메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages 21-29

Emerging treatment options for the treatment of neuroblastoma: Potential role of perifosine

Author keywords

Akt pathway; Neuroblastoma; Perifosine

Indexed keywords

CAPECITABINE; MAMMALIAN TARGET OF RAPAMYCIN; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TEMSIROLIMUS;

EID: 84861409093     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S14578     Document Type: Review
Times cited : (24)

References (111)
  • 1
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010; 362(23):2202-2211.
    • (2010) N Engl J Med , vol.362 , Issue.23 , pp. 2202-2211
    • Maris, J.M.1
  • 2
    • 77953024995 scopus 로고    scopus 로고
    • Neuroblastoma: Therapeutic strategies for a clinical enigma
    • Modak S, Cheung NK. Neuroblastoma: Therapeutic strategies for a clinical enigma. Cancer Treat Rev. 2010;36(4):307-317.
    • (2010) Cancer Treat Rev , vol.36 , Issue.4 , pp. 307-317
    • Modak, S.1    Cheung, N.K.2
  • 3
    • 33947223233 scopus 로고    scopus 로고
    • Disialoganglioside directed immunotherapy of neuroblastoma
    • Modak S, Cheung NK. Disialoganglioside directed immunotherapy of neuroblastoma. Cancer Invest. 2007;25(1):67-77.
    • (2007) Cancer Invest , vol.25 , Issue.1 , pp. 67-77
    • Modak, S.1    Cheung, N.K.2
  • 4
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GMCSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GMCSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363(14):1324-1334.
    • (2010) N Engl J Med , vol.363 , Issue.14 , pp. 1324-1334
    • Yu, A.L.1    Gilman, A.L.2    Ozkaynak, M.F.3
  • 5
    • 33745528911 scopus 로고    scopus 로고
    • FCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factor
    • Cheung NK, Sowers R, Vickers AJ, Cheung IY, Kushner BH, Gorlick R. FCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factor. J Clin Oncol. 2006;24(18):2885-2890.
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 2885-2890
    • Cheung, N.K.1    Sowers, R.2    Vickers, A.J.3    Cheung, I.Y.4    Kushner, B.H.5    Gorlick, R.6
  • 6
    • 79851512935 scopus 로고    scopus 로고
    • Changes over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: A report from the International Neuroblastoma Risk Group Project
    • Moroz V, Machin D, Faldum A, et al. Changes over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: a report from the International Neuroblastoma Risk Group Project. Eur J Cancer. 2011;47(4):561-571.
    • (2011) Eur J Cancer , vol.47 , Issue.4 , pp. 561-571
    • Moroz, V.1    Machin, D.2    Faldum, A.3
  • 7
    • 61449245548 scopus 로고    scopus 로고
    • Poor survival for infants with MYCN-amplif ied metastatic neuroblastoma despite intensif ied treatment: The International Society of Paediatric Oncology European Neuroblastoma Experience
    • Canete A, Gerrard M, Rubie H, et al. Poor survival for infants with MYCN-amplif ied metastatic neuroblastoma despite intensif ied treatment: the International Society of Paediatric Oncology European Neuroblastoma Experience. J Clin Oncol. 2009;27(7):1014-1019.
    • (2009) J Clin Oncol , vol.27 , Issue.7 , pp. 1014-1019
    • Canete, A.1    Gerrard, M.2    Rubie, H.3
  • 8
    • 0038179739 scopus 로고    scopus 로고
    • Disseminated neuroblastoma in children older than one year at diagnosis: Comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma
    • De Bernardi B, Nicolas B, Boni L, et al. Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma. J Clin Oncol. 2003;21(8):1592-1601.
    • (2003) J Clin Oncol , vol.21 , Issue.8 , pp. 1592-1601
    • de Bernardi, B.1    Nicolas, B.2    Boni, L.3
  • 9
    • 0033554684 scopus 로고    scopus 로고
    • Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group
    • Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med. 1999;341(16):1165-1173.
    • (1999) N Engl J Med , vol.341 , Issue.16 , pp. 1165-1173
    • Matthay, K.K.1    Villablanca, J.G.2    Seeger, R.C.3
  • 10
    • 80051979836 scopus 로고    scopus 로고
    • Clinical and biologic features predictive of survival after relapse of neuroblastoma: A report from the International Neuroblastoma Risk Group project
    • London WB, Castel V, Monclair T, et al. Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol. 2011;29(24):3286-3292.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3286-3292
    • London, W.B.1    Castel, V.2    Monclair, T.3
  • 11
    • 0037018510 scopus 로고    scopus 로고
    • Neuroblastoma screening at one year of age
    • Schilling FH, Spix C, Berthold F, et al. Neuroblastoma screening at one year of age. N Engl J Med. 2002;346(14):1047-1053.
