Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 1, 2008, Pages 234-238

  Patzelt, Alexa ^a   Richter, Heike ^a   Buettemeyer, Rolf ^a   Huber, Hans Joachim Roewert ^a   Blume Peytavi, Ulrike ^a   Sterry, Wolfram ^a   Lademann, Juergen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Elastic fibres; Follicle penetration; Hair follicle reservoir; In vitro skin model; In vivo

Indexed keywords

CURCUMIN;

ARTICLE; COMPARATIVE STUDY; DRUG PENETRATION; ELASTIC FIBER; FEMALE; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NORMAL HUMAN; TECHNIQUE;

ADMINISTRATION, CUTANEOUS; ADULT; BIOPSY; CURCUMIN; DRUG EVALUATION, PRECLINICAL; ELASTIC TISSUE; FEMALE; HAIR FOLLICLE; HUMANS; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SKIN; SKIN ABSORPTION;

EID: 50149112395     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.02.024     Document Type: Article

References (25)

1. Genina E.A., Bashkatov A.N., Sinichkin Y.P., Kochubey V.I., Lakodina N.A., Altshuler G.B., and Tuchin V.V. In vitro and in vivo study of dye diffusion into the human skin and hair follicles. J. Biomed. Opt. 7 (2002) 471-477
2. Lademann J., Otberg N., Richter H., Weigmann H.J., Lindemann U., Schaefer H., and Sterry W. Investigation of follicular penetration of topically applied substances. Skin Pharmacol. Appl. Skin Physiol. 14 Suppl. 1 (2001) 17-22
3. Lauer A.C., Ramachandran C., Lieb L.M., Niemiec S., and Weiner N.D. Targeted delivery to the pilosebaceous unit via liposomes. Adv. Drug Deliv. Rev. 18 (1996) 311-324
4. Ogiso T., Shiraki T., Okajima K., Tanino T., Iwaki M., and Wada T. Transfollicular drug delivery: penetration of drugs through human scalp skin and comparison of penetration between scalp and abdominal skins in vitro. J. Drug Target. 10 (2002) 369-378
5. H. Schaefer, T. Redelmeier, Skin barrier: principles of percutaneous absorption, Karger, Basel, (1996) 56.
6. Otberg N., Richter H., Schaefer H., Blume-Peytavi U., Sterry W., and Lademann J. Variations of hair follicle size and distribution in different body sites. J. Invest. Dermatol. 122 (2004) 14-19
7. Vogt A., Combadiere B., Hadam S., Stieler K.M., Lademann J., Schaefer H., Autran B., Sterry W., and Blume-Peytavi U. 40 nm, but not 750 or 1,500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin. J. Invest. Dermatol. 126 (2006) 1316-1322
8. Barry B.W. Drug delivery routes in skin: a novel approach. Adv. Drug Deliv. Rev. 54 Suppl. 1 (2002) S31-S40
9. Lademann J., Otberg N., Jacobi U., Hoffman R.M., and Blume-Peytavi U. Follicular penetration and targeting. J. Investig. Dermatol. Symp. Proc. 10 (2005) 301-303
10. Lademann J., Richter H., Schaefer U.F., Blume-Peytavi U., Teichmann A., Otberg N., and Sterry W. Hair follicles - a long-term reservoir for drug delivery. Skin Pharmacol. Physiol. 19 (2006) 232-236
11. Teichmann A., Jacobi U., Ossadnik M., Richter H., Koch S., Sterry W., and Lademann J. Differential stripping: determination of the amount of topically applied substances penetrated into the hair follicles. J. Invest. Dermatol. 125 (2005) 264-269
12. Krugluger W., Rohrbacher W., Laciak K., Moser K., Moser C., and Hugeneck J. Reorganization of hair follicles in human skin organ culture induced by cultured human follicle-derived cells. Exp. Dermatol. 14 (2005) 580-585
13. Wagner H., Kostka K.H., Lehr C.M., and Schaefer U.F. Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject. J. Invest. Dermatol. 118 (2002) 540-544
14. Jacobi U., Taube H., Schafer U.F., Sterry W., and Lademann J. Comparison of four different in vitro systems to study the reservoir capacity of the stratum corneum. J. Control. Release 103 (2005) 61-71
15. Teichmann A., Otberg N., Jacobi U., Sterry W., and Lademann J. Follicular penetration: development of a method to block the follicles selectively against the penetration of topically applied substances. Skin Pharmacol. Physiol. 19 (2006) 216-223
16. Kielty C.M., Sherratt M.J., and Shuttleworth C.A. Elastic fibres. J. Cell Sci. 115 (2002) 2817-2828
17. Starcher B., Aycock R.L., and Hill C.H. Multiple roles for elastic fibers in the skin. J. Histochem. Cytochem. 53 (2005) 431-443
18. Lademann J., Richter H., Teichmann A., Otberg N., Blume-Peytavi U., Luengo J., Weiss B., Schaefer U.F., Lehr C.M., Wepf R., and Sterry W. Nanoparticles - an efficient carrier for drug delivery into the hair follicles. Eur. J. Pharm. Biopharm. 66 (2007) 159-164
19. Weigmann H.J., Lademann J., Meffert H., Schaefer H., and Sterry W. Determination of the horny layer profile by tape stripping in combination with optical spectroscopy in the visible range as a prerequisite to quantify percutaneous absorption. Skin Pharmacol. Appl. Skin Physiol. 12 (1999) 34-45
20. Lademann J., Weigmann H.J., Schanzer S., Richter H., Audring H., Antoniou C., Tsikrikas G., Gers-Barlag H., and Sterry W. Optical investigations to avoid the disturbing influences of furrows and wrinkles quantifying penetration of drugs and cosmetics into the skin by tape stripping. J. Biomed. Opt. 10 (2005)
21. Toll R., Jacobi U., Richter H., Lademann J., Schaefer H., and Blume-Peytavi U. Penetration profile of microspheres in follicular targeting of terminal hair follicles. J. Invest. Dermatol. 123 (2004) 168-176
22. Otberg, Teichmann A., Rasulev U., Sinkgraven R., Sterry W., and Lademann J. Follicular penetration of topically applied caffeine a shampoo formulation. Skin Pharmacol. Physiol. 20 (2007) 195-198
23. Simon G.A., and Maibach H.I. The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations - an overview. Skin Pharmacol. Appl. Skin Physiol. 13 (2000) 229-234
24. Benech-Kieffer F., Wegrich P., Schwarzenbach R., Klecak G., Weber T., Leclaire J., and Schaefer H. Percutaneous absorption of sunscreens in vitro: interspecies comparison, skin models and reproducibility aspects. Skin Pharmacol. Appl. Skin Physiol. 13 (2000) 324-335
25. Feldmann R.J., and Maibach H.I. Regional variation in percutaneous penetration of 14C cortisol in man. J. Invest. Dermatol. 48 (1967) 181-183