-
1
-
-
70449421920
-
Impaired glucose homeostasis in Shb-/- mice
-
Akerblom B., Barg S., Calounova G., Mokhtari D., Jansson L., Welsh M. Impaired glucose homeostasis in Shb-/- mice. J. Endocrinol. 2009.
-
(2009)
J. Endocrinol.
-
-
Akerblom, B.1
Barg, S.2
Calounova, G.3
Mokhtari, D.4
Jansson, L.5
Welsh, M.6
-
2
-
-
0036148176
-
Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin
-
Anneren C. Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin. J. Endocrinol. 2002, 172:145-153.
-
(2002)
J. Endocrinol.
, vol.172
, pp. 145-153
-
-
Anneren, C.1
-
3
-
-
0038443927
-
The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation
-
Anneren C., Lindholm C.K., Kriz V., Welsh M. The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation. Curr. Mol. Med. 2003, 3:313-324.
-
(2003)
Curr. Mol. Med.
, vol.3
, pp. 313-324
-
-
Anneren, C.1
Lindholm, C.K.2
Kriz, V.3
Welsh, M.4
-
4
-
-
84873074877
-
-
ENCYCLOPEDIA Of LIFE SCIENCES Copyright © 2003, John Wiley & Sons, Ltd.
-
Atwood W., Shah K. Polyomaviruses 2003, ENCYCLOPEDIA Of LIFE SCIENCES Copyright © 2003, John Wiley & Sons, Ltd. http://www.els.net, 10.1038/npg.els.0001082.
-
(2003)
Polyomaviruses
-
-
Atwood, W.1
Shah, K.2
-
5
-
-
0000391746
-
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
-
Bergers G., Brekken R., McMahon G., Vu T.H., Itoh T., Tamaki K., Tanzawa K., Thorpe P., Itohara S., Werb Z., Hanahan D. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2000, 2:737-744.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 737-744
-
-
Bergers, G.1
Brekken, R.2
McMahon, G.3
Vu, T.H.4
Itoh, T.5
Tamaki, K.6
Tanzawa, K.7
Thorpe, P.8
Itohara, S.9
Werb, Z.10
Hanahan, D.11
-
6
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers G., Javaherian K., Lo K.M., Folkman J., Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science 1999, 284:808-812.
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
7
-
-
77955298871
-
The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation
-
Calounova G., Livera G., Zhang X.Q., Liu K., Gosden R.G., Welsh M. The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation. PLoS One 2010, 5:e11155.
-
(2010)
PLoS One
, vol.5
-
-
Calounova, G.1
Livera, G.2
Zhang, X.Q.3
Liu, K.4
Gosden, R.G.5
Welsh, M.6
-
8
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
Casanovas O., Hicklin D.J., Bergers G., Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005, 8:299-309.
-
(2005)
Cancer Cell
, vol.8
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
9
-
-
78049287075
-
Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis
-
Chun M.G., Hanahan D. Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. PLoS Genet. 2010, 6.
-
(2010)
PLoS Genet.
, vol.6
-
-
Chun, M.G.1
Hanahan, D.2
-
10
-
-
0034671392
-
Fibroblast growth factors are required for efficient tumor angiogenesis
-
Compagni A., Wilgenbus P., Impagnatiello M.A., Cotten M., Christofori G. Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Res. 2000, 60:7163-7169.
-
(2000)
Cancer Res.
, vol.60
, pp. 7163-7169
-
-
Compagni, A.1
Wilgenbus, P.2
Impagnatiello, M.A.3
Cotten, M.4
Christofori, G.5
-
11
-
-
0036679107
-
The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells
-
Cross M.J., Lu L., Magnusson P., Nyqvist D., Holmqvist K., Welsh M., Claesson-Welsh L. The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. Mol. Biol. Cell 2002, 13:2881-2893.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 2881-2893
-
-
Cross, M.J.1
Lu, L.2
Magnusson, P.3
Nyqvist, D.4
Holmqvist, K.5
Welsh, M.6
Claesson-Welsh, L.7
-
12
-
-
34548728661
-
Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein
-
Davoodpour P., Landstrom M., Welsh M. Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein. BMC Cancer 2007, 7:161.