    • (2002) N Engl J Med , vol.346 , Issue.14 , pp. 1047-1053
    • Schilling, F.H.1    Spix, C.2    Berthold, F.3
  • 12
    • 0037018509 scopus 로고    scopus 로고
    • Screening of infants and mortality due to neuroblastoma
    • Woods WG, Gao RN, Shuster JJ, et al. Screening of infants and mortality due to neuroblastoma. N Engl J Med. 2002;346(14):1041-1046.
    • (2002) N Engl J Med , vol.346 , Issue.14 , pp. 1041-1046
    • Woods, W.G.1    Gao, R.N.2    Shuster, J.J.3
  • 14
    • 58149289668 scopus 로고    scopus 로고
    • High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours
    • Caren H, Abel F, Kogner P, Martinsson T. High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours. Biochem J. 2008;416(2):153-159.
    • (2008) Biochem J , vol.416 , Issue.2 , pp. 153-159
    • Caren, H.1    Abel, F.2    Kogner, P.3    Martinsson, T.4
  • 15
    • 54049120220 scopus 로고    scopus 로고
    • Activating mutations in ALK provide a therapeutic target in neuroblastoma
    • George RE, Sanda T, Hanna M, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008; 455(7215):975-978.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 975-978
    • George, R.E.1    Sanda, T.2    Hanna, M.3
  • 16
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as a major familial neuroblastoma predisposition gene
    • Mosse YP, Laudenslager M, Longo L, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008;455(7215):930-935.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 930-935
    • Mosse, Y.P.1    Laudenslager, M.2    Longo, L.3
  • 17
    • 0028107269 scopus 로고
    • Expression and function of TRK-B and BDNF in human neuroblastomas
    • Nakagawara A, Azar CG, Scavarda NJ, Brodeur GM. Expression and function of TRK-B and BDNF in human neuroblastomas. Mol Cell Biol. 1994;14(1):759-767.
    • (1994) Mol Cell Biol , vol.14 , Issue.1 , pp. 759-767
    • Nakagawara, A.1    Azar, C.G.2    Scavarda, N.J.3    Brodeur, G.M.4
  • 18
    • 82455188382 scopus 로고    scopus 로고
    • Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma
    • Norris RE, Minturn JE, Brodeur GM, Maris JM, Adamson PC. Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma. Cancer Chemother Pharmacol. 2011;68(6):1469-1475.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.6 , pp. 1469-1475
    • Norris, R.E.1    Minturn, J.E.2    Brodeur, G.M.3    Maris, J.M.4    Adamson, P.C.5
  • 19
    • 80054754771 scopus 로고    scopus 로고
    • Phase I trial of lestaurtinib for children with refractory neuroblastoma: A new approaches to neuroblastoma therapy consortium study
    • Minturn JE, Evans AE, Villablanca JG, et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study. Cancer Chemother Pharmacol. 2011;68(4):1057-1065.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.4 , pp. 1057-1065
    • Minturn, J.E.1    Evans, A.E.2    Villablanca, J.G.3
  • 20
    • 37349096959 scopus 로고    scopus 로고
    • Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: Lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway
    • Li Z, Thiele CJ. Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway. Expert Opin Ther Targets. 2007;11(12):1611-1621.
    • (2007) Expert Opin Ther Targets , vol.11 , Issue.12 , pp. 1611-1621
    • Li, Z.1    Thiele, C.J.2
  • 21
    • 45849145429 scopus 로고    scopus 로고
    • AKT pathway in neuroblastoma and its therapeutic implication
    • Sartelet H, Oligny LL, Vassal G. AKT pathway in neuroblastoma and its therapeutic implication. Expert Rev Anticancer Ther. 2008;8(5): 757-769.
    • (2008) Expert Rev Anticancer Ther , vol.8 , Issue.5 , pp. 757-769
    • Sartelet, H.1    Oligny, L.L.2    Vassal, G.3
  • 22
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 23
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441(7092):424-430.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 24
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins. Getting in on the Akt
    • Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell. 2002;111(3):293-303.
    • (2002) Cell , vol.111 , Issue.3 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 25
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411(6835):355-365.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 26
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81(5):727-736.
    • (1995) Cell , vol.81 , Issue.5 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3
  • 27
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2(7):489-501.
    • (2002) Nat Rev Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 28
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer. 2006;6(3):184-192.
    • (2006) Nat Rev Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 29
    • 23944526062 scopus 로고    scopus 로고
    • Activation of AKT kinases in cancer: Implications for therapeutic targeting
    • Bellacosa A, Kumar CC, Di Cristofano A, Testa JR. Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res. 2005;94:29-86.
    • (2005) Adv Cancer Res , vol.94 , pp. 29-86
    • Bellacosa, A.1    Kumar, C.C.2    di Cristofano, A.3    Testa, J.R.4
  • 30
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7(8):606-619.
