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Volumn 5, Issue , 2012, Pages 31-46

Targeted agents for the treatment of metastatic melanoma

Author keywords

Antitumor; Ipilimumab; Metastatic melanoma; Vemurafenib

Indexed keywords

B RAF KINASE INHIBITOR; CARBOPLATIN; CHIR 265; DACARBAZINE; GSK 436; INTERLEUKIN 2; IPILIMUMAB; MAMMALIAN TARGET OF RAPAMYCIN; MELANOCYTE PROTEIN PMEL 17; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MOLECULAR MARKER; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; PACLITAXEL; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; SELUMETINIB; SORAFENIB; STEM CELL FACTOR RECEPTOR; TEMOZOLOMIDE; TRAMETINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VEMURAFENIB; ZELBORAFR;

EID: 84861398281     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S21259     Document Type: Review
Times cited : (20)

References (136)
  • 1
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society, Available from, Accessed January 16, 2012
    • American Cancer Society. Cancer Facts and Figures 2011. 2011:1-60. Available from: http://www.cancer.org/Research/CancerFactsFigures/CancerFactsFigures/cancer-facts-figures-2011. Accessed January 16, 2012.
    • (2011) Cancer Facts and Figures 2011 , pp. 1-60
  • 2
    • 70450190156 scopus 로고    scopus 로고
    • Canadian Cancer Society, Available from, Accessed January 16, 2012
    • Canadian Cancer Society. Canadian Cancer Statistics 2011. 2011:1-133. Available from: http://www.cancer.ca. Accessed January 16, 2012.
    • (2011) Canadian Cancer Statistics 2011 , pp. 1-133
  • 3
    • 0035881074 scopus 로고    scopus 로고
    • Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma
    • Balch CM, Buzaid AC, Soong SJ, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001;19(16):3635-3648.
    • (2001) J Clin Oncol , vol.19 , Issue.16 , pp. 3635-3648
    • Balch, C.M.1    Buzaid, A.C.2    Soong, S.J.3
  • 5
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: Long-term survival update
    • Atkins MB, Kunkel L, Sznol M, Rosenberg SA. High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J Sci Am. 2000;6 Suppl 1:S11-S14.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL. 1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3    Rosenberg, S.A.4
  • 6
    • 79960914401 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes: Apparently good for melanoma patients. But why?
    • Cipponi A, Wieers G, van Baren N, Coulie PG. Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why? Cancer Immunol Immunother. 2011;60(8):1153-1160.
    • (2011) Cancer Immunol Immunother , vol.60 , Issue.8 , pp. 1153-1160
    • Cipponi, A.1    Wieers, G.2    van Baren, N.3    Coulie, P.G.4
  • 7
    • 67649616555 scopus 로고    scopus 로고
    • Parallel detection of antigenspecific T-cell responses by multidimensional encoding of MHC multimers
    • Hadrup SR, Bakker AH, Shu CJ, et al. Parallel detection of antigenspecific T-cell responses by multidimensional encoding of MHC multimers. Nat Methods. 2009;6(7):520-526.
    • (2009) Nat Methods , vol.6 , Issue.7 , pp. 520-526
    • Hadrup, S.R.1    Bakker, A.H.2    Shu, C.J.3
  • 8
    • 73349134996 scopus 로고    scopus 로고
    • Spontaneous regression of metastases from melanoma: Review of the literature
    • Kalialis LV, Drzewiecki KT, Klyver H. Spontaneous regression of metastases from melanoma: review of the literature. Melanoma Res. 2009;19(5):275-282.
    • (2009) Melanoma Res , vol.19 , Issue.5 , pp. 275-282
    • Kalialis, L.V.1    Drzewiecki, K.T.2    Klyver, H.3
  • 9
    • 4744355872 scopus 로고    scopus 로고
    • Escape from immunotherapy: Possible mechanisms that influence tumor regression/progression
    • Ahmad M, Rees RC, Ali SA. Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunol Immunother. 2004;53(10):844-854.
    • (2004) Cancer Immunol Immunother , vol.53 , Issue.10 , pp. 844-854
    • Ahmad, M.1    Rees, R.C.2    Ali, S.A.3
  • 10
    • 0031944224 scopus 로고    scopus 로고
    • Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma
    • Krasagakis K, Thölke D, Farthmann B, et al. Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma. Br J Cancer. 1998;77(9):1492-1494.
    • (1998) Br J Cancer , vol.77 , Issue.9 , pp. 1492-1494
    • Krasagakis, K.1    Thölke, D.2    Farthmann, B.3
  • 11
    • 45549099784 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
    • Hunder NN, Wallen H, Cao J, et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Eng J Med. 2008;358(25):2698-2703.
    • (2008) N Eng J Med , vol.358 , Issue.25 , pp. 2698-2703
    • Hunder, N.N.1    Wallen, H.2    Cao, J.3
  • 12
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-723.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 13
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Eng J Med. 2011;364(26):2517-2526.
    • (2011) N Eng J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 14
    • 0032807417 scopus 로고    scopus 로고
    • The role of B7 costimulation in T-cell immunity
    • Harris NL, Ronchese F. The role of B7 costimulation in T-cell immunity. Immunol Cell Biol. 1999;77(4):304-311.
    • (1999) Immunol Cell Biol , vol.77 , Issue.4 , pp. 304-311
    • Harris, N.L.1    Ronchese, F.2
  • 15
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engd J Med. 2011;364(26):2507-2516.
    • (2011) N Engd J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 16
    • 34248597065 scopus 로고    scopus 로고
    • Differential regulation and properties of MAPKs
    • Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 2007;26(22):3100-3112.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3100-3112
    • Raman, M.1    Chen, W.2    Cobb, M.H.3
  • 17
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged: B-RAF is a human oncogene
    • Garnett MJ, Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell. 2004;6(4):313-319.
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 313-319
    • Garnett, M.J.1    Charged, M.R.2
  • 18
    • 0028074621 scopus 로고
    • Ras-dependent growth factor regulation of MEK kinase in PC12 cells
    • Lange-Carter CA, Johnson GL. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science. 1994;265(5177):1458-1461.
