-
1
-
-
77953523121
-
Recent advances in neuroblastoma
-
Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010; 362(23):2202-2211.
-
(2010)
N Engl J Med
, vol.362
, Issue.23
, pp. 2202-2211
-
-
Maris, J.M.1
-
2
-
-
77953024995
-
Neuroblastoma: Therapeutic strategies for a clinical enigma
-
Modak S, Cheung NK. Neuroblastoma: Therapeutic strategies for a clinical enigma. Cancer Treat Rev. 2010;36(4):307-317.
-
(2010)
Cancer Treat Rev
, vol.36
, Issue.4
, pp. 307-317
-
-
Modak, S.1
Cheung, N.K.2
-
3
-
-
33947223233
-
Disialoganglioside directed immunotherapy of neuroblastoma
-
Modak S, Cheung NK. Disialoganglioside directed immunotherapy of neuroblastoma. Cancer Invest. 2007;25(1):67-77.
-
(2007)
Cancer Invest
, vol.25
, Issue.1
, pp. 67-77
-
-
Modak, S.1
Cheung, N.K.2
-
4
-
-
77957341503
-
Anti-GD2 antibody with GMCSF, interleukin-2, and isotretinoin for neuroblastoma
-
Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GMCSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363(14):1324-1334.
-
(2010)
N Engl J Med
, vol.363
, Issue.14
, pp. 1324-1334
-
-
Yu, A.L.1
Gilman, A.L.2
Ozkaynak, M.F.3
-
5
-
-
33745528911
-
FCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factor
-
Cheung NK, Sowers R, Vickers AJ, Cheung IY, Kushner BH, Gorlick R. FCGR2A polymorphism is correlated with clinical outcome after immunotherapy of neuroblastoma with anti-GD2 antibody and granulocyte macrophage colony-stimulating factor. J Clin Oncol. 2006;24(18):2885-2890.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18
, pp. 2885-2890
-
-
Cheung, N.K.1
Sowers, R.2
Vickers, A.J.3
Cheung, I.Y.4
Kushner, B.H.5
Gorlick, R.6
-
6
-
-
79851512935
-
Changes over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: A report from the International Neuroblastoma Risk Group Project
-
Moroz V, Machin D, Faldum A, et al. Changes over three decades in outcome and the prognostic influence of age-at-diagnosis in young patients with neuroblastoma: a report from the International Neuroblastoma Risk Group Project. Eur J Cancer. 2011;47(4):561-571.
-
(2011)
Eur J Cancer
, vol.47
, Issue.4
, pp. 561-571
-
-
Moroz, V.1
Machin, D.2
Faldum, A.3
-
7
-
-
61449245548
-
Poor survival for infants with MYCN-amplif ied metastatic neuroblastoma despite intensif ied treatment: The International Society of Paediatric Oncology European Neuroblastoma Experience
-
Canete A, Gerrard M, Rubie H, et al. Poor survival for infants with MYCN-amplif ied metastatic neuroblastoma despite intensif ied treatment: the International Society of Paediatric Oncology European Neuroblastoma Experience. J Clin Oncol. 2009;27(7):1014-1019.
-
(2009)
J Clin Oncol
, vol.27
, Issue.7
, pp. 1014-1019
-
-
Canete, A.1
Gerrard, M.2
Rubie, H.3
-
8
-
-
0038179739
-
Disseminated neuroblastoma in children older than one year at diagnosis: Comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma
-
De Bernardi B, Nicolas B, Boni L, et al. Disseminated neuroblastoma in children older than one year at diagnosis: comparable results with three consecutive high-dose protocols adopted by the Italian Co-Operative Group for Neuroblastoma. J Clin Oncol. 2003;21(8):1592-1601.
-
(2003)
J Clin Oncol
, vol.21
, Issue.8
, pp. 1592-1601
-
-
de Bernardi, B.1
Nicolas, B.2
Boni, L.3
-
9
-
-
0033554684
-
Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group
-
Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. N Engl J Med. 1999;341(16):1165-1173.
-
(1999)
N Engl J Med
, vol.341
, Issue.16
, pp. 1165-1173
-
-
Matthay, K.K.1
Villablanca, J.G.2
Seeger, R.C.3
-
10
-
-
80051979836
-
Clinical and biologic features predictive of survival after relapse of neuroblastoma: A report from the International Neuroblastoma Risk Group project
-
London WB, Castel V, Monclair T, et al. Clinical and biologic features predictive of survival after relapse of neuroblastoma: a report from the International Neuroblastoma Risk Group project. J Clin Oncol. 2011;29(24):3286-3292.
-
(2011)
J Clin Oncol
, vol.29
, Issue.24
, pp. 3286-3292
-
-
London, W.B.1
Castel, V.2
Monclair, T.3
-
11
-
-
0037018510
-
Neuroblastoma screening at one year of age
-
Schilling FH, Spix C, Berthold F, et al. Neuroblastoma screening at one year of age. N Engl J Med. 2002;346(14):1047-1053.