    • (2006) Nat Rev Genet , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 32
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003;4(4): 257-262.
    • (2003) Cancer Cell , vol.4 , Issue.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 33
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway. Proc Natl Acad Sci U S A. 1999;96(8):4240-4245.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.8 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 34
    • 33846694864 scopus 로고    scopus 로고
    • Activation of Akt predicts poor outcome in neuroblastoma
    • Opel D, Poremba C, Simon T, Debatin KM, Fulda S. Activation of Akt predicts poor outcome in neuroblastoma. Cancer Res. 2007;67(2): 735-745.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 735-745
    • Opel, D.1    Poremba, C.2    Simon, T.3    Debatin, K.M.4    Fulda, S.5
  • 35
    • 79953319630 scopus 로고    scopus 로고
    • Analysis of PI3K/ AKT/mTOR signalling pathway in high risk neuroblastic tumours
    • Izycka-Swieszewska E, Drozynska E, Rzepko R, et al. Analysis of PI3K/ AKT/mTOR signalling pathway in high risk neuroblastic tumours. Pol J Pathol. 2010;61(4):192-198.
    • (2010) Pol J Pathol , vol.61 , Issue.4 , pp. 192-198
    • Izycka-Swieszewska, E.1    Drozynska, E.2    Rzepko, R.3
  • 36
    • 42949133285 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
    • Johnsen JI, Segerstrom L, Orrego A, et al. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene. 2008;27(20): 2910-2922.
    • (2008) Oncogene , vol.27 , Issue.20 , pp. 2910-2922
    • Johnsen, J.I.1    Segerstrom, L.2    Orrego, A.3
  • 37
    • 77950497366 scopus 로고    scopus 로고
    • High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma
    • Sartelet H, Ohta S, Barrette S, et al. High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. Histopathology. 2010;56(5):607-616.
    • (2010) Histopathology , vol.56 , Issue.5 , pp. 607-616
    • Sartelet, H.1    Ohta, S.2    Barrette, S.3
  • 38
    • 16844374910 scopus 로고    scopus 로고
    • Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/ TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death
    • Li Z, Jaboin J, Dennis PA, Thiele CJ. Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/ TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. Cancer Res. 2005;65(6):2070-2075.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2070-2075
    • Li, Z.1    Jaboin, J.2    Dennis, P.A.3    Thiele, C.J.4
  • 39
    • 0942290417 scopus 로고    scopus 로고
    • Insulin-like growth factor-I signaling in human neuroblastoma cells
    • Kim B, van Golen CM, Feldman EL. Insulin-like growth factor-I signaling in human neuroblastoma cells. Oncogene. 2004;23(1):130-141.
    • (2004) Oncogene , vol.23 , Issue.1 , pp. 130-141
    • Kim, B.1    van Golen, C.M.2    Feldman, E.L.3
  • 40
    • 45949109906 scopus 로고    scopus 로고
    • IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth
    • Coulter DW, Blatt J, D'Ercole AJ, Moats-Staats BM. IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth. Anticancer Res. 2008;28(3A):1509-1516.
    • (2008) Anticancer Res , vol.28 , Issue.3 A , pp. 1509-1516
    • Coulter, D.W.1    Blatt, J.2    D'ercole, A.J.3    Moats-Staats, B.M.4
  • 41
    • 18844460415 scopus 로고    scopus 로고
    • Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR
    • Evangelopoulos ME, Weis J, Kruttgen A. Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR. Oncogene. 2005;24(20):3309-3318.
    • (2005) Oncogene , vol.24 , Issue.20 , pp. 3309-3318
    • Evangelopoulos, M.E.1    Weis, J.2    Kruttgen, A.3
  • 42
    • 33748761930 scopus 로고    scopus 로고
    • Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent
    • Chiu B, Mirkin B, Madonna MB. Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent. J Surg Res. 2006;135(2):209-212.
    • (2006) J Surg Res , vol.135 , Issue.2 , pp. 209-212
    • Chiu, B.1    Mirkin, B.2    Madonna, M.B.3
  • 43
    • 33744931651 scopus 로고    scopus 로고
    • Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation
    • Servidei T, Riccardi A, Sanguinetti M, Dominici C, Riccardi R. Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation. J Cell Physiol. 2006;208(1):220-228.
    • (2006) J Cell Physiol , vol.208 , Issue.1 , pp. 220-228
    • Servidei, T.1    Riccardi, A.2    Sanguinetti, M.3    Dominici, C.4    Riccardi, R.5
  • 44
    • 20444498228 scopus 로고    scopus 로고
    • VEGF-mediated survivin expression in neuroblastoma cells
    • Beierle EA, Nagaram A, Dai W, Iyengar M, Chen MK. VEGF-mediated survivin expression in neuroblastoma cells. J Surg Res. 2005;127(1): 21-28.