    • (1994) Science , vol.265 , Issue.5177 , pp. 1458-1461
    • Lange-Carter, C.A.1    Johnson, G.L.2
  • 19
    • 0029006126 scopus 로고
    • Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
    • Marais R, Light Y, Paterson HF, Marshall CJ. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 1995;14(13):3136-3145.
    • (1995) EMBO J , vol.14 , Issue.13 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Marshall, C.J.4
  • 20
    • 0028568217 scopus 로고
    • Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
    • Minden A, Lin A, McMahon M, et al. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science. 1994;266(5191):1719-1723.
    • (1994) Science , vol.266 , Issue.5191 , pp. 1719-1723
    • Minden, A.1    Lin, A.2    McMahon, M.3
  • 21
    • 0031041171 scopus 로고    scopus 로고
    • Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
    • Marais R, Light Y, Paterson HF, Mason CS, Marshall CJ. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J Biol Chem. 1997;272(7):4378-4383.
    • (1997) J Biol Chem , vol.272 , Issue.7 , pp. 4378-4383
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Mason, C.S.4    Marshall, C.J.5
  • 22
    • 0033561041 scopus 로고    scopus 로고
    • Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
    • Mason CS, Springer CJ, Cooper RG, et al. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 1999;18(8):2137-2148.
    • (1999) EMBO J , vol.18 , Issue.8 , pp. 2137-2148
    • Mason, C.S.1    Springer, C.J.2    Cooper, R.G.3
  • 23
    • 0029081006 scopus 로고
    • MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase
    • Xu S, Robbins D, Frost J, et al. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Pro Nat Acad Sci U S A. 1995;92(15):6808-6812.
    • (1995) Pro Nat Acad Sci U S A , vol.92 , Issue.15 , pp. 6808-6812
    • Xu, S.1    Robbins, D.2    Frost, J.3
  • 24
    • 0036896253 scopus 로고    scopus 로고
    • Mitogen-actived protein kinase activation is an early event in melanoma progression
    • Cohen C, Zavala-Pompa A, Sequeira JH, et al. Mitogen-actived protein kinase activation is an early event in melanoma progression. Clin Cancer Res. 2002;8(12):3728-3733.
    • (2002) Clin Cancer Res , vol.8 , Issue.12 , pp. 3728-3733
    • Cohen, C.1    Zavala-Pompa, A.2    Sequeira, J.H.3
  • 25
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-954.
    • (2002) Nature , vol.417 , Issue.6892 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 26
    • 0036850146 scopus 로고    scopus 로고
    • Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: Mutations occur early and persist throughout tumor progression
    • Omholt K, Karsberg S, Platz A, et al. Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin Cancer Res. 2002;8(11):3468-3474.
    • (2002) Clin Cancer Res , vol.8 , Issue.11 , pp. 3468-3474
    • Omholt, K.1    Karsberg, S.2    Platz, A.3
  • 27
    • 0037228055 scopus 로고    scopus 로고
    • High frequency of BRAF mutations in nevi
    • Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33(1):19-20.
    • (2003) Nat Genet , vol.33 , Issue.1 , pp. 19-20
    • Pollock, P.M.1    Harper, U.L.2    Hansen, K.S.3
  • 28
    • 27544453376 scopus 로고    scopus 로고
    • Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF
    • Emuss V, Garnett M, Mason C, Marais R. Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. Cancer Res. 2005;65(21):9719-9726.
    • (2005) Cancer Res , vol.65 , Issue.21 , pp. 9719-9726
    • Emuss, V.1    Garnett, M.2    Mason, C.3    Marais, R.4
  • 29
    • 0028877441 scopus 로고
    • Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
    • Pritchard CA, Samuels ML, Bosch E, McMahon M. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Mol Cell Biol. 1995;15(11):6430-6442.
    • (1995) Mol Cell Biol , vol.15 , Issue.11 , pp. 6430-6442
    • Pritchard, C.A.1    Samuels, M.L.2    Bosch, E.3    McMahon, M.4
  • 30
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
    • Tsai J, Lee JT, Wang W, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Pro Nat Acad Sci U S A. 2008;105(8):3041-3046.
    • (2008) Pro Nat Acad Sci U S A , vol.105 , Issue.8 , pp. 3041-3046
    • Tsai, J.1    Lee, J.T.2    Wang, W.3
  • 32
    • 34447125840 scopus 로고    scopus 로고
    • Differential oncogenic potential of activated RAS isoforms in melanocytes
    • Whitwam T, Vanbrocklin MW, Russo ME, et al. Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene. 2007;26(31):4563-4570.
    • (2007) Oncogene , vol.26 , Issue.31 , pp. 4563-4570
    • Whitwam, T.1    Vanbrocklin, M.W.2    Russo, M.E.3
  • 33
    • 0028178840 scopus 로고
    • Ras mutations in human melanoma: A marker of malignant progression
    • Ball NJ, Yohn JJ, Morelli JG, et al. Ras mutations in human melanoma: a marker of malignant progression. J Invest Dermatol. 1994;102(3):285-290.
    • (1994) J Invest Dermatol , vol.102 , Issue.3 , pp. 285-290
    • Ball, N.J.1    Yohn, J.J.2    Morelli, J.G.3
  • 34
    • 0029199911 scopus 로고
    • Analysis of N-ras mutations in human cutaneous melanoma: Tumor heterogeneity detected by polymerase chain reaction/single-stranded conformation polymorphism analysis
    • van Elsas A, Zerp S, van der Flier S, et al. Analysis of N-ras mutations in human cutaneous melanoma: tumor heterogeneity detected by polymerase chain reaction/single-stranded conformation polymorphism analysis. Recent Results Cancer Res. 1995;139:57-67.
    • (1995) Recent Results Cancer Res , vol.139 , pp. 57-67
    • van Elsas, A.1    Zerp, S.2    van der Flier, S.3
  • 35
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer. 2006;6(3):184-192.
    • (2006) Nat Rev Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 36
    • 21544483506 scopus 로고    scopus 로고
    • Functional and therapeutic signif icance of Akt deregulation in malignant melanoma
    • Robertson GP. Functional and therapeutic signif icance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev. 2005;24(2):273-285.
