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Volumn 22, Issue 1, 2008, Pages 147-160

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CD135 ANTIGEN; CD34 ANTIGEN; ETOPOSIDE; FAS ANTIGEN; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE 1; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

EID: 38349074064     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404980     Document Type: Article
Times cited : (104)

References (60)
  • 2
    • 33750525785 scopus 로고    scopus 로고
    • Tumor progression - targets for differential therapy
    • Pardee AB. Tumor progression - targets for differential therapy. J Cell Physiol 2006; 209: 589-591.
    • (2006) J Cell Physiol , vol.209 , pp. 589-591
    • Pardee, A.B.1
  • 3
    • 0037075173 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is essential for the proliferation of lymphoblastoid cells
    • Brennan P, Mehl AM, Jones M, Rowe M. Phosphatidylinositol 3-kinase is essential for the proliferation of lymphoblastoid cells. Oncogene 2002; 21: 1263-1271.
    • (2002) Oncogene , vol.21 , pp. 1263-1271
    • Brennan, P.1    Mehl, A.M.2    Jones, M.3    Rowe, M.4
  • 4
    • 0036968347 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt pathway and chemotherapeutic resistance
    • West KA, Castillo SS, Dennis PA. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist Updat 2002; 5: 234-248.
    • (2002) Drug Resist Updat , vol.5 , pp. 234-248
    • West, K.A.1    Castillo, S.S.2    Dennis, P.A.3
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-901.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-901
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005; 24: 7455-7464.
    • (2005) Oncogene , vol.24 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 7
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation ind function of PKB/ AKT - a major therapeutic target
    • Hanada M, Feng J, Hemmings BA. Structure, regulation ind function of PKB/ AKT - a major therapeutic target. Biochim Biophys Acta 2004; 1697: 3-16.
    • (2004) Biochim Biophys Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 8
    • 27744507024 scopus 로고    scopus 로고
    • Recher C, Pos Santos C, Demur C, Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 2005; 4: 1540-1549.
    • Recher C, Pos Santos C, Demur C, Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 2005; 4: 1540-1549.
  • 9
    • 27844598284 scopus 로고    scopus 로고
    • Cheng JQ, Lindsley CW, Cheng-GZ, Yang H, Nicosia SV. The Akt/PKB pathway: Molecular target for cancer drug discovery. Oncogene 2005; 24: 7482-7492.
    • Cheng JQ, Lindsley CW, Cheng-GZ, Yang H, Nicosia SV. The Akt/PKB pathway: Molecular target for cancer drug discovery. Oncogene 2005; 24: 7482-7492.
  • 11
    • 13244284844 scopus 로고    scopus 로고
    • Recent advances in the development of smalt-molecule inhibitors for the treatment of acute myeloid leukemia
    • Levis M. Recent advances in the development of smalt-molecule inhibitors for the treatment of acute myeloid leukemia. Curr Opin Hematol 2005; 12: 55-61.
    • (2005) Curr Opin Hematol , vol.12 , pp. 55-61
    • Levis, M.1
  • 12
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell 2003; 4: 257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 13
    • 0036345448 scopus 로고    scopus 로고
    • Phase I and pharmacological study of daily-oral administration of perifosine (D-21266) in patients with advanced solid tumours
    • Crul M, Rosing H, de Klerk GJ, Dubbelman R, Traiser M, Reichert S et al. Phase I and pharmacological study of daily-oral administration of perifosine (D-21266) in patients with advanced solid tumours. Eur J Cancer 2002; 38: 1615-1621.
    • (2002) Eur J Cancer , vol.38 , pp. 1615-1621
    • Crul, M.1    Rosing, H.2    de Klerk, G.J.3    Dubbelman, R.4    Traiser, M.5    Reichert, S.6
  • 14
    • 9344270514 scopus 로고    scopus 로고
    • A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer
    • Van Ummersen L, Binger K, Volkman J, Marnocha R, Tutsch K, Kolesar J et al. A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer. Clin Cancer Res 2004; 10: 7450-7456.
    • (2004) Clin Cancer Res , vol.10 , pp. 7450-7456
    • Van Ummersen, L.1    Binger, K.2    Volkman, J.3    Marnocha, R.4    Tutsch, K.5    Kolesar, J.6
  • 15
    • 33646577479 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
    • Hideshima T, Catley L, Yasui H, Ishitsuka K, Raje N, Mitsiades C et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 2006; 107: 4053-4062.