    • (2005) J Surg Res , vol.127 , Issue.1 , pp. 21-28
    • Beierle, E.A.1    Nagaram, A.2    Dai, W.3    Iyengar, M.4    Chen, M.K.5
  • 45
    • 33847394476 scopus 로고    scopus 로고
    • Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression
    • Ngan ES, Sit FY, Lee K, et al. Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression. Clin Cancer Res. 2007;13(3):868-875.
    • (2007) Clin Cancer Res , vol.13 , Issue.3 , pp. 868-875
    • Ngan, E.S.1    Sit, F.Y.2    Lee, K.3
  • 46
    • 19644376976 scopus 로고    scopus 로고
    • Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
    • Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ. Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res. 2005;65(11):4775-4781.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4775-4781
    • Beppu, K.1    Nakamura, K.2    Linehan, W.M.3    Rapisarda, A.4    Thiele, C.J.5
  • 47
    • 34548508404 scopus 로고    scopus 로고
    • Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death
    • Mookherjee P, Quintanilla R, Roh MS, Zmijewska AA, Jope RS, Johnson GV. Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. J Cell Biochem. 2007;102(1):196-210.
    • (2007) J Cell Biochem , vol.102 , Issue.1 , pp. 196-210
    • Mookherjee, P.1    Quintanilla, R.2    Roh, M.S.3    Zmijewska, A.A.4    Jope, R.S.5    Johnson, G.V.6
  • 48
    • 0344994491 scopus 로고    scopus 로고
    • Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis
    • Francois F, Grimes ML. Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis. J Neurochem. 1999;73(4):1773-1776.
    • (1999) J Neurochem , vol.73 , Issue.4 , pp. 1773-1776
    • Francois, F.1    Grimes, M.L.2
  • 49
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13(22):2905-2927.
    • (1999) Genes Dev , vol.13 , Issue.22 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 50
    • 2642538349 scopus 로고    scopus 로고
    • Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells
    • Dozza B, Smith MA, Perry G, Tabaton M, Strocchi P. Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells. J Neurochem. 2004;89(5):1224-1232.
    • (2004) J Neurochem , vol.89 , Issue.5 , pp. 1224-1232
    • Dozza, B.1    Smith, M.A.2    Perry, G.3    Tabaton, M.4    Strocchi, P.5
  • 51
    • 68949154348 scopus 로고    scopus 로고
    • Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
    • Zhou XW, Winblad B, Guan Z, Pei JJ. Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells. J Alzheimers Dis. 2009;17(4):929-937.
    • (2009) J Alzheimers Dis , vol.17 , Issue.4 , pp. 929-937
    • Zhou, X.W.1    Winblad, B.2    Guan, Z.3    Pei, J.J.4
  • 52
    • 78049231803 scopus 로고    scopus 로고
    • Microrna signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma
    • Lin RJ, Lin YC, Chen J, et al. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010;70(20):7841-7850.
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 7841-7850
    • Lin, R.J.1    Lin, Y.C.2    Chen, J.3
  • 53
    • 77951030589 scopus 로고    scopus 로고
    • MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
    • Foley NH, Bray IM, Tivnan A, et al. MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Mol Cancer. 2010;9:83.
    • (2010) Mol Cancer , vol.9 , pp. 83
    • Foley, N.H.1    Bray, I.M.2    Tivnan, A.3
  • 54
    • 54049118823 scopus 로고    scopus 로고
    • Oncogenic mutations of ALK kinase in neuroblastoma
    • Chen Y, Takita J, Choi YL, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008;455(7215):971-974.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 971-974
    • Chen, Y.1    Takita, J.2    Choi, Y.L.3
  • 55
    • 54049149961 scopus 로고    scopus 로고
    • Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
    • Janoueix-Lerosey I, Lequin D, Brugieres L, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008;455(7215):967-970.
    • (2008) Nature , vol.455 , Issue.7215 , pp. 967-970
    • Janoueix-Lerosey, I.1    Lequin, D.2    Brugieres, L.3
  • 56
    • 57349120674 scopus 로고    scopus 로고
    • Aberrant methylation of candidate tumor suppressor genes in neuroblastoma
    • Hoebeeck J, Michels E, Pattyn F, et al. Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. Cancer Lett. 2009;273(2):336-346.
    • (2009) Cancer Lett , vol.273 , Issue.2 , pp. 336-346
    • Hoebeeck, J.1    Michels, E.2    Pattyn, F.3
  • 57
    • 17044443175 scopus 로고    scopus 로고
    • Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines
    • Munoz J, Lazcoz P, Inda MM, et al. Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines. Int J Cancer. 2004;109(5):673-679.
    • (2004) Int J Cancer , vol.109 , Issue.5 , pp. 673-679
    • Munoz, J.1    Lazcoz, P.2    Inda, M.M.3
  • 58
    • 16544395058 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
    • Kim S, Kang J, Qiao J, Thomas RP, Evers BM, Chung DH. Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. J Pediatr Surg. 2004;39(4):516-521.
