Negligible systemic absorption of topical isotretinoin cream: Implications for teratogenicity

Journal of Clinical Pharmacology

Volumn 37, Issue 4, 1997, Pages 279-284

  Chen, Chao ^a   Jensen, Bradford K ^a   Mistry, Goutam ^a   Wyss, Ronald ^b   Zultak, Maurice ^c   Patel, Indravadan H ^a   Rakhit, Ashok K ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c Roche Intl Clinical Research Center   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXOISOTRETINOIN; 4 OXORETINOIC ACID; ISOTRETINOIN; RETINOIC ACID; RETINOID;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREAM; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FEMALE; HUMAN; SKIN DEFECT; SUN EXPOSURE; TERATOGENICITY; TOPICAL DRUG ADMINISTRATION;

EID: 0030951729     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1552-4604.1997.tb04303.x     Document Type: Article

References (13)

1. Gilchrest BA: Skin and Aging Processes. Boca Raton, FL: CRC Press, 1984.
2. Bryce GF, Bogdan NJ, Brown CC: Retinoic acids promote the repair of the dermal damage and the effacement of wrinkles in the UVB-irradiated hairless mouse. J Invest Dermatol 1988; 91:175-180.
3. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ: Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA 1988; 259:527-532.
4. Sendagorta E, Leslewicz J, Armstrong RB: Topical isotretinoin for photodamaged skin. J Am Acad Dermatol 1992; 27(suppl):S15-S18.
5. Gibaldi M, Perrier D: Pharmacokinetics. Second Edition. New York: Marcel Dekker, 1982.
6. Zar J: Biostatistical Analysis. Englewood, NJ: Prentice-Hall, 1974.
7. Hands ES: Food Finder. Second Edition. Salem, OR: ESHA Research, 1990; 1-8.
8. Lucek RW, Colburn WA: Clinical pharmacokinetics of retinoids. Clin Pharmacokinet 1985; 10:38-62.
9. Chen C, Mistry G, Jensen B, Heizmann P, Timm U, van Brummelen P, Rakhit A: Pharmacokinetics of retinoids following meal consumption or vitamin A supplementation. J Clin Pharmacol 1996; 36:799-808.
10. Teratology Society Position Paper: Recommendations for vitamin A use during pregnancy. Teratology 1987; 35:269-275.
11. Russell-Briefed R, Caggiula AW, Kuller LH: A comparison of three dietary methods for estimating vitamin A intake. Am J Epidemiol 1985; 122:628-636.
12. Rosa FW, Wilk AL, Kelsey FO: Vitamin A congeners. Teratology 1986; 33:355-364.
13. Nau H: Embryotoxicity and teratogenicity of topical retinoic acid. Skin Pharmacol 1993; 6(suppl):35-44.