    • (2005) Cancer Metastasis Rev , vol.24 , Issue.2 , pp. 273-285
    • Robertson, G.P.1
  • 37
    • 4944249733 scopus 로고    scopus 로고
    • Deregulated Akt3 activity promotes development of malignant melanoma
    • Stahl JM, Sharma A, Cheung M, et al. Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res. 2004;64(19): 7002-7010.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7002-7010
    • Stahl, J.M.1    Sharma, A.2    Cheung, M.3
  • 38
    • 0033819340 scopus 로고    scopus 로고
    • Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
    • Zhou XP, Gimm O, Hampel H, et al. Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol. 2000;157(4):1123-1128.
    • (2000) Am J Pathol , vol.157 , Issue.4 , pp. 1123-1128
    • Zhou, X.P.1    Gimm, O.2    Hampel, H.3
  • 39
    • 0034921007 scopus 로고    scopus 로고
    • Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis
    • Yamada KM, Araki M. Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci. 2001;114(Pt 13): 2375-2382.
    • (2001) J Cell Sci , vol.114 , Issue.Pt 13 , pp. 2375-2382
    • Yamada, K.M.1    Araki, M.2
  • 41
    • 0142244844 scopus 로고    scopus 로고
    • PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma
    • Tsao H, Mihm MC Jr, Sheehan C. PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma. J Am A Dermatol. 2003;49(5):865-872.
    • (2003) J Am a Dermatol , vol.49 , Issue.5 , pp. 865-872
    • Tsao, H.1    Mihm Jr., M.C.2    Sheehan, C.3
  • 42
    • 0036568378 scopus 로고    scopus 로고
    • Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
    • Whiteman DC, Zhou XP, Cummings MC, et al. Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer. 2002;99(1):63-67.
    • (2002) Int J Cancer , vol.99 , Issue.1 , pp. 63-67
    • Whiteman, D.C.1    Zhou, X.P.2    Cummings, M.C.3
  • 43
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • Wu H, Goel V, Haluska FG. PTEN signaling pathways in melanoma. Oncogene. 2003;22(20):3113-3122.
    • (2003) Oncogene , vol.22 , Issue.20 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 44
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. New Eng J Med. 2005;353(20):2135-2147.
    • (2005) New Eng J Med , vol.353 , Issue.20 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 45
    • 25844522712 scopus 로고    scopus 로고
    • Expression of activated Akt and PTEN in malignant melanomas: Relationship with clinical outcome
    • Slipicevic A, Holm R, Nguyen MT, et al. Expression of activated Akt and PTEN in malignant melanomas: relationship with clinical outcome. Am J Clin Pathol. 2005;124(4):528-536.
    • (2005) Am J Clin Pathol , vol.124 , Issue.4 , pp. 528-536
    • Slipicevic, A.1    Holm, R.2    Nguyen, M.T.3
  • 46
    • 21344456180 scopus 로고    scopus 로고
    • The RAS/RAF/MEK/ERK and PI3K/ AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma
    • Meier F, Schittek B, Busch S, et al. The RAS/RAF/MEK/ERK and PI3K/ AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci. 2005;10:2986-3001.
    • (2005) Front Biosci , vol.10 , pp. 2986-3001
    • Meier, F.1    Schittek, B.2    Busch, S.3
  • 47
    • 44849096481 scopus 로고    scopus 로고
    • Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development
    • Cheung M, Sharma A, Madhunapantula SV, Robertson GP. Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res. 2008;68(9):3429-3439.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3429-3439
    • Cheung, M.1    Sharma, A.2    Madhunapantula, S.V.3    Robertson, G.P.4
  • 48
    • 0032518262 scopus 로고    scopus 로고
    • MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    • Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature. 1998;391(6664):298-301.
    • (1998) Nature , vol.391 , Issue.6664 , pp. 298-301
    • Hemesath, T.J.1    Price, E.R.2    Takemoto, C.3    Badalian, T.4    Fisher, D.E.5
  • 49
    • 27744551009 scopus 로고    scopus 로고
    • Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor
    • Roskoski R Jr. Structure and regulation of Kit protein-tyrosine kinase - the stem cell factor receptor. Biochem Biophys Res Commun. 2005;338(3):1307-1315.
    • (2005) Biochem Biophys Res Commun , vol.338 , Issue.3 , pp. 1307-1315
    • Roskoski Jr., R.1
  • 50
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147.
    • (2005) N Engl J Med , vol.353 , Issue.20 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 51
    • 58149461573 scopus 로고    scopus 로고
    • Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
    • Ashida A, Takata M, Murata H, Kido K, Saida T. Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas. Int J Cancer. 2009;124(4):862-868.
    • (2009) Int J Cancer , vol.124 , Issue.4 , pp. 862-868
    • Ashida, A.1    Takata, M.2    Murata, H.3    Kido, K.4    Saida, T.5
  • 52
    • 59449085455 scopus 로고    scopus 로고
    • Imatinib targeting of KIT-mutant oncoprotein in melanoma
    • Jiang X, Zhou J, Yuen NK, et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res. 2008;14(23):7726-7732.
    • (2008) Clin Cancer Res , vol.14 , Issue.23 , pp. 7726-7732
    • Jiang, X.1    Zhou, J.2    Yuen, N.K.3
  • 53
    • 77949406203 scopus 로고    scopus 로고
    • Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
    • Handolias D, Salemi R, Murray W, et al. Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. Pigment Cell Melanoma Res. 2010;23(2):210-215.
    • (2010) Pigment Cell Melanoma Res , vol.23 , Issue.2 , pp. 210-215
    • Handolias, D.1    Salemi, R.2    Murray, W.3
  • 54
    • 79953324920 scopus 로고    scopus 로고
    • Large-scale analysis of KIT aberrations in Chinese patients with melanoma
    • Kong Y, Si L, Zhu Y, et al. Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin Cancer Res. 2011;17(7): 1684-1691.
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1684-1691
    • Kong, Y.1    Si, L.2    Zhu, Y.3
  • 55
    • 79955965083 scopus 로고    scopus 로고
    • KIT amplification and gene mutations in acral/mucosal melanoma in Korea
    • Yun J, Lee J, Jang J, et al. KIT amplification and gene mutations in acral/mucosal melanoma in Korea. APMIS. 2011;119(6):330-335.