-
(2007)
BMC Cancer
, vol.7
, pp. 161
-
-
Davoodpour, P.1
Landstrom, M.2
Welsh, M.3
-
13
-
-
4143136640
-
Vascular endothelial growth factor: basic science and clinical progress
-
Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 2004, 25:581-611.
-
(2004)
Endocr. Rev.
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
14
-
-
0024549349
-
Induction of angiogenesis during the transition from hyperplasia to neoplasia
-
Folkman J., Watson K., Ingber D., Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989, 339:58-61.
-
(1989)
Nature
, vol.339
, pp. 58-61
-
-
Folkman, J.1
Watson, K.2
Ingber, D.3
Hanahan, D.4
-
15
-
-
62449083531
-
Dysfunctional microvasculature as a consequence of Shb gene inactivation causes impaired tumor growth
-
Funa N.S., Kriz V., Zang G., Calounova G., Akerblom B., Mares J., Larsson E., Sun Y., Betsholtz C., Welsh M. Dysfunctional microvasculature as a consequence of Shb gene inactivation causes impaired tumor growth. Cancer Res. 2009, 69:2141-2148.
-
(2009)
Cancer Res.
, vol.69
, pp. 2141-2148
-
-
Funa, N.S.1
Kriz, V.2
Zang, G.3
Calounova, G.4
Akerblom, B.5
Mares, J.6
Larsson, E.7
Sun, Y.8
Betsholtz, C.9
Welsh, M.10
-
16
-
-
39149121840
-
Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo
-
Funa N.S., Reddy K., Bhandarkar S., Kurenova E.V., Yang L., Cance W.G., Welsh M., Arbiser J.L. Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo. J. Invest. Dermatol. 2008, 128:710-716.
-
(2008)
J. Invest. Dermatol.
, vol.128
, pp. 710-716
-
-
Funa, N.S.1
Reddy, K.2
Bhandarkar, S.3
Kurenova, E.V.4
Yang, L.5
Cance, W.G.6
Welsh, M.7
Arbiser, J.L.8
-
17
-
-
0021212003
-
Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
-
Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 1984, 133:1710-1715.
-
(1984)
J. Immunol.
, vol.133
, pp. 1710-1715
-
-
Gerdes, J.1
Lemke, H.2
Baisch, H.3
Wacker, H.H.4
Schwab, U.5
Stein, H.6
-
18
-
-
0026425565
-
Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice
-
Grant S.G., Seidman I., Hanahan D., Bautch V.L. Early invasiveness characterizes metastatic carcinoid tumors in transgenic mice. Cancer Res. 1991, 51:4917-4923.
-
(1991)
Cancer Res.
, vol.51
, pp. 4917-4923
-
-
Grant, S.G.1
Seidman, I.2
Hanahan, D.3
Bautch, V.L.4
-
19
-
-
78651074922
-
Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells
-
Gustafsson K., Calounova G., Hjelm F., Kriz V., Heyman B., Gronvik K.O., Mostoslavsky G., Welsh M. Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells. BMC Immunol. 2011, 12:3.
-
(2011)
BMC Immunol.
, vol.12
, pp. 3
-
-
Gustafsson, K.1
Calounova, G.2
Hjelm, F.3
Kriz, V.4
Heyman, B.5
Gronvik, K.O.6
Mostoslavsky, G.7
Welsh, M.8
-
20
-
-
33846044082
-
Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli
-
Hagerkvist R., Mokhtari D., Lindholm C., Farnebo F., Mostoslavsky G., Mulligan R.C., Welsh N., Welsh M. Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. Exp. Cell Res. 2007, 313:284-291.