    • (2004) J Pediatr Surg , vol.39 , Issue.4 , pp. 516-521
    • Kim, S.1    Kang, J.2    Qiao, J.3    Thomas, R.P.4    Evers, B.M.5    Chung, D.H.6
  • 59
    • 0036312613 scopus 로고    scopus 로고
    • PKC and Raf-1 inhibition- related apoptotic signalling in N2a cells
    • Bronisz A, Gajkowska B, Domanska-Janik K. PKC and Raf-1 inhibition- related apoptotic signalling in N2a cells. J Neurochem. 2002;81(6):1176-1184.
    • (2002) J Neurochem , vol.81 , Issue.6 , pp. 1176-1184
    • Bronisz, A.1    Gajkowska, B.2    Domanska-Janik, K.3
  • 60
    • 2942682872 scopus 로고    scopus 로고
    • Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
    • Zhu W, Bijur GN, Styles NA, Li X. Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. Brain Res Mol Brain Res. 2004;126(1):45-56.
    • (2004) Brain Res Mol Brain Res , vol.126 , Issue.1 , pp. 45-56
    • Zhu, W.1    Bijur, G.N.2    Styles, N.A.3    Li, X.4
  • 61
    • 84856555606 scopus 로고    scopus 로고
    • Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways
    • Epub ahead of print
    • Shukla NN, Ameur N, Yilmaz I, et al. Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways. Clin Cancer Res. 2011. [Epub ahead of print.]
    • (2011) Clin Cancer Res
    • Shukla, N.N.1    Ameur, N.2    Yilmaz, I.3
  • 62
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of disease: Oncogene addiction - a rationale for molecular targeting in cancer therapy
    • Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction - a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006;3(8):448-457.
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.8 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 63
    • 17144392548 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation
    • Barnett SF, Bilodeau MT, Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation. Curr Top Med Chem. 2005;5(2):109-125.
    • (2005) Curr Top Med Chem , vol.5 , Issue.2 , pp. 109-125
    • Barnett, S.F.1    Bilodeau, M.T.2    Lindsley, C.W.3
  • 64
    • 77958509195 scopus 로고    scopus 로고
    • Akt inhibitors in clinical development for the treatment of cancer
    • Pal SK, Reckamp K, Yu H, Figlin RA. Akt inhibitors in clinical development for the treatment of cancer. Expert Opin Investig Drugs. 2010;19(11):1355-1366.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.11 , pp. 1355-1366
    • Pal, S.K.1    Reckamp, K.2    Yu, H.3    Figlin, R.A.4
  • 66
    • 33847289770 scopus 로고    scopus 로고
    • Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
    • Vink SR, van Blitterswijk WJ, Schellens JH, Verheij M. Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy. Cancer Treat Rev. 2007;33(2):191-202.
    • (2007) Cancer Treat Rev , vol.33 , Issue.2 , pp. 191-202
    • Vink, S.R.1    van Blitterswijk, W.J.2    Schellens, J.H.3    Verheij, M.4
  • 68
    • 60349088457 scopus 로고    scopus 로고
    • Perifosine: Update on a novel Akt inhibitor
    • Gills JJ, Dennis PA. Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep. 2009;11(2):102-110.
    • (2009) Curr Oncol Rep , vol.11 , Issue.2 , pp. 102-110
    • Gills, J.J.1    Dennis, P.A.2
  • 70
    • 0037331989 scopus 로고    scopus 로고
    • Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway
    • Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M. Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs. 2003;14(2): 167-173.
    • (2003) Anticancer Drugs , vol.14 , Issue.2 , pp. 167-173
    • Ruiter, G.A.1    Zerp, S.F.2    Bartelink, H.3    van Blitterswijk, W.J.4    Verheij, M.5
  • 71
    • 31544448038 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells
    • Li X, Luwor R, Lu Y, Liang K, Fan Z. Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells. Oncogene. 2006;25(4):525-535.
    • (2006) Oncogene , vol.25 , Issue.4 , pp. 525-535
    • Li, X.1    Luwor, R.2    Lu, Y.3    Liang, K.4    Fan, Z.5
  • 72
    • 45149121372 scopus 로고    scopus 로고
    • The novel Akt inhibitor, perifosine, nduces caspase-dependent apoptosis and downregulates -glycoprotein xpression in multidrug-resistant human T-acute leukemia cells by a NK-dependent mechanism
    • Chiarini F, Del Sole M, Mongiorgi S, et al. The novel Akt inhibitor, perifosine, nduces caspase-dependent apoptosis and downregulates -glycoprotein xpression in multidrug-resistant human T-acute leukemia cells by a NK-dependent mechanism. Leukemia. 2008;22(6):1106-1116.