-
(2002)
N Engl J Med
, vol.346
, Issue.14
, pp. 1047-1053
-
-
Schilling, F.H.1
Spix, C.2
Berthold, F.3
-
12
-
-
0037018509
-
Screening of infants and mortality due to neuroblastoma
-
Woods WG, Gao RN, Shuster JJ, et al. Screening of infants and mortality due to neuroblastoma. N Engl J Med. 2002;346(14):1041-1046.
-
(2002)
N Engl J Med
, vol.346
, Issue.14
, pp. 1041-1046
-
-
Woods, W.G.1
Gao, R.N.2
Shuster, J.J.3
-
13
-
-
34250683435
-
Neuroblastoma
-
Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369(9579):2106-2120.
-
(2007)
Lancet
, vol.369
, Issue.9579
, pp. 2106-2120
-
-
Maris, J.M.1
Hogarty, M.D.2
Bagatell, R.3
Cohn, S.L.4
-
14
-
-
58149289668
-
High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours
-
Caren H, Abel F, Kogner P, Martinsson T. High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours. Biochem J. 2008;416(2):153-159.
-
(2008)
Biochem J
, vol.416
, Issue.2
, pp. 153-159
-
-
Caren, H.1
Abel, F.2
Kogner, P.3
Martinsson, T.4
-
15
-
-
54049120220
-
Activating mutations in ALK provide a therapeutic target in neuroblastoma
-
George RE, Sanda T, Hanna M, et al. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008; 455(7215):975-978.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 975-978
-
-
George, R.E.1
Sanda, T.2
Hanna, M.3
-
16
-
-
54049094708
-
Identification of ALK as a major familial neuroblastoma predisposition gene
-
Mosse YP, Laudenslager M, Longo L, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008;455(7215):930-935.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 930-935
-
-
Mosse, Y.P.1
Laudenslager, M.2
Longo, L.3
-
17
-
-
0028107269
-
Expression and function of TRK-B and BDNF in human neuroblastomas
-
Nakagawara A, Azar CG, Scavarda NJ, Brodeur GM. Expression and function of TRK-B and BDNF in human neuroblastomas. Mol Cell Biol. 1994;14(1):759-767.
-
(1994)
Mol Cell Biol
, vol.14
, Issue.1
, pp. 759-767
-
-
Nakagawara, A.1
Azar, C.G.2
Scavarda, N.J.3
Brodeur, G.M.4
-
18
-
-
82455188382
-
Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma
-
Norris RE, Minturn JE, Brodeur GM, Maris JM, Adamson PC. Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma. Cancer Chemother Pharmacol. 2011;68(6):1469-1475.
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, Issue.6
, pp. 1469-1475
-
-
Norris, R.E.1
Minturn, J.E.2
Brodeur, G.M.3
Maris, J.M.4
Adamson, P.C.5
-
19
-
-
80054754771
-
Phase I trial of lestaurtinib for children with refractory neuroblastoma: A new approaches to neuroblastoma therapy consortium study
-
Minturn JE, Evans AE, Villablanca JG, et al. Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study. Cancer Chemother Pharmacol. 2011;68(4):1057-1065.
-
(2011)
Cancer Chemother Pharmacol
, vol.68
, Issue.4
, pp. 1057-1065
-
-
Minturn, J.E.1
Evans, A.E.2
Villablanca, J.G.3
-
20
-
-
37349096959
-
Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: Lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway
-
Li Z, Thiele CJ. Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy: lessons learned from the brain-derived neurotrophic factor/TrkB signal transduction pathway. Expert Opin Ther Targets. 2007;11(12):1611-1621.
-
(2007)
Expert Opin Ther Targets
, vol.11
, Issue.12
, pp. 1611-1621
-
-
Li, Z.1
Thiele, C.J.2
-
21
-
-
45849145429
-
AKT pathway in neuroblastoma and its therapeutic implication
-
Sartelet H, Oligny LL, Vassal G. AKT pathway in neuroblastoma and its therapeutic implication. Expert Rev Anticancer Ther. 2008;8(5): 757-769.
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, Issue.5
, pp. 757-769
-
-
Sartelet, H.1
Oligny, L.L.2
Vassal, G.3
-
22
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
23
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441(7092):424-430.
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
24
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell. 2002;111(3):293-303.
-
(2002)
Cell
, vol.111
, Issue.3
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
25
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411(6835):355-365.
-
(2001)
Nature
, vol.411
, Issue.6835
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
26
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995;81(5):727-736.
-
(1995)
Cell
, vol.81
, Issue.5
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
-
27
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer. 2002;2(7):489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
28
-
-
33644513730
-
Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
-
Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer. 2006;6(3):184-192.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.3
, pp. 184-192
-
-
Cully, M.1
You, H.2
Levine, A.J.3
Mak, T.W.4
-
30
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7(8):606-619.
-
(2006)
Nat Rev Genet
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
31
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005;4(12):988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.12
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
32
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003;4(4): 257-262.
-
(2003)
Cancer Cell
, vol.4
, Issue.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
33
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway. Proc Natl Acad Sci U S A. 1999;96(8):4240-4245.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
34
-
-
33846694864
-
Activation of Akt predicts poor outcome in neuroblastoma
-
Opel D, Poremba C, Simon T, Debatin KM, Fulda S. Activation of Akt predicts poor outcome in neuroblastoma. Cancer Res. 2007;67(2): 735-745.