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 284-291
-
-
Hagerkvist, R.1
Mokhtari, D.2
Lindholm, C.3
Farnebo, F.4
Mostoslavsky, G.5
Mulligan, R.C.6
Welsh, N.7
Welsh, M.8
-
21
-
-
20444486922
-
Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion
-
Hakansson J., Xian X., He L., Stahlberg A., Nelander S., Samuelsson T., Kubista M., Semb H. Neural cell adhesion molecule-deficient beta-cell tumorigenesis results in diminished extracellular matrix molecule expression and tumour cell-matrix adhesion. Tumour Biol. 2005, 26:103-112.
-
(2005)
Tumour Biol.
, vol.26
, pp. 103-112
-
-
Hakansson, J.1
Xian, X.2
He, L.3
Stahlberg, A.4
Nelander, S.5
Samuelsson, T.6
Kubista, M.7
Semb, H.8
-
22
-
-
0021888904
-
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
-
Hanahan D. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 1985, 315:115-122.
-
(1985)
Nature
, vol.315
, pp. 115-122
-
-
Hanahan, D.1
-
23
-
-
34147093740
-
Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling
-
Herzig M., Savarese F., Novatchkova M., Semb H., Christofori G. Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. Oncogene 2007, 26:2290-2298.
-
(2007)
Oncogene
, vol.26
, pp. 2290-2298
-
-
Herzig, M.1
Savarese, F.2
Novatchkova, M.3
Semb, H.4
Christofori, G.5
-
24
-
-
0037290643
-
The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells
-
Holmqvist K., Cross M., Riley D., Welsh M. The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. Cell Signal. 2003, 15:171-179.
-
(2003)
Cell Signal.
, vol.15
, pp. 171-179
-
-
Holmqvist, K.1
Cross, M.2
Riley, D.3
Welsh, M.4
-
25
-
-
2542455474
-
The adaptor protein Shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration
-
Holmqvist K., Cross M.J., Rolny C., Hagerkvist R., Rahimi N., Matsumoto T., Claesson-Welsh L., Welsh M. The adaptor protein Shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J. Biol. Chem. 2004, 279:22267-22275.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22267-22275
-
-
Holmqvist, K.1
Cross, M.J.2
Rolny, C.3
Hagerkvist, R.4
Rahimi, N.5
Matsumoto, T.6
Claesson-Welsh, L.7
Welsh, M.8
-
26
-
-
0036491615
-
VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis
-
Inoue M., Hager J.H., Ferrara N., Gerber H.P., Hanahan D. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell 2002, 1:193-202.
-
(2002)
Cancer Cell
, vol.1
, pp. 193-202
-
-
Inoue, M.1
Hager, J.H.2
Ferrara, N.3
Gerber, H.P.4
Hanahan, D.5
-
27
-
-
0029760277
-
Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb
-
Karlsson T., Welsh M. Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. Oncogene 1996, 13:955-961.
-
(1996)
Oncogene
, vol.13
, pp. 955-961
-
-
Karlsson, T.1
Welsh, M.2
-
28
-
-
34548860663
-
Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero
-
Kriz V., Mares J., Wentzel P., Funa N.S., Calounova G., Zhang X.Q., Forsberg-Nilsson K., Forsberg M., Welsh M. Shb null allele is inherited with a transmission ratio distortion and causes reduced viability in utero. Dev. Dyn. 2007, 236:2485-2492.
-
(2007)
Dev. Dyn.
, vol.236
, pp. 2485-2492
-
-
Kriz, V.1
Mares, J.2
Wentzel, P.3
Funa, N.S.4
Calounova, G.5
Zhang, X.Q.6
Forsberg-Nilsson, K.7
Forsberg, M.8
Welsh, M.9
-
29
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez T., Hanahan D. Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002, 1:339-353.