    • (2011) APMIS , vol.119 , Issue.6 , pp. 330-335
    • Yun, J.1    Lee, J.2    Jang, J.3
  • 56
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363(9): 809-819.
    • (2010) N Engl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 57
    • 79952003197 scopus 로고    scopus 로고
    • RAF inhibition and induction of cutaneous squamous cell carcinoma
    • Robert C, Arnault JP, Mateus C. RAF inhibition and induction of cutaneous squamous cell carcinoma. Cur Opin Oncol. 2011;23(2):177-182.
    • (2011) Cur Opin Oncol , vol.23 , Issue.2 , pp. 177-182
    • Robert, C.1    Arnault, J.P.2    Mateus, C.3
  • 58
    • 68949094219 scopus 로고    scopus 로고
    • Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib
    • Arnault JP, Wechsler J, Escudier B, et al. Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib. J Clin Oncol. 2009;27(23):e59-e61.
    • (2009) J Clin Oncol , vol.27 , Issue.23
    • Arnault, J.P.1    Wechsler, J.2    Escudier, B.3
  • 59
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell. 2010;140(2):209-221.
    • (2010) Cell , vol.140 , Issue.2 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3
  • 60
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I, et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature. 2010;464(7287):431-435.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 61
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010;464(7287):427-430.
    • (2010) Nature , vol.464 , Issue.7287 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 62
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen CM, Boehm JS, Kim SY, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468(7326):968-972.
    • (2010) Nature , vol.468 , Issue.7326 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2    Kim, S.Y.3
  • 63
    • 79953325104 scopus 로고    scopus 로고
    • PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
    • Paraiso KH, Xiang Y, Rebecca VW, et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res. 2011;71(7):2750-2760.
    • (2011) Cancer Res , vol.71 , Issue.7 , pp. 2750-2760
    • Paraiso, K.H.1    Xiang, Y.2    Rebecca, V.W.3
  • 64
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468(7326):973-977.
    • (2010) Nature , vol.468 , Issue.7326 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3
  • 65
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010;18(6):683-695.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2    Lee, J.T.3
  • 66
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle N, Emery C, Berger MF, et al. Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol. 2011;29(22):3085-3096.
    • (2011) J Clin Oncol , vol.29 , Issue.22 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2    Berger, M.F.3
  • 67
    • 80052358465 scopus 로고    scopus 로고
    • Treatment implications of the emerging molecular classification system for melanoma
    • Romano E, Schwartz GK, Chapman PB, Wolchock JD, Carvajal RD. Treatment implications of the emerging molecular classification system for melanoma. Lancet Oncol. 2011;12(9):913-922.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 913-922
    • Romano, E.1    Schwartz, G.K.2    Chapman, P.B.3    Wolchock, J.D.4    Carvajal, R.D.5
  • 68
    • 77957350123 scopus 로고    scopus 로고
    • Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors [abstract]
    • Kefford R, Arkenau H, Brown MP, et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors [abstract]. ASCO Annual Meeting. 2010:8503.
    • (2010) ASCO Annual Meeting , pp. 8503
    • Kefford, R.1    Arkenau, H.2    Brown, M.P.3
  • 69
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Research. 2004;64(19):7099-7109.
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 70
    • 33744513575 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
    • Adnane L, Trail PA, Taylor I, Wilhelm SM. Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol. 2006;407:597-612.
    • (2006) Methods Enzymol , vol.407 , pp. 597-612
    • Adnane, L.1    Trail, P.A.2    Taylor, I.3    Wilhelm, S.M.4
  • 71
    • 13144281830 scopus 로고    scopus 로고
    • BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience [abstract]
    • Ahmad T, Marais R, Pyle L, et al. BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience [abstract]. ASCO Annual Meeting. 2004:7506.
    • (2004) ASCO Annual Meeting , pp. 7506
    • Ahmad, T.1    Marais, R.2    Pyle, L.3
  • 72
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis
    • Eisen T, Ahmad T, Flaherty KT, et al. Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer. 2006;95(5):581-586.
    • (2006) Br J Cancer , vol.95 , Issue.5 , pp. 581-586
    • Eisen, T.1    Ahmad, T.2    Flaherty, K.T.3
  • 73
    • 16844376769 scopus 로고    scopus 로고
    • Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma [abstract]
    • Flaherty K, Brose M, Schuchter L, et al. Phase I/II trial of BAY 43-9006, carboplatin (C) and paclitaxel (P) demonstrates preliminary antitumor activity in the expansion cohort of patients with metastatic melanoma [abstract]. ASCO Annual Meeting. 2004:7507.
    • (2004) ASCO Annual Meeting , pp. 7507
    • Flaherty, K.1    Brose, M.2    Schuchter, L.3
  • 74
    • 77956033802 scopus 로고    scopus 로고
    • Final results of E2603: A double-blind, randomized phase III trial comparing carboplatin (C)/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma [abstract]
    • Flaherty KT, Lee SJ, Schuchter LM, et al. Final results of E2603: A double-blind, randomized phase III trial comparing carboplatin (C)/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma [abstract]. ASCO Annual Meeting. 2010:8511.
    • (2010) ASCO Annual Meeting , pp. 8511
    • Flaherty, K.T.1    Lee, S.J.2    Schuchter, L.M.3
  • 75
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol. 2009;27(17):2823-2830.
    • (2009) J Clin Oncol , vol.27 , Issue.17 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 76
    • 80052539696 scopus 로고    scopus 로고
    • Results from the first-inhuman (FIH) phase I study of the oral RAF inhibitor RAF265 administered daily to patients with advanced cutaneous melanoma [abstract]
    • Sharfman WH, Hodi FS, Lawrence DP, et al. Results from the first-inhuman (FIH) phase I study of the oral RAF inhibitor RAF265 administered daily to patients with advanced cutaneous melanoma [abstract]. ASCO Annual Meeting. 2011:8508.
