Evaluation of spontaneous DNA damage in lymphocytes of healthy adult individuals from high-level natural radiation areas of Kerala in India

Radiation Research

Volumn 177, Issue 5, 2012, Pages 643-650

  Kumar, P R Vivek ^a   Cheriyan, V D ^a   Seshadri, M ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE DNA GLYCOSYLASE1; ALKALI; DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; ENDONUCLEASE III; UNCLASSIFIED DRUG;

ADULT; AGE; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMOGRAPHY; DNA DAMAGE; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INDIA; LYMPHOCYTE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SENSITIVITY AND SPECIFICITY; SMOKING HABIT;

ADULT; BACKGROUND RADIATION; COMET ASSAY; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; INDIA; LYMPHOCYTES; MALE; OXIDATION-REDUCTION; SMOKING; THORIUM;

EID: 84861380702     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2681.1     Document Type: Article

References (50)

1. Effect of radiation on human heredity: Investigations of areas of high natural radiation. WHO Technical Report Series No. 166. Geneva: World Health Organization; 1959.
2. Thampi MV, Cheriyan VD, Jaikrishan G, Das B, Kurien CJ, Ramachandran EN, et al. Investigations on the health effects of human population residing in the high level natural radiation areas in Kerala in the southwest coast of India. Int Congress Ser 2005; 1276:8-12. (Pubitemid 43693320)
3. Jayakrishan G, Andrews VJ, Thampi V, Koya PKM, Rajan VK, Chauhan PS. Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. I. Prevalence of congenital malformations in newborns. Radiat Res 1999; 152 Suppl:S149-53.
4. Cheriyan VD, Kurien CJ, Das B, Ramachandran EN, Karuppasamy CV, Thampi MV, et al. Genetic monitoring of the human population from high-level natural radiation areas of Kerala on the southwest coast of India. II. Incidence of numerical and structural chromosome aberrations in the lymphocytes of newborns. Radiat Res 1999; 152 Suppl:S154-8.
5. Das BL, Karuppasamy CV. Spontaneous frequency of micronuclei among the newborns from high level natural radiation areas of Kerala in the southwest coast of India. Int J Radiat Biol 2009; 85:272-80.
6. Forster L, Forster P, Lutz-Bonengel S, Willkomm H, Brinkmann B. Natural radioactivity and human mitochondrial DNA mutations. Proc Natl Acad Sci USA 2002; 99:13950-4. (Pubitemid 35215486)
7. Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000; 35:206-21. (Pubitemid 30196665)
8. Fairbairn DW, Olive PL, O'Neill KL. The comet assay: a comprehensive review. Mutat Res 1995; 339:37-59.
9. Mohammadi S, Taghavi-Dehaghani M, Gharaati MR, Masoomi R, Ghiassi-Nejad M. Adaptive response of blood lymphocytes of inhabitants residing in high background radiation areas of Ramsar-micronuclei, apoptosis and comet assay. J Radiat Res 2006; 47:279-85.
10. Wojewodzka M, Kruszewski M, Iwanenko T, Collins AR, Szumiel I. Application of the comet assay for monitoring DNA damage in workers exposed to chronic low dose irradiation. I. Strand breakage. Mutat Res 1998; 416:21-35. (Pubitemid 28398844)
11. Masoomi JR, Mohammadi S, Amini M, Ghiassi-Nejad M. High background radiation areas of Ramsar in Iran: evaluation of DNA damage by alkaline single cell gel electrophoresis (SCGE). J Environ Radioact 2006; 86:176-86. (Pubitemid 41821332)
12. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175:184-91.
13. Smith CC, O'Donovan MR, Martin EA. hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDO III. Mutagenesis 2006; 21:185-90. (Pubitemid 43882069)
14. Collins AR, Dusinska M, Gedik CM, Stetina R. Oxidative damage to DNA: Do we have a reliable biomarker? Environ Health Perspect 1996; 104:465-9. (Pubitemid 26197677)