-
(2007)
Cancer Res
, vol.67
, Issue.2
, pp. 735-745
-
-
Opel, D.1
Poremba, C.2
Simon, T.3
Debatin, K.M.4
Fulda, S.5
-
35
-
-
79953319630
-
Analysis of PI3K/ AKT/mTOR signalling pathway in high risk neuroblastic tumours
-
Izycka-Swieszewska E, Drozynska E, Rzepko R, et al. Analysis of PI3K/ AKT/mTOR signalling pathway in high risk neuroblastic tumours. Pol J Pathol. 2010;61(4):192-198.
-
(2010)
Pol J Pathol
, vol.61
, Issue.4
, pp. 192-198
-
-
Izycka-Swieszewska, E.1
Drozynska, E.2
Rzepko, R.3
-
36
-
-
42949133285
-
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
-
Johnsen JI, Segerstrom L, Orrego A, et al. Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene. 2008;27(20): 2910-2922.
-
(2008)
Oncogene
, vol.27
, Issue.20
, pp. 2910-2922
-
-
Johnsen, J.I.1
Segerstrom, L.2
Orrego, A.3
-
37
-
-
77950497366
-
High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma
-
Sartelet H, Ohta S, Barrette S, et al. High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma. Histopathology. 2010;56(5):607-616.
-
(2010)
Histopathology
, vol.56
, Issue.5
, pp. 607-616
-
-
Sartelet, H.1
Ohta, S.2
Barrette, S.3
-
38
-
-
16844374910
-
Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/ TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death
-
Li Z, Jaboin J, Dennis PA, Thiele CJ. Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/ TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. Cancer Res. 2005;65(6):2070-2075.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2070-2075
-
-
Li, Z.1
Jaboin, J.2
Dennis, P.A.3
Thiele, C.J.4
-
39
-
-
0942290417
-
Insulin-like growth factor-I signaling in human neuroblastoma cells
-
Kim B, van Golen CM, Feldman EL. Insulin-like growth factor-I signaling in human neuroblastoma cells. Oncogene. 2004;23(1):130-141.
-
(2004)
Oncogene
, vol.23
, Issue.1
, pp. 130-141
-
-
Kim, B.1
van Golen, C.M.2
Feldman, E.L.3
-
40
-
-
45949109906
-
IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth
-
Coulter DW, Blatt J, D'Ercole AJ, Moats-Staats BM. IGF-I receptor inhibition combined with rapamycin or temsirolimus inhibits neuroblastoma cell growth. Anticancer Res. 2008;28(3A):1509-1516.
-
(2008)
Anticancer Res
, vol.28
, Issue.3 A
, pp. 1509-1516
-
-
Coulter, D.W.1
Blatt, J.2
D'ercole, A.J.3
Moats-Staats, B.M.4
-
41
-
-
18844460415
-
Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR
-
Evangelopoulos ME, Weis J, Kruttgen A. Signalling pathways leading to neuroblastoma differentiation after serum withdrawal: HDL blocks neuroblastoma differentiation by inhibition of EGFR. Oncogene. 2005;24(20):3309-3318.
-
(2005)
Oncogene
, vol.24
, Issue.20
, pp. 3309-3318
-
-
Evangelopoulos, M.E.1
Weis, J.2
Kruttgen, A.3
-
42
-
-
33748761930
-
Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent
-
Chiu B, Mirkin B, Madonna MB. Mitogenic and apoptotic actions of epidermal growth factor on neuroblastoma cells are concentration-dependent. J Surg Res. 2006;135(2):209-212.
-
(2006)
J Surg Res
, vol.135
, Issue.2
, pp. 209-212
-
-
Chiu, B.1
Mirkin, B.2
Madonna, M.B.3
-
43
-
-
33744931651
-
Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation
-
Servidei T, Riccardi A, Sanguinetti M, Dominici C, Riccardi R. Increased sensitivity to the platelet-derived growth factor (PDGF) receptor inhibitor STI571 in chemoresistant glioma cells is associated with enhanced PDGF-BB-mediated signaling and STI571-induced Akt inactivation. J Cell Physiol. 2006;208(1):220-228.
-
(2006)
J Cell Physiol
, vol.208
, Issue.1
, pp. 220-228
-
-
Servidei, T.1
Riccardi, A.2
Sanguinetti, M.3
Dominici, C.4
Riccardi, R.5
-
44
-
-
20444498228
-
VEGF-mediated survivin expression in neuroblastoma cells
-
Beierle EA, Nagaram A, Dai W, Iyengar M, Chen MK. VEGF-mediated survivin expression in neuroblastoma cells. J Surg Res. 2005;127(1): 21-28.