    • (2011) ASCO Annual Meeting , pp. 8508
    • Sharfman, W.H.1    Hodi, F.S.2    Lawrence, D.P.3
  • 77
    • 31144453233 scopus 로고    scopus 로고
    • BRAF mutation predicts sensitivity to MEK inhibition
    • Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature. 2006;439(7074):358-362.
    • (2006) Nature , vol.439 , Issue.7074 , pp. 358-362
    • Solit, D.B.1    Garraway, L.A.2    Pratilas, C.A.3
  • 78
    • 77949766280 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers
    • LoRusso PM, Krishnamurthi SS, Rinehart JJ, et al. Phase I pharmacokinetic and pharmacodynamic study of the oral MAPK/ERK kinase inhibitor PD-0325901 in patients with advanced cancers. Clin Cancer Res. 2010;16(6):1924-1937.
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1924-1937
    • Lorusso, P.M.1    Krishnamurthi, S.S.2    Rinehart, J.J.3
  • 79
    • 79960921963 scopus 로고    scopus 로고
    • Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer
    • Boasberg PD, Redfern CH, Daniels GA, et al. Pilot study of PD-0325901 in previously treated patients with advanced melanoma, breast cancer, and colon cancer. Cancer Chemother Pharmacol. 2011;68(2):547-552.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.2 , pp. 547-552
    • Boasberg, P.D.1    Redfern, C.H.2    Daniels, G.A.3
  • 80
    • 79952261716 scopus 로고    scopus 로고
    • GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition
    • Gilmartin AG, Bleam MR, Groy A, et al. GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition. Clin Cancer Res. 2011;17(5):989-1000.
    • (2011) Clin Cancer Res , vol.17 , Issue.5 , pp. 989-1000
    • Gilmartin, A.G.1    Bleam, M.R.2    Groy, A.3
  • 81
    • 84861366453 scopus 로고    scopus 로고
    • Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212 [abstract]
    • Infante JR, Fecher LA, Nallapareddy S, et al. Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK1120212 [abstract]. ASCO Annual Meeting. 2010:2503.
    • (2503) ASCO Annual Meeting , pp. 2010
    • Infante, J.R.1    Fecher, L.A.2    Nallapareddy, S.3
  • 82
    • 33947401129 scopus 로고    scopus 로고
    • Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogenactivated protein kinase kinase 1/2 inhibitor
    • Yeh TC, Marsh V, Bernat BA, et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogenactivated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007;13(5):1576-1583.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1576-1583
    • Yeh, T.C.1    Marsh, V.2    Bernat, B.A.3
  • 83
    • 65649108998 scopus 로고    scopus 로고
    • AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study [abstract]
    • Dummer R, Robert C, Chapman PB, et al. AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study [abstract]. ASCO Annual Meeting. 2008:9033.
    • (2008) ASCO Annual Meeting , pp. 9033
    • Dummer, R.1    Robert, C.2    Chapman, P.B.3
  • 84
    • 77950261074 scopus 로고    scopus 로고
    • Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)
    • Dry JR, Pavey S, Pratilas C a, et al. Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Res. 2010;70(6):2264-2273.
    • (2010) Cancer Res , vol.70 , Issue.6 , pp. 2264-2273
    • Dry, J.R.1    Pavey, S.2    Pratilas, C.A.3
  • 85
    • 63149194964 scopus 로고    scopus 로고
    • (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway
    • Pratilas CA, Taylor BS, Ye Q, et al. (V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway. Proc Nat Acad Sci U S A. 2009;106(11):4519-4524.
    • (2009) Proc Nat Acad Sci U S A , vol.106 , Issue.11 , pp. 4519-4524
    • Pratilas, C.A.1    Taylor, B.S.2    Ye, Q.3
  • 86
    • 31544448600 scopus 로고    scopus 로고
    • Phase II study of perifosine in previously untreated patients with metastatic melanoma
    • Ernst DS, Eisenhauer E, Wainman N, et al. Phase II study of perifosine in previously untreated patients with metastatic melanoma. Invest New Drugs. 2005;23(6):569-575.
    • (2005) Invest New Drugs , vol.23 , Issue.6 , pp. 569-575
    • Ernst, D.S.1    Eisenhauer, E.2    Wainman, N.3
  • 87
    • 80054747639 scopus 로고    scopus 로고
    • Safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of the oral AKT inhibitor GSK2141795 (GSK795) in a phase I first-in-human study [abstract]
    • Burris HA, Siu LL, Infante JR, et al. Safety, pharmacokinetics (PK), pharmacodynamics (PD), and clinical activity of the oral AKT inhibitor GSK2141795 (GSK795) in a phase I first-in-human study [abstract]. Asco Annual Meeting. 2011:3003.
    • (2011) Asco Annual Meeting , pp. 3003
    • Burris, H.A.1    Siu, L.L.2    Infante, J.R.3
  • 88
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Nat Acad Sci U S A. 2001;98(18):10314-10319.
    • (2001) Proc Nat Acad Sci U S A , vol.98 , Issue.18 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 89
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000;103(2):253-262.
    • (2000) Cell , vol.103 , Issue.2 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 90
    • 1642535431 scopus 로고    scopus 로고
    • AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
    • Gera JF, Mellinghoff IK, Shi Y, et al. AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Bio Chem. 2004;279(4):2737-2746.
    • (2004) J Bio Chem , vol.279 , Issue.4 , pp. 2737-2746
    • Gera, J.F.1    Mellinghoff, I.K.2    Shi, Y.3
  • 91
    • 23844476134 scopus 로고    scopus 로고
    • CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
    • Margolin K, Longmate J, Baratta T, et al. CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer. 2005;104(5):1045-1048.
    • (2005) Cancer , vol.104 , Issue.5 , pp. 1045-1048
    • Margolin, K.1    Longmate, J.2    Baratta, T.3
  • 92
    • 33750266504 scopus 로고    scopus 로고
    • Phase II trial of the mTOR inhibitor everolimus (RAD-001) in metastatic melanoma [abstract]
    • Rao RD, Windschitl HE, Allred JB, et al. Phase II trial of the mTOR inhibitor everolimus (RAD-001) in metastatic melanoma [abstract]. ASCO Annual Meeting. 2006:8043.