    • (2006) Blood , vol.107 , pp. 4053-4062
    • Hideshima, T.1    Catley, L.2    Yasui, H.3    Ishitsuka, K.4    Raje, N.5    Mitsiades, C.6
  • 16
    • 0037331989 scopus 로고    scopus 로고
    • Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway
    • Ruiter GA, Zerp SF, Bartelink H, van Blitterswijk WJ, Verheij M. Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anticancer Drugs 2003; 14 167-173.
    • (2003) Anticancer Drugs , vol.14 , pp. 167-173
    • Ruiter, G.A.1    Zerp, S.F.2    Bartelink, H.3    van Blitterswijk, W.J.4    Verheij, M.5
  • 17
    • 2542547908 scopus 로고    scopus 로고
    • Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA, Roy KK. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther 2003; 2: 1093-1103.
    • Kondapaka SB, Singh SS, Dasmahapatra GP, Sausville EA, Roy KK. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Mol Cancer Ther 2003; 2: 1093-1103.
  • 18
    • 23844457178 scopus 로고    scopus 로고
    • Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo
    • Momota H, Nerio E, Holland EC. Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo. Cancer Res 2005; 65: 7429-7435.
    • (2005) Cancer Res , vol.65 , pp. 7429-7435
    • Momota, H.1    Nerio, E.2    Holland, E.C.3
  • 19
    • 32944465388 scopus 로고    scopus 로고
    • Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
    • Granville CA, Memmott RM, Gills JJ, Dennis PA. Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin Cancer Res 2006; 12: 679-689.
    • (2006) Clin Cancer Res , vol.12 , pp. 679-689
    • Granville, C.A.1    Memmott, R.M.2    Gills, J.J.3    Dennis, P.A.4
  • 20
    • 0742272099 scopus 로고    scopus 로고
    • Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway
    • Birkenkamp KU, Geugien M, Schepers H, Westra J, Lemmink HH, Vellenga E. Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway. Leukemia 2004; 18: 103-112.
    • (2004) Leukemia , vol.18 , pp. 103-112
    • Birkenkamp, K.U.1    Geugien, M.2    Schepers, H.3    Westra, J.4    Lemmink, H.H.5    Vellenga, E.6
  • 21
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-κB, Mapkinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-κB, Mapkinase and p53 pathways. Leukemia 2005; 19: 586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 22
    • 33744468497 scopus 로고    scopus 로고
    • The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells
    • Matkovic K, Brugnoli F, Bertagnolo V, Banfic H, Visnjic D. The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells. Leukemia 2006; 20: 941-951.
    • (2006) Leukemia , vol.20 , pp. 941-951
    • Matkovic, K.1    Brugnoli, F.2    Bertagnolo, V.3    Banfic, H.4    Visnjic, D.5
  • 23
    • 33744457653 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia
    • Martelli AM, Nyakem M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C et al. Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. Leukemia 2006; 20: 911-928.
    • (2006) Leukemia , vol.20 , pp. 911-928
    • Martelli, A.M.1    Nyakem, M.2    Tabellini, G.3    Bortul, R.4    Tazzari, P.L.5    Evangelisti, C.6
  • 24
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Komblau SM, Womble M, Qiu YH, Jackson CE, Chen W, Konopleva M et al Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood 2006; 108: 2358-2365.
    • (2006) Blood , vol.108 , pp. 2358-2365
    • Komblau, S.M.1    Womble, M.2    Qiu, Y.H.3    Jackson, C.E.4    Chen, W.5    Konopleva, M.6
  • 25
    • 34548138930 scopus 로고    scopus 로고
    • Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway
    • Doepfner KT, Spertini O, Arcaro A. Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. Leukemia 2007; 21: 1921-1930.
    • (2007) Leukemia , vol.21 , pp. 1921-1930
    • Doepfner, K.T.1    Spertini, O.2    Arcaro, A.3
  • 26
    • 31444440033 scopus 로고    scopus 로고
    • Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndromo patients
    • Nyakern M, Tazzari PL, Finelli C, Bosi C, Follo MY, Grafone T et al Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndromo patients. Leukemia 2006; 20: 230-238.
    • (2006) Leukemia , vol.20 , pp. 230-238
    • Nyakern, M.1    Tazzari, P.L.2    Finelli, C.3    Bosi, C.4    Follo, M.Y.5    Grafone, T.6
  • 27
    • 15944406971 scopus 로고    scopus 로고
    • Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species
    • Rahmani M, Feese E, Dai Y, Bauer C, Payne SG, Dent P et al. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res 2005; 65: 2422-2432,
    • (2005) Cancer Res , vol.65 , pp. 2422-2432
    • Rahmani, M.1    Feese, E.2    Dai, Y.3    Bauer, C.4    Payne, S.G.5    Dent, P.6
  • 29
    • 33847225602 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts
    • Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T et al. Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. Leukemia 2007; 21: 427-438.