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
30
-
-
0036251203
-
Role of the Src homology 2 domain-containing protein Shb in murine brain endothelial cell proliferation and differentiation
-
Lu L., Holmqvist K., Cross M., Welsh M. Role of the Src homology 2 domain-containing protein Shb in murine brain endothelial cell proliferation and differentiation. Cell Growth Differ. 2002, 13:141-148.
-
(2002)
Cell Growth Differ.
, vol.13
, pp. 141-148
-
-
Lu, L.1
Holmqvist, K.2
Cross, M.3
Welsh, M.4
-
31
-
-
78650018824
-
Conversion of vascular endothelial cells into multipotent stem-like cells
-
Medici D., Shore E.M., Lounev V.Y., Kaplan F.S., Kalluri R., Olsen B.R. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat. Med. 2010, 16:1400-1406.
-
(2010)
Nat. Med.
, vol.16
, pp. 1400-1406
-
-
Medici, D.1
Shore, E.M.2
Lounev, V.Y.3
Kaplan, F.S.4
Kalluri, R.5
Olsen, B.R.6
-
32
-
-
68249105033
-
Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice
-
Mokhtari D., Kerblom B., Mehmeti I., Wang X., Funa N.S., Olerud J., Lenzen S., Welsh N., Welsh M. Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice. Biochem. Biophys. Res. Commun. 2009.
-
(2009)
Biochem. Biophys. Res. Commun.
-
-
Mokhtari, D.1
Kerblom, B.2
Mehmeti, I.3
Wang, X.4
Funa, N.S.5
Olerud, J.6
Lenzen, S.7
Welsh, N.8
Welsh, M.9
-
33
-
-
0029833679
-
The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors
-
Naik P., Karrim J., Hanahan D. The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev. 1996, 10:2105-2116.
-
(1996)
Genes Dev.
, vol.10
, pp. 2105-2116
-
-
Naik, P.1
Karrim, J.2
Hanahan, D.3
-
34
-
-
0029068871
-
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
-
Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 376:37-43.
-
(1995)
Nature
, vol.376
, pp. 37-43
-
-
Nicholson, D.W.1
Ali, A.2
Thornberry, N.A.3
Vaillancourt, J.P.4
Ding, C.K.5
Gallant, M.6
Gareau, Y.7
Griffin, P.R.8
Labelle, M.9
Lazebnik, Y.A.10
-
35
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M., Allen E., Hudock J., Takeda T., Okuyama H., Vinals F., Inoue M., Bergers G., Hanahan D., Casanovas O. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009, 15:220-231.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
Inoue, M.7
Bergers, G.8
Hanahan, D.9
Casanovas, O.10
-
36
-
-
77950900273
-
Regulation of hypoxia-inducible genes by PGC-1 alpha
-
Shoag J., Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler. Thromb. Vasc. Biol. 2010, 30:662-666.
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, pp. 662-666
-
-
Shoag, J.1
Arany, Z.2
-
37
-
-
77953467092
-
Micro computed tomography for vascular exploration
-
Zagorchev L., Oses P., Zhuang Z.W., Moodie K., Mulligan-Kehoe M.J., Simons M., Couffinhal T. Micro computed tomography for vascular exploration. J. Angiogenes Res. 2010, 2:7.
-
(2010)
J. Angiogenes Res.
, vol.2
, pp. 7
-
-
Zagorchev, L.1
Oses, P.2
Zhuang, Z.W.3
Moodie, K.4
Mulligan-Kehoe, M.J.5
Simons, M.6
Couffinhal, T.7
-
38
-
-
33747598265
-
Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents
-
Zhuang Z.W., Gao L., Murakami M., Pearlman J.D., Sackett T.J., Simons M., de Muinck E.D. Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents. Radiology 2006, 240:698-707.
-
(2006)
Radiology
, vol.240
, pp. 698-707
-
-
Zhuang, Z.W.1
Gao, L.2
Murakami, M.3
Pearlman, J.D.4
Sackett, T.J.5
Simons, M.6
de Muinck, E.D.7
|