    • (2006) ASCO Annual Meeting , pp. 8043
    • Rao, R.D.1    Windschitl, H.E.2    Allred, J.B.3
  • 94
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methylphenyl)- 2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin- 4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methylphenyl)- 2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin- 4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004;47(27):6658-6661.
    • (2004) J Med Chem , vol.47 , Issue.27 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 95
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344(14):1031-1037.
    • (2001) N Engl J Med , vol.344 , Issue.14 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 96
    • 72549086626 scopus 로고    scopus 로고
    • Dasatinib and chronic myeloid leukemia: Twoyear follow-up in eight clinical trials
    • Pavlů J, Marin D. Dasatinib and chronic myeloid leukemia: twoyear follow-up in eight clinical trials. Clin Lymphoma Myeloma. 2009;9(6):417-424.
    • (2009) Clin Lymphoma Myeloma , vol.9 , Issue.6 , pp. 417-424
    • Pavlů, J.1    Marin, D.2
  • 97
    • 80052383499 scopus 로고    scopus 로고
    • Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
    • Kantarjian HM, Hochhaus A, Saglio G, et al. Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol. 2011;12(9):841-851.
    • (2011) Lancet Oncol , vol.12 , Issue.9 , pp. 841-851
    • Kantarjian, H.M.1    Hochhaus, A.2    Saglio, G.3
  • 98
    • 20844433223 scopus 로고    scopus 로고
    • Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet. 2004;364(9440):1127-1134.
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3
  • 99
    • 34248512697 scopus 로고    scopus 로고
    • Beyond imatinib: Second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors
    • von Mehren M. Beyond imatinib: second generation c-KIT inhibitors for the management of gastrointestinal stromal tumors. Clin Colorectal Cancer. 2006;6 Suppl 1:S30-S34.
    • (2006) Clin Colorectal Cancer , vol.6 , Issue.SUPPL. 1
    • von Mehren, M.1
  • 100
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011;305(22):2327-2334.
    • (2011) JAMA , vol.305 , Issue.22 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 101
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
    • Guo J, Si L, Kong Y, et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol. 2011;29(21):2904-2909.
    • (2011) J Clin Oncol , vol.29 , Issue.21 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3
  • 102
    • 50249141632 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with metastatic melanoma
    • Kim KB, Eton O, Davis DW, et al. Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer. 2008;99(5): 734-740.
    • (2008) Br J Cancer , vol.99 , Issue.5 , pp. 734-740
    • Kim, K.B.1    Eton, O.2    Davis, D.W.3
  • 103
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • Ugurel S, Hildenbrand R, Zimpfer A, et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer. 2005;92(8):1398-1405.
    • (2005) Br J Cancer , vol.92 , Issue.8 , pp. 1398-1405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3
  • 104
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, et al. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer. 2006;106(9):2005-2011.
    • (2006) Cancer , vol.106 , Issue.9 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3
  • 105
    • 79955500900 scopus 로고    scopus 로고
    • A phase 2 trial of dasatinib in advanced melanoma
    • Kluger HM, Dudek AZ, McCann C, et al. A phase 2 trial of dasatinib in advanced melanoma. Cancer. 2011;117(10):2202-2208.
    • (2011) Cancer , vol.117 , Issue.10 , pp. 2202-2208
    • Kluger, H.M.1    Dudek, A.Z.2    McCann, C.3
  • 106
    • 79953896726 scopus 로고    scopus 로고
    • A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607) [abstract]
    • Kalinsky K, Lee SJ, Lawrence DP, Kirkwood JM. A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607) [abstract]. ASCO Annual Meeting. 2010:TPS312.
    • (2010) ASCO Annual Meeting
    • Kalinsky, K.1    Lee, S.J.2    Lawrence, D.P.3    Kirkwood, J.M.4
  • 107
    • 84861366456 scopus 로고    scopus 로고
    • Efficacy of nilotinib in first or second line treatment of primary melanomas stage III unresectable melanomas. (NILOMEL)
    • Assistance Publique - Hôpitaux de Paris, Bethseda, MD: US National Library of Medicine; 2010 [updated February 7, 2011]. Available from, Accessed February 8, 2012
    • Assistance Publique - Hôpitaux de Paris. Efficacy of nilotinib in first or second line treatment of primary melanomas stage III unresectable melanomas. (NILOMEL). In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2010 [updated February 7, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT01168050.NLMidentifier:NCT01168050. Accessed February 8, 2012.
    • ClinicalTrials.gov [website On the Internet]
  • 108
    • 84861386742 scopus 로고    scopus 로고
    • Nilotinib in TKI resistant or intolerant patients with metastatic mucosal, acral, or chronically sun damaged melanoma
    • Dana-Farber Cancer Institute, Bethseda, MD: US National Library of Medicine; 2008 [updated October 27, 2011]. Available from, Accessed February 8, 2012
    • Dana-Farber Cancer Institute. Nilotinib in TKI resistant or intolerant patients with metastatic mucosal, acral, or chronically sun damaged melanoma. In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2008 [updated October 27, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT00788775.NLMidentifier:NCT00788775. Accessed February 8, 2012.
    • ClinicalTrials.gov [website On the Internet]
  • 109
    • 84861355753 scopus 로고    scopus 로고
    • United Kingdom. A trial looking at nilotinib to treat acral and mucosal melanoma skin cancer that has spread (NICAM)
    • Institute of Cancer Research, Bethseda, MD: US National Library of Medicine; 2011 [updated July 14, 2011]. Available from, Accessed February 8, 2012
    • Institute of Cancer Research, United Kingdom. A trial looking at nilotinib to treat acral and mucosal melanoma skin cancer that has spread (NICAM). In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2011 [updated July 14, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT01395121.NLMidentifier:NCT01395121. Accessed February 8, 2012.