    • (2007) Leukemia , vol.21 , pp. 427-438
    • Tazzari, P.L.1    Cappellini, A.2    Ricci, F.3    Evangelisti, C.4    Papa, V.5    Grafone, T.6
  • 30
    • 0034060621 scopus 로고    scopus 로고
    • Quantitation of Fas and Fas ligand gene expression in human ovarian cervical and endometrial carcinomas using real-time quantitative RT-PCR
    • Das H, Koizumi T, Sugimoto T, Chakraborty S, Ichimura T, Hasegawa K et al. Quantitation of Fas and Fas ligand gene expression in human ovarian cervical and endometrial carcinomas using real-time quantitative RT-PCR. Br J Cancer 2000; 82: 1682-1688,
    • (2000) Br J Cancer , vol.82 , pp. 1682-1688
    • Das, H.1    Koizumi, T.2    Sugimoto, T.3    Chakraborty, S.4    Ichimura, T.5    Hasegawa, K.6
  • 31
    • 0035339697 scopus 로고    scopus 로고
    • Supravital exposure to propidium iodide identifies apoptosis on adherent cells
    • Zamai L, Canonico B, Luchetti F, Ferri P, Melloni E, Guidotti L et al Supravital exposure to propidium iodide identifies apoptosis on adherent cells. Cytometry 2001; 44: 57-64.
    • (2001) Cytometry , vol.44 , pp. 57-64
    • Zamai, L.1    Canonico, B.2    Luchetti, F.3    Ferri, P.4    Melloni, E.5    Guidotti, L.6
  • 32
    • 33745096533 scopus 로고    scopus 로고
    • Apoptogis effector mechanisms: A requiem performed in different keys
    • Hail Jr N, Carter BZ, Konopleva M, Andreeff M. Apoptogis effector mechanisms: A requiem performed in different keys. Apoptosis 2006; 11: 889-904.
    • (2006) Apoptosis , vol.11 , pp. 889-904
    • Hail Jr, N.1    Carter, B.Z.2    Konopleva, M.3    Andreeff, M.4
  • 33
    • 0033199841 scopus 로고    scopus 로고
    • Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo
    • Casamayor A, Morrice NA, Alessi DR. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: Identification of five sites of phosphorylation in vivo. Biochem J 1999; 342: 267-292.
    • (1999) Biochem J , vol.342 , pp. 267-292
    • Casamayor, A.1    Morrice, N.A.2    Alessi, D.R.3
  • 34
    • 33746046785 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways
    • Nyakern M, Cappellini A, Mantovani I, Martelli AM. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Mol Cancer Ther 2006; 5: 1559-1570.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1559-1570
    • Nyakern, M.1    Cappellini, A.2    Mantovani, I.3    Martelli, A.M.4
  • 35
    • 0034731505 scopus 로고    scopus 로고
    • p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
    • King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemminge BA et al p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J. Biol Chem 2000; 275: 41201-41209.
    • (2000) J. Biol Chem , vol.275 , pp. 41201-41209
    • King, C.C.1    Gardiner, E.M.2    Zenke, F.T.3    Bohl, B.P.4    Newton, A.C.5    Hemminge, B.A.6
  • 36
    • 1242285048 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apcotosis in myeloid leukemias
    • Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M et al Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apcotosis in myeloid leukemias. Leukemia 2004; 18: 267-275.
    • (2004) Leukemia , vol.18 , pp. 267-275
    • Zhao, S.1    Konopleva, M.2    Cabreira-Hansen, M.3    Xie, Z.4    Hu, W.5    Milella, M.6
  • 37
    • 26644449670 scopus 로고    scopus 로고
    • The BAD protein integrates survival signaling by EGFR/MAPK and P13K/Akt kinase pathways in PTEN-deficient tumor cells
    • She QB, Solit DB, Ye Q, O'Reilly KE, Lobo J, Rosen N. The BAD protein integrates survival signaling by EGFR/MAPK and P13K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell 2005; 8: 287-297.
    • (2005) Cancer Cell , vol.8 , pp. 287-297
    • She, Q.B.1    Solit, D.B.2    Ye, Q.3    O'Reilly, K.E.4    Lobo, J.5    Rosen, N.6
  • 38
    • 33847725556 scopus 로고    scopus 로고
    • Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1
    • Lee SY, Cherla RP, Tesh VL. Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infect Immun 2007; 75: 1291-1302.