    • (2008) Leukemia , vol.22 , Issue.6 , pp. 1106-1116
    • Chiarini, F.1    del Sole, M.2    Mongiorgi, S.3
  • 73
    • 34447304357 scopus 로고    scopus 로고
    • The alkylphospholipid perifosine nduces apoptosis of human lung cancer cells requiring inhibition of kt and activation of the extrinsic apoptotic pathway
    • Elrod HA, Lin YD, Yue P, et al. The alkylphospholipid perifosine nduces apoptosis of human lung cancer cells requiring inhibition of kt and activation of the extrinsic apoptotic pathway. Mol Cancer Ther. 2007;6(7):2029-2038.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 2029-2038
    • Elrod, H.A.1    Lin, Y.D.2    Yue, P.3
  • 74
    • 56449084185 scopus 로고    scopus 로고
    • Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
    • Tazzari PL, Tabellini G, Ricci F, et al. Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 2008;68(22):9394-9403.
    • (2008) Cancer Res , vol.68 , Issue.22 , pp. 9394-9403
    • Tazzari, P.L.1    Tabellini, G.2    Ricci, F.3
  • 75
    • 44849099444 scopus 로고    scopus 로고
    • Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors
    • Festuccia C, Gravina GL, Muzi P, et al. Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors. Prostate. 2008;68(9):965-974.
    • (2008) Prostate , vol.68 , Issue.9 , pp. 965-974
    • Festuccia, C.1    Gravina, G.L.2    Muzi, P.3
  • 76
    • 45049086503 scopus 로고    scopus 로고
    • Perifosine induces differentiation and cell death in prostate cancer cells
    • Floryk D, Thompson TC. Perifosine induces differentiation and cell death in prostate cancer cells. Cancer Lett. 2008;266(2):216-226.
    • (2008) Cancer Lett , vol.266 , Issue.2 , pp. 216-226
    • Floryk, D.1    Thompson, T.C.2
  • 77
    • 33746046785 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
    • Nyakern M, Cappellini A, Mantovani I, Martelli AM. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Mol Cancer Ther. 2006;5(6): 1559-1570.
    • (2006) Mol Cancer Ther , vol.5 , Issue.6 , pp. 1559-1570
    • Nyakern, M.1    Cappellini, A.2    Mantovani, I.3    Martelli, A.M.4
  • 78
    • 78651521276 scopus 로고    scopus 로고
    • Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation
    • Fei HR, Chen G, Wang JM, Wang FZ. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. 2010;62(5):449-460.
    • (2010) Cytotechnology , vol.62 , Issue.5 , pp. 449-460
    • Fei, H.R.1    Chen, G.2    Wang, J.M.3    Wang, F.Z.4
  • 79
    • 79951725560 scopus 로고    scopus 로고
    • Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers
    • Engel JB, Schonhals T, Hausler S, et al. Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers. Arch Gynecol Obstet. 2011;283(3):603-610.
    • (2011) Arch Gynecol Obstet , vol.283 , Issue.3 , pp. 603-610
    • Engel, J.B.1    Schonhals, T.2    Hausler, S.3
  • 80
    • 72449158057 scopus 로고    scopus 로고
    • The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma
    • Kumar A, Fillmore HL, Kadian R, Broaddus WC, Tye GW, Van Meter TE. The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma. Mol Cancer Res. 2009;7(11):1813-1821.
    • (2009) Mol Cancer Res , vol.7 , Issue.11 , pp. 1813-1821
    • Kumar, A.1    Fillmore, H.L.2    Kadian, R.3    Broaddus, W.C.4    Tye, G.W.5    van Meter, T.E.6
  • 81
    • 34250371001 scopus 로고    scopus 로고
    • Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model
    • Catley L, Hideshima T, Chauhan D, et al. Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model. Exp Hematol. 2007;35(7):1038-1046.
    • (2007) Exp Hematol , vol.35 , Issue.7 , pp. 1038-1046
    • Catley, L.1    Hideshima, T.2    Chauhan, D.3
  • 82
    • 33646577479 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
    • Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood. 2006;107(10):4053-4062.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4053-4062
    • Hideshima, T.1    Catley, L.2    Yasui, H.3
  • 83
    • 34548181762 scopus 로고    scopus 로고
    • Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
    • Hideshima T, Catley L, Raje N, et al. Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol. 2007;138(6):783-791.
    • (2007) Br J Haematol , vol.138 , Issue.6 , pp. 783-791
    • Hideshima, T.1    Catley, L.2    Raje, N.3
  • 84
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res. 2005;65(16):7429-7435.
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 85
    • 39149141606 scopus 로고    scopus 로고
    • The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia
    • Leleu X, Jia X, Runnels J, et al. The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood. 2007;110(13):4417-4426.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4417-4426
    • Leleu, X.1    Jia, X.2    Runnels, J.3
  • 86
    • 37549010727 scopus 로고    scopus 로고
    • Pharmacodynamic markers of perifosine efficacy
    • Hennessy BT, Lu Y, Poradosu E, et al. Pharmacodynamic markers of perifosine efficacy. Clin Cancer Res. 2007;13(24):7421-7431.