-
(2005)
J Surg Res
, vol.127
, Issue.1
, pp. 21-28
-
-
Beierle, E.A.1
Nagaram, A.2
Dai, W.3
Iyengar, M.4
Chen, M.K.5
-
45
-
-
33847394476
-
Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression
-
Ngan ES, Sit FY, Lee K, et al. Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression. Clin Cancer Res. 2007;13(3):868-875.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.3
, pp. 868-875
-
-
Ngan, E.S.1
Sit, F.Y.2
Lee, K.3
-
46
-
-
19644376976
-
Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
-
Beppu K, Nakamura K, Linehan WM, Rapisarda A, Thiele CJ. Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res. 2005;65(11):4775-4781.
-
(2005)
Cancer Res
, vol.65
, Issue.11
, pp. 4775-4781
-
-
Beppu, K.1
Nakamura, K.2
Linehan, W.M.3
Rapisarda, A.4
Thiele, C.J.5
-
47
-
-
34548508404
-
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death
-
Mookherjee P, Quintanilla R, Roh MS, Zmijewska AA, Jope RS, Johnson GV. Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death. J Cell Biochem. 2007;102(1):196-210.
-
(2007)
J Cell Biochem
, vol.102
, Issue.1
, pp. 196-210
-
-
Mookherjee, P.1
Quintanilla, R.2
Roh, M.S.3
Zmijewska, A.A.4
Jope, R.S.5
Johnson, G.V.6
-
48
-
-
0344994491
-
Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis
-
Francois F, Grimes ML. Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis. J Neurochem. 1999;73(4):1773-1776.
-
(1999)
J Neurochem
, vol.73
, Issue.4
, pp. 1773-1776
-
-
Francois, F.1
Grimes, M.L.2
-
49
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999;13(22):2905-2927.
-
(1999)
Genes Dev
, vol.13
, Issue.22
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
50
-
-
2642538349
-
Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells
-
Dozza B, Smith MA, Perry G, Tabaton M, Strocchi P. Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells. J Neurochem. 2004;89(5):1224-1232.
-
(2004)
J Neurochem
, vol.89
, Issue.5
, pp. 1224-1232
-
-
Dozza, B.1
Smith, M.A.2
Perry, G.3
Tabaton, M.4
Strocchi, P.5
-
51
-
-
68949154348
-
Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells
-
Zhou XW, Winblad B, Guan Z, Pei JJ. Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells. J Alzheimers Dis. 2009;17(4):929-937.
-
(2009)
J Alzheimers Dis
, vol.17
, Issue.4
, pp. 929-937
-
-
Zhou, X.W.1
Winblad, B.2
Guan, Z.3
Pei, J.J.4
-
52
-
-
78049231803
-
Microrna signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma
-
Lin RJ, Lin YC, Chen J, et al. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010;70(20):7841-7850.
-
(2010)
Cancer Res
, vol.70
, Issue.20
, pp. 7841-7850
-
-
Lin, R.J.1
Lin, Y.C.2
Chen, J.3
-
53
-
-
77951030589
-
MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2
-
Foley NH, Bray IM, Tivnan A, et al. MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2. Mol Cancer. 2010;9:83.
-
(2010)
Mol Cancer
, vol.9
, pp. 83
-
-
Foley, N.H.1
Bray, I.M.2
Tivnan, A.3
-
54
-
-
54049118823
-
Oncogenic mutations of ALK kinase in neuroblastoma
-
Chen Y, Takita J, Choi YL, et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008;455(7215):971-974.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 971-974
-
-
Chen, Y.1
Takita, J.2
Choi, Y.L.3
-
55
-
-
54049149961
-
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
-
Janoueix-Lerosey I, Lequin D, Brugieres L, et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008;455(7215):967-970.
-
(2008)
Nature
, vol.455
, Issue.7215
, pp. 967-970
-
-
Janoueix-Lerosey, I.1
Lequin, D.2
Brugieres, L.3
-
56
-
-
57349120674
-
Aberrant methylation of candidate tumor suppressor genes in neuroblastoma
-
Hoebeeck J, Michels E, Pattyn F, et al. Aberrant methylation of candidate tumor suppressor genes in neuroblastoma. Cancer Lett. 2009;273(2):336-346.
-
(2009)
Cancer Lett
, vol.273
, Issue.2
, pp. 336-346
-
-
Hoebeeck, J.1
Michels, E.2
Pattyn, F.3
-
57
-
-
17044443175
-
Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines
-
Munoz J, Lazcoz P, Inda MM, et al. Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines. Int J Cancer. 2004;109(5):673-679.
-
(2004)
Int J Cancer
, vol.109
, Issue.5
, pp. 673-679
-
-
Munoz, J.1
Lazcoz, P.2
Inda, M.M.3
-
58
-
-
16544395058
-
Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
-
Kim S, Kang J, Qiao J, Thomas RP, Evers BM, Chung DH. Phosphatidylinositol 3-kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas. J Pediatr Surg. 2004;39(4):516-521.
-
(2004)
J Pediatr Surg
, vol.39
, Issue.4
, pp. 516-521
-
-
Kim, S.1
Kang, J.2
Qiao, J.3
Thomas, R.P.4
Evers, B.M.5
Chung, D.H.6
-
59
-
-
0036312613
-
PKC and Raf-1 inhibition- related apoptotic signalling in N2a cells
-
Bronisz A, Gajkowska B, Domanska-Janik K. PKC and Raf-1 inhibition- related apoptotic signalling in N2a cells. J Neurochem. 2002;81(6):1176-1184.