    • ClinicalTrials.gov [website On the Internet]
  • 110
    • 84861386743 scopus 로고    scopus 로고
    • A study of AMNN107 in the treatment of metastatic and/or inoperable melanoma harboring a c-Kit mutation (TEAM)
    • Novartis Pharmaceuticals., Bethseda, MD: US National Library of Medicine; 2009 [updated August 11, 2011]. Available from, Accessed February 8, 2012
    • Novartis Pharmaceuticals. A study of AMNN107 in the treatment of metastatic and/or inoperable melanoma harboring a c-Kit mutation (TEAM). In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2009 [updated August 11, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT01028222.NLMidentifier:NCT01028222. Accessed February 8, 2012.
    • ClinicalTrials.gov [website On the Internet]
  • 111
    • 84861366457 scopus 로고    scopus 로고
    • Study of nilotinib in metastatic melanoma with KIT aberrations
    • Samsung Medical Center, Bethseda, MD: US National Library of Medicine; 2010 [updated January 10, 2012]. Available from, Accessed February 8, 2012
    • Samsung Medical Center. Study of nilotinib in metastatic melanoma with KIT aberrations. In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2010 [updated January 10, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01099514.NLMidentifier:NCT01099514. Accessed February 8, 2012.
    • ClinicalTrials.gov [website On the Internet]
  • 112
    • 76649142577 scopus 로고    scopus 로고
    • Phase I/II study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma [abstract]
    • Kim KB, Davies MA, Papadopoulos NE, et al. Phase I/II study of the combination of sorafenib and temsirolimus in patients with metastatic melanoma [abstract]. ASCO Annual Meeting. 2009:9026.
    • (2009) ASCO Annual Meeting , pp. 9026
    • Kim, K.B.1    Davies, M.A.2    Papadopoulos, N.E.3
  • 113
    • 1242273875 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors
    • Sebti SM, Adjei AA. Farnesyltransferase inhibitors. Semin Oncol. 2004;31(1 Suppl 1):S28-S39.
    • (2004) Semin Oncol , vol.31 , Issue.1 SUPPL 1
    • Sebti, S.M.1    Adjei, A.A.2
  • 114
    • 47549092775 scopus 로고    scopus 로고
    • A phase I safety, pharmacological, and biological study of the farnesyl protein transferase inhibitor, lonafarnib (SCH 663366), in combination with cisplatin and gemcitabine in patients with advanced solid tumors
    • Chow LQ, Eckhardt SG, O'Bryant CL, et al. A phase I safety, pharmacological, and biological study of the farnesyl protein transferase inhibitor, lonafarnib (SCH 663366), in combination with cisplatin and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2008;62(4):631-646.
    • (2008) Cancer Chemother Pharmacol , vol.62 , Issue.4 , pp. 631-646
    • Chow, L.Q.1    Eckhardt, S.G.2    O'Bryant, C.L.3
  • 115
    • 33947390695 scopus 로고    scopus 로고
    • Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 [abstract]
    • Gajewski TF, Niedzwiecki D, Johnson J, et al. Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma: CALGB 500104 [abstract]. ASCO Annual Meeting. 2006:8014.
    • (2006) ASCO Annual Meeting , pp. 8014
    • Gajewski, T.F.1    Niedzwiecki, D.2    Johnson, J.3
  • 116
    • 0000409316 scopus 로고    scopus 로고
    • Phase I study of continuous oral lonafarnib plus weekly paclitaxel for advanced cancer [abstract]
    • Lipton A, Ready N, Bukowski RM, et al. Phase I study of continuous oral lonafarnib plus weekly paclitaxel for advanced cancer [abstract]. ASCO Annual Meeting. 2002:364.
    • (2002) ASCO Annual Meeting , pp. 364
    • Lipton, A.1    Ready, N.2    Bukowski, R.M.3
  • 117
    • 18544412314 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer
    • Zujewski J, Horak ID, Bol CJ, et al. Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol. 2000;18(4):927-941.
    • (2000) J Clin Oncol , vol.18 , Issue.4 , pp. 927-941
    • Zujewski, J.1    Horak, I.D.2    Bol, C.J.3
  • 118
    • 72549092909 scopus 로고    scopus 로고
    • Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
    • Hong DS, Sebti SM, Newman RA, et al. Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res. 2009;15(22):7061-7068.
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 7061-7068
    • Hong, D.S.1    Sebti, S.M.2    Newman, R.A.3
  • 119
    • 79956023748 scopus 로고    scopus 로고
    • Randomized phase II trial of sorafenib (SO) with temsirolimus (TEM) or tipifarnib (TIPI) in metastatic melanoma: Southwest Oncology Group Trial S0438 [abstract]
    • Margolin KA, Moon J, Flaherty LE, et al. Randomized phase II trial of sorafenib (SO) with temsirolimus (TEM) or tipifarnib (TIPI) in metastatic melanoma: Southwest Oncology Group Trial S0438 [abstract]. ASCO Annual Meeting. 2010:8502.
    • (2010) ASCO Annual Meeting , pp. 8502
    • Margolin, K.A.1    Moon, J.2    Flaherty, L.E.3
  • 120
    • 0035863552 scopus 로고    scopus 로고
    • Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival
    • Ugurel S, Rappl G, Tilgen W, Reinhold U. Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival. J Clin Oncol. 2001;19(2):577-583.
    • (2001) J Clin Oncol , vol.19 , Issue.2 , pp. 577-583
    • Ugurel, S.1    Rappl, G.2    Tilgen, W.3    Reinhold, U.4
  • 121
    • 77952301116 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma
    • Hainsworth JD, Spigel DR, Burris 3rd HA, et al. Phase II trial of bevacizumab and everolimus in patients with advanced renal cell carcinoma. J Clin Oncol. 2010;28(13):2131-2136.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2131-2136
    • Hainsworth, J.D.1    Spigel, D.R.2    Burris, H.A.3
  • 122
    • 77956839364 scopus 로고    scopus 로고
    • Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: A phase 2 trial of the Sarah Cannon Oncology Research Consortium
    • Hainsworth JD, Infante JR, Spigel DR, et al. Bevacizumab and everolimus in the treatment of patients with metastatic melanoma: a phase 2 trial of the Sarah Cannon Oncology Research Consortium. Cancer. 2010;116(17):4122-4129.