    • (2007) Clin Cancer Res , vol.13 , Issue.24 , pp. 7421-7431
    • Hennessy, B.T.1    Lu, Y.2    Poradosu, E.3
  • 87
    • 77950232139 scopus 로고    scopus 로고
    • Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
    • Becher OJ, Hambardzumyan D, Walker TR, et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 2010;70(6):2548-2557.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2548-2557
    • Becher, O.J.1    Hambardzumyan, D.2    Walker, T.R.3
  • 88
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova- Todorova K, Holland EC. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 2008;22(4):436-448.
    • (2008) Genes Dev , vol.22 , Issue.4 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3    Pandolfi, P.P.4    Manova-Todorova, K.5    Holland, E.C.6
  • 89
    • 9344270514 scopus 로고    scopus 로고
    • A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer
    • Van Ummersen L, Binger K, Volkman J, et al. A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. Clin Cancer Res. 2004; 10(22):7450-7456.
    • (2004) Clin Cancer Res , vol.10 , Issue.22 , pp. 7450-7456
    • van Ummersen, L.1    Binger, K.2    Volkman, J.3
  • 90
    • 0036345448 scopus 로고    scopus 로고
    • Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours
    • Crul M, Rosing H, de Klerk GJ, et al. Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours. Eur J Cancer. 2002;38(12):1615-1621.
    • (2002) Eur J Cancer , vol.38 , Issue.12 , pp. 1615-1621
    • Crul, M.1    Rosing, H.2    de Klerk, G.J.3
  • 91
    • 77649144161 scopus 로고    scopus 로고
    • First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours
    • Unger C, Berdel W, Hanauske AR, Sindermann H, Engel J, Mross K. First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours. Eur J Cancer. 2010;46(5):920-925.
    • (2010) Eur J Cancer , vol.46 , Issue.5 , pp. 920-925
    • Unger, C.1    Berdel, W.2    Hanauske, A.R.3    Sindermann, H.4    Engel, J.5    Mross, K.6
  • 92
    • 33751002361 scopus 로고    scopus 로고
    • Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma
    • Bailey HH, Mahoney MR, Ettinger DS, et al. Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma. Cancer. 2006;107(10):2462-2467.
    • (2006) Cancer , vol.107 , Issue.10 , pp. 2462-2467
    • Bailey, H.H.1    Mahoney, M.R.2    Ettinger, D.S.3
  • 93
    • 76049121742 scopus 로고    scopus 로고
    • Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia
    • Ghobrial IM, Roccaro A, Hong F, et al. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clin Cancer Res. 2010;16(3):1033-1041.
    • (2010) Clin Cancer Res , vol.16 , Issue.3 , pp. 1033-1041
    • Ghobrial, I.M.1    Roccaro, A.2    Hong, F.3
  • 94
    • 81755172138 scopus 로고    scopus 로고
    • Randomized placebo- controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer
    • Bendell JC, Nemunaitis J, Vukelja SJ, et al. Randomized placebo- controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer. J Clin Oncol. 2011;29(33):4394-4400.
    • (2011) J Clin Oncol , vol.29 , Issue.33 , pp. 4394-4400
    • Bendell, J.C.1    Nemunaitis, J.2    Vukelja, S.J.3
  • 95
    • 81155151824 scopus 로고    scopus 로고
    • Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
    • Richardson PG, Wolf J, Jakubowiak A, et al. Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. J Clin Oncol. 2011;29(32):4243-4249.
    • (2011) J Clin Oncol , vol.29 , Issue.32 , pp. 4243-4249
    • Richardson, P.G.1    Wolf, J.2    Jakubowiak, A.3
  • 96
    • 77953215965 scopus 로고    scopus 로고
    • In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine
    • Li Z, Tan F, Liewehr DJ, Steinberg SM, Thiele CJ. In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine. J Natl Cancer Inst. 2010;102(11):758-770.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.11 , pp. 758-770
    • Li, Z.1    Tan, F.2    Liewehr, D.J.3    Steinberg, S.M.4    Thiele, C.J.5
  • 97
    • 80054752480 scopus 로고    scopus 로고
    • Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance n neuroblastoma in vivo
    • Li Z, Oh DY, Nakamura K, Thiele CJ. Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance n neuroblastoma in vivo. Cancer. 2011;117(23):5412-5422.
    • (2011) Cancer , vol.117 , Issue.23 , pp. 5412-5422
    • Li, Z.1    Oh, D.Y.2    Nakamura, K.3    Thiele, C.J.4
  • 98
    • 4143143098 scopus 로고    scopus 로고
    • In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines
    • Dasmahapatra GP, Didolkar P, Alley MC, Ghosh S, Sausville EA, Roy KK. In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines. Clin Cancer Res. 2004;10(15):5242-5252.