-
(2002)
J Neurochem
, vol.81
, Issue.6
, pp. 1176-1184
-
-
Bronisz, A.1
Gajkowska, B.2
Domanska-Janik, K.3
-
60
-
-
2942682872
-
Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells
-
Zhu W, Bijur GN, Styles NA, Li X. Regulation of FOXO3a by brain-derived neurotrophic factor in differentiated human SH-SY5Y neuroblastoma cells. Brain Res Mol Brain Res. 2004;126(1):45-56.
-
(2004)
Brain Res Mol Brain Res
, vol.126
, Issue.1
, pp. 45-56
-
-
Zhu, W.1
Bijur, G.N.2
Styles, N.A.3
Li, X.4
-
61
-
-
84856555606
-
Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways
-
Epub ahead of print
-
Shukla NN, Ameur N, Yilmaz I, et al. Oncogene Mutation Profiling of Pediatric Solid Tumors Reveals Significant Subsets of Embryonal Rhabdomyosarcoma and Neuroblastoma with Mutated Genes in Growth Signaling Pathways. Clin Cancer Res. 2011. [Epub ahead of print.]
-
(2011)
Clin Cancer Res
-
-
Shukla, N.N.1
Ameur, N.2
Yilmaz, I.3
-
62
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction - a rationale for molecular targeting in cancer therapy
-
Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction - a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006;3(8):448-457.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, Issue.8
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
63
-
-
17144392548
-
The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation
-
Barnett SF, Bilodeau MT, Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation. Curr Top Med Chem. 2005;5(2):109-125.
-
(2005)
Curr Top Med Chem
, vol.5
, Issue.2
, pp. 109-125
-
-
Barnett, S.F.1
Bilodeau, M.T.2
Lindsley, C.W.3
-
64
-
-
77958509195
-
Akt inhibitors in clinical development for the treatment of cancer
-
Pal SK, Reckamp K, Yu H, Figlin RA. Akt inhibitors in clinical development for the treatment of cancer. Expert Opin Investig Drugs. 2010;19(11):1355-1366.
-
(2010)
Expert Opin Investig Drugs
, vol.19
, Issue.11
, pp. 1355-1366
-
-
Pal, S.K.1
Reckamp, K.2
Yu, H.3
Figlin, R.A.4
-
65
-
-
0031105972
-
D-21266, a new heterocyclic alkylphospholipid with antitumour activity
-
Hilgard P, Klenner T, Stekar J, Nossner G, Kutscher B, Engel J. D-21266, a new heterocyclic alkylphospholipid with antitumour activity. Eur J Cancer. 1997;33(3):442-446.
-
(1997)
Eur J Cancer
, vol.33
, Issue.3
, pp. 442-446
-
-
Hilgard, P.1
Klenner, T.2
Stekar, J.3
Nossner, G.4
Kutscher, B.5
Engel, J.6
-
66
-
-
33847289770
-
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
-
Vink SR, van Blitterswijk WJ, Schellens JH, Verheij M. Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy. Cancer Treat Rev. 2007;33(2):191-202.
-
(2007)
Cancer Treat Rev
, vol.33
, Issue.2
, pp. 191-202
-
-
Vink, S.R.1
van Blitterswijk, W.J.2
Schellens, J.H.3
Verheij, M.4
-
67
-
-
2542547908
-
Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation
-
Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA, Roy KK. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther. 2003;2(11):1093-1103.
-
(2003)
Mol Cancer Ther
, vol.2
, Issue.11
, pp. 1093-1103
-
-
Kondapaka, S.B.1
Singh, S.S.2
Dasmahapatra, G.P.3
Sausville, E.A.4
Roy, K.K.5
-
68
-
-
60349088457
-
Perifosine: Update on a novel Akt inhibitor
-
Gills JJ, Dennis PA. Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep. 2009;11(2):102-110.
-
(2009)
Curr Oncol Rep
, vol.11
, Issue.2
, pp. 102-110
-
-
Gills, J.J.1
Dennis, P.A.2
-
69
-
-
34547650639
-
Targeting Akt in cancer therapy
-
LoPiccolo J, Granville CA, Gills JJ, Dennis PA. Targeting Akt in cancer therapy. Anticancer Drugs. 2007;18(8):861-874.
-
(2007)
Anticancer Drugs
, vol.18
, Issue.8
, pp. 861-874
-
-
Lopiccolo, J.1
Granville, C.A.2
Gills, J.J.3
Dennis, P.A.4
-
70
-
-
0037331989
-
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway
-
Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M. Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs. 2003;14(2): 167-173.
-
(2003)
Anticancer Drugs
, vol.14
, Issue.2
, pp. 167-173
-
-
Ruiter, G.A.1
Zerp, S.F.2
Bartelink, H.3
van Blitterswijk, W.J.4
Verheij, M.5
-
71
-
-
31544448038
-
Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells
-
Li X, Luwor R, Lu Y, Liang K, Fan Z. Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in PTEN-deficient cancer cells. Oncogene. 2006;25(4):525-535.