15. Gedik CM, Collins A. ESCODD (European Standards Committee on Oxidative DNA Damage). Establishing the background level of base oxidation in human lymphocyte DNA: results of an inter laboratory validation study. FASEB J 2005; 19:82-4. (Pubitemid 40069925)
16. Nair RRK, Akiba S, Binu VS, Jayalekshmi P, Gangadharan P, Nair MK, et al. Individual dose estimation\our experience with the Karunagapally study in Kerala, India. Int Congress Ser 2005; 1276:41-45. (Pubitemid 43693238)
17. United Nations Scientific Committee on the Effects of Atomic Radiation. 2000 Report to the General Assembly with scientific annexes. Vol I. Annex B: Exposures from natural radiation sources. New York: United Nations; 2000.
18. Konca K, Lankoff A, Banasik A, Lisowska H, Kuszewski T, Gozdz S, et al. A cross-platform public domain PC image-analysis program for the comet assay. Mutat Res 2003; 534:15-20. (Pubitemid 36015835)
19. Valverde M, Rojas E. Environmental and occupational biomon-itoring using the comet assay. Mutat Res 2009; 681:93-109.
20. Jiang T, Hayata I, Wang C, Nakai S, Yao S, Yuan Y, et al. Dose-effect relationship of dicentric and ring chromosomes in lymphocytes of individuals living in the high background radiation areas in China. J Radiat Res 2000; 41 Suppl:63-8.
21. Hayata I, Wang C, Zhang W, Chen D, Minamihisamastu M, Morishima H, et al. Chromosome translocations in residents of the high background radiation areas in southern China. J Radiat Res 2000; 41 Suppl:69-74.
22. Kruszewski M, Wojewodzka M, Iwanenko T, Collins AR, Szumiel I. Application of the comet assay for monitoring DNA damage in workers exposed to chronic low dose irradiation. II. Base damage. Mutat Res 1998; 416:37-57. (Pubitemid 28398845)
23. Tates AD, van Dam FJ, van Mossel H, Schoemaker H, Thijssen JCP, Woldring VM, et al. Use of the clonal assay for the measurement of HPRT mutants in T-lymphocytes from five control populations. Mutat Res 1991; 253:199-213.
24. Kumar PRV, Hamza V Z, Mohankumar MN, Jeevanram RK. Studies on the HPRT mutant frequency in T lymphocytes from healthy Indian male population as a function of age and smoking. Mutat Res 2004; 556:107-16. (Pubitemid 39371183)
25. Jones IM, Galick H, Kato P, Langlois RG, Mendelsohn ML, Murphy GA, et al. Three somatic genetic biomarkers and covariates in radiation-exposed Russian cleanup workers of the Chernobyl nuclear reactor 6-13 years after exposure. Radiat Res 2002; 158:424-42.
26. Aaron CS, Zimmer DM, Harbach PR, Yu RL. Endpoints for biomonitoring: assay sensitivity/selectivity. Environ Health Per-spect 1996; 104:521-5.
27. Singh NP, Stephens RE, Schneider EL. Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int J Radiat Biol 1994; 66:23-8. (Pubitemid 24231348)
28. Bajpayee M, Dhawan A, Parmar D, Pandey AK, Mathur N, Seth PK. Gender-related differences in basal DNA damage in lymphocytes of a healthy Indian population using the alkaline comet assay. Mutat Res 2002; 520:83-91. (Pubitemid 35247576)
29. Moller P. Assessment of reference values for DNA damage detected by the comet assay in human blood cell DNA. Mutat Res 2006; 612:84-104. (Pubitemid 43222095)
30. Kopjar N, Zeljzic D, Garaj-Vrhovac V. Evaluation of DNA damage in white blood cells of healthy human volunteers using the alkaline comet assay and the chromosome aberration test. Acta Biochem Pol 2006; 53:321-36. (Pubitemid 44033931)
31. Dusinska M, Dzupinkova Z, Wsolova L, Harrington V, Collins AR. Possible involvement of XPA in repair of oxidative DNA damage deduced from analysis of damage, repair and genotype in a human population study. Mutagenesis 2006; 21:205-11. (Pubitemid 43882071)