    • (2007) Infect Immun , vol.75 , pp. 1291-1302
    • Lee, S.Y.1    Cherla, R.P.2    Tesh, V.L.3
  • 39
    • 33947588147 scopus 로고    scopus 로고
    • Pgp and FLT3: Identification and modulation of two proteins that lead to chemotherapy resistance in acute myeloid leukemia
    • Kappelmayer J, Udvardy-M, Antal-Szalmas P. Pgp and FLT3: Identification and modulation of two proteins that lead to chemotherapy resistance in acute myeloid leukemia. Curr Med Chem 2007; 14: 519-530.
    • (2007) Curr Med Chem , vol.14 , pp. 519-530
    • Kappelmayer, J.1    Udvardy-M2    Antal-Szalmas, P.3
  • 40
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3-feceptor tyrosine kinase
    • Yee KW, O'Farrell AM, Smolich BD, Cherrington JM, McMahon G, Wait CL et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3-feceptor tyrosine kinase. Blood 2002; 100: 2941-2949.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.1    O'Farrell, A.M.2    Smolich, B.D.3    Cherrington, J.M.4    McMahon, G.5    Wait, C.L.6
  • 41
    • 33847289770 scopus 로고    scopus 로고
    • Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
    • Vink SR, van Blitterswijk WJ, Schellens JH, Verheij M. Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy. Cancer Treat Rev 2007; 33: 191-202.
    • (2007) Cancer Treat Rev , vol.33 , pp. 191-202
    • Vink, S.R.1    van Blitterswijk, W.J.2    Schellens, J.H.3    Verheij, M.4
  • 42
    • 33751184394 scopus 로고    scopus 로고
    • A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer
    • Argiris A, Cohen E, Karrison T, Esparaz B, Mauer A, Ansari R et al A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer. Cancer Biol Ther 2006; 5: 766-770.
    • (2006) Cancer Biol Ther , vol.5 , pp. 766-770
    • Argiris, A.1    Cohen, E.2    Karrison, T.3    Esparaz, B.4    Mauer, A.5    Ansari, R.6
  • 44
    • 26944451381 scopus 로고    scopus 로고
    • Quantitative single tell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia
    • Ricciardi MR, McQueen T, Chism D, Milella M, Estey E, Kaldjian E et al. Quantitative single tell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia. Leukemia 2005; 19: 1543-1549.
    • (2005) Leukemia , vol.19 , pp. 1543-1549
    • Ricciardi, M.R.1    McQueen, T.2    Chism, D.3    Milella, M.4    Estey, E.5    Kaldjian, E.6
  • 45
    • 0141502208 scopus 로고    scopus 로고
    • Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts
    • Lunghi P, Tabilio A, Dall'Aglio PP, Ridolo E, Carlo-Stella C, Pelicci PG et al. Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts. Leukemia 2003; 17: 1783-1793.
    • (2003) Leukemia , vol.17 , pp. 1783-1793
    • Lunghi, P.1    Tabilio, A.2    Dall'Aglio, P.P.3    Ridolo, E.4    Carlo-Stella, C.5    Pelicci, P.G.6
  • 46
    • 33750459743 scopus 로고    scopus 로고
    • A selectve inhibitor of the p110§ isoform of Pl 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
    • Billottet C, Grandage VL, Gale RE, Quattropani A, Rommel C, Vanhaesebroeck B et al. A selectve inhibitor of the p110§ isoform of Pl 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16. Oncogene. 2006; 25: 6648-6659.
    • (2006) Oncogene , vol.25 , pp. 6648-6659
    • Billottet, C.1    Grandage, V.L.2    Gale, R.E.3    Quattropani, A.4    Rommel, C.5    Vanhaesebroeck, B.6
  • 47
    • 31544448038 scopus 로고    scopus 로고
    • Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in RTEN-deficieht cancer cells
    • Li X, Luwor R, Lu Y, Liang K, Fan Z. Enhancement of antitumor activity of the anti-EGF receptor monoclonal antibody cetuximab/C225 by perifosine in RTEN-deficieht cancer cells. Oncogene 2006; 25 525-535.