-
(2006)
Oncogene
, vol.25
, Issue.4
, pp. 525-535
-
-
Li, X.1
Luwor, R.2
Lu, Y.3
Liang, K.4
Fan, Z.5
-
72
-
-
45149121372
-
The novel Akt inhibitor, perifosine, nduces caspase-dependent apoptosis and downregulates -glycoprotein xpression in multidrug-resistant human T-acute leukemia cells by a NK-dependent mechanism
-
Chiarini F, Del Sole M, Mongiorgi S, et al. The novel Akt inhibitor, perifosine, nduces caspase-dependent apoptosis and downregulates -glycoprotein xpression in multidrug-resistant human T-acute leukemia cells by a NK-dependent mechanism. Leukemia. 2008;22(6):1106-1116.
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1106-1116
-
-
Chiarini, F.1
del Sole, M.2
Mongiorgi, S.3
-
73
-
-
34447304357
-
The alkylphospholipid perifosine nduces apoptosis of human lung cancer cells requiring inhibition of kt and activation of the extrinsic apoptotic pathway
-
Elrod HA, Lin YD, Yue P, et al. The alkylphospholipid perifosine nduces apoptosis of human lung cancer cells requiring inhibition of kt and activation of the extrinsic apoptotic pathway. Mol Cancer Ther. 2007;6(7):2029-2038.
-
(2007)
Mol Cancer Ther
, vol.6
, Issue.7
, pp. 2029-2038
-
-
Elrod, H.A.1
Lin, Y.D.2
Yue, P.3
-
74
-
-
56449084185
-
Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells
-
Tazzari PL, Tabellini G, Ricci F, et al. Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 2008;68(22):9394-9403.
-
(2008)
Cancer Res
, vol.68
, Issue.22
, pp. 9394-9403
-
-
Tazzari, P.L.1
Tabellini, G.2
Ricci, F.3
-
75
-
-
44849099444
-
Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors
-
Festuccia C, Gravina GL, Muzi P, et al. Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors. Prostate. 2008;68(9):965-974.
-
(2008)
Prostate
, vol.68
, Issue.9
, pp. 965-974
-
-
Festuccia, C.1
Gravina, G.L.2
Muzi, P.3
-
76
-
-
45049086503
-
Perifosine induces differentiation and cell death in prostate cancer cells
-
Floryk D, Thompson TC. Perifosine induces differentiation and cell death in prostate cancer cells. Cancer Lett. 2008;266(2):216-226.
-
(2008)
Cancer Lett
, vol.266
, Issue.2
, pp. 216-226
-
-
Floryk, D.1
Thompson, T.C.2
-
77
-
-
33746046785
-
Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
-
Nyakern M, Cappellini A, Mantovani I, Martelli AM. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Mol Cancer Ther. 2006;5(6): 1559-1570.
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.6
, pp. 1559-1570
-
-
Nyakern, M.1
Cappellini, A.2
Mantovani, I.3
Martelli, A.M.4
-
78
-
-
78651521276
-
Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation
-
Fei HR, Chen G, Wang JM, Wang FZ. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. 2010;62(5):449-460.
-
(2010)
Cytotechnology
, vol.62
, Issue.5
, pp. 449-460
-
-
Fei, H.R.1
Chen, G.2
Wang, J.M.3
Wang, F.Z.4
-
79
-
-
79951725560
-
Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers
-
Engel JB, Schonhals T, Hausler S, et al. Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers. Arch Gynecol Obstet. 2011;283(3):603-610.
-
(2011)
Arch Gynecol Obstet
, vol.283
, Issue.3
, pp. 603-610
-
-
Engel, J.B.1
Schonhals, T.2
Hausler, S.3
-
80
-
-
72449158057
-
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma
-
Kumar A, Fillmore HL, Kadian R, Broaddus WC, Tye GW, Van Meter TE. The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma. Mol Cancer Res. 2009;7(11):1813-1821.
-
(2009)
Mol Cancer Res
, vol.7
, Issue.11
, pp. 1813-1821
-
-
Kumar, A.1
Fillmore, H.L.2
Kadian, R.3
Broaddus, W.C.4
Tye, G.W.5
van Meter, T.E.6
-
81
-
-
34250371001
-
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model
-
Catley L, Hideshima T, Chauhan D, et al. Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model. Exp Hematol. 2007;35(7):1038-1046.
-
(2007)
Exp Hematol
, vol.35
, Issue.7
, pp. 1038-1046
-
-
Catley, L.1
Hideshima, T.2
Chauhan, D.3
-
82
-
-
33646577479
-
Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
-
Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood. 2006;107(10):4053-4062.
-
(2006)
Blood
, vol.107
, Issue.10
, pp. 4053-4062
-
-
Hideshima, T.1
Catley, L.2
Yasui, H.3
-
83
-
-
34548181762
-
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
-
Hideshima T, Catley L, Raje N, et al. Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol. 2007;138(6):783-791.
-
(2007)
Br J Haematol
, vol.138
, Issue.6
, pp. 783-791
-
-
Hideshima, T.1
Catley, L.2
Raje, N.3
-
84
-
-
23844457178
-
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
-
Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res. 2005;65(16):7429-7435.