    • (2004) Clin Cancer Res , vol.10 , Issue.15 , pp. 5242-5252
    • Dasmahapatra, G.P.1    Didolkar, P.2    Alley, M.C.3    Ghosh, S.4    Sausville, E.A.5    Roy, K.K.6
  • 99
    • 15944406971 scopus 로고    scopus 로고
    • Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
    • Rahmani M, Reese E, Dai Y, et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res. 2005;65(6):2422-2432.
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2422-2432
    • Rahmani, M.1    Reese, E.2    Dai, Y.3
  • 100
    • 52649101930 scopus 로고    scopus 로고
    • Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    • David E, Sinha R, Chen J, Sun SY, Kaufman JL, Lonial S. Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors. Clin Cancer Res. 2008;14(16):5090-5098.
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5090-5098
    • David, E.1    Sinha, R.2    Chen, J.3    Sun, S.Y.4    Kaufman, J.L.5    Lonial, S.6
  • 101
    • 38949121666 scopus 로고    scopus 로고
    • Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment
    • Huston A, Leleu X, Jia X, et al. Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment. Clin Cancer Res. 2008;14(3):865-874.
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 865-874
    • Huston, A.1    Leleu, X.2    Jia, X.3
  • 102
    • 79251575938 scopus 로고    scopus 로고
    • Perifosine and CCI 779 cooperate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma
    • Pitter KL, Galban CJ, Galban S, et al. Perifosine and CCI 779 cooperate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PLoS One. 2011;6(1):e14545.
    • (2011) PLoS One , vol.6 , Issue.1
    • Pitter, K.L.1    Galban, C.J.2    Galban, S.3
  • 103
    • 54849405505 scopus 로고    scopus 로고
    • Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation
    • Engel JB, Honig A, Schonhals T, et al. Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. Eur J Obstet Gynecol Reprod Biol. 2008;141(1): 64-69.
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.141 , Issue.1 , pp. 64-69
    • Engel, J.B.1    Honig, A.2    Schonhals, T.3
  • 104
    • 38349074064 scopus 로고    scopus 로고
    • Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
    • Papa V, Tazzari PL, Chiarini F, et al. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. Leukemia. 2008;22(1):147-160.
    • (2008) Leukemia , vol.22 , Issue.1 , pp. 147-160
    • Papa, V.1    Tazzari, P.L.2    Chiarini, F.3
  • 105
    • 77950232139 scopus 로고    scopus 로고
    • Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
    • Becher OJ, Hambardzumyan D, Walker TR, et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 2010;70(6):2548-2557.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2548-2557
    • Becher, O.J.1    Hambardzumyan, D.2    Walker, T.R.3
  • 106
    • 77649134988 scopus 로고    scopus 로고
    • Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma
    • Iyer R, Evans AE, Qi X, et al. Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma. Clin Cancer Res. 2010;16(5):1478-1485.
    • (2010) Clin Cancer Res , vol.16 , Issue.5 , pp. 1478-1485
    • Iyer, R.1    Evans, A.E.2    Qi, X.3
  • 107
    • 81755181310 scopus 로고    scopus 로고
    • Phase I study of single-agent perifosine for recurrent pediatric solid tumors [abstract]
    • Becher OJ, Trippett T, Kolesar J, et al. Phase I study of single-agent perifosine for recurrent pediatric solid tumors [abstract]. J Clin Oncol. 2010;28(15s):9540.
    • (2010) J Clin Oncol , vol.28 , Issue.15 s , pp. 9540
    • Becher, O.J.1    Trippett, T.2    Kolesar, J.3
  • 109
    • 80655126355 scopus 로고    scopus 로고
    • Mtor kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
    • Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, et al. mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. Cancer Discov. 2011;1(3):248-259.
    • (2011) Cancer Discov , vol.1 , Issue.3 , pp. 248-259
    • Rodrik-Outmezguine, V.S.1    Chandarlapaty, S.2    Pagano, N.C.3
  • 110
    • 79960744694 scopus 로고    scopus 로고
    • Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors
    • Spunt SL, Grupp SA, Vik TA, et al. Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. J Clin Oncol. 2011;29(21):2933-2940.
    • (2011) J Clin Oncol , vol.29 , Issue.21 , pp. 2933-2940
    • Spunt, S.L.1    Grupp, S.A.2    Vik, T.A.3
  • 111
    • 84655175068 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma
    • Geoerger B, Kieran MW, Grupp S, et al. Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma. Eur J Cancer. 2012;48(2):253-262.
    • (2012) Eur J Cancer , vol.48 , Issue.2 , pp. 253-262
    • Geoerger, B.1    Kieran, M.W.2    Grupp, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.