32. Nakayama T, Kodama M, Nagata C. Generation of hydrogen peroxide and superoxide anion radical from cigarette smoke. Gann 1984; 75:95-8. (Pubitemid 14155193)
33. Cosgrove JP, Borish ET, Church DF, Pryor WA. The metal mediated formation of hydroxyl radicals by aqueous extracts of cigarette tar. Biochem Biophys Res Commun 1985; 132:390-6. (Pubitemid 16196157)
34. Rojas E, Valverde M, Sordo M, Ostrosky-Wegman P. DNA damage in exfoliated buccal cells of smokers assed by the single cell gel electrophoresis assay. Mutat Res 1996; 370:115-20. (Pubitemid 26343822)
35. Piperakis SM, Visvardis EE, Sagnou M, Tassiou AM. Effects of smoking and ageing on oxidative DNA damage of human lymphocytes. Carcinogenesis 1998; 19:695-8. (Pubitemid 28376817)
36. Wei Q, Cheng L, Hong WK, Spitz MR. Reduced DNA repair capacity in lung cancer patients. Cancer Res 1996; 56:4103-7. (Pubitemid 26304997)
37. Zhu CQ, Lam TH, Jiang CQ, Wei BX, Lou X, Liu WW, et al. Lymphocyte DNA damage in cigarette factory workers measured by the comet assay. Mutat Res 1999; 444:1-6. (Pubitemid 29341519)
38. Wojewodzka M, Kruszewski M, Iwanenko T, Collins AR, Szumiel I. Lack of adverse effect of smoking habit on DNA strand breakage and base damage, as revealed by the alkaline comet assay. Mutat Res 1999; 440:19-25. (Pubitemid 29129523)
39. Pitarque M, Creus A, Marcos R, Hughes JA, Anderson D. Examination of various biomarkers measuring genotoxic endpoints from Barcelona airport personnel. Mutat Res 1999; 440:195-204. (Pubitemid 29168567)
40. Andreoli C, Leopardi P, Crebelli R. Detection of DNA damage in human lymphocytes by alkaline single cell gel electrophoresis after exposure to benzene or benzene metabolites. Mutat Res 1997; 377:95-104. (Pubitemid 27264922)
41. Speit G, Witton-Davies T, Heepchantree W, Trenz K, Hoffmann H. Investigations on the cigarette smoking in the comet assay. Mutat Res 2003; 542: 33-42. (Pubitemid 37486095)
42. Moller P, Knudsen LE, Loft S, Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 2000; 9:1005-15.
43. Faust F, Kassie F, Knasmuller S, Boedecker RH, Mann M, Mersch-Sundermann V. The use of the alkaline comet assay with lymphocytes in human biomonitoring studies. Mutat Res 2004; 566:209-29. (Pubitemid 38472028)
44. Collins AR, Dobson VL, Dusinska M, Kennedy G, Stetina R. The comet assay: what can it really tell us? Mutat Res 1997; 375:183-93. (Pubitemid 27226696)
45. Lee HC, Lim MLR, Lu CY, Liu VWS, Fahn HJ, Zhang C, et al. Conactive increase of oxidative DNA damage and lipid peroxida-tion together with mitochondrial DNA mutation in human lung tissues during aging\smoking enhances oxidative stress on the aged tissues. Arch Biochem Biophys 1999; 362:309-16. (Pubitemid 29394360)
46. Nia AB, Van Schooten FJ, Schilderman PAEL, De Kok TMCM, Haenen GR, Van Herwijnen MHM, et al. A multi-biomarker approach to study the effects of smoking on oxidative DNA damage and repair and antioxidative defense mechanisms. Carcinogenesis 2001; 21:395-401. (Pubitemid 32203817)
47. Moller P. The alkaline comet assay: towards validation in biomonitoring of DNA damaging exposures. Basic Clin Pharmacol Toxicol 2006; 98:336-45.
48. Dusinska M, Collins AR. The comet assay in human biomonitor-ing: gene-environment interactions. Mutagenesis 2008; 23:191-205.
49. Somorovska M, Szabova E, Vodicka P, Tulinska J, Barancokova M, Fabry R, et al. Biomonitoring of genotoxic risk in workers in a rubber factory: comparison of the comet assay with cytogenetic methods and immunology. Mutat Res 1999; 445:181-92. (Pubitemid 29518329)
50. Russo GL, Tedesco I, Russo M, Cioppa A, Andressi MG, Picano E. Cellular adaptive response to chronic radiation exposure in interventional cardiologists. Eur Heart J 2011 Aug 23. doi:10. 1093/eurheartj/ehr263. Epub ahead of print.