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7429-7435
-
-
Momota, H.1
Nerio, E.2
Holland, E.C.3
-
85
-
-
39149141606
-
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia
-
Leleu X, Jia X, Runnels J, et al. The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood. 2007;110(13):4417-4426.
-
(2007)
Blood
, vol.110
, Issue.13
, pp. 4417-4426
-
-
Leleu, X.1
Jia, X.2
Runnels, J.3
-
86
-
-
37549010727
-
Pharmacodynamic markers of perifosine efficacy
-
Hennessy BT, Lu Y, Poradosu E, et al. Pharmacodynamic markers of perifosine efficacy. Clin Cancer Res. 2007;13(24):7421-7431.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.24
, pp. 7421-7431
-
-
Hennessy, B.T.1
Lu, Y.2
Poradosu, E.3
-
87
-
-
77950232139
-
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
-
Becher OJ, Hambardzumyan D, Walker TR, et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 2010;70(6):2548-2557.
-
(2010)
Cancer Res
, vol.70
, Issue.6
, pp. 2548-2557
-
-
Becher, O.J.1
Hambardzumyan, D.2
Walker, T.R.3
-
88
-
-
39449135834
-
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
-
Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova- Todorova K, Holland EC. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev. 2008;22(4):436-448.
-
(2008)
Genes Dev
, vol.22
, Issue.4
, pp. 436-448
-
-
Hambardzumyan, D.1
Becher, O.J.2
Rosenblum, M.K.3
Pandolfi, P.P.4
Manova-Todorova, K.5
Holland, E.C.6
-
89
-
-
9344270514
-
A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer
-
Van Ummersen L, Binger K, Volkman J, et al. A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. Clin Cancer Res. 2004; 10(22):7450-7456.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.22
, pp. 7450-7456
-
-
van Ummersen, L.1
Binger, K.2
Volkman, J.3
-
90
-
-
0036345448
-
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours
-
Crul M, Rosing H, de Klerk GJ, et al. Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours. Eur J Cancer. 2002;38(12):1615-1621.
-
(2002)
Eur J Cancer
, vol.38
, Issue.12
, pp. 1615-1621
-
-
Crul, M.1
Rosing, H.2
de Klerk, G.J.3
-
91
-
-
77649144161
-
First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours
-
Unger C, Berdel W, Hanauske AR, Sindermann H, Engel J, Mross K. First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours. Eur J Cancer. 2010;46(5):920-925.
-
(2010)
Eur J Cancer
, vol.46
, Issue.5
, pp. 920-925
-
-
Unger, C.1
Berdel, W.2
Hanauske, A.R.3
Sindermann, H.4
Engel, J.5
Mross, K.6
-
92
-
-
33751002361
-
Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma
-
Bailey HH, Mahoney MR, Ettinger DS, et al. Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma. Cancer. 2006;107(10):2462-2467.
-
(2006)
Cancer
, vol.107
, Issue.10
, pp. 2462-2467
-
-
Bailey, H.H.1
Mahoney, M.R.2
Ettinger, D.S.3
-
93
-
-
76049121742
-
Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia
-
Ghobrial IM, Roccaro A, Hong F, et al. Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. Clin Cancer Res. 2010;16(3):1033-1041.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 1033-1041
-
-
Ghobrial, I.M.1
Roccaro, A.2
Hong, F.3
-
94
-
-
81755172138
-
Randomized placebo- controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer
-
Bendell JC, Nemunaitis J, Vukelja SJ, et al. Randomized placebo- controlled phase II trial of perifosine plus capecitabine as second- or third-line therapy in patients with metastatic colorectal cancer. J Clin Oncol. 2011;29(33):4394-4400.
-
(2011)
J Clin Oncol
, vol.29
, Issue.33
, pp. 4394-4400
-
-
Bendell, J.C.1
Nemunaitis, J.2
Vukelja, S.J.3
-
95
-
-
81155151824
-
Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: Results of a multicenter phase I/II trial
-
Richardson PG, Wolf J, Jakubowiak A, et al. Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial. J Clin Oncol. 2011;29(32):4243-4249.
-
(2011)
J Clin Oncol
, vol.29
, Issue.32
, pp. 4243-4249
-
-
Richardson, P.G.1
Wolf, J.2
Jakubowiak, A.3
-
96
-
-
77953215965
-
In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine
-
Li Z, Tan F, Liewehr DJ, Steinberg SM, Thiele CJ. In vitro and in vivo inhibition of neuroblastoma tumor cell growth by AKT inhibitor perifosine. J Natl Cancer Inst. 2010;102(11):758-770.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.11
, pp. 758-770
-
-
Li, Z.1
Tan, F.2
Liewehr, D.J.3
Steinberg, S.M.4
Thiele, C.J.5
-
97
-
-
80054752480
-
Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance n neuroblastoma in vivo
-
Li Z, Oh DY, Nakamura K, Thiele CJ. Perifosine-induced inhibition of akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance n neuroblastoma in vivo. Cancer. 2011;117(23):5412-5422.