    • (2010) Cancer , vol.116 , Issue.17 , pp. 4122-4129
    • Hainsworth, J.D.1    Infante, J.R.2    Spigel, D.R.3
  • 123
    • 80052544390 scopus 로고    scopus 로고
    • A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma [abstract]
    • Hodi FS, Friedlander PA, Atkins MB, et al. A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma [abstract]. ASCO Annual Meeting. 2011:8511.
    • (2011) ASCO Annual Meeting , pp. 8511
    • Hodi, F.S.1    Friedlander, P.A.2    Atkins, M.B.3
  • 124
    • 78650385895 scopus 로고    scopus 로고
    • Active immunotherapy induces antibody responses that target tumor angiogenesis
    • Schoenfeld J, Jinushi M, Nakazaki Y, et al. Active immunotherapy induces antibody responses that target tumor angiogenesis. Cancer Res. 2010;70(24):10150-10160.
    • (2010) Cancer Res , vol.70 , Issue.24 , pp. 10150-10160
    • Schoenfeld, J.1    Jinushi, M.2    Nakazaki, Y.3
  • 125
    • 80053154225 scopus 로고    scopus 로고
    • Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436) [abstract]
    • Infante JR, Falchook GS, Lawrence DP, et al. Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436) [abstract]. ASCO Annual Meeting. 2011:CRA8503.
    • (2011) ASCO Annual Meeting
    • Infante, J.R.1    Falchook, G.S.2    Lawrence, D.P.3
  • 126
    • 55949137090 scopus 로고    scopus 로고
    • Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma [abstract]
    • Ribas A, Hauschild A, Kefford R, et al. Phase III, open-label, randomized, comparative study of tremelimumab (CP-675,206) and chemotherapy (temozolomide [TMZ] or dacarbazine [DTIC]) in patients with advanced melanoma [abstract]. ASCO Annual Meeting. 2008:LBA9011.
    • (2008) ASCO Annual Meeting
    • Ribas, A.1    Hauschild, A.2    Kefford, R.3
  • 127
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of singleagent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of singleagent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(19):3167-3175.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 128
    • 55949113750 scopus 로고    scopus 로고
    • Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA) [absract]
    • Sznol M, Hodi FS, Margolin K, et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA) [absract]. ASCO Annual Meeting. 2008:3007.
    • (2008) ASCO Annual Meeting , pp. 3007
    • Sznol, M.1    Hodi, F.S.2    Margolin, K.3
  • 129
    • 65649129679 scopus 로고    scopus 로고
    • Immunization with recombinant MAGE-A3 protein combined with adjuvant systems AS15 or AS02B in patients with unresectable and progressive metastatic cutaneous melanoma: A randomized open-label phase II study of the EORTC Melanoma Group (16032-18031) [abstract]
    • Kruit WH, Suciu S, Dreno B, et al. Immunization with recombinant MAGE-A3 protein combined with adjuvant systems AS15 or AS02B in patients with unresectable and progressive metastatic cutaneous melanoma: A randomized open-label phase II study of the EORTC Melanoma Group (16032-18031) [abstract]. ASCO Annual Meeting. 2008:9065.
    • (2008) ASCO Annual Meeting , pp. 9065
    • Kruit, W.H.1    Suciu, S.2    Dreno, B.3
  • 130
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 2011;364(22):2119-2127.
    • (2011) N Engl J Med , vol.364 , Issue.22 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 131
    • 73349133717 scopus 로고    scopus 로고
    • Phase II clinical trial of a granulocyte-macrophage colony-stimulating factorencoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma
    • Senzer NN, Kaufman HL, Amatruda T, et al. Phase II clinical trial of a granulocyte-macrophage colony-stimulating factorencoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma. J Clin Oncol. 2009;27(34): 5763-5771.
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5763-5771
    • Senzer, N.N.1    Kaufman, H.L.2    Amatruda, T.3
  • 132
    • 77149141965 scopus 로고    scopus 로고
    • Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma
    • Kaufman HL, Kim DW, DeRaffele G, et al. Local and distant immunity induced by intralesional vaccination with an oncolytic herpes virus encoding GM-CSF in patients with stage IIIc and IV melanoma. Ann Surg Oncol. 2010;17(3):718-730.
    • (2010) Ann Surg Oncol , vol.17 , Issue.3 , pp. 718-730
    • Kaufman, H.L.1    Kim, D.W.2    Deraffele, G.3
  • 133
    • 34250168681 scopus 로고    scopus 로고
    • Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
    • Escudier B, Lassau N, Angevin E, et al. Phase I trial of sorafenib in combination with IFN alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res. 2007;13(6):1801-1809.
    • (2007) Clin Cancer Res , vol.13 , Issue.6 , pp. 1801-1809
    • Escudier, B.1    Lassau, N.2    Angevin, E.3
  • 134
    • 79959736969 scopus 로고    scopus 로고
    • Sorafenib and pegylated interferon-alpha-2b in advanced metastatic melanoma: A multicenter phase II DeCOG trial
    • Hauschild A, Gutzmer R, Ugurel S, et al. Sorafenib and pegylated interferon-alpha-2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial. Ann Oncol. 2011;22(7):1667-1674.
    • (2011) Ann Oncol , vol.22 , Issue.7 , pp. 1667-1674
    • Hauschild, A.1    Gutzmer, R.2    Ugurel, S.3
  • 135
    • 43749110700 scopus 로고    scopus 로고
    • Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
    • McDermott DF, Sosman JA, Gonzalez R, et al. Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol. 2008;26(13):2178-2185.
    • (2008) J Clin Oncol , vol.26 , Issue.13 , pp. 2178-2185
    • McDermott, D.F.1    Sosman, J.A.2    Gonzalez, R.3
  • 136
    • 36849079626 scopus 로고    scopus 로고
    • An open-label phase II study of sorafenib and dacarbazine as first-line therapy in patients with advanced melanoma [abstract]
    • Eisen T, Marais R, Affolter A, et al. An open-label phase II study of sorafenib and dacarbazine as first-line therapy in patients with advanced melanoma [abstract]. ASCO Annual Meeting. 2007:8529.
    • (2007) ASCO Annual Meeting , pp. 8529
    • Eisen, T.1    Marais, R.2    Affolter, A.3


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