    • (2006) Oncogene , vol.25 , pp. 525-535
    • Li, X.1    Luwor, R.2    Lu, Y.3    Liang, K.4    Fan, Z.5
  • 49
    • 24944460366 scopus 로고    scopus 로고
    • PLT3 and acute myelogenous leukemia biology, clinical significante and therapeutic applications
    • Advani AS. PLT3 and acute myelogenous leukemia biology, clinical significante and therapeutic applications. Curr Pharm Des 2005; 11: 3449-3457.
    • (2005) Curr Pharm Des , vol.11 , pp. 3449-3457
    • Advani, A.S.1
  • 50
    • 33846243705 scopus 로고    scopus 로고
    • Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
    • Gajate C, Mollinedo F. Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood 2007; 109: 711-719.
    • (2007) Blood , vol.109 , pp. 711-719
    • Gajate, C.1    Mollinedo, F.2
  • 51
    • 0344441258 scopus 로고    scopus 로고
    • Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells
    • Ciechomska I, Pyrzynska B, Kazmierczak P, Kaminska B. Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells. Oncogene 2003; 22: 7617-7627.
    • (2003) Oncogene , vol.22 , pp. 7617-7627
    • Ciechomska, I.1    Pyrzynska, B.2    Kazmierczak, P.3    Kaminska, B.4
  • 52
    • 0242643643 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression
    • Cappellini A, Tabellini G, Zweyer M, Bortul R, Tazzari PL, Billi AM et al. The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression. Leukemia 2003; 17: 2157-2167.
    • (2003) Leukemia , vol.17 , pp. 2157-2167
    • Cappellini, A.1    Tabellini, G.2    Zweyer, M.3    Bortul, R.4    Tazzari, P.L.5    Billi, A.M.6
  • 53
    • 33645283870 scopus 로고    scopus 로고
    • BID as a double agent in cell life and death
    • Gross A. BID as a double agent in cell life and death. Cell Cycle 2006; 5: 582-584.
    • (2006) Cell Cycle , vol.5 , pp. 582-584
    • Gross, A.1
  • 54
    • 0035869463 scopus 로고    scopus 로고
    • Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells
    • Droin N, Bichat F, Rebe C, Wotawa A, Sordet O, Hammann A et al. Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells. Blood 2001; 97: 1835-1844.
    • (2001) Blood , vol.97 , pp. 1835-1844
    • Droin, N.1    Bichat, F.2    Rebe, C.3    Wotawa, A.4    Sordet, O.5    Hammann, A.6
  • 55
    • 4544274785 scopus 로고    scopus 로고
    • Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
    • Wagner KW, Engels IH, Deveraux QL. Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway. J Biol Chem 2004; 279: 35047-35052.
    • (2004) J Biol Chem , vol.279 , pp. 35047-35052
    • Wagner, K.W.1    Engels, I.H.2    Deveraux, Q.L.3
  • 56
    • 33745818640 scopus 로고    scopus 로고
    • ROS-triggered caspase 2 activation and feedback amplification loop in betacarotene-induced apoptosis
    • Prasad V, Chandele A, Jagtap JC, Sudheer Kumar P, Shastry P. ROS-triggered caspase 2 activation and feedback amplification loop in betacarotene-induced apoptosis. Free Radic Biol Med 2006; 41 431-442.
    • (2006) Free Radic Biol Med , vol.41 , pp. 431-442
    • Prasad, V.1    Chandele, A.2    Jagtap, J.C.3    Sudheer Kumar, P.4    Shastry, P.5
  • 57
    • 12944294341 scopus 로고    scopus 로고
    • Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK
    • Barthelemy C, Henderson CE, Pettmann B. Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK. BMC Neurosci 2004; 5: 48.
    • (2004) BMC Neurosci , vol.5 , pp. 48
    • Barthelemy, C.1    Henderson, C.E.2    Pettmann, B.3
  • 58
    • 33746544343 scopus 로고    scopus 로고
    • New paradigms in anticancer therapy: Targeting multiple signaling pathways with kinase inhibitors
    • Faivre S, Djelloul S, Raymond E. New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors. Semin Oncol 2006; 33: 407-420.
    • (2006) Semin Oncol , vol.33 , pp. 407-420
    • Faivre, S.1    Djelloul, S.2    Raymond, E.3
  • 60
    • 0037018847 scopus 로고    scopus 로고
    • A role for Pl 3-kinase and PKB activity in the G2/M phase of the cell cycle
    • Shtivelman E, Sussman J, Stokoe D. A role for Pl 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol 2002; 12: 919-924.
    • (2002) Curr Biol , vol.12 , pp. 919-924
    • Shtivelman, E.1    Sussman, J.2    Stokoe, D.3


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