-
(2011)
Cancer
, vol.117
, Issue.23
, pp. 5412-5422
-
-
Li, Z.1
Oh, D.Y.2
Nakamura, K.3
Thiele, C.J.4
-
98
-
-
4143143098
-
In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines
-
Dasmahapatra GP, Didolkar P, Alley MC, Ghosh S, Sausville EA, Roy KK. In vitro combination treatment with perifosine and UCN-01 demonstrates synergism against prostate (PC-3) and lung (A549) epithelial adenocarcinoma cell lines. Clin Cancer Res. 2004;10(15):5242-5252.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.15
, pp. 5242-5252
-
-
Dasmahapatra, G.P.1
Didolkar, P.2
Alley, M.C.3
Ghosh, S.4
Sausville, E.A.5
Roy, K.K.6
-
99
-
-
15944406971
-
Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
-
Rahmani M, Reese E, Dai Y, et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res. 2005;65(6):2422-2432.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2422-2432
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
-
100
-
-
52649101930
-
Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
-
David E, Sinha R, Chen J, Sun SY, Kaufman JL, Lonial S. Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors. Clin Cancer Res. 2008;14(16):5090-5098.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.16
, pp. 5090-5098
-
-
David, E.1
Sinha, R.2
Chen, J.3
Sun, S.Y.4
Kaufman, J.L.5
Lonial, S.6
-
101
-
-
38949121666
-
Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment
-
Huston A, Leleu X, Jia X, et al. Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment. Clin Cancer Res. 2008;14(3):865-874.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.3
, pp. 865-874
-
-
Huston, A.1
Leleu, X.2
Jia, X.3
-
102
-
-
79251575938
-
Perifosine and CCI 779 cooperate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma
-
Pitter KL, Galban CJ, Galban S, et al. Perifosine and CCI 779 cooperate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma. PLoS One. 2011;6(1):e14545.
-
(2011)
PLoS One
, vol.6
, Issue.1
-
-
Pitter, K.L.1
Galban, C.J.2
Galban, S.3
-
103
-
-
54849405505
-
Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation
-
Engel JB, Honig A, Schonhals T, et al. Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. Eur J Obstet Gynecol Reprod Biol. 2008;141(1): 64-69.
-
(2008)
Eur J Obstet Gynecol Reprod Biol
, vol.141
, Issue.1
, pp. 64-69
-
-
Engel, J.B.1
Honig, A.2
Schonhals, T.3
-
104
-
-
38349074064
-
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells
-
Papa V, Tazzari PL, Chiarini F, et al. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. Leukemia. 2008;22(1):147-160.
-
(2008)
Leukemia
, vol.22
, Issue.1
, pp. 147-160
-
-
Papa, V.1
Tazzari, P.L.2
Chiarini, F.3
-
105
-
-
77950232139
-
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
-
Becher OJ, Hambardzumyan D, Walker TR, et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 2010;70(6):2548-2557.
-
(2010)
Cancer Res
, vol.70
, Issue.6
, pp. 2548-2557
-
-
Becher, O.J.1
Hambardzumyan, D.2
Walker, T.R.3
-
106
-
-
77649134988
-
Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma
-
Iyer R, Evans AE, Qi X, et al. Lestaurtinib enhances the antitumor efficacy of chemotherapy in murine xenograft models of neuroblastoma. Clin Cancer Res. 2010;16(5):1478-1485.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1478-1485
-
-
Iyer, R.1
Evans, A.E.2
Qi, X.3
-
107
-
-
81755181310
-
Phase I study of single-agent perifosine for recurrent pediatric solid tumors [abstract]
-
Becher OJ, Trippett T, Kolesar J, et al. Phase I study of single-agent perifosine for recurrent pediatric solid tumors [abstract]. J Clin Oncol. 2010;28(15s):9540.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 s
, pp. 9540
-
-
Becher, O.J.1
Trippett, T.2
Kolesar, J.3
-
109
-
-
80655126355
-
Mtor kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
-
Rodrik-Outmezguine VS, Chandarlapaty S, Pagano NC, et al. mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling. Cancer Discov. 2011;1(3):248-259.
-
(2011)
Cancer Discov
, vol.1
, Issue.3
, pp. 248-259
-
-
Rodrik-Outmezguine, V.S.1
Chandarlapaty, S.2
Pagano, N.C.3
-
110
-
-
79960744694
-
Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors
-
Spunt SL, Grupp SA, Vik TA, et al. Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors. J Clin Oncol. 2011;29(21):2933-2940.
-
(2011)
J Clin Oncol
, vol.29
, Issue.21
, pp. 2933-2940
-
-
Spunt, S.L.1
Grupp, S.A.2
Vik, T.A.3
-
111
-
-
84655175068
-
Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma
-
Geoerger B, Kieran MW, Grupp S, et al. Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma. Eur J Cancer. 2012;48(2):253-262.
-
(2012)
Eur J Cancer
, vol.48
, Issue.2
, pp. 253-262
-
-
Geoerger, B.1
Kieran, M.W.2
Grupp, S.3
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