Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein

BMC Cancer

Volumn 7, Issue , 2007, Pages

  Davoodpour, Padideh ^a   Landström, Maréne ^b,c   Welsh, Michael ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Ludwig Institute of Cancer Research   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ABELSON KINASE; ADAPTOR PROTEIN; CASPASE 3; COMPLEMENTARY DNA; DNA; IMATINIB; KI 67 ANTIGEN; PROTEIN SHB; UNCLASSIFIED DRUG; 2-METHOXYESTRADIOL; DRUG DERIVATIVE; ENZYME INHIBITOR; ESTRADIOL; MITOGEN ACTIVATED PROTEIN KINASE P38; ONCOPROTEIN; SHB PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUBULIN MODULATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CLONE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECT; GENETICS; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; ENZYME INHIBITORS; ESTRADIOL; FEMALE; HUMANS; MALE; MICE; MICE, NUDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ABL; SIGNAL TRANSDUCTION; TRANSFECTION; TUBULIN MODULATORS; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 34548728661     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-7-161     Document Type: Article

References (36)

1. Salesi N Carlini P Ruggeri EM Ferretti G Bria E Cognetti F Prostate cancer: The role of hormonal therapy. J Exp Clin Cancer Res 2005, 24(2):175-180. 16110748
2. Kent EC Hussain MH The patient with hormone-refractory prostate cancer: determining who, when, and how to treat. Urology 2003, 62 Suppl 1:134-140. 10.1016/j.urology.2003.09.005 14747051
3. Bu S Blaukat A Fu X Heldin NE Landstrom M Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett 2002, 531(2):141-151. 10.1016/S0014-5793(02)03478-6 12417302
4. Fotsis T Zhang Y Pepper MS Adlercreutz H Montesano R Nawroth PP Schweigerer L The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature 1994, 368(6468):237-239. 10.1038/368237a0 7511798
5. D'Amato RJ Lin CM Flynn E Folkman J Hamel E 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc Natl Acad Sci U S A 1994, 91(9):3964-3968. 43703 8171020 10.1073/pnas.91.9.3964
6. Lottering ML Haag M Seegers JC Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells. Cancer Res 1992, 52(21):5926-5932. 1327520
7. Mabjeesh NJ Escuin D LaVallee TM Pribluda VS Swartz GM Johnson MS Willard MT Zhong H Simons JW Giannakakou P 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003, 3(4):363-375. 10.1016/S1535-6108(03)00077-1 12726862
8. Huang P Feng L Oldham EA Keating MJ Plunkett W Superoxide dismutase as a target for the selective killing of cancer cells. Nature 2000, 407(6802):390-395. 10.1038/35030140 11014196
9. Shimada K Nakamura M Ishida E Kishi M Konishi N Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 2003, 24(6):1067-1075. 10.1093/ carcin/bgg058 12807754
10. Davis RJ Signal transduction by the JNK group of MAP kinases. Cell 2000, 103 (2):239-252. 10.1016/S0092-8674(00)00116-1 11057897
11. Davoodpour P Landstrom M 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. J Biol Chem 2005, 280(15):14773-14779. 10.1074/jbc.M414470200 15708859
12. Anneren C Lindholm CK Kriz V Welsh M The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation. Curr Mol Med 2003, 3(4):313-324. 10.2174/1566524033479744 12776987
13. Karlsson T Songyang Z Landgren E Lavergne C Di Fiore PP Anafi M Pawson T Cantley LC Claesson-Welsh L Welsh M Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. Oncogene 1995, 10(8):1475-1483. 7537362
14. Welsh M Songyang Z Frantz JD Trub T Reedquist KA Karlsson T Miyazaki M Cantley LC Band H Shoelson SE Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene 1998, 16(7):891-901. 10.1038/sj.onc.1201607 9484780
15. Lindholm CK Frantz JD Shoelson SE Welsh M Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Biochem Biophys Res Commun 2000, 278(3):537-543. 10.1006/bbrc.2000.3847 11095946
16. Oda T Kujovich J Reis M Newman B Druker BJ Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene 1997, 15(11):1255-1262. 10.1038/sj.onc.1201299 9315092
