibitors) in cutaneous tissues. Acta Dermato-Venereologica 49 (1969) 490-492
22. Griesemer R.D., Blank I.H., and Gould E. The penetration of an anticholinesterase agent (sarin) into skin. III. A method for studying the rate of penetration into the skin of the living rabbit. Journal of Investigative Dermatology 31 (1958) 255-258
23. Hawkins Jr. G.S., and Reifenrath W.G. Development of an in vitro model for determining the fate of chemicals applied to skin. Fundamental and Applied Toxicology 4 (1984) S133-S144
24. Hawkins G.S., and Reifenrath W.G. Influence of skin source, penetration cell fluid, and partition coefficient on in vitro skin penetration. Journal of Pharmaceutical Sciences 75 (1986) 378-381
25. Hoskin F.C. The enzymatic product of sarin. Canadian Journal of Biochemistry and Physiology 34 (1956) 75-79
26. Jacobi U., Taube H., Schafer U.F., Sterry W., and Lademann J. Comparison of four different in vitro systems to study the reservoir capacity of the stratum corneum. Journal of Controlled Release 103 (2005) 61-71
27. Lee F.W., Earl L., and Williams F.M. Interindividual variability in the percutaneous penetration of testosterone through human skin in vitro. Toxicology 168 (2001) 63
28. Loden M. The in vitro hydrolysis of diisopropyl fluorophosphate during penetration through human full-thickness skin and isolated epidermis. Journal of Investigative Dermatology 85 (1985) 335-339
29. Marty, J.P., 1976. Fixation des substances chimiques dans les structures superficielles de la peau: Importance dans les problèmes de décontamination et de biodisponibilité, Ph.D. Thesis, University of Paris-Sud.
30. Maynard R.L., and Beswick F.W. Organophosphorus compounds as chemical warfare agents. In: Ballantyne B., and Marrs T.C. (Eds). Clinical and Experimental Toxicology of Organophosphates and Carbamates (1992), Butterworth-Heinemann, London 373-385
31. Meyer W., Zschemisch N.H., and Godynicki S. The porcine ear skin as a model system for the human integument: influence of storage conditions on basic features of epidermis structure and function - a histological and histochemical study. Polish Journal of Veterinary Sciences 6 (2003) 17-28
32. Moody R.P., and Nadeau B. An automated in vitro dermal absorption procedure: III. In vivo and in vitro comparison with the insect repellent N,N-diethyl-m-toluamide in mouse, rat, guinea pig, pig, human and tissue-cultured skin. Toxicology in Vitro 7 (1993) 167-176
33. OECD (Organisation for Economic Co-operation and Development), 2004. Guideline for the testing of chemicals. Skin absoprtion: in vitro method. Adopted 13 april 2004, OECD, Paris.
34. Ramsey J.D., Woollen B.H., Auton T.R., and Scott R.C. The predictive accuracy of in vitro measurements for the dermal absorption of a lipophilic penetrant (fluazifop-butyl) through rat and human skin. Fundamental and Applied Toxicology 23 (1994) 230-236
35. Reifenrath W.G., Mershon M.M., Brinkley F.B., Miura G.A., Broomfield C.A., and Cranford H.B. Evaluation of diethyl malonate as a simulant for 1,2,2-trimethylpropyl methylphosphonofluoridate (soman) in shower decontamination of the skin. Journal of Pharmaceutical Sciences 73 (1984) 1388-1392
36. Riviere J.E., Baynes R.E., Brooks J.D., Yeatts J.L., and Monteiro-Riviere N.A. Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants. Journal of Toxicology and Environmental Health 66 (2003) 133-151
37. Rosado C., Cross S.E., Pugh W.J., Roberts M.S., and Hadgraft J. Effect of vehicle pretraitement on the flux, retention, and diffusion of topically applied penetrants in vitro. Pharmaceutical Research 20 (2003) 1502-1507
38. Santhanam A., Miller M.A., and Kasting G.B. Absorption and evaporation of N,N-diethyl-m-toluamide from human skin in vitro. Toxicology and Applied Pharmacology 204 (2005) 81-90
39. Schmook F.P., Meingassner J.G., and Billich A. Comparison of human skin or epidermis models with human and animal skin in in vitro percutaneous absorption. International Journal of Pharmaceutics 215 (2001) 51-56
40. Sidell F.R., and Borak J. Chemical warfare agents: II. Nerve agents. Annals of Emergency Medicine 21 (1992) 865-871
41. Simon G.A., and Maibach H.I. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations - an overview. Skin Pharmacology and Applied Skin Physiology 13 (2000) 229-234
42. Southwell D., Barry B.W., and Woodford R. Variations in permeability of human skin within and between specimens. International Journal of Pharmaceutics 18 (1984) 299-309
43. Spencer, P.S., Bischoff, M.C., 1983. Skin as a route of entry for neurotoxic substances. In: Marzulli, F.N., Maibach, H.I., Dermatotoxicology, second ed., Hemisphere Publishing Corporation, Washington, Grant No. 0H-00851, pp. 611-626.
44. Tregear R.T. Molecular movement, the permeability of the skin. Physical Functions of Skin (1966), Academic Press, New York 1-52
45. Van der Merwe D., and Riviere J.E. Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane. Toxicology in Vitro 19 (2005) 69-77
46. van de Sandt J.J., Meuling W.J., Elliott G.R., Cnubben N.H., and Hakkert B.C. Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur. Toxicological Sciences 58 (2000) 15-22
47. van de Sandt J.J., van Burgsteden J.A., Cage S., Carmichael P.L., Dick I., Kenyon S., Korinth G., Larese F., Limasset J.C., Maas W.J., Montomoli L., Nielsen J.B., Payan J.P., Robinson E., Sartorelli P., Schaller K.H., Wilkinson S.C., and Williams F.M. In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study. Regulatory Toxicology and Pharmacology 39 (2004) 271-281
48. van Genderen J., Mol M.A., and Wolthuis O.L. On the development of skin models for toxicity testing. Fundamental and Applied Toxicology 5 (1985) S98-S111
49. van Hooidonk C., Ceulen B.I., Kienhuis H., and Bock J. Rate of skin penetration of organophosphates measured in diffusion cells. Developments in Toxicology and Environmental Science 8 (1980) 643-646
50. Wagner H., Kostka K.H., Lehr C.M., and Schaefer U.F. Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject. Journal of Investigative Dermatology 118 (2002) 540-544
51. Wester R.M., Tanojo H., Maibach H.I., and Wester R.C. Predicted chemical warfare agent VX toxicity to uniformed soldier using parathion in vitro human skin exposure and absorption. Toxicology and Applied Pharmacology 168 (2000) 149-152
52. Wiener S.W., and Hoffman R.S. Nerve agents: A comprehensive review. Journal of Intensive Care Medicine 19 (2004) 22-37
53. Wilkinson S.C., Maas W.J., Nielsen J.B., Greaves L.C., van de Sandt J.J., and Williams F.M. Interactions of skin thickness and physicochemical properties of test compounds in percutaneous penetration studies. International Archives of Occupational and Environmental Health 79 (2006) 405-413
54. Williams F.M. In vitro studies - how good are they at replacing in vivo studies for measurement of skin absorption?. Environmental Toxicology and Pharmacology 21 (2006) 199-203
55. Yanagisawa N., Morita H., and Nakajima T. Sarin experiences in Japan: acute toxicity and long-term effects. Journal of Neurological Sciences 249 (2006) 76-85