Phosphatidylinositol 3-Kinase Inhibition Down-Regulates Survivin and Facilitates TRAIL-Mediated Apoptosis in Neuroblastomas

Journal of Pediatric Surgery

Volumn 39, Issue 4, 2004, Pages 516-521

  Kim, Sunghoon ^a   Kang, Junghee ^a   Qiao, Jingbo ^a   Thomas, Robert P ^a   Evers, B Mark ^a   Chung, Dai H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Neuroblastoma; PI3K; Survivin; Tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CASPASE 3 INHIBITOR; DNA FRAGMENT; INHIBITOR OF APOPTOSIS PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P85; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; RIBONUCLEASE PROTECTION ASSAY; WESTERN BLOTTING;

EID: 16544395058     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2003.12.008     Document Type: Article

References (30)

1. Gurney JG, Ross JA, Wall DA, et al: Infant cancer in the U.S.: Histology-specific incidence and trends, 1973 to 1992. J Pediatr Hematol Oncol 19:428-432, 1997
2. Brodeur GM: Molecular basis for heterogeneity in human neuroblastomas. Eur J Cancer 31A:505-510, 1995
3. Nakagawara A: Molecular basis of spontaneous regression of neuroblastoma: Role of neurotrophic signals and genetic abnormalities. Hum Cell 11:115-124, 1998
4. Salvesen GS, Dixit VM: Caspases: Intracellular signaling by proteolysis. Cell 91:443-446, 1997
5. Liston P, Roy N, Tamai K, et al: Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349-353, 1996
6. LaCasse EC, Baird S, Korneluk RG, et al: The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17:3247-3259, 1998
7. Deveraux QL, Reed JC: IAP family proteins-Suppressors of apoptosis. Genes Dev 13:239-252, 1999
8. Shin S, Sung BJ, Cho YS, et al: An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40:1117-1123, 2001
9. Li F, Ambrosini G, Chu EY, et al: Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396:580-584, 1998
10. Ambrosini G, Adida C, Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917-921, 1997
11. Adida C, Berrebi D, Peuchmaur M, et al: Anti-apoptosis gene, survivin, and prognosis of neuroblastoma. Lancet 351:882-883, 1998
12. Azuhata T, Scott D, Takamizawa S, et al: The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma. J Pediatr Surg 36:1785-1791, 2001
13. Wang CY, Mayo MW, Korneluk RG, et al: NF-kappaB anti-apoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683, 1998
14. del Peso L, Gonzalez-Garcia M, Page C, et al: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689, 1997
15. Cardone MH, Roy N, Stennicke HR, et al: Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321, 1998
16. Duronio V, Scheid MP, Ettinger S: Downstream signalling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal 10:233-239, 1998
17. Walczak H, Miller RE, Ariail K, et al: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5:157-163, 1999
18. Kimura K, Hattori S, Kabuyama Y, et al: Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961-18967, 1994
19. Kim S, Kang J, Hu W, et al: Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. Int J Cancer 103:352-359, 2003
20. Kim S, Domon-Dell C, Wang Q, et al: PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway. Gastroenterology 123:1163-1178, 2002
21. Datta SR, Dudek H, Tao X, et al: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241, 1997
22. Wong P, Taillefer D, Lakins J, et al: Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration. Eur J Biochem 221:917-925, 1994
23. Wyllie AH, Kerr JF, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 68:251-306, 1980
24. Luo X, Budihardjo I, Zou H, et al: Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490, 1998
25. Green DR, Reed JC: Mitochondria and apoptosis. Science 281:1309-1312, 1998
26. Dudek H, Datta SR, Franke TF, et al: Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665, 1997
27. Sato T, Irie S, Kitada S, et al: FAP-1: A protein tyrosine phosphatase that associates with Fas. Science 268:411-415, 1995
28. Hausler P, Papoff G, Eramo A, et al: Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B. Eur J Immunol 28:57-69, 1998
29. Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science 267:1456-1462, 1995
30. Li F, Ackermann EJ, Bennett CF, et al: Pleiotropic cell-division defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1:461-466, 1999