17. Kharbanda S Ren R Pandey P Shafman TD Feller SM Weichselbaum RR Kufe DW Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 1995, 376(6543):785-788. 10.1038/376785a0 7651539
18. Sun X Wu F Datta R Kharbanda S Kufe D Interaction between protein kinase C delta and the c-Abl tyrosine kinase in the cellular response to oxidative stress. J Biol Chem 2000, 275(11):7470-7473. 10.1074/ jbc.275.11.7470 10713049
19. Hantschel O Superti-Furga G Regulation of the c-Abl and Bcr-Abl tyrosine kinases. Nat Rev Mol Cell Biol 2004, 5(1):33-44. 10.1038/nrm1280 14708008
20. Brasher BB Van Etten RA c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines. J Biol Chem 2000, 275(45):35631-35637. 10.1074/jbc.M005401200 10964922
21. Hagerkvist R Mokhtari D Lindholm C Farnebo F Mostoslavsky G Mulligan RC Welsh N Welsh M Consequences of Shb and c-Abl interactions for cell death in response to various stress stimuli. Exp Cell Res 2007, 313(2):284-291. 10.1016/j.yexcr.2006.10.011 17112510
22. Karlsson T Welsh M Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. Oncogene 1996, 13(5):955-961. 8806685
23. Hagerkvist R Mokhtari D Myers JW Tengholm A Welsh N siRNA Produced by Recombinant Dicer Mediates Efficient Gene Silencing in Islet Cells. Ann N Y Acad Sci 2005, 1040:114-122. 10.1196/annals.1327.014 15891014
24. Davoodpour P Bergstrom M Landstrom M Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates. Nucl Med Biol 2004, 31(7):867-874. 10.1016/ j.nucmedbio.2004.03.015 15464388
25. Weller GE Wong MK Modzelewski RA Lu E Klibanov AL Wagner WR Villanueva FS Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res 2005, 65(2):533-539. 15695396
26. Sanchez AM Sanchez MG Malagarie-Cazenave S Olea N Diaz-Laviada I Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin. Apoptosis 2006, 11(1):89-99. 10.1007/s10495-005-3275-z 16374544
27. Edlund S Bu S Schuster N Aspenstrom P Heuchel R Heldin NE ten Dijke P Heldin CH Landstrom M Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell 2003, 14(2):529-544. 149990 12589052 10.1091/mbc.02-03-0037
28. Welsh M Christmansson L Karlsson T Sandler S Welsh N Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells. Mol Med 1999, 5 (3):169-180. 10404514
29. Dixelius J Larsson H Sasaki T Holmqvist K Lu L Engstrom A Timpl R Welsh M Claesson-Welsh L Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood 2000, 95(11):3403-3411. 10828022
30. Larsson H Klint P Landgren E Claesson-Welsh L Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem 1999, 274(36):25726-25734. 10.1074/jbc.274.36.25726 10464310
31. Ricote M Garcia-Tunon I Fraile B Fernandez C Aller P Paniagua R Royuela M P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells. Apoptosis 2006, 11(11):1969-1975. 10.1007/ s10495-006-0086-9 17031491
32. Yuan ZM Shioya H Ishiko T Sun X Gu J Huang YY Lu H Kharbanda S Weichselbaum R Kufe D p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 1999, 399(6738):814-817. 10.1038/21704 10391251
33. Barila D Mangano R Gonfloni S Kretzschmar J Moro M Bohmann D Superti-Furga G A nuclear tyrosine phosphorylation circuit: C-Jun as an activator and substrate of c-Abl and JNK. Embo J 2000, 19(2):273-281. 305561 10637231 10.1093/emboj/19.2.273
34. Kawai H Nie L Yuan ZM Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol 2002, 22(17):6079-6088. 134000 12167702 10.1128/MCB.22.17.6079-6088.2002
35. Sausville EA Elsayed Y Monga M Kim G Signal transduction--directed cancer treatments. Annu Rev Pharmacol Toxicol 2003, 43:199-231. 10.1146/ annurev.pharmtox.43.100901.135813 12195027
36. Kubler HR van Randenborgh H Treiber U Wutzler S Battistel C Lehmer A Wagenpfeil S Hartung R Paul R In vitro cytotoxic effects of imatinib in combination with anticancer drugs in human prostate cancer cell lines. Prostate 2005, 63(4):385-394. 10.1002/pros